{"id":"https://openalex.org/W4385563530","doi":"https://doi.org/10.1111/ejn.16106","title":"D2 dopamine receptor\u2010mediated mechanisms of dopaminergic system modulation in in vivo and in vitro experimental models of migraine","display_name":"D2 dopamine receptor\u2010mediated mechanisms of dopaminergic system modulation in in vivo and in vitro experimental models of migraine","publication_year":2023,"publication_date":"2023-08-04","ids":{"openalex":"https://openalex.org/W4385563530","doi":"https://doi.org/10.1111/ejn.16106","pmid":"https://pubmed.ncbi.nlm.nih.gov/37539658"},"language":"en","primary_location":{"id":"doi:10.1111/ejn.16106","doi":"https://doi.org/10.1111/ejn.16106","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ejn.16106","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.authorea.com/doi/pdf/10.22541/au.168311913.34285206","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015960342","display_name":"Yasemin Barano\u011flu K\u0131l\u0131n\u00e7","orcid":"https://orcid.org/0000-0002-1795-5677","observed_orcids":["https://orcid.org/0000-0002-1795-5677"]},"institutions":[{"id":"https://openalex.org/I76973811","display_name":"Bolu Abant \u0130zzet Baysal University","ror":"https://ror.org/01x1kqx83","country_code":"TR","type":"education","lineage":["https://openalex.org/I76973811"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Yasemin Baranoglu Kilinc","raw_affiliation_strings":["Department of Pediatrics, Bolu Izzet Baysal State Hospital, Bolu, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Bolu Izzet Baysal State Hospital, Bolu, Turkey","institution_ids":["https://openalex.org/I76973811"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046509744","display_name":"\u0130brahim Ethem Torun","orcid":"https://orcid.org/0000-0001-7035-3336","observed_orcids":["https://orcid.org/0000-0001-7035-3336"]},"institutions":[{"id":"https://openalex.org/I76973811","display_name":"Bolu Abant \u0130zzet Baysal University","ror":"https://ror.org/01x1kqx83","country_code":"TR","type":"education","lineage":["https://openalex.org/I76973811"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ibrahim Ethem Torun","raw_affiliation_strings":["Department of Physiology, Medical School, University of Bolu Abant Izzet Baysal, Bolu, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical School, University of Bolu Abant Izzet Baysal, Bolu, Turkey","institution_ids":["https://openalex.org/I76973811"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025955226","display_name":"Erkan K\u0131l\u0131n\u00e7","orcid":"https://orcid.org/0000-0001-9261-2634","observed_orcids":["https://orcid.org/0000-0001-9261-2634"]},"institutions":[{"id":"https://openalex.org/I76973811","display_name":"Bolu Abant \u0130zzet Baysal University","ror":"https://ror.org/01x1kqx83","country_code":"TR","type":"education","lineage":["https://openalex.org/I76973811"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Erkan Kilinc","raw_affiliation_strings":["Department of Physiology, Medical School, University of Bolu Abant Izzet Baysal, Bolu, Turkey"],"raw_orcid":"https://orcid.org/0000-0001-9261-2634","affiliations":[{"raw_affiliation_string":"Department of Physiology, Medical School, University of Bolu Abant Izzet Baysal, Bolu, Turkey","institution_ids":["https://openalex.org/I76973811"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025955226"],"corresponding_institution_ids":["https://openalex.org/I76973811"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":2.2629,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.87899969,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"59","issue":"6","first_page":"1177","last_page":"1193"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/migraine","display_name":"migraine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dopamine-d2-receptor","display_name":"dopamine D2 receptor","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dopaminergic-system","display_name":"dopaminergic system","score":0.8489999771118164},{"id":"https://openalex.org/keywords/apomorphine","display_name":"apomorphine","score":0.9070000052452087},{"id":"https://openalex.org/keywords/haloperidol","display_name":"haloperidol","score":0.8349999785423279},{"id":"https://openalex.org/keywords/metoclopramide","display_name":"metoclopramide","score":1.0},{"id":"https://openalex.org/keywords/ondansetron","display_name":"ondansetron","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nitroglycerin-induced-migraine","display_name":"nitroglycerin-induced migraine","score":0.8050000071525574},{"id":"https://openalex.org/keywords/calcitonin-gene-related-peptide","display_name":"calcitonin gene-related peptide","score":0.8299999833106995},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":0.8029999732971191},{"id":"https://openalex.org/keywords/mast-cell-degranulation","display_name":"mast cell degranulation","score":0.9539999961853027},{"id":"https://openalex.org/keywords/c-fos-expression","display_name":"Fos expression","score":0.9150000214576721},{"id":"https://openalex.org/keywords/5-ht3-receptor-antagonism","display_name":"5-HT3 receptor antagonism","score":0.7870000004768372},{"id":"https://openalex.org/keywords/trigeminal-ganglion","display_name":"trigeminal