{"id":"https://openalex.org/W4385622189","doi":"https://doi.org/10.1136/bmjopen-2022-069176","title":"Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease","display_name":"Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease","publication_year":2023,"publication_date":"2023-08-01","ids":{"openalex":"https://openalex.org/W4385622189","doi":"https://doi.org/10.1136/bmjopen-2022-069176","pmid":"https://pubmed.ncbi.nlm.nih.gov/37550022","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10407406"},"language":"en","primary_location":{"id":"doi:10.1136/bmjopen-2022-069176","doi":"https://doi.org/10.1136/bmjopen-2022-069176","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2022-069176","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/13/8/e069176.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjopen.bmj.com/content/bmjopen/13/8/e069176.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022525482","display_name":"Oghenekome A. Gbinigie","orcid":"https://orcid.org/0000-0002-2963-4491","observed_orcids":["https://orcid.org/0000-0002-2963-4491"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oghenekome Gbinigie","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0002-2963-4491","affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034507700","display_name":"Emma Ogburn","orcid":"https://orcid.org/0000-0001-7643-572X","observed_orcids":["https://orcid.org/0000-0001-7643-572X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma Ogburn","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085878666","display_name":"Julie Allen","orcid":"https://orcid.org/0000-0002-2114-5861","observed_orcids":["https://orcid.org/0000-0002-2114-5861"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julie Allen","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081748396","display_name":"Jienchi Dorward","orcid":"https://orcid.org/0000-0001-6072-1430","observed_orcids":["https://orcid.org/0000-0001-6072-1430"]},"institutions":[{"id":"https://openalex.org/I2800715850","display_name":"Centre for the AIDS Programme of Research in South Africa","ror":"https://ror.org/04qkg4668","country_code":"ZA","type":"other","lineage":["https://openalex.org/I2800715850"]},{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["GB","ZA"],"is_corresponding":false,"raw_author_name":"Jienchi Dorward","raw_affiliation_strings":["Centre for the Aids Programme of Research in South Africa (CAPRISA), University of KwaZulu\u2013Natal, Durban, South Africa","Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0001-6072-1430","affiliations":[{"raw_affiliation_string":"Centre for the Aids Programme of Research in South Africa (CAPRISA), University of KwaZulu\u2013Natal, Durban, South Africa","institution_ids":["https://openalex.org/I2800715850","https://openalex.org/I95023434"]},{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000868546","display_name":"Melissa Dobson","orcid":"https://orcid.org/0000-0002-4906-3956","observed_orcids":["https://orcid.org/0000-0002-4906-3956"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melissa Dobson","raw_affiliation_strings":["Nuffield Department of Medicine, Oxford Respiratory Trials Unit, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Medicine, Oxford Respiratory Trials Unit, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109353555","display_name":"Tracie\u2010Ann Madden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Tracie-Ann Madden","raw_affiliation_strings":["Centre for Trials Research, Cardiff University, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Trials Research, Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045695482","display_name":"Ly\u2010Mee Yu","orcid":"https://orcid.org/0000-0003-0331-7364","observed_orcids":["https://orcid.org/0000-0003-0331-7364"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ly-Mee Yu","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030239949","display_name":"David M. Lowe","orcid":"https://orcid.org/0000-0001-6102-2375","observed_orcids":["https://orcid.org/0000-0001-6102-2375"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David M Lowe","raw_affiliation_strings":["University College London, Institute of Immunity and Transplantation, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, Institute of Immunity and Transplantation, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059272486","display_name":"Najib\u00a0Mahboob Rahman","orcid":"https://orcid.org/0000-0003-1195-1680","observed_orcids":["https://orcid.org/0000-0003-1195-1680"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210088942","display_name":"NIHR Oxford Biomedical Research Centre","ror":"https://ror.org/00aps1a34","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210088942","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Najib Rahman","raw_affiliation_strings":["Chinese Academy of Medicine Oxford