{"id":"https://openalex.org/W4385685662","doi":"https://doi.org/10.4049/jimmunol.210.supp.63.14","title":"RGC-32 facilitates reactive astrocytosis by modulating the expression of axonal guidance molecules","display_name":"RGC-32 facilitates reactive astrocytosis by modulating the expression of axonal guidance molecules","publication_year":2023,"publication_date":"2023-05-01","ids":{"openalex":"https://openalex.org/W4385685662","doi":"https://doi.org/10.4049/jimmunol.210.supp.63.14"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.210.supp.63.14","doi":"https://doi.org/10.4049/jimmunol.210.supp.63.14","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.63.14","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/63.14/1634236/63_14.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/63.14/1634236/63_14.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024891879","display_name":"Horea Rus","orcid":"https://orcid.org/0000-0003-2415-5130","observed_orcids":["https://orcid.org/0000-0003-2415-5130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Horea G Rus","raw_affiliation_strings":["Univesity of Maryland, School of Medicine","1Univesity of Maryland, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univesity of Maryland, School of Medicine","institution_ids":[]},{"raw_affiliation_string":"1Univesity of Maryland, School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077179478","display_name":"Alexandru Tatomir","orcid":"https://orcid.org/0000-0003-2674-3278","observed_orcids":["https://orcid.org/0000-0003-2674-3278"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandru Tatomir","raw_affiliation_strings":["University of Maryland, School of Medicine","2University of Maryland, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, School of Medicine","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"2University of Maryland, School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073392961","display_name":"Jacob Cuevas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob Cuevas","raw_affiliation_strings":["University of Maryland, School of Medicine","2University of Maryland, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, School of Medicine","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"2University of Maryland, School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070794279","display_name":"Vinh Q Nguyen","orcid":"https://orcid.org/0000-0001-9564-9037","observed_orcids":["https://orcid.org/0000-0001-9564-9037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinh Nguyen","raw_affiliation_strings":["University of Maryland. School of Medicine","3University of Maryland. School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland. School of Medicine","institution_ids":[]},{"raw_affiliation_string":"3University of Maryland. School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063791039","display_name":"Cornelia Diana Cudrici","orcid":"https://orcid.org/0000-0002-9077-8195","observed_orcids":["https://orcid.org/0000-0002-9077-8195"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210106489","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cornelia Cudrici","raw_affiliation_strings":["NHLBI, NIH","4NHLBI, NIH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NHLBI, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]},{"raw_affiliation_string":"4NHLBI, NIH","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210106489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039973533","display_name":"Tudor C. Badea","orcid":"https://orcid.org/0000-0003-3086-6713","observed_orcids":["https://orcid.org/0000-0003-3086-6713"]},"institutions":[{"id":"https://openalex.org/I78641905","display_name":"Transylvania University","ror":"https://ror.org/01h4hqc60","country_code":"US","type":"education","lineage":["https://openalex.org/I78641905"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tudor Badea","raw_affiliation_strings":["Transylvania University","5Transylvania University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transylvania University","institution_ids":["https://openalex.org/I78641905"]},{"raw_affiliation_string":"5Transylvania University","institution_ids":["https://openalex.org/I78641905"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111541015","display_name":"Violeta Rus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Violeta Rus","raw_affiliation_strings":["University of Maryland, School of Medicine","2University of Maryland, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland, School of Medicine","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"2University of Maryland, School of Medicine","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"Supplement_1","first_page":"63.14","last_page":"63.14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.7217000126838684,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.12389999628067017,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rgc-32","display_name":"RGC-32","score":0.9869999885559082},{"id":"https://openalex.org/keywords/reactive-astrogliosis","display_name":"reactive