ganglion","score":0.671999990940094},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.5964519381523132},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5814351439476013},{"id":"https://openalex.org/C2777525119","wikidata":"https://www.wikidata.org/wiki/Q269111","display_name":"Apomorphine","level":4,"score":0.5658435225486755},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5322098135948181},{"id":"https://openalex.org/C2778479196","wikidata":"https://www.wikidata.org/wiki/Q421095","display_name":"Metoclopramide","level":3,"score":0.4777633249759674},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4732402265071869},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4619050621986389},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45846614241600037},{"id":"https://openalex.org/C163170386","wikidata":"https://www.wikidata.org/wiki/Q419432","display_name":"Calcitonin gene-related peptide","level":4,"score":0.42413246631622314},{"id":"https://openalex.org/C44208683","wikidata":"https://www.wikidata.org/wiki/Q15335165","display_name":"Dopamine receptor D2","level":3,"score":0.42194581031799316},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.345825731754303},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3268255591392517},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24748480319976807},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.19905167818069458},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.14849111437797546},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001058","descriptor_name":"Apomorphine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005996","descriptor_name":"Nitroglycerin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006220","descriptor_name":"Haloperidol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D006930","descriptor_name":"Hyperalgesia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008787","descriptor_name":"Metoclopramide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011954","descriptor_name":"Receptors, Dopamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015740","descriptor_name":"Calcitonin Gene-Related Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017294","descriptor_name":"Ondansetron","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D044406","descriptor_name":"Receptors, Serotonin, 5-HT3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/ejn.16106","doi":"https://doi.org/10.1111/ejn.16106","is_oa":false,"landing_page_url":"https://doi.org/10.1111/ejn.16106","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"doi:10.22541/au.168311913.34285206/v1","doi":"https://doi.org/10.22541/au.168311913.34285206/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.168311913.34285206/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.168311913.34285206","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:37539658","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37539658","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.22541/au.168311913.34285206/v1","doi":"https://doi.org/10.22541/au.168311913.34285206/v1","is_oa":true,"landing_page_url":"https://doi.org/10.22541/au.168311913.34285206/v1","pdf_url":"https://www.authorea.com/doi/pdf/10.22541/au.168311913.34285206","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321395","display_name":"Abant Izzet Baysal \u00dcniversitesi","ror":"https://ror.org/01x1kqx83"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385563530.pdf","grobid_xml":"https://content.openalex.org/works/W4385563530.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W410379109","https://openalex.org/W1542291218","https://openalex.org/W1862349412","https://openalex.org/W1963787378","https://openalex.org/W1968465725","https://openalex.org/W1970860218","https://openalex.org/W1974332774","https://openalex.org/W1975215969","https://openalex.org/W1975416011","https://openalex.org/W1979535431","https://openalex.org/W1980299033","https://openalex.org/W1987845024","https://openalex.org/W1988102338","https://openalex.org/W1988313191","https://openalex.org/W1990077831","https://openalex.org/W1997552524","https://openalex.org/W1999232704","https://openalex.org/W2002664456","https://openalex.org/W2002759179","https://openalex.org/W2006191956","https://openalex.org/W2006472378","https://openalex.org/W2008574501","https://openalex.org/W2013033676","https://openalex.org/W2016991277","https://openalex.org/W2018058412","https://openalex.org/W2018174825","https://openalex.org/W2026322513","https://openalex.org/W2039458015","https://openalex.org/W2039605898","https://openalex.org/W2042624620","https://openalex.org/W2047295580","https://openalex.org/W2047361963","https://openalex.org/W2049124574","https://openalex.org/W2051332182","https://openalex.org/W2053803086","https://openalex.org/W2055122214","https://openalex.org/W2057088794","https://openalex.org/W2057132284","https://openalex.org/W2060115105","https://openalex.org/W2072756227","https://openalex.org/W2074082327","https://openalex.org/W2077693540","https://openalex.org/W2079561658","https://openalex.org/W2084114882","https://openalex.org/W2085447391","https://openalex.org/W2088850685","https://openalex.org/W2094632660","https://openalex.org/W2094676587","https://openalex.org/W2104230751","https://openalex.org/W2110968589","https://openalex.org