Institute, University of Oxford, Oxford, UK","NIHR Oxford Biomedical Research Centre, Oxford, UK","Nuffield Department of Medicine, Oxford Respiratory Trials Unit, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medicine Oxford Institute, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"NIHR Oxford Biomedical Research Centre, Oxford, UK","institution_ids":["https://openalex.org/I4210088942"]},{"raw_affiliation_string":"Nuffield Department of Medicine, Oxford Respiratory Trials Unit, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089167457","display_name":"Stavros Petrou","orcid":"https://orcid.org/0000-0003-3121-6050","observed_orcids":["https://orcid.org/0000-0003-3121-6050"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stavros Petrou","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050970663","display_name":"Duncan B. Richards","orcid":"https://orcid.org/0000-0002-8093-7084","observed_orcids":["https://orcid.org/0000-0002-8093-7084"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Duncan Richards","raw_affiliation_strings":["Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002227290","display_name":"Kerenza Hood","orcid":"https://orcid.org/0000-0002-5268-8631","observed_orcids":["https://orcid.org/0000-0002-5268-8631"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kerenza Hood","raw_affiliation_strings":["Centre for Trials Research, Cardiff University, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Trials Research, Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055308228","display_name":"Mihir Patel","orcid":"https://orcid.org/0000-0002-7942-1945","observed_orcids":["https://orcid.org/0000-0002-7942-1945"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mahendra Patel","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068530075","display_name":"Benjamin R. Saville","orcid":"https://orcid.org/0000-0001-6058-7171","observed_orcids":["https://orcid.org/0000-0001-6058-7171"]},"institutions":[{"id":"https://openalex.org/I4405267949","display_name":"Berry Consultants, LLC (United States)","ror":"https://ror.org/054btrt70","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267949"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin R Saville","raw_affiliation_strings":["Berry Consultants, Austin, Texas, USA","Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berry Consultants, Austin, Texas, USA","institution_ids":["https://openalex.org/I4405267949"]},{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086200154","display_name":"Joe Marion","orcid":"https://orcid.org/0000-0003-0347-5194","observed_orcids":["https://orcid.org/0000-0003-0347-5194"]},"institutions":[{"id":"https://openalex.org/I4405267949","display_name":"Berry Consultants, LLC (United States)","ror":"https://ror.org/054btrt70","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267949"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joe Marion","raw_affiliation_strings":["Berry Consultants, Austin, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Berry Consultants, Austin, Texas, USA","institution_ids":["https://openalex.org/I4405267949"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058496095","display_name":"Jane Holmes","orcid":"https://orcid.org/0000-0001-7123-0004","observed_orcids":["https://orcid.org/0000-0001-7123-0004"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jane Holmes","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079899525","display_name":"May Ee Png","orcid":"https://orcid.org/0000-0001-5876-9363","observed_orcids":["https://orcid.org/0000-0001-5876-9363"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"May Ee Png","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0001-5876-9363","affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023574292","display_name":"Gail Hayward","orcid":"https://orcid.org/0000-0003-0852-627X","observed_orcids":["https://orcid.org/0000-0003-0852-627X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gail Hayward","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0003-0852-627X","affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044276903","display_name":"Mark T. Lown","orcid":"https://orcid.org/0000-0001-8309-568X","observed_orcids":["https://orcid.org/0000-0001-8309-568X"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Lown","raw_affiliation_strings":["Primary Care Research Centre, University of Southampton, Southampton, UK"],"raw_orcid":"https://orcid.org/0000-0001-8309-568X","affiliations":[{"raw_affiliation_string":"Primary Care Research Centre, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102715322","display_name":"Victoria Harris","orcid":"https://orcid.org/0000-0002-3345-2826","observed_orcids":["https://orcid.org/0000-0002-3345-2826"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Victoria Harris","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076869670","display_name":"Bhautesh