{"id":"https://openalex.org/W4385606242","doi":"https://doi.org/10.1101/2023.08.04.552083","title":"Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World Hantaviruses","display_name":"Comparative Analysis of Molecular Pathogenic Mechanisms and Antiviral Development Targeting Old and New World Hantaviruses","publication_year":2023,"publication_date":"2023-08-05","ids":{"openalex":"https://openalex.org/W4385606242","doi":"https://doi.org/10.1101/2023.08.04.552083","pmid":"https://pubmed.ncbi.nlm.nih.gov/37577539","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10418258"},"language":"en","primary_location":{"id":"doi:10.1101/2023.08.04.552083","doi":"https://doi.org/10.1101/2023.08.04.552083","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.08.04.552083","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/08/05/2023.08.04.552083.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/08/05/2023.08.04.552083.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060381857","display_name":"Arjit Vijey Jeyachandran","orcid":"https://orcid.org/0009-0003-5341-0804","observed_orcids":["https://orcid.org/0009-0003-5341-0804"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arjit Vijey Jeyachandran","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038873261","display_name":"Joseph Ignatius Irudayam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Ignatius Irudayam","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014784358","display_name":"Swati Dubey","orcid":"https://orcid.org/0000-0002-6957-4294","observed_orcids":["https://orcid.org/0000-0002-6957-4294","https://orcid.org/0000-0003-1632-7940"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swati Dubey","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073340158","display_name":"Nikhil Chakravarty","orcid":"https://orcid.org/0000-0002-4603-1713","observed_orcids":["https://orcid.org/0000-0002-4603-1713"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nikhil Chakravarty","raw_affiliation_strings":["Department of Epidemiology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067711555","display_name":"Bindu M. Konda","orcid":"https://orcid.org/0000-0001-5949-922X","observed_orcids":["https://orcid.org/0000-0001-5949-922X"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bindu Konda","raw_affiliation_strings":["Department of Medicine, Lung and Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lung and Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Aayushi Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aayushi Shah","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013465555","display_name":"Baolong Su","orcid":"https://orcid.org/0000-0002-1970-4417","observed_orcids":["https://orcid.org/0000-0002-1970-4417"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Baolong Su","raw_affiliation_strings":["Dept. of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, USA","UCLA Lipidomics Lab, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"UCLA Lipidomics Lab, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100417022","display_name":"Cheng Wang","orcid":"https://orcid.org/0000-0002-9838-748X","observed_orcids":["https://orcid.org/0000-0002-9838-748X"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng Wang","raw_affiliation_strings":["Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101054765","display_name":"Qi Cui","orcid":"https://orcid.org/0009-0009-5054-5221","observed_orcids":["https://orcid.org/0009-0009-5054-5221"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Cui","raw_affiliation_strings":["Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087040428","display_name":"Kevin J. Williams","orcid":"https://orcid.org/0000-0001-8091-7924","observed_orcids":["https://orcid.org/0000-0001-8091-7924"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Williams","raw_affiliation_strings":["Dept. of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, USA","UCLA Lipidomics Lab, University of California, Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"UCLA Lipidomics Lab, University of California, Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044814548","display_name":"Sonal Srikanth","orcid":"https://orcid.org/0000-0002-3034-095X","observed_orcids":["https://orcid.org/0000-0002-3034-095X"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sonal Srikanth","raw_affiliation_strings":["Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100632209","display_name":"Yanhong Shi","orcid":"https://orcid.org/0000-0002-3938-5839","observed_orcids":["https://orcid.org/0000-0002-3938-5839"]},"institutions":[{"id":"https://openalex.org/I1301076528","display_name":"City Of Hope National Medical Center","ror":"https://ror.org/00w6g5w60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528"]},{"id":"https://openalex.org/I4210110459","display_name":"City of Hope","ror":"https://ror.org/01z1vct10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4210110459"]},{"id":"https://openalex.org/I4387156432","display_name":"Beckman Research Institute","ror":"https://ror.org/05fazth07","country_code":"US","type":"facility","lineage":["https://openalex.org/I1301076528","https://openalex.org/I4387156432"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanhong