{"id":"https://openalex.org/W4385644672","doi":"https://doi.org/10.1097/01.hs9.0000967664.04864.bb","title":"S188: CAR-T CELLS SHAPE THE IMMUNOLOGICAL POTENTIAL OF THE TUMOR MICROENVIRONMENT","display_name":"S188: CAR-T CELLS SHAPE THE IMMUNOLOGICAL POTENTIAL OF THE TUMOR MICROENVIRONMENT","publication_year":2023,"publication_date":"2023-08-01","ids":{"openalex":"https://openalex.org/W4385644672","doi":"https://doi.org/10.1097/01.hs9.0000967664.04864.bb"},"language":"en","primary_location":{"id":"doi:10.1097/01.hs9.0000967664.04864.bb","doi":"https://doi.org/10.1097/01.hs9.0000967664.04864.bb","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1097/01.hs9.0000967664.04864.bb","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1097/01.hs9.0000967664.04864.bb","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061110758","display_name":"Julia Frede","orcid":"https://orcid.org/0000-0002-4380-9673","observed_orcids":["https://orcid.org/0000-0002-4380-9673"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Frede","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092609717","display_name":"Julia C Poller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Poller","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102542897","display_name":"Kayleen Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayleen Shi","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hannah Stuart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah Stuart","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092609718","display_name":"Noori Sotoudeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noori Sotoudeh","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030750380","display_name":"Klothilda Lim","orcid":"https://orcid.org/0000-0002-9791-6503","observed_orcids":["https://orcid.org/0000-0002-9791-6503"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Klothilda Lim","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087962472","display_name":"Caroline R.M. Wiggers","orcid":"https://orcid.org/0000-0001-6633-1468","observed_orcids":["https://orcid.org/0000-0001-6633-1468"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Wiggers","raw_affiliation_strings":["Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085953389","display_name":"Johannes Moritz Waldschmidt","orcid":"https://orcid.org/0000-0001-5340-1818","observed_orcids":["https://orcid.org/0000-0001-5340-1818"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johannes Waldschmidt","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003845362","display_name":"Valeriya Dimitrova","orcid":"https://orcid.org/0000-0002-8621-7301","observed_orcids":["https://orcid.org/0000-0002-8621-7301"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeriya Dimitrova","raw_affiliation_strings":["Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091779744","display_name":"Anna Montanaro","orcid":"https://orcid.org/0000-0002-5229-5395","observed_orcids":["https://orcid.org/0000-0002-5229-5395"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Montanaro","raw_affiliation_strings":["Dana-Farber Cancer Institute, Pediatric Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Pediatric Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109352835","display_name":"Eugene Cho","orcid":"https://orcid.org/0009-0000-1267-4932","observed_orcids":["https://orcid.org/0009-0000-1267-4932"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene Cho","raw_affiliation_strings":["Dana-Farber Cancer Institute, Pediatric Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Pediatric Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109602197","display_name":"Tushara Vijaykumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tushara Vijaykumar","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043526996","display_name":"Paul Gerard Guy Richardson","orcid":"https://orcid.org/0000-0002-7426-8865","observed_orcids":["https://orcid.org/0000-0002-7426-8865"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Richardson","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045740077","display_name":"Nikhil C. Munshi","orcid":"https://orcid.org/0000-0002-7344-9795","observed_orcids":["https://orcid.org/0000-0002-7344-9795","https://orcid.org/0000-0002-8397-100X"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil Munshi","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Anderson","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069553021","display_name":"Nathan T. Martin","orcid":"https://orcid.org/0000-0002-2899-7610","observed_orcids":["https://orcid.org/0000-0002-2899-7610"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Martin","raw_affiliation_strings":["Bristol Myers Squibb, Seattle, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Myers Squibb, Seattle, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078833195","display_name":"Shari M. Kaiser","orcid":"https://orcid.org/0009-0003-8337-9123","observed_orcids":["https://orcid.org/0009-0003-8337-9123"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shari Kaiser","raw_affiliation_strings":["Bristol Myers Squibb, Seattle, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Myers