Jani","orcid":"https://orcid.org/0000-0001-7348-514X","observed_orcids":["https://orcid.org/0000-0001-7348-514X"]},"institutions":[{"id":"https://openalex.org/I7882870","display_name":"University of Glasgow","ror":"https://ror.org/00vtgdb53","country_code":"GB","type":"education","lineage":["https://openalex.org/I7882870"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Bhautesh Jani","raw_affiliation_strings":["General Practice and Primary Care, School of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"General Practice and Primary Care, School of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, UK","institution_ids":["https://openalex.org/I7882870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075574916","display_name":"Nigel David Hart","orcid":"https://orcid.org/0000-0002-8168-1746","observed_orcids":["https://orcid.org/0000-0002-8168-1746"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nigel Hart","raw_affiliation_strings":["School of Medicine, Dentistry and Biomedical Sciences - Centre for Public Health, Queen's University Belfast, Belfast, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Dentistry and Biomedical Sciences - Centre for Public Health, Queen's University Belfast, Belfast, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041365930","display_name":"Saye Khoo","orcid":"https://orcid.org/0000-0002-2769-0967","observed_orcids":["https://orcid.org/0000-0002-2769-0967"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Saye Khoo","raw_affiliation_strings":["Department of Pharmacology, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080610056","display_name":"Heather Rutter","orcid":"https://orcid.org/0000-0002-7297-2234","observed_orcids":["https://orcid.org/0000-0002-7297-2234"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Heather Rutter","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081540134","display_name":"Jem Chalk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jem Chalk","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069317379","display_name":"Joseph Frank Standing","orcid":"https://orcid.org/0000-0002-4561-7173","observed_orcids":["https://orcid.org/0000-0002-4561-7173"]},"institutions":[{"id":"https://openalex.org/I2800129641","display_name":"Great Ormond Street Hospital","ror":"https://ror.org/00zn2c847","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800129641","https://openalex.org/I2800349819"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph F Standing","raw_affiliation_strings":["Department of Pharmacy, Great Ormond Street Hospital for Children, London, UK","Infection Inflammation and Immunology, UCL Great Ormond Street Institute of Child Health Population Policy and Practice, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Great Ormond Street Hospital for Children, London, UK","institution_ids":["https://openalex.org/I2800129641"]},{"raw_affiliation_string":"Infection Inflammation and Immunology, UCL Great Ormond Street Institute of Child Health Population Policy and Practice, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070647783","display_name":"Judith Breuer","orcid":"https://orcid.org/0000-0001-8246-0534","observed_orcids":["https://orcid.org/0000-0001-8246-0534"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Judith Breuer","raw_affiliation_strings":["Infection Inflammation and Immunology, UCL Great Ormond Street Institute of Child Health Population Policy and Practice, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Inflammation and Immunology, UCL Great Ormond Street Institute of Child Health Population Policy and Practice, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058624862","display_name":"Layla Lavallee","orcid":"https://orcid.org/0000-0002-3823-9311","observed_orcids":["https://orcid.org/0000-0002-3823-9311"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Layla Lavallee","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019910459","display_name":"Elizabeth Hadley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Hadley","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069076021","display_name":"Lucy Cureton","orcid":"https://orcid.org/0000-0003-0082-8468","observed_orcids":["https://orcid.org/0000-0003-0082-8468"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucy Cureton","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033411775","display_name":"Magdalena Benysek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Magdalena Benysek","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013729992","display_name":"Monique Ingrid Andersson","orcid":"https://orcid.org/0000-0003-0619-1074","observed_orcids":["https://orcid.org/0000-0003-0619-1074","https://orcid.org/0000-0003-0610-2393"]},"institutions":[{"id":"https://openalex.org/I4210147381","display_name":"Oxford University Hospitals NHS