/W2118176563","https://openalex.org/W2121070581","https://openalex.org/W2130194314","https://openalex.org/W2131570638","https://openalex.org/W2131994445","https://openalex.org/W2144693103","https://openalex.org/W2161127835","https://openalex.org/W2162533304","https://openalex.org/W2163421692","https://openalex.org/W2165575058","https://openalex.org/W2166688989","https://openalex.org/W2170202412","https://openalex.org/W2317268469","https://openalex.org/W2332989614","https://openalex.org/W2413599583","https://openalex.org/W2414758237","https://openalex.org/W2418567906","https://openalex.org/W2512785196","https://openalex.org/W2550010320","https://openalex.org/W2592163340","https://openalex.org/W2598139181","https://openalex.org/W2751007471","https://openalex.org/W2752665059","https://openalex.org/W2765936018","https://openalex.org/W2790167276","https://openalex.org/W2793245171","https://openalex.org/W2809978622","https://openalex.org/W2849561320","https://openalex.org/W2905515525","https://openalex.org/W2911889580","https://openalex.org/W2911947360","https://openalex.org/W2931614135","https://openalex.org/W2950234145","https://openalex.org/W2954842454","https://openalex.org/W2955580540","https://openalex.org/W2971102518","https://openalex.org/W2981964842","https://openalex.org/W2988691333","https://openalex.org/W3001392145","https://openalex.org/W3003830787","https://openalex.org/W3011029213","https://openalex.org/W3030102664","https://openalex.org/W3040739497","https://openalex.org/W3086515099","https://openalex.org/W3115770555","https://openalex.org/W3116452987","https://openalex.org/W3127343438","https://openalex.org/W3128295184","https://openalex.org/W3173310397","https://openalex.org/W3200459505","https://openalex.org/W3205117884","https://openalex.org/W4280648063","https://openalex.org/W4286493966","https://openalex.org/W4297328594","https://openalex.org/W4311672115"],"related_works":["https://openalex.org/W4367842164","https://openalex.org/W2592163340","https://openalex.org/W3131814673","https://openalex.org/W2068957321","https://openalex.org/W2003127653","https://openalex.org/W2094676587","https://openalex.org/W2006191956","https://openalex.org/W1963787378","https://openalex.org/W2989720492","https://openalex.org/W2051089493"],"abstract_inverted_index":{"The":[0],"dopaminergic":[1,23,184,244],"system":[2,24],"is":[3,219],"implicated":[4],"in":[5,26,28,31,56,60,77,91,95,101,139,175,201,239,243],"the":[6,11,18,27,63,102,178,211],"pathophysiology":[7],"of":[8,22,35,65,167,213],"migraine.":[9,36],"However,":[10],"underlying":[12],"mechanisms":[13,21],"remain":[14],"unclear.":[15],"We":[16],"explored":[17],"effects":[19,146,212],"and":[20,30,44,46,52,94,98,130,134,147,157,169,197],"modulation":[25],"vivo":[29],"vitro":[32,78,96],"rat":[33],"models":[34],"Dopaminergic":[37],"agonist":[38],"apomorphine,":[39,214],"D2":[40,228],"receptor":[41,48,223,229],"antagonists":[42],"metoclopramide":[43,238],"haloperidol":[45,168],"5-HT3":[47,222],"antagonist":[49],"ondansetron":[50,158,170],"alone":[51],"together":[53],"were":[54,67,104,113,181],"tested":[55,69,84],"nitroglycerin-induced":[57,122,163],"migraine":[58,206],"model,":[59],"vivo.":[61,140],"Likewise,":[62],"combinations":[64],"drugs":[66],"also":[68,148,220],"on":[70],"basal":[71,172],"calcitonin":[72],"gene-related":[73],"peptide":[74],"(CGRP)":[75],"release":[76,196],"hemiskull":[79],"preparations.":[80],"Mechanical":[81],"allodynia":[82],"was":[83],"by":[85,106,152,190],"von":[86],"Frey":[87],"filaments.":[88],"CGRP":[89,132,173,195],"concentrations":[90,133],"trigeminovascular":[92],"structures":[93,203],"superfusates":[97],"c-Fos":[99],"levels":[100],"brainstem":[103,125,131],"determined":[105],"enzyme-linked":[107],"immunosorbent":[108],"assay.":[109],"Meningeal":[110],"mast":[111,136,198],"cells":[112],"evaluated":[114],"with":[115,205,226],"toluidine":[116],"blue":[117],"staining.":[118],"Apomorphine":[119],"further":[120,191],"enhanced":[121],"mechanical":[123],"allodynia,":[124],"c-fos":[126,193],"expression,":[127,194],"trigeminal":[128],"ganglion":[129],"meningeal":[135],"cell":[137,199],"degranulation,":[138],"Haloperidol":[141,225],"completely":[142],"antagonised":[143],"all":[144],"apomorphine-induced":[145],"alleviated":[149],"changes":[150],"induced":[151],"nitroglycerin":[153],"without":[154],"apomorphine.":[155],"Metoclopramide":[156,208],"partially":[159,209],"attenuated":[160,210],"apomorphine-":[161],"or":[162],"effects.":[164],"A":[165],"combination":[166],"decreased":[171],"release,":[174],"vitro,":[176],"whereas":[177],"other":[179],"administrations":[180],"ineffective.":[182],"Apomorphine-mediated":[183],"activation":[185],"exacerbated":[186],"nitroglycerin-stimulated":[187],"nociceptive":[188],"reactions":[189],"enhancing":[192],"degranulation":[200],"strategical":[202],"associated":[204],"pain.":[207],"most":[215],"likely":[216],"because":[217],"it":[218],"a":[221],"antagonist.":[224],"pure":[227],"antagonism":[230],"feature":[231],"appears":[232],"to":[233],"be":[234],"more":[235],"effective":[236],"than":[237],"reducing":[240],"migraine-related":[241],"parameters":[242],"activation-":[245],"and/or":[246],"NTG-induced":[247],"migraine-like":[248],"conditions.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-08-05T00:00:00"}