{"id":"https://openalex.org/W4385628866","doi":"https://doi.org/10.1016/j.isci.2023.107566","title":"Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and function","display_name":"Stress-mediated dysregulation of the Rap1 small GTPase impairs hippocampal structure and function","publication_year":2023,"publication_date":"2023-08-07","ids":{"openalex":"https://openalex.org/W4385628866","doi":"https://doi.org/10.1016/j.isci.2023.107566","pmid":"https://pubmed.ncbi.nlm.nih.gov/37461459","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10349939"},"language":"en","primary_location":{"id":"doi:10.1016/j.isci.2023.107566","doi":"https://doi.org/10.1016/j.isci.2023.107566","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2023.107566","pdf_url":"http://www.cell.com/article/S2589004223016437/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2589004223016437/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035255277","display_name":"Kathryn J. Bjornson","orcid":"https://orcid.org/0000-0001-5366-1230","observed_orcids":["https://orcid.org/0000-0001-5366-1230"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn J. Bjornson","raw_affiliation_strings":["Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005831234","display_name":"Amanda M. Vanderplow","orcid":"https://orcid.org/0000-0002-2659-8587","observed_orcids":["https://orcid.org/0000-0002-2659-8587"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda M. Vanderplow","raw_affiliation_strings":["Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007192467","display_name":"Yezi Yang","orcid":"https://orcid.org/0000-0003-3320-9110","observed_orcids":["https://orcid.org/0000-0003-3320-9110"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yezi Yang","raw_affiliation_strings":["Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043382059","display_name":"Danielle R. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Danielle R. Anderson","raw_affiliation_strings":["Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061252605","display_name":"Bailey A. Kermath","orcid":"https://orcid.org/0000-0001-8237-3641","observed_orcids":["https://orcid.org/0000-0001-8237-3641"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bailey A. Kermath","raw_affiliation_strings":["Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057272818","display_name":"Michael E. Cahill","orcid":"https://orcid.org/0000-0003-0574-2655","observed_orcids":["https://orcid.org/0000-0003-0574-2655"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael E. Cahill","raw_affiliation_strings":["Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA"],"raw_orcid":"https://orcid.org/0000-0003-0574-2655","affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5057272818"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":3150,"currency":"USD","value_usd":3150},"apc_paid":{"value":3150,"currency":"USD","value_usd":3150},"fwci":0.7804,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.65975412,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"26","issue":"9","first_page":"107566","last_page":"107566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.021400000900030136,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rap1","display_name":"Rap1","score":0.796999990940094},{"id":"https://openalex.org/keywords/small-gtpases","display_name":"small GTPases","score":0.9769999980926514},{"id":"https://openalex.org/keywords/chronic-stress","display_name":"chronic stress","score":0.6060000061988831},{"id":"https://openalex.org/keywords/dendritic-spines","display_name":"dendritic spines","score":0.7390000224113464},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ca3","display_name":"CA3","score":0.8880000114440918},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8370000123977661},{"id":"https://openalex.org/keywords/learning-and-memory","display_name":"learning and memory","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.9064335227012634},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.8206634521484375},{"id":"https://openalex.org/C2776179587","wikidata":"https://www.wikidata.org/wiki/Q54461864","display_name":"Rap1","level":3,"score":0.7580879330635071},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6992483735084534},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.6925798654556274},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6781689524650574},{"id":"https://openalex.org/C2780298669","wikidata":"https://www.wikidata.org/wiki/Q415071","display_name":"Small GTPase","level":3,"score":0.5940808057785034},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.43637317419052124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43594372272491455},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4173862934112549},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34613844752311707},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3349267244338989},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1748162806034088},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14342057704925537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07181188464164734},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1016/j.isci.2023.107566","doi":"https://doi.org/10.1016/j.isci.2023.107566","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2023.107566","pdf_url":"http://www.cell.com/article/S2589004223016437/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},{"id":"doi:10.1101/2023.07.03.547282","doi":"https://doi.org/10.1101/2023.07.03.547282","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.03.547282","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/03/2023.07.03.547282.