{"id":"https://openalex.org/W4385628404","doi":"https://doi.org/10.1200/jco.23.00286","title":"Flashback Foreword: Gemcitabine/Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Transitional Cell Carcinoma","display_name":"Flashback Foreword: Gemcitabine/Cisplatin Versus Methotrexate, Vinblastine, Doxorubicin, and Cisplatin in Transitional Cell Carcinoma","publication_year":2023,"publication_date":"2023-08-07","ids":{"openalex":"https://openalex.org/W4385628404","doi":"https://doi.org/10.1200/jco.23.00286","pmid":"https://pubmed.ncbi.nlm.nih.gov/37549481"},"language":"en","primary_location":{"id":"doi:10.1200/jco.23.00286","doi":"https://doi.org/10.1200/jco.23.00286","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.23.00286","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007578304","display_name":"Eric Jay Small","orcid":"https://orcid.org/0000-0003-3191-6268","observed_orcids":["https://orcid.org/0000-0003-3191-6268"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eric J. Small","raw_affiliation_strings":["Department of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA","Former Associate Editor, Journal of Clinical Oncology, Alexandria, VA"],"raw_orcid":"https://orcid.org/0000-0003-3191-6268","affiliations":[{"raw_affiliation_string":"Department of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]},{"raw_affiliation_string":"Former Associate Editor, Journal of Clinical Oncology, Alexandria, VA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007578304"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"23","first_page":"3879","last_page":"3880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12695","display_name":"Urinary and Genital Oncology Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/m-vac-chemotherapy","display_name":"M-VAC chemotherapy","score":0.6449999809265137},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8980000019073486},{"id":"https://openalex.org/keywords/vinblastine","display_name":"vinblastine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/metastatic-bladder-cancer","display_name":"metastatic bladder cancer","score":0.8320000171661377},{"id":"https://openalex.org/keywords/urothelial-carcinoma","display_name":"urothelial carcinoma","score":0.949999988079071},{"id":"https://openalex.org/keywords/chemotherapy-regimen-comparison","display_name":"chemotherapy regimen comparison","score":0.5720000267028809},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.4059999883174896},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.44999998807907104},{"id":"https://openalex.org/keywords/access-to-cancer-therapy","display_name":"access to cancer therapy","score":0.39399999380111694}],"concepts":[{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.8407058715820312},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.7452647686004639},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7362785339355469},{"id":"https://openalex.org/C2777132456","wikidata":"https://www.wikidata.org/wiki/Q282629","display_name":"Vinblastine","level":3,"score":0.702218234539032},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5490227341651917},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5162020325660706},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.4964650273323059},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4622582793235779},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.452440470457077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4282219707965851},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3529602289199829},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.33193957805633545}],"mesh":[{"descriptor_ui":"D000093542","descriptor_name":"Gemcitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001749","descriptor_name":"Urinary Bladder Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002295","descriptor_name":"Carcinoma, Transitional Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003841","descriptor_name":"Deoxycytidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014747","descriptor_name":"Vinblastine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.23.00286","doi":"https://doi.org/10.1200/jco.23.00286","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.23.00286","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:37549481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37549481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2101562875"],"related_works":["https://openalex.org/W2156133317","https://openalex.org/W3133883772","https://openalex.org/W1968997279","https://openalex.org/W2105084597","https://openalex.org/W4206100111","https://openalex.org/W7217985428","https://openalex.org/W1986710101","https://openalex.org/W2027960392","https://openalex.org/W2993522276","