{"id":"https://openalex.org/W4385556367","doi":"https://doi.org/10.58530/2022/1355","title":"Deuterated \u03b1-ketoglutarate has the potential to detect the isocitrate dehydrogenase 1 mutation in low-grade gliomas.","display_name":"Deuterated \u03b1-ketoglutarate has the potential to detect the isocitrate dehydrogenase 1 mutation in low-grade gliomas.","publication_year":2023,"publication_date":"2023-08-03","ids":{"openalex":"https://openalex.org/W4385556367","doi":"https://doi.org/10.58530/2022/1355"},"language":"en","primary_location":{"id":"doi:10.58530/2022/1355","doi":"https://doi.org/10.58530/2022/1355","is_oa":false,"landing_page_url":"http://dx.doi.org/10.58530/2022/1355","pdf_url":null,"source":{"id":"https://openalex.org/S4393917449","display_name":"Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition","issn_l":"1524-6965","issn":["1524-6965","1545-4428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISMRM Annual Meeting","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003512442","display_name":"C\u00e9line Taglang","orcid":"https://orcid.org/0000-0002-3927-6675","observed_orcids":["https://orcid.org/0000-0002-3927-6675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Celine Taglang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035221576","display_name":"Georgios Batsios","orcid":"https://orcid.org/0000-0002-2340-1486","observed_orcids":["https://orcid.org/0000-0002-2340-1486"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgios Batsios","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057139721","display_name":"Meryssa Tran","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meryssa Tran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111474565","display_name":"Anne-Marie Gillespie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne-Marie Gillespie","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060105335","display_name":"Sabrina M. Ronen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabrina Ronen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073732331","display_name":"Pavithra Viswanath","orcid":"https://orcid.org/0000-0003-2980-3109","observed_orcids":["https://orcid.org/0000-0003-2980-3109"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pavithra Viswanath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.3423913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.49390000104904175,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.49390000104904175,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.13490000367164612,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.12489999830722809,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idh1-mutation","display_name":"IDH1 mutation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/2-hydroxyglutarate","display_name":"2-hydroxyglutarate","score":0.9390000104904175},{"id":"https://openalex.org/keywords/oncometabolites","display_name":"oncometabolites","score":0.7720000147819519},{"id":"https://openalex.org/keywords/tumor-response-to-therapy","display_name":"tumor response to therapy","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2777150147","wikidata":"https://www.wikidata.org/wiki/Q261968","display_name":"Isocitrate dehydrogenase","level":3,"score":0.9168288707733154},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7338441014289856},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46428123116493225},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.44253745675086975},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4394379258155823},{"id":"https://openalex.org/C127848430","wikidata":"https://www.wikidata.org/wiki/Q18027543","display_name":"IDH1","level":4,"score":0.41232171654701233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33902856707572937},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3262922167778015},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30350619554519653},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30214712023735046},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.085010826587677}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.58530/2022/1355","doi":"https://doi.org/10.58530/2022/1355","is_oa":false,"landing_page_url":"http://dx.doi.org/10.58530/2022/1355","pdf_url":null,"source":{"id":"https://openalex.org/S4393917449","display_name":"Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition","issn_l":"1524-6965","issn":["1524-6965","1545-4428"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ISMRM Annual Meeting","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3045093497","https://openalex.org/W2625310957","https://openalex.org/W2196531476","https://openalex.org/W2170272880","https://openalex.org/W2266413649","https://openalex.org/W2308732970","https://openalex.org/W2334630636","https://openalex.org/W2083820071","https://openalex.org/W4412333368","https://openalex.org/W2588948489"],"abstract_inverted_index":{"2H-MRS":[0,15],"is":[1,60],"a":[2,70,90],"novel":[3],"method":[4],"of":[5,30,87,92],"imaging":[6],"flux":[7],"through":[8],"metabolic":[9],"pathways.":[10],"Here,":[11],"we":[12],"show":[13],"that":[14,41],"can":[16,46],"be":[17,47],"used":[18],"to":[19,84,98],"probe":[20,91],"the":[21,31,85],"isocitrate":[22],"dehydrogenase":[23],"1":[24],"mutation":[25],"(IDHmut),":[26],"which":[27,59],"catalyzes":[28],"production":[29,43,75],"oncometabolite":[32],"2-hydroxyglutarate":[33],"(2-HG)":[34],"in":[35,50,61,69,73,78],"low-grade":[36,65],"gliomas.":[37],"Our":[38,81],"results":[39,68,82],"indicate":[40],"2-HG":[42,74],"from":[44,76],"[3,3\u2019-2H]-\u03b1-KG":[45,77,88],"specifically":[48],"observed":[49],"IDHmut":[51,57,79,94],"cells.":[52,80],"Importantly,":[53],"treatment":[54],"with":[55],"an":[56],"inhibitor,":[58],"clinical":[62],"trials":[63],"for":[64],"glioma":[66,93],"patients,":[67],"significant":[71],"reduction":[72],"point":[83],"potential":[86],"as":[89],"status":[95],"and":[96],"response":[97],"therapy.":[99]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-04T00:00:00"}