Shi","raw_affiliation_strings":["Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurodegenerative Diseases, Beckman Research Institute of City of Hope, CA, USA","institution_ids":["https://openalex.org/I1301076528","https://openalex.org/I4210110459","https://openalex.org/I4387156432"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071178498","display_name":"Arjun Deb","orcid":"https://orcid.org/0000-0003-0978-2611","observed_orcids":["https://orcid.org/0000-0003-0978-2611"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arjun Deb","raw_affiliation_strings":["Division of Cardiology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA","Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045676945","display_name":"Robert D. Damoiseaux","orcid":"https://orcid.org/0000-0002-7611-7534","observed_orcids":["https://orcid.org/0000-0002-7611-7534"]},"institutions":[{"id":"https://openalex.org/I142207940","display_name":"California NanoSystems Institute","ror":"https://ror.org/00q7fqf35","country_code":"US","type":"facility","lineage":["https://openalex.org/I142207940","https://openalex.org/I154570441","https://openalex.org/I161318765"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Damoiseaux","raw_affiliation_strings":["California NanoSystems Institute, UCLA, Los Angeles, CA, USA","Department of Bioengineering, Samueli School of Engineering, UCLA, Los Angeles, CA, USA","Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA","Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California NanoSystems Institute, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I142207940","https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Bioengineering, Samueli School of Engineering, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062224123","display_name":"Barry R. Stripp","orcid":"https://orcid.org/0000-0003-4348-2137","observed_orcids":["https://orcid.org/0000-0003-4348-2137"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry R. Stripp","raw_affiliation_strings":["Department of Medicine, Lung and Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Lung and Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013711277","display_name":"Arunachalam Ramaiah","orcid":"https://orcid.org/0000-0003-3573-6141","observed_orcids":["https://orcid.org/0000-0003-3573-6141"]},"institutions":[{"id":"https://openalex.org/I4210148948","display_name":"Milwaukee Health Department","ror":"https://ror.org/0561hjj97","country_code":"US","type":"government","lineage":["https://openalex.org/I4210148948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arunachalam Ramaiah","raw_affiliation_strings":["City of Milwaukee Health Department, Milwaukee, WI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"City of Milwaukee Health Department, Milwaukee, WI, USA","institution_ids":["https://openalex.org/I4210148948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070367677","display_name":"Vaithilingaraja Arumugaswami","orcid":"https://orcid.org/0000-0002-6872-5118","observed_orcids":["https://orcid.org/0000-0002-6872-5118"]},"institutions":[{"id":"https://openalex.org/I142207940","display_name":"California NanoSystems Institute","ror":"https://ror.org/00q7fqf35","country_code":"US","type":"facility","lineage":["https://openalex.org/I142207940","https://openalex.org/I154570441","https://openalex.org/I161318765"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Vaithilingaraja Arumugaswami","raw_affiliation_strings":["California NanoSystems Institute, UCLA, Los Angeles, CA, USA","Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA","Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California NanoSystems Institute, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I142207940","https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5013711277","https://openalex.org/A5070367677"],"corresponding_institution_ids":["https://openalex.org/I142207940","https://openalex.org/I161318765","https://openalex.org/I4210148948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hantavirus","display_name":"hantavirus","score":0.9580000042915344},{"id":"https://openalex.org/keywords/andes-virus","display_name":"Andes virus","score":0.9399999976158142},{"id":"https://openalex.org/keywords/sin-nombre-virus","display_name":"Sin Nombre virus","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hantaan-virus","display_name":"Hantaan virus","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cell-tropism","display_name":"cell tropism","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pluripotent-stem-cell-derived-cardiomyocytes","display_name":"pluripotent stem cell-derived cardiomyocytes","score":0.9869999885559082},{"id":"https://openalex.org/keywords/lung-organoids","display_name":"lung organoids","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cholesterol-synthesis","display_name":"cholesterol biosynthesis","score":0.6549999713897705},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.8790000081062317},{"id":"https://openalex.org/keywords/transcriptomics","display_name":"transcriptomics","score":0.921999990940094},{"id":"https://openalex.org/keywords/sting-agonist","display_name":"STING agonist","score":0.8980000019073486},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.9150000214576721},{"id":"https://openalex.org/keywords/urolithin-b","display_name":"urolithin