https://openalex.org/W2973440092"],"abstract_inverted_index":{"Article":[0,4],"Tools":[1,5],"FLASHBACK":[2],"FOREWORD":[3],"OPTIONS":[6],"&":[7,17],"TOOLS":[8],"Export":[9],"Citation":[10,12],"Track":[11],"Add":[13],"To":[14],"Favorites":[15],"Rights":[16],"Permissions":[18],"COMPANION":[19],"ARTICLES":[20],"Gemcitabine":[21,356],"and":[22,28,74,128,149,164,172,192,223,239,324,335,357,363],"Cisplatin":[23,29,75,240,358,364],"Versus":[24,70,235,359],"Methotrexate,":[25,71,236,360],"Vinblastine,":[26,72,237,361],"Doxorubicin,":[27,73,362],"in":[30,76,167,188,241,365],"Advanced":[31,366],"or":[32,302,337,367],"Metastatic":[33,368],"Bladder":[34,369],"Cancer:":[35,370],"Results":[36,371],"of":[37,54,99,104,114,135,153,185,197,205,214,253,286,295,351,372],"a":[38,190,194,306,373],"Large,":[39,374],"Randomized,":[40,375],"Multinational,":[41,376],"Multicenter,":[42,377],"Phase":[43,378],"III":[44,379],"Study.":[45],"August":[46,62],"07,":[47],"2023":[48,64,131],"ARTICLE":[49],"CITATION":[50],"DOI:":[51],"10.1200/JCO.23.00286":[52],"Journal":[53,98],"Clinical":[55,100,136],"Oncology":[56],"-":[57],"published":[58],"online":[59],"before":[60],"print":[61],"7,":[63],"PMID:":[65],"37549481":[66],"Flashback":[67],"Foreword:":[68,233],"Gemcitabine/Cisplatin":[69,234],"Transitional":[77,242],"Cell":[78,243],"Carcinoma":[79],"Eric":[80],"J.":[81,86,322],"Small":[82],",":[83],"MD,":[84],"FASCO1,2xEric":[85],"SmallSearch":[87],"for":[88,208],"articles":[89],"by":[90,132,250,312],"this":[91,254,287],"author":[92,252],"Show":[93],"More":[94],"1Former":[95],"Associate":[96],"Editor,":[97],"Oncology,":[101,341],"Alexandria,":[102],"VA2Department":[103],"Medicine,":[105],"UCSF":[106],"Helen":[107],"Diller":[108],"Family":[109,272],"Comprehensive":[110],"Cancer":[111],"Center,":[112],"University":[113],"California":[115],"San":[116,118],"Francisco,":[117,119],"CA":[120],"https://doi.org/10.1200/JCO.23.00286":[121],"First":[122],"Page":[123],"Full":[124],"Text":[125],"PDF":[126],"Figures":[127],"Tables":[129],"\u00a9":[130],"American":[133],"Society":[134],"OncologyTHE":[137],"TAKEAWAYIn":[138],"2000,":[139],"von":[140],"der":[141],"Maase":[142],"et":[143],"al1":[144],"demonstrated":[145],"the":[146,159,181,251,283],"therapeutic":[147],"equivalence":[148],"improved":[150],"safety":[151],"profile":[152],"gemcitabine":[154],"plus":[155],"cisplatin,":[156],"compared":[157],"with":[158,169],"time-tested":[160],"methotrexate,":[161],"vinblastine,":[162],"doxorubicin,":[163],"cisplatin":[165],"regimen":[166],"patients":[168],"locally":[170],"advanced":[171,209],"metastatic":[173],"transitional":[174],"cell":[175],"bladder":[176,186,210],"cancer.":[177],"This":[178],"study":[179],"identified":[180],"first":[182],"new":[183],"treatment":[184],"cancer":[187,211],"over":[189],"decade":[191],"presaged":[193],"large":[195],"body":[196],"work":[198],"directed":[199],"not":[200,280],"only":[201],"at":[202],"improving":[203],"efficacy":[204],"systemic":[206],"therapy":[207],"but":[212],"also":[213],"making":[215],"it":[216],"more":[217,290],"broadly":[218],"available":[219],"to":[220,282,300,317],"an":[221],"older":[222],"less":[224],"fit":[225],"population.AUTHOR'S":[226],"DISCLOSURES":[227],"OF":[228,231],"POTENTIAL":[229],"CONFLICTS":[230],"INTERESTFlashback":[232],"Doxorubicin":[238],"CarcinomaThe":[244],"following":[245],"represents":[246],"disclosure":[247],"information":[248,291,310],"provided":[249],"manuscript.":[255,288],"All":[256],"relationships":[257],"are":[258,265],"considered":[259],"compensated":[260],"unless":[261,267],"otherwise":[262],"noted.":[263,268],"Relationships":[264,278],"self-held":[266],"I":[269],"=":[270,275],"Immediate":[271],"Member,":[273],"Inst":[274],"My":[276],"Institution.":[277],"may":[279],"relate":[281],"subject":[284],"matter":[285],"For":[289],"about":[292,314],"ASCO's":[293],"conflict":[294],"interest":[296,352],"policy,":[297],"please":[298],"refer":[299],"www.asco.org/rwc":[301],"ascopubs.org/jco/authors/author-center.Open":[303],"Payments":[304,345],"is":[305],"public":[307],"database":[308],"containing":[309],"reported":[311],"companies":[313],"payments":[315],"made":[316],"US-licensed":[318],"physicians":[319],"(Open":[320],"Payments).Eric":[321],"SmallStock":[323],"Other":[325],"Ownership":[326],"Interests:":[327],"Fortis,":[328],"Harpoon":[329],"Therapeutics,":[330,343],"Teon":[331,342],"TherapeuticsHonoraria:":[332],"Janssen,":[333],"Johnson":[334],"JohnsonConsulting":[336],"Advisory":[338],"Role:":[339],"Janssen":[340],"FortisOpen":[344],"Link:":[346],"https://openpaymentsdata.cms.gov/physician/660367No":[347],"other":[348],"potential":[349],"conflicts":[350],"were":[353],"reported.":[354],"Companion":[355],"Study":[380]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-08T00:00:00"}