astrogliosis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7360000014305115},{"id":"https://openalex.org/keywords/nfia","display_name":"NFIA","score":0.8960000276565552},{"id":"https://openalex.org/keywords/epha7","display_name":"EphA7","score":0.890999972820282},{"id":"https://openalex.org/keywords/plexin-a1","display_name":"PLXNA1","score":0.9620000123977661},{"id":"https://openalex.org/keywords/slit2","display_name":"Slit2","score":0.8339999914169312},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.7049999833106995},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.5249999761581421},{"id":"https://openalex.org/keywords/gliogenesis","display_name":"gliogenesis","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.704739511013031},{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.6879504919052124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6375448703765869},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.590221107006073},{"id":"https://openalex.org/C2777594495","wikidata":"https://www.wikidata.org/wiki/Q5569540","display_name":"Glial scar","level":4,"score":0.5096893310546875},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4903695583343506},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48972585797309875},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.45048758387565613},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3990720212459564},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.39329490065574646},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39288991689682007},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2351018786430359},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21680688858032227},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.20047253370285034},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.18100956082344055},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.14837247133255005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08722618222236633}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4049/jimmunol.210.supp.63.14","doi":"https://doi.org/10.4049/jimmunol.210.supp.63.14","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.63.14","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/63.14/1634236/63_14.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.210.supp.63.14","doi":"https://doi.org/10.4049/jimmunol.210.supp.63.14","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.210.supp.63.14","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/210/1_Supplement/63.14/1634236/63_14.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385685662.pdf","grobid_xml":"https://content.openalex.org/works/W4385685662.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4320061554","https://openalex.org/W3186164808","https://openalex.org/W3123740447","https://openalex.org/W2883512314","https://openalex.org/W4416448515","https://openalex.org/W4313373675","https://openalex.org/W4313359077","https://openalex.org/W1598978392","https://openalex.org/W2048700419","https://openalex.org/W309066248"],"abstract_inverted_index":{"Abstract":[0],"Response":[1],"Gene":[2],"to":[3,16],"Complement":[4],"(RGC)-32":[5],"modulates":[6],"TGF-\u03b2-induced":[7],"extracellular":[8],"matrix":[9],"secretion":[10],"and":[11,52,78,101,110,122,131,185,200,217,249],"the":[12,28,49,53,117,144,245],"ability":[13],"of":[14,46,55,134,137,176,213,247],"astrocytes":[15,61,72,205,214],"undergo":[17],"reactive":[18,158,238],"changes":[19],"in":[20,60,157,190,219],"vivo":[21],"during":[22,62,206,240],"experimental":[23],"autoimmune":[24],"encephalomyelitis":[25],"(EAE).":[26],"However,":[27],"molecular":[29],"pathways":[30],"underlying":[31],"these":[32],"effects":[33],"are":[34,202],"still":[35],"not":[36],"well":[37],"understood.":[38],"In":[39],"this":[40],"study,":[41],"we":[42],"investigated":[43],"how":[44],"lack":[45],"RGC-32":[47,79,102,138,191,220,235],"affects":[48],"transcriptomic":[50,145],"profile":[51],"expression":[54,246],"axonal":[56],"guidance":[57,187],"molecules":[58],"(AGM)":[59],"EAE.":[63,207],"We":[64,171,208],"performed":[65],"next-generation":[66],"RNA":[67],"sequencing":[68],"on":[69,143],"brain":[70,150],"neonatal":[71],"isolated":[73],"from":[74,99],"wild":[75],"type":[76,180],"(WT)":[77],"knock-out":[80],"(KO)":[81],"mice,":[82],"either":[83],"unstimulated":[84],"or":[85],"stimulated":[86],"with":[87,105,149,223,228],"TGF-\u03b2.":[88],"Results":[89],"were":[90,112,168],"then":[91],"validated":[92],"by":[93,114,204],"using":[94],"Real-Time":[95],"PCR.":[96],"Spinal":[97],"cords":[98],"WT":[100,229],"KO":[103,192,221],"mice":[104,222],"EAE":[106,225,242],"(at":[107],"days":[108],"0":[109],"14)":[111],"stained":[113],"immunohistochemistry":[115],"for":[116,123,166],"astrocyte":[118],"marker":[119],"GFAP,":[120],"AGM,":[121],"nuclear":[124],"factor":[125,130],"IA":[126],"(NFIA),":[127],"a":[128,140,210],"gliogenic":[129],"transcriptional":[132],"regulator":[133],"AGM.":[135],"Lack":[136],"had":[139],"significant":[141],"impact":[142],"programs":[146],"normally":[147],"associated":[148],"development":[151],"whose":[152],"re-expression":[153],"is":[154],"usually":[155],"seen":[156],"astrocytes.":[159,193],"Connectivity":[160],"analysis":[161],"revealed":[162],"that":[163,198,234],"genes":[164],"coding":[165],"AGM":[167,248],"particularly":[169],"affected.":[170],"found":[172,209],"lower":[173,211],"transcript":[174],"levels":[175],"ephrin":[177],"receptor":[178],"A":[179],"7":[181],"(Epha7),":[182],"plexin":[183],"A1":[184],"Slit":[186],"ligand":[188],"2":[189],"Moreover,":[194],"our":[195],"results":[196,232],"showed":[197],"NFIA":[199,218],"EPHA7":[201,216],"expressed":[203],"number":[212],"expressing":[215],"acute":[224,241],"when":[226],"compared":[227],"mice.":[230],"These":[231],"suggest":[233],"might":[236],"facilitate":[237],"astrogliosis":[239],"through":[243],"regulating":[244],"NFIA.":[250],"Veterans":[251],"Administration":[252],"Merit":[253],"Award":[254],"I01BX001458":[255],"(to":[256],"HR)":[257]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-08-10T00:00:00"}