Trust","ror":"https://ror.org/03h2bh287","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Monique I Andersson","raw_affiliation_strings":["Department of Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0003-0619-1074","affiliations":[{"raw_affiliation_string":"Department of Microbiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK","institution_ids":["https://openalex.org/I4210147381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011449104","display_name":"Nick A Francis","orcid":"https://orcid.org/0000-0001-8939-7312","observed_orcids":["https://orcid.org/0000-0001-8939-7312"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Francis","raw_affiliation_strings":["Primary Care Research Centre, University of Southampton, Southampton, UK"],"raw_orcid":"https://orcid.org/0000-0001-8939-7312","affiliations":[{"raw_affiliation_string":"Primary Care Research Centre, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079121335","display_name":"Nicholas P B Thomas","orcid":"https://orcid.org/0000-0003-0460-6870","observed_orcids":["https://orcid.org/0000-0003-0460-6870"]},"institutions":[{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]},{"id":"https://openalex.org/I4394709266","display_name":"Clinical Research Network Thames Valley and South Midlands","ror":"https://ror.org/00j9bjx58","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I34931013","https://openalex.org/I4394709266"]},{"id":"https://openalex.org/I7780909","display_name":"Royal College of General Practitioners","ror":"https://ror.org/01gdbf303","country_code":"GB","type":"education","lineage":["https://openalex.org/I7780909"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas P B Thomas","raw_affiliation_strings":["Royal College of General Practitioners, London, UK","Thames Valley and South Midlands Clinical Research Network, National Institute for Health and Care Research, Oxford, UK","Windrush Medical Practice, Witney, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal College of General Practitioners, London, UK","institution_ids":["https://openalex.org/I7780909"]},{"raw_affiliation_string":"Thames Valley and South Midlands Clinical Research Network, National Institute for Health and Care Research, Oxford, UK","institution_ids":["https://openalex.org/I34931013","https://openalex.org/I4394709266"]},{"raw_affiliation_string":"Windrush Medical Practice, Witney, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013802638","display_name":"Philip Hugh Evans","orcid":"https://orcid.org/0000-0002-5277-3545","observed_orcids":["https://orcid.org/0000-0002-5277-3545"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I34931013","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08","country_code":"GB","type":"government","lineage":["https://openalex.org/I34931013"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Philip Evans","raw_affiliation_strings":["Faculty of Health and Life Sciences, University of Exeter, Exeter, UK","National Institute for Health Research Clinical Research Network, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health and Life Sciences, University of Exeter, Exeter, UK","institution_ids":["https://openalex.org/I23923803"]},{"raw_affiliation_string":"National Institute for Health Research Clinical Research Network, London, UK","institution_ids":["https://openalex.org/I34931013"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057054298","display_name":"Oliver van Hecke","orcid":"https://orcid.org/0000-0002-6229-5057","observed_orcids":["https://orcid.org/0000-0002-6229-5057"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Oliver van Hecke","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013344503","display_name":"Mona Koshkouei","orcid":"https://orcid.org/0000-0003-0831-8198","observed_orcids":["https://orcid.org/0000-0003-0831-8198"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mona Koshkouei","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023150296","display_name":"Maria Coates","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria Coates","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028199839","display_name":"Sarah Barrett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Barrett","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028427544","display_name":"Clare Bateman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clare Bateman","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101779479","display_name":"Jennifer C. Davies","orcid":"https://orcid.org/0000-0003-1683-220X","observed_orcids":["https://orcid.org/0000-0003-1683-220X"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jennifer Davies","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046032964","display_name":"Ivy Raymundo-Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ivy Raymundo-Wood","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002152360","display_name":"Andrew