B","score":0.9390000104904175},{"id":"https://openalex.org/keywords/favipiravir","display_name":"favipiravir","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antiviral-drug-screening","display_name":"antiviral drug screening","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pandemic-preparedness","display_name":"pandemic preparedness","score":0.6949999928474426},{"id":"https://openalex.org/keywords/zoonotic-transmission","display_name":"zoonotic transmission","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7266512513160706},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6869412660598755},{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.655964732170105},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4843836724758148},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4458749294281006},{"id":"https://openalex.org/C107459253","wikidata":"https://www.wikidata.org/wiki/Q674925","display_name":"Induced pluripotent stem cell","level":4,"score":0.4374719262123108},{"id":"https://openalex.org/C2779635636","wikidata":"https://www.wikidata.org/wiki/Q476209","display_name":"Dengue virus","level":3,"score":0.4216978847980499},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.41216203570365906},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19468098878860474},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12426134943962097},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.07475706934928894},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2023.08.04.552083","doi":"https://doi.org/10.1101/2023.08.04.552083","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.08.04.552083","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/08/05/2023.08.04.552083.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:37577539","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37577539","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Preprint"},{"id":"pmh:oai:pubmedcentral.nih.gov:10418258","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10418258","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10418258/pdf/nihpp-2023.08.04.552083v1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2023.08.04.552083","doi":"https://doi.org/10.1101/2023.08.04.552083","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.08.04.552083","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/08/05/2023.08.04.552083.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1401667396","display_name":"Interplay between AMPK and Hippo Signaling Regulates Ocular Antiviral Response to Zika virus infection","funder_award_id":"R01EY032149","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G1756706648","display_name":"Metabolic and epigenetic reprogramming of vital organs in SARS-CoV-2 induced systemic toxicity","funder_award_id":"R01DK132735","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1826740938","display_name":"Regulation of the STING pathway under sterile conditions","funder_award_id":"R01AI146352","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G350121412","display_name":null,"funder_award_id":"5R01AI163216-02","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8079969785","display_name":"Developing three-dimensional antisense oligonucleotide drugs against COVID-19","funder_award_id":"5r01ai163216-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337965","display_name":"California NanoSystems Institute","ror":"https://ror.org/00q7fqf35"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385606242.pdf","grobid_xml":"https://content.openalex.org/works/W4385606242.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W204936577","https://openalex.org/W1528783460","https://openalex.org/W1973052078","https://openalex.org/W1984178787","https://openalex.org/W2016333467","https://openalex.org/W2018549296","https://openalex.org/W2023588767","https://openalex.org/W2034053213","https://openalex.org/W2034105601","https://openalex.org/W2040276464","https://openalex.org/W2043168822","https://openalex.org/W2045060353","https://openalex.org/W2045613499","https://openalex.org/W2060563373","https://openalex.org/W2069413021","https://openalex.org/W2084620335","https://openalex.org/W2093727433","https://openalex.org/W2100642437","https://openalex.org/W2116818883","https://openalex.org/W2124758932","https://openalex.org/W2126999668","https://openalex.org/W2129092356","https://openalex.org/W2137557761","https://openalex.org/W2140160390","https://openalex.org/W2156242168","https://openalex.org/W2163062455","https://openalex.org/W2171372164","https://openalex.org/W2232578306","https://openalex.org/W2332012211","https://openalex.org/W2529259446","https://openalex.org/W2534733506","https://openalex.org/W2535967370","https://openalex.org/W2604581406","https://openalex.org/W2614081736","https://openalex.org/W2746482698","https://openalex.org/W2751583588","https://openalex.org/W2884799708","https://openalex.org/W2885338433","https://openalex.org/W2887543408","https://openalex.org/W2901557802","https://openalex.org/W2948832005","https://openalex.org/W2964424807","https://openalex.org/W2990032304","https://openalex.org/W3005235420","https://openalex.org/W3044358307","https://openalex.org/W3047054214