Squibb, Seattle, United States","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070221339","display_name":"Marc Steffen Raab","orcid":"https://orcid.org/0000-0003-4181-6922","observed_orcids":["https://orcid.org/0000-0003-4181-6922"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marc-Steffen Raab","raw_affiliation_strings":["University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013722454","display_name":"Birgit Knoechel","orcid":"https://orcid.org/0000-0002-8040-0535","observed_orcids":["https://orcid.org/0000-0002-8040-0535"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Birgit Knoechel","raw_affiliation_strings":["Harvard Medical School, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050075424","display_name":"Jens G. Lohr","orcid":"https://orcid.org/0000-0003-3486-2445","observed_orcids":["https://orcid.org/0000-0003-3486-2445"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jens Lohr","raw_affiliation_strings":["Dana-Farber Cancer Institute, Medical Oncology, Boston, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dana-Farber Cancer Institute, Medical Oncology, Boston, United States","institution_ids":["https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2480,"currency":"USD","value_usd":2480},"apc_paid":{"value":2480,"currency":"USD","value_usd":2480},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1327617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":"S3","first_page":"e04864bb","last_page":"e04864bb"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9399999976158142},{"id":"https://openalex.org/keywords/b-cell-maturation-antigen","display_name":"BCMA","score":0.8939999938011169},{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9520000219345093},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.8840000033378601},{"id":"https://openalex.org/keywords/myeloid-expansion","display_name":"myeloid expansion","score":0.7250000238418579},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.574999988079071},{"id":"https://openalex.org/keywords/treatment-resistance","display_name":"treatment resistance","score":0.6290000081062317},{"id":"https://openalex.org/keywords/effector-cd8-t-cells","display_name":"CD8+ effector T cells","score":0.621999979019165},{"id":"https://openalex.org/keywords/t-cell-self-renewal","display_name":"T cell self-renewal","score":0.6420000195503235},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7536174058914185},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.671008825302124},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.574861466884613},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5464739203453064},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.5154279470443726},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4942028820514679},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.48685234785079956},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46418020129203796},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4542045295238495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45244497060775757},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4125867784023285},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3376559913158417},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1097/01.hs9.0000967664.04864.bb","doi":"https://doi.org/10.1097/01.hs9.0000967664.04864.bb","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1097/01.hs9.0000967664.04864.bb","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10428259","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10428259","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10428259/pdf/hs9-7-e04864bb.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hemasphere","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:37887b7d013c49af82780d0224567747","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/37887b7d013c49af82780d0224567747","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"HemaSphere, Vol 7, p e04864bb (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1097/01.hs9.0000967664.04864.bb","doi":"https://doi.org/10.1097/01.hs9.0000967664.04864.bb","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1097/01.hs9.0000967664.04864.bb","pdf_url":null,"source":{"id":"https://openalex.org/S4210211592","display_name":"HemaSphere","issn_l":"2572-9241","issn":["2572-9241"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HemaSphere","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385644672.pdf","grobid_xml":"https://content.openalex.org/works/W4385644672.