Ustianowski","orcid":"https://orcid.org/0000-0002-6134-7855","observed_orcids":["https://orcid.org/0000-0002-6134-7855"]},"institutions":[{"id":"https://openalex.org/I2801440235","display_name":"North Manchester General Hospital","ror":"https://ror.org/02xesw687","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801440235","https://openalex.org/I4210092852"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Ustianowski","raw_affiliation_strings":["Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Regional Infectious Diseases Unit, North Manchester General Hospital, Manchester, UK","institution_ids":["https://openalex.org/I2801440235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011296226","display_name":"Jonathan S. Nguyen\u2010Van\u2010Tam","orcid":"https://orcid.org/0000-0003-2579-4655","observed_orcids":["https://orcid.org/0000-0003-2579-4655"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan Nguyen-Van-Tam","raw_affiliation_strings":["Lifespan and Population Health Unit, University of Nottingham School of Medicine, Nottingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lifespan and Population Health Unit, University of Nottingham School of Medicine, Nottingham, UK","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002812932","display_name":"Andrew Carson\u2010Stevens","orcid":"https://orcid.org/0000-0002-7580-7699","observed_orcids":["https://orcid.org/0000-0002-7580-7699"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Carson-Stevens","raw_affiliation_strings":["Centre for Trials Research, Cardiff University, Cardiff, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Trials Research, Cardiff University, Cardiff, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008167189","display_name":"Richard F. Hobbs","orcid":"https://orcid.org/0000-0001-7976-7172","observed_orcids":["https://orcid.org/0000-0001-7976-7172"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard Hobbs","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029134034","display_name":"Paul S Little","orcid":"https://orcid.org/0000-0003-3664-1873","observed_orcids":["https://orcid.org/0000-0003-3664-1873"]},"institutions":[{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul Little","raw_affiliation_strings":["Primary Care Research Centre, University of Southampton, Southampton, UK"],"raw_orcid":"https://orcid.org/0000-0003-3664-1873","affiliations":[{"raw_affiliation_string":"Primary Care Research Centre, University of Southampton, Southampton, UK","institution_ids":["https://openalex.org/I43439940"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079149152","display_name":"Christopher Butler","orcid":"https://orcid.org/0000-0002-0102-3453","observed_orcids":["https://orcid.org/0000-0002-0102-3453"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher C Butler","raw_affiliation_strings":["Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK"],"raw_orcid":"https://orcid.org/0000-0002-0102-3453","affiliations":[{"raw_affiliation_string":"Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5079149152"],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":1500,"currency":"GBP","value_usd":1839},"apc_paid":{"value":1500,"currency":"GBP","value_usd":1839},"fwci":4.8522,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.96366376,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"13","issue":"8","first_page":"e069176","last_page":"e069176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9919999837875366},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"antiviral therapy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/early-treatment","display_name":"early treatment","score":0.6650000214576721},{"id":"https://openalex.org/keywords/community-dwelling-patients","display_name":"community-dwelling patients","score":0.8579999804496765},{"id":"https://openalex.org/keywords/molnupiravir","display_name":"molnupiravir","score":0.9589999914169312},{"id":"https://openalex.org/keywords/nirmatrelvir-ritonavir","display_name":"nirmatrelvir/ritonavir","score":0.9990000128746033},{"id":"https://openalex.org/keywords/master-protocols","display_name":"master protocols","score":0.6439999938011169},{"id":"https://openalex.org/keywords/adaptive-platform-trial","display_name":"adaptive platform trial","score":0.8889999985694885},{"id":"https://openalex.org/keywords/high-risk-patients","display_name":"high-risk patients","score":0.6259999871253967},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.6830000281333923},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hospitalization","display_name":"hospitalization","score":0.6380000114440918},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.7749999761581421},{"id":"https://openalex.org/keywords/economic-evaluation","display_name":"economic evaluation","score":0.671999990940094},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.6650000214576721},{"id":"https://openalex.org/keywords/symptom-diary","display_name":"symptom