","https://openalex.org/W3084625233","https://openalex.org/W3093900830","https://openalex.org/W3100375649","https://openalex.org/W3117151028","https://openalex.org/W3117551966","https://openalex.org/W3131579240","https://openalex.org/W3155419928","https://openalex.org/W3156458251","https://openalex.org/W3161332376","https://openalex.org/W3178377702","https://openalex.org/W3190680796","https://openalex.org/W3206682079","https://openalex.org/W3215331148","https://openalex.org/W4200310117","https://openalex.org/W4211007515","https://openalex.org/W4240377005","https://openalex.org/W4253836631","https://openalex.org/W4367312031"],"related_works":["https://openalex.org/W4413748113","https://openalex.org/W7213282206","https://openalex.org/W2081396473","https://openalex.org/W1501889836","https://openalex.org/W3044043174","https://openalex.org/W3190680796","https://openalex.org/W2737938462","https://openalex.org/W2609875611","https://openalex.org/W3017979176","https://openalex.org/W1991804237"],"abstract_inverted_index":{"Background:":[0],"Hantaviruses":[1],"-":[2,22],"dichotomized":[3],"into":[4],"New":[5,322],"World":[6,323],"(i.e.":[7,18],"Andes":[8],"virus,":[9,13,20],"ANDV;":[10],"Sin":[11],"Nombre":[12],"SNV)":[14],"and":[15,66,83,94,99,104,109,139,159,167,184,205,218,237,245,263,273,311,314,321],"Old-World":[16],"viruses":[17,25,122],"Hantaan":[19],"HTNV)":[21],"are":[23],"zoonotic":[24],"transmitted":[26],"from":[27],"rodents":[28],"to":[29,42,52,59,115,133,216,292,296,317],"humans.":[30],"Currently,":[31],"no":[32],"FDA-approved":[33],"vaccines":[34],"against":[35],"hantaviruses":[36],"exist.":[37],"Given":[38],"the":[39,46,117,258,277,341],"recent":[40],"breakthrough":[41],"human-human":[43],"transmission":[44],"by":[45],"ANDV,":[47,102,286],"an":[48,54],"essential":[49],"step":[50],"is":[51],"establish":[53,134,297],"effective":[55,67],"pandemic":[56],"preparedness":[57],"infrastructure":[58],"rapidly":[60],"identify":[61,116],"cell":[62,77,97,125,149,225,290,299],"tropism,":[63,325],"infective":[64],"potential,":[65],"therapeutic":[68],"agents":[69],"through":[70],"systematic":[71],"investigation.":[72],"Methods:":[73],"We":[74],"established":[75],"human":[76,166,307],"model":[78,309],"systems":[79,310],"in":[80,123,157,165,180,190,270,284,288,340],"lung":[81,85,171,191,224],"(airway":[82],"distal":[84,170],"epithelial":[86],"cells),":[87],"heart":[88,158],"(pluripotent":[89],"stem":[90],"cell-derived":[91],"(PSC-)":[92],"cardiomyocytes),":[93],"brain":[95,160],"(PSC-astrocytes)":[96],"types":[98,150],"subsequently":[100],"evaluated":[101],"HTNV":[103,152],"SNV":[105,217],"tropisms.":[106],"Transcriptomic,":[107],"lipidomic":[108,315],"bioinformatic":[110],"data":[111,255,316],"analyses":[112],"were":[113,268],"performed":[114],"molecular":[118,211],"pathogenic":[119],"mechanisms":[120],"of":[121,186,202,209,261,280,343],"different":[124],"types.":[126],"This":[127],"cell-based":[128],"infection":[129,178,221,244],"system":[130],"was":[131,154],"utilized":[132],"a":[135,344],"drug":[136,230,329],"testing":[137],"platform":[138],"pharmacogenomic":[140],"comparisons.":[141],"Results:":[142],"ANDV":[143,162,177,220,242],"showed":[144,175,199,213],"broad":[145],"tropism":[146],"for":[147,336],"all":[148],"assessed.":[151],"replication":[153],"predominantly":[155],"observed":[156],"cells.":[161,192],"efficiently":[163],"replicated":[164],"mouse":[168],"3D":[169],"organoids.":[172],"Transcriptomic":[173],"analysis":[174,208],"that":[176,196,240,257,331],"resulted":[179],"pronounced":[181],"inflammatory":[182],"response":[183],"downregulation":[185],"cholesterol":[187,203],"biosynthesis":[188],"pathway":[189],"Lipidomic":[193],"profiling":[194],"revealed":[195],"ANDV-infected":[197],"cells":[198],"reduced":[200],"level":[201],"esters":[204],"triglycerides.":[206],"Further":[207],"pathway-based":[210],"signatures":[212],"that,":[214],"compared":[215],"HTNV,":[219],"caused":[222],"drastic":[223],"injury":[226],"responses.":[227],"A":[228],"selective":[229],"screening":[231],"identified":[232,269],"STING":[233],"agonists,":[234],"nucleoside":[235],"analogues":[236],"plant-derived":[238],"compounds":[239],"inhibited":[241],"viral":[243],"rescued":[246],"cellular":[247],"metabolism.":[248],"In":[249],"line":[250],"with":[251],"experimental":[252],"results,":[253],"transcriptome":[254],"shows":[256],"least":[259],"number":[260],"total":[262],"unique":[264],"differentially":[265],"expressed":[266],"genes":[267],"urolithin":[271],"B-":[272],"favipiravir-treated":[274],"cells,":[275],"confirming":[276],"higher":[278],"efficiency":[279],"these":[281],"two":[282],"drugs":[283],"inhibiting":[285],"resulting":[287],"host":[289],"ability":[291],"balance":[293],"gene":[294],"expression":[295],"proper":[298],"functioning.":[300],"Conclusions:":[301],"Overall,":[302],"our":[303],"study":[304],"describes":[305],"advanced":[306],"PSC-derived":[308],"systems-level":[312],"transcriptomics":[313],"better":[318],"understand":[319],"Old":[320],"hantaviral":[324],"as":[326,328],"well":[327],"candidates":[330],"can":[332],"be":[333],"further":[334],"assessed":[335],"potential":[337],"rapid":[338],"deployment":[339],"event":[342],"pandemic.":[345]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-08-06T00:00:00"}