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10470260","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10470260","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10470260/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Text"},{"id":"pmid:37461459","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37461459","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmid:37664580","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37664580","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10349939","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10349939","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:73280224e82645998199eac1d6281f3e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/73280224e82645998199eac1d6281f3e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"iScience, Vol 26, Iss 9, Pp 107566- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.isci.2023.107566","doi":"https://doi.org/10.1016/j.isci.2023.107566","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.isci.2023.107566","pdf_url":"http://www.cell.com/article/S2589004223016437/pdf","source":{"id":"https://openalex.org/S2898358376","display_name":"iScience","issn_l":"2589-0042","issn":["2589-0042"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"iScience","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G373488393","display_name":null,"funder_award_id":"R21MH125227","funder_id":"https://openalex.org/F4320309434","funder_display_name":"University of Wisconsin-Madison"},{"id":"https://openalex.org/G6596002045","display_name":"The role of Akt signaling in prefrontal circuit function and cognitive impairment","funder_award_id":"R21MH125227","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332747","display_name":"College of Engineering, University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385628866.pdf","grobid_xml":"https://content.openalex.org/works/W4385628866.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W12593514","https://openalex.org/W1798313689","https://openalex.org/W1886307983","https://openalex.org/W1956829805","https://openalex.org/W1969430973","https://openalex.org/W1971541597","https://openalex.org/W1973502710","https://openalex.org/W1977197102","https://openalex.org/W1981225314","https://openalex.org/W1981847881","https://openalex.org/W1983553517","https://openalex.org/W1990409413","https://openalex.org/W1992523889","https://openalex.org/W1993249717","https://openalex.org/W1999601502","https://openalex.org/W1999964025","https://openalex.org/W2001750328","https://openalex.org/W2004643104","https://openalex.org/W2007596877","https://openalex.org/W2018737214","https://openalex.org/W2028281706","https://openalex.org/W2029442966","https://openalex.org/W2031137065","https://openalex.org/W2032946496","https://openalex.org/W2033125075","https://openalex.org/W2037267899","https://openalex.org/W2037836204","https://openalex.org/W2038145167","https://openalex.org/W2059890547","https://openalex.org/W2060720527","https://openalex.org/W2062317659","https://openalex.org/W2076201141","https://openalex.org/W2077822166","https://openalex.org/W2089741501","https://openalex.org/W2089923669","https://openalex.org/W2095056606","https://openalex.org/W2098542074","https://openalex.org/W2100423235","https://openalex.org/W2111155182","https://openalex.org/W2114129553","https://openalex.org/W2117248853","https://openalex.org/W2123329302","https://openalex.org/W2124610146","https://openalex.org/W2125990256","https://openalex.org/W2137006544","https://openalex.org/W2137833570","https://openalex.org/W2141391979","https://openalex.org/W2143520326","https://openalex.org/W2150498836","https://openalex.org/W2152003886","https://openalex.org/W2152287997","https://openalex.org/W2158723752","https://openalex.org/W2160383565","https://openalex.org/W2162743207","https://openalex.org/W2164670684","https://openalex.org/W2164811687","https://openalex.org/W2177482336","https://openalex.org/W2221233020","https://openalex.org/W2224527671","https://openalex.org/W2270338484","https://openalex.org/W2345996515","https://openalex.org/W2516100705","https://openalex.org/W2586974243","https://openalex.org/W2592683674","https://openalex.org/W2619236908","https://openalex.org/W2762366315","https://openalex.org/W2765504358","https://openalex.org/W2789340405","https://openalex.org/W2802172273","https://openalex.org/W2803304487","https://openalex.org/W2887096933","https://openalex.org/W2889000691","https://openalex.org/W2905210080","https://openalex.org/W2929935816","https://openalex.org/W2952710756","https://openalex.org/W2957263456","https://openalex.org/W2968886545","https://openalex.org/W2970142577","https://openalex.org/W3000467576","https://openalex.org/W3041536621","https://openalex.org/W3047323931","https://openalex.org/W3086674788","https://openalex.org/W3087948039","https://openalex.org/W3093690489","https://openalex.org/W3106943974","https://openalex.org/W3118456888","https://openalex.org/W3121698375","https://openalex.org/W3139230337","https://openalex.org/W3155773864","https://openalex.org/W3168611089","https://openalex.org/W3212199033","https://openalex.org/W4210601302","https://openalex.org/W4214641408","https://openalex.org/W4225407792","https://openalex.org/W4246659915","https://openalex.org/W4286853184","https://openalex.org/W4295350560"],"related_works":["https://openalex.org/W4382986926","https://openalex.org/W3041536621","https://openalex.org/W4225407792","https://openalex.org/W2088857895","https://openalex.org/W1992523889","https://openalex.org/W2162743207","https://openalex.org/W2745382188","https://openalex.org/W4232171882","https://openalex.org/W4410631638","https://openalex.org/W3108578427"],"abstract_inverted_index":{"The":[0],"effects":[1,121,147],"of":[2,22,43,56,67,94,113,125,135,148],"repeated":[3],"stress":[4],"on":[5,122],"cognitive":[6,102],"impairment":[7],"are":[8,39],"thought":[9],"to":[10,77,96,116,144],"be":[11],"mediated,":[12],"at":[13],"least":[14],"in":[15,19,25,50,61,70,75,87,92,139,142],"part,":[16],"by":[17],"reductions":[18],"the":[20,35,54,71,88,111,123,133,140,145],"stability":[21,124],"dendritic":[23,44,99,127],"spines":[24],"brain":[26],"regions":[27],"critical":[28],"for":[29],"proper":[30],"learning":[31],"and":[32,48,93,101],"memory,":[33],"including":[34],"hippocampus.":[36],"Small":[37],"GTPases":[38],"particularly":[40],"potent":[41],"regulators":[42],"spine":[45,100,128],"formation,":[46],"stability,":[47],"morphology":[49],"hippocampal":[51,72],"neurons.":[52],"Through":[53],"use":[55],"small":[57],"GTPase":[58],"protein":[59],"profiling":[60],"mice,":[62],"we":[63,108],"identify":[64],"increased":[65,85],"levels":[66],"synaptic":[68],"Rap1":[69,86,114,137],"CA3":[73,89],"region":[74],"response":[76],"escalating,":[78],"intermittent":[79],"stress.":[80,149],"We":[81],"then":[82],"demonstrate":[83],"that":[84],"is":[90],"sufficient":[91],"itself":[95],"produce":[97],"stress-relevant":[98],"phenotypes.":[103],"Further,":[104],"using":[105],"super-resolution":[106],"imaging,":[107],"investigate":[109],"how":[110],"pattern":[112],"trafficking":[115],"synapses":[117],"likely":[118],"underlies":[119],"its":[120],"select":[126],"subtypes.":[129],"These":[130],"findings":[131],"illuminate":[132],"involvement":[134],"aberrant":[136],"regulation":[138],"hippocampus":[141],"contributing":[143],"psychobiological":[146]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-08-08T00:00:00"}