diary","score":0.5339999794960022},{"id":"https://openalex.org/keywords/remote-recruitment","display_name":"remote recruitment","score":0.4189999997615814},{"id":"https://openalex.org/keywords/covid-19-vaccination","display_name":"COVID-19 vaccination","score":0.47600001096725464}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9190633296966553},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.6504974365234375},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.640711784362793},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.6205686330795288},{"id":"https://openalex.org/C2776957806","wikidata":"https://www.wikidata.org/wiki/Q4895105","display_name":"Interim","level":2,"score":0.6112691164016724},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5806490778923035},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5642987489700317},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.49052637815475464},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.2501158118247986},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21341750025749207},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12844514846801758},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C166957645","wikidata":"https://www.wikidata.org/wiki/Q23498","display_name":"Archaeology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075522","descriptor_name":"Adaptive Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007769","descriptor_name":"Lactams","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":14,"locations":[{"id":"doi:10.1136/bmjopen-2022-069176","doi":"https://doi.org/10.1136/bmjopen-2022-069176","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2022-069176","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/13/8/e069176.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10407406","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10407406","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10407406/pdf/bmjopen-2022-069176.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"Text"},{"id":"pmid:37550022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37550022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ open","raw_type":"Clinical Trial Protocol"},{"id":"pmh:oai:eprints.gla.ac.uk:305031","doi":null,"is_oa":true,"landing_page_url":"https://eprints.gla.ac.uk/305031/1/305031.pdf","pdf_url":"https://eprints.gla.ac.uk/305031/1/305031.pdf","source":{"id":"https://openalex.org/S4210235606","display_name":"ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)","issn_l":"2622-8912","issn":["2622-8912","2622-8920"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/I4405259220","host_organization_name":"Institut Agama Islam Negeri Langsa","host_organization_lineage":["https://openalex.org/I4405259220"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Articles"},{"id":"pmh:oai:eprints.soton.ac.uk:481215","doi":null,"is_oa":true,"landing_page_url":"http://doi.org/10.1136/bmjopen-2022-069176>).","pdf_url":"https://eprints.soton.ac.uk/481215/1/e069176.full.pdf","source":{"id":"https://openalex.org/S4306401019","display_name":"ePrints Soton (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:161569","doi":null,"is_oa":true,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/161569/1/bmjopen-2022-069176.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/161569/1/bmjopen-2022-069176.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:figshare.com:article/29797361","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Platform_adaptive_trial_of_novel_antivirals_for_early_treatment_of_COVID-19_In_the_community_PANORAMIC_protocol_for_a_randomised_controlled_open-label_adaptive_platform_trial_of_community_novel_antiviral_treatment_of_COVID-19_in_people_at_i/29797361","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:https://nottingham-repository.worktribe.com/:24414621","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.1136/bmjopen-2022-069176","pdf_url":null,"source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:pure.qub.ac.uk/portal:openaire/8a090cb8-bd3e-48dc-bc27-db90256db89c","doi":null,"is_oa":true,"landing_page_url":"https://pure.qub.ac.uk/en/publications/8a090cb8-bd3e-48dc-bc27-db90256db89c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10174973","doi":null,"is_oa":true,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10174973/","pdf_url":"https://discovery.ucl.ac.uk/10174973/1/e069176.full.pdf","source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open , 13 (8) , Article