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4400773931","https://openalex.org/W4375955418","https://openalex.org/W4309190943","https://openalex.org/W3212992657","https://openalex.org/W4414347992","https://openalex.org/W4400451886","https://openalex.org/W4310126191","https://openalex.org/W4394955462","https://openalex.org/W7148766240","https://openalex.org/W4417016283"],"abstract_inverted_index":{"Background:":[0],"Cell-based":[1],"immunotherapies,":[2,369],"particularly":[3],"chimeric":[4],"antigen":[5],"receptor":[6],"modified":[7],"(CAR-)":[8],"T":[9,140,204,266,276,287,304,319,332,341,421,495],"cells,":[10,44],"have":[11,458],"produced":[12],"impressive":[13],"responses":[14,28,366],"in":[15,99,102,114,171,229,261,263,281,318,388],"a":[16,48,76,215,241,279,310,437,471,484,488],"subset":[17],"of":[18,27,32,42,59,68,79,139,151,159,199,214,217,244,272,329,339,413,431,466,479],"patients":[19,119,162,219],"with":[20,82,173,269],"hematological":[21],"malignancies.":[22],"However,":[23,254],"the":[24,30,57,66,83,106,137,156,208,230,245,257,264,330,384,399,414,432,462,477,480],"limited":[25],"durability":[26],"and":[29,40,47,72,86,105,131,176,185,202,211,239,278,284,326,356,392,396,424,464,475,487],"development":[31],"treatment":[33,74,300],"resistance":[34],"present":[35],"significant":[36],"challenges.":[37],"Limited":[38],"expansion":[39,243,271,338],"persistence":[41],"CAR-T":[43,60,69,103,111,165,189,200,236,252,298,347,433,498],"T-cell":[45],"exhaustion,":[46,321],"hostile":[49],"immune":[50,84,107,153,174,233,313,426,439,481],"microenvironment":[51,85,234,440],"are":[52],"key":[53],"factors":[54,401],"that":[55,297,358,418],"restrict":[56],"efficacy":[58,67],"cell":[61,70,112,122,166,197,237,267,288,299,320,333,342,390,404,422,496],"therapies.":[62,143],"Aims:":[63],"To":[64,376],"enhance":[65],"therapy":[71,113,167,238],"overcome":[73],"resistance,":[75],"better":[77],"understanding":[78],"their":[80,87],"co-evolution":[81],"reciprocal":[88],"interactions":[89,130,412],"is":[90,380],"needed.":[91],"Therefore,":[92],"this":[93],"study":[94],"aimed":[95,126],"to":[96,127,295,367,373,420,435],"define":[97],"alterations":[98],"cellular":[100],"states":[101,391],"cells":[104,154,201,205,277,434],"compartment":[108,247],"upon":[109,235],"BCMA":[110],"relapsed/refractory":[115],"multiple":[116],"myeloma":[117],"(RRMM)":[118],"at":[120,248],"single":[121,196],"resolution.":[123],"We":[124,145,191,225,292,335,363],"further":[125,192,368],"investigate":[128,377],"cell-cell":[129,407,415],"identify":[132],"novel":[133],"immunomodulatory":[134],"pathways":[135],"for":[136,324,461,473],"optimization":[138],"cell-based":[141],"cancer":[142],"Methods:":[144],"performed":[146,193],"droplet-based":[147],"single-cell":[148],"RNA":[149],"sequencing":[150,465],"CD45+":[152],"from":[155,207],"bone":[157,212,231],"marrow":[158,213,232],"4":[160],"RRMM":[161],"receiving":[163],"BCMA-directed":[164],"(KarMMa-2":[168],"trial;":[169],"NCT03601078)":[170],"combination":[172],"profiling":[175],"VdJ":[177],"sequencing,":[178],"before":[179],"as":[180,182,371,483],"well":[181],"one":[183,249],"month":[184,250],"six":[186,344],"months":[187,345],"after":[188,346],"infusion.":[190,253],"longitudinal":[194],"full-length":[195],"RNA-sequencing":[198],"CD8+":[203,303],"isolated":[206],"peripheral":[209],"blood":[210],"total":[216],"24":[218],"(on":[220],"KarMMA-2/KarMMa-3":[221],"trials;":[222],"NCT03651128).":[223],"Results:":[224],"defined":[226],"compositional":[227],"changes":[228,260],"observed":[240,336],"temporary":[242],"myeloid":[246],"following":[251],"we":[255,382,409],"detected":[256],"greatest":[258],"relative":[259],"abundance":[262],"CD8":[265,274,282,285],"compartment,":[268],"an":[270,337],"GZMB+":[273],"effector":[275],"decrease":[280],"na\u00efve":[283],"memory":[286],"populations":[289],"over":[290],"time.":[291],"were":[293],"able":[294],"show":[296],"drives":[301],"bystander":[302],"lymphocyte":[305],"differentiation,":[306],"which":[307],"initially":[308],"supports":[309],"clonal":[311],"anti-tumor":[312],"response,":[314,497],"but":[315],"ultimately":[316],"results":[317],"reduced":[322],"potential":[323],"self-renewal":[325],"sustained":[327],"depletion":[328],"tumor-reactive":[331],"repertoire.":[334],"pre-existing":[340],"clones":[343],"infusion":[348],"(P":[349],"=":[350],"0.00018":[351],"by":[352],"paired":[353],"Wilcoxon":[354],"test)":[355],"found":[357],"these":[359],"undergo":[360],"terminal":[361],"differentiation.":[362],"predict":[364],"diminished":[365],"such":[370],"response":[372],"checkpoint":[374],"blockade.":[375],"how":[378],"exhaustion":[379,423],"regulated,":[381],"analyzed":[383],"transcriptional":[385],"modules":[386],"active":[387],"different":[389],"identified":[393,410],"TCF7,":[394],"IKZF1":[395],"PRDM1":[397],"among":[398],"transcription":[400],"regulating":[402],"divergent":[403],"states.":[405],"Inferring":[406],"interactions,":[408],"crucial":[411],"communication":[416],"network":[417],"contribute":[419],"regulate":[425],"capacity.":[427],"Summary/Conclusion:":[428],"The":[429],"ability":[430],"shape":[436],"regulatory":[438],"may":[441],"explain":[442],"why":[443],"repeated":[444],"immunotherapies":[445],"become":[446],"increasingly":[447],"less":[448],"successful,":[449],"even":[450],"when":[451],"targeting":[452],"distinct":[453],"antigens.":[454],"Our":[455,468],"studies":[456,469],"therefore":[457],"important":[459],"implications":[460],"timing":[463],"immunotherapies.":[467],"provide":[470],"framework":[472],"assessing":[474],"manipulating":[476],"\u2018mileage\u2019":[478],"system":[482],"predictive":[485],"marker":[486],"therapeutic":[489],"opportunity.":[490],"Keywords:":[491],"Myeloma,":[492],"Cancer":[493],"immunotherapy,":[494]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-08T00:00:00"}