e069176. (2023)","raw_type":"Article"},{"id":"pmh:oai:nottingham-repository.worktribe.com:24414621","doi":null,"is_oa":true,"landing_page_url":"https://nottingham-repository.worktribe.com/output/24414621","pdf_url":"https://nottingham-repository.worktribe.com/file/24414621/1/Platform%20adaptive%20trial%20of%20novel%20antivirals%20for%20early%20treatment%20of%20COVID-19%20In%20the%20community%20%28PANORAMIC%29%3A%20protocol%20for%20a%20randomised%2C%20controlled%2C%20open-label%2C%20adaptive%20platform%20trial%20of%20community%20novel%20antiviral%20treatment%20of%20COVID-19%20in%20people%20at%20increased%20","source":{"id":"https://openalex.org/S4306402483","display_name":"Repository@Nottingham (University of Nottingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I142263535","host_organization_name":"University of Nottingham","host_organization_lineage":["https://openalex.org/I142263535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f284538c5d9a4aadbf25f6d87d454717","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/f284538c5d9a4aadbf25f6d87d454717","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMJ Open, Vol 13, Iss 8 (2023)","raw_type":"article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:d70f24ae-6049-49a8-8bc3-a2800f5ab216","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:d70f24ae-6049-49a8-8bc3-a2800f5ab216","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements","raw_type":"Journal article"},{"id":"pmh:oai:ore.exeter.ac.uk:10871/133739","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10871/133739","pdf_url":null,"source":{"id":"https://openalex.org/S4306401998","display_name":"Open Research Exeter (University of Exeter)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I23923803","host_organization_name":"University of Exeter","host_organization_lineage":["https://openalex.org/I23923803"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1136/bmjopen-2022-069176","doi":"https://doi.org/10.1136/bmjopen-2022-069176","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjopen-2022-069176","pdf_url":"https://bmjopen.bmj.com/content/bmjopen/13/8/e069176.full.pdf","source":{"id":"https://openalex.org/S79054089","display_name":"BMJ Open","issn_l":"2044-6055","issn":["2044-6055"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[{"id":"https://openalex.org/G1975896744","display_name":"Point-of-care viral load testing to enhance primary care HIV services in South Africa","funder_award_id":"216421","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G2300835955","display_name":"NIHR Development and Skills Enhancement Award","funder_award_id":"NIHR302395","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G3616782395","display_name":"Platform Adaptive trial of NOvel antiviRals for eArly treatMent of COVID-19 In the Community (PANORAMIC)","funder_award_id":"NIHR135366","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G4715507480","display_name":"MICA: Pharmacokinetic/Pharmacodynamic (PKPD) Model Development to Inform SARS-CoV-2 Antiviral Development","funder_award_id":"MR/W015560/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5365565055","display_name":null,"funder_award_id":"10103","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G5563029912","display_name":"Point-of-care viral load testing to enhance primary care HIV services in South Africa","funder_award_id":"216421/Z/19/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6196811712","display_name":null,"funder_award_id":"UKRI/NIHR - Grant number NIHR135366","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G6321804012","display_name":"NIHR Senior Investigator Award","funder_award_id":"NF-SI-0616-10103","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G7673198320","display_name":"Mathematical and Statistical Modelling to Optimise Paediatric Medicines Research","funder_award_id":"MR/M008665/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8415457339","display_name":null,"funder_award_id":"COVID-19","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8473222607","display_name":"NIHR Senior Investigator Award","funder_award_id":"NIHR202402","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G863365162","display_name":"Improving the Diagnosis of Recurrent Urinary Tract Infection in Primary Care","funder_award_id":"NIHR300105","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320313245","display_name":"Health and Care Research Wales","ror":null},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320318095","display_name":"National Institute for Health Research Health Protection Research Unit","ror":null},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320320853","display_name":"Public Health Agency","ror":"https://ror.org/03ek62e72"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337310","display_name":"National Institute for Health and Care Research Applied Research Collaboration Oxford and Thames Valley","ror":"https://ror.org/01m1zqs59"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385622189.pdf","grobid_xml":"https://content.openalex.org/works/W4385622189.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1990166011","https://openalex.org/W2013564592","https://openalex.org/W2086805083","https://openalex.org/W2168416023","https://openalex.org/W2726405642","https://openalex.org/W2805439597","https://openalex.org/W3001993019","https://openalex.org/W3002696059","https://openalex.org/W3042270788","https://openalex.org/W3047833576","https://openalex.org/W3091990645","https://openalex.org/W3135226293","https://openalex.org/W3137687331","https://openalex.org/W3153499045","https://openalex.org/W3170964438","https://openalex.org/W3182163984","https://openalex.org/W3184172540","https://openalex.org/W3185983882","https://openalex.org/W3199320310","https://openalex.org/W3200797487","https://openalex.org/W3209596279","https://openalex.org/W4200051875","https://openalex.org/W4200487269","https://openalex.org/W4221020415","https://openalex.org/W4229038932","https://openalex.org/W4286009332","https://openalex.org/W4312134853","https://openalex.org/W4312580289"],"related_works":["https://openalex.org/W6940331520","https://openalex.org/W4205936483","https://openalex.org/W4206423957","https://openalex.org/W4205111453","https://openalex.org/W4312580289","https://openalex.org/W4213342577","https://openalex.org/W4226247616","https://openalex.org/W4312163207","https://openalex.org/W3170964438","https://openalex.org/W4412957766"],"abstract_inverted_index":{"INTRODUCTION:":[0],"There":[1],"is":[2,38,203,210,220,253],"an":[3],"urgent":[4],"need":[5],"to":[6,87,156,212,237,278],"determine":[7],"the":[8,23,56,62,73,133,143,191,201,208,214,256],"safety,":[9],"effectiveness":[10],"and":[11,30,72,75,93,114,120,136,198,280,283],"cost-effectiveness":[12],"of":[13,28,64,77,102,104,229],"novel":[14],"antiviral":[15,51,66],"treatments":[16,52,67],"for":[17,53,178,240],"COVID-19":[18,54,106],"in":[19,22,55,148,285],"vaccinated":[20],"patients":[21],"community":[24],"at":[25,281],"increased":[26],"risk":[27],"morbidity":[29],"mortality":[31],"from":[32],"COVID-19.":[33],"METHODS":[34],"AND":[35,259],"ANALYSIS:":[36],"PANORAMIC":[37],"a":[39,162,172],"UK-wide,":[40],"open-label,":[41],"prospective,":[42],"adaptive,":[43],"multiarm":[44],"platform,":[45],"randomised":[46,155],"clinical":[47,151],"trial":[48,134,145,163],"that":[49],"evaluates":[50],"community.":[57],"A":[58,249],"master":[59],"protocol":[60],"governs":[61],"addition":[63],"new":[65],"as":[68],"they":[69],"become":[70],"available,":[71],"introduction":[74],"cessation":[76],"existing":[78],"interventions":[79,86,236],"via":[80,132,171],"interim":[81,233],"analyses.":[82],"The":[83,216],"first":[84],"two":[85],"be":[88,238,276],"evaluated":[89],"are":[90,154,169,188],"molnupiravir":[91],"(Lagevrio)":[92],"nirmatrelvir/ritonavir":[94],"(Paxlovid).":[95],"ELIGIBILITY":[96],"CRITERIA:":[97],"community-dwelling":[98],"within":[99,226,255],"5":[100],"days":[101,180,195,228],"onset":[103],"symptomatic":[105],"(confirmed":[107],"by":[108,137,190,264],"PCR":[109],"or":[110,122,147,161,206,242],"lateral":[111],"flow":[112],"test),":[113],"either":[115,158],"(1)":[116],"aged":[117,124],"50":[118],"years":[119,126],"over,":[121],"(2)":[123],"18-49":[125],"with":[127],"qualifying":[128],"comorbidities.":[129],"Registration":[130],"occurs":[131,140],"website":[135],"telephone.":[138],"Recruitment":[139],"remotely":[141],"through":[142,150],"central":[144],"team,":[146],"person":[149],"sites.":[152],"Participants":[153,183],"receive":[157],"usual":[159,166],"care":[160],"drug":[164],"plus":[165],"care.":[167],"Outcomes":[168],"collected":[170],"participant-completed":[173],"daily":[174],"electronic":[175],"symptom":[176],"diary":[177,202],"28":[179,199,227],"post":[181],"randomisation.":[182,230],"and/or":[184,224],"their":[185],"Trial":[186],"Partner":[187],"contacted":[189],"research":[192],"team":[193],"after":[194],"7,":[196],"14":[197],"if":[200,207],"not":[204],"completed,":[205],"participant":[209],"unable":[211],"access":[213],"diary.":[215],"primary":[217],"efficacy":[218],"endpoint":[219],"all-cause,":[221],"non-elective":[222],"hospitalisation":[223],"death":[225],"Multiple":[231],"prespecified":[232,246],"analyses":[234],"allow":[235],"stopped":[239],"futility":[241],"superiority":[243],"based":[244],"on":[245],"decision":[247],"criteria.":[248],"prospective":[250],"economic":[251],"evaluation":[252],"embedded":[254],"trial.":[257],"ETHICS":[258],"DISSEMINATION:":[260],"Ethical":[261],"approval":[262],"granted":[263],"South":[265],"Central-Berkshire":[266],"REC":[267],"number:":[268,293],"21/SC/0393;":[269],"IRAS":[270],"project":[271],"ID:":[272],"1004274.":[273],"Results":[274],"will":[275],"presented":[277],"policymakers":[279],"conferences,":[282],"published":[284],"peer-reviewed":[286],"journals.":[287],"TRIAL":[288],"REGISTRATION":[289],"NUMBER:":[290],"ISRCTN30448031;":[291],"EudraCT":[292],"2021-005748-31.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-08-08T00:00:00"}