{"id":"https://openalex.org/W4385514801","doi":"https://doi.org/10.1186/s12967-023-04341-x","title":"Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration","display_name":"Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration","publication_year":2023,"publication_date":"2023-08-02","ids":{"openalex":"https://openalex.org/W4385514801","doi":"https://doi.org/10.1186/s12967-023-04341-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/37533102","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10398918"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-023-04341-x","doi":"https://doi.org/10.1186/s12967-023-04341-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-023-04341-x","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-023-04341-x","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-023-04341-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076728347","display_name":"Jean Bastin","orcid":"https://orcid.org/0000-0001-8350-8667","observed_orcids":["https://orcid.org/0000-0001-8350-8667"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean Bastin","raw_affiliation_strings":["Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026178746","display_name":"Marine Sroussi","orcid":"https://orcid.org/0000-0003-3545-5518","observed_orcids":["https://orcid.org/0000-0003-3545-5518"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"id":"https://openalex.org/I4210111777","display_name":"Laboratoire de Biochimie","ror":"https://ror.org/01thw2g46","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I4210111777","https://openalex.org/I4210139971","https://openalex.org/I4210161506","https://openalex.org/I98910050"]},{"id":"https://openalex.org/I98910050","display_name":"ESPCI Paris","ror":"https://ror.org/03zx86w41","country_code":"FR","type":"education","lineage":["https://openalex.org/I190752583","https://openalex.org/I2746051580","https://openalex.org/I98910050"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marine Sroussi","raw_affiliation_strings":["Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France","Laboratoire de Biochimie, Ecole Sup\u00e9rieure de Physique et de Chimie Industrielle de la Ville de Paris, 75005, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Laboratoire de Biochimie, Ecole Sup\u00e9rieure de Physique et de Chimie Industrielle de la Ville de Paris, 75005, Paris, France","institution_ids":["https://openalex.org/I4210111777","https://openalex.org/I98910050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033772913","display_name":"Ivan Nemazanyy","orcid":"https://orcid.org/0000-0001-8080-839X","observed_orcids":["https://orcid.org/0000-0001-8080-839X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4403386587","display_name":"Structure f\u00e9d\u00e9rative de recherche Necker","ror":"https://ror.org/053p5te48","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4403386587"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ivan Nemazanyy","raw_affiliation_strings":["Plate Plateforme d'\u00e9tude du M\u00e9tabolisme, SFR Necker, INSERM US24/CNRS UAR3633, 75015, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Plate Plateforme d'\u00e9tude du M\u00e9tabolisme, SFR Necker, INSERM US24/CNRS UAR3633, 75015, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4403386587"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089818289","display_name":"Pierre Laurent\u2010Puig","orcid":"https://orcid.org/0000-0001-8475-5459","observed_orcids":["https://orcid.org/0000-0001-8475-5459"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Laurent-Puig","raw_affiliation_strings":["Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France","Institut du Cancer Paris CARPEM, Department of Biology H\u00f4pital Georges Pompidou, 75015, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Institut du Cancer Paris CARPEM, Department of Biology H\u00f4pital Georges Pompidou, 75015, Paris, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052188741","display_name":"Sophie Mouillet\u2010Richard","orcid":"https://orcid.org/0000-0002-8950-1949","observed_orcids":["https://orcid.org/0000-0002-8950-1949"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sophie Mouillet-Richard","raw_affiliation_strings":["Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018666707","display_name":"Fatima Djouadi","orcid":"https://orcid.org/0000-0003-0350-0935","observed_orcids":["https://orcid.org/0000-0003-0350-0935"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210092322","display_name":"Centre de Recherche des Cordeliers","ror":"https://ror.org/00dmms154","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Fatima Djouadi","raw_affiliation_strings":["Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France. fatima.djouadi@inserm.fr","Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France"],"raw_orcid":"https://orcid.org/0000-0003-0350-0935","affiliations":[{"raw_affiliation_string":"Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France. fatima.djouadi@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]},{"raw_affiliation_string":"Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Universit\u00e9, Universit\u00e9 Paris-Cit\u00e9, 15, Rue de l'Ecole de M\u00e9decine, 75006, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5018666707"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I39804081","https://openalex.org/I4210092322"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":2945,"currency":"EUR","value_usd":3176},"fwci":2.0854,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.88741068,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"21","issue":"1","first_page":"522","last_page":"522"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.6996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.1348000019788742,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9430000185966492},{"id":"https://openalex.org/keywords/mitochondrial-complex-i","display_name":"mitochondrial complex I","score":0.9259999990463257},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8679999709129333},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.6209999918937683},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.7699999809265137},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sod2-acetylation","display_name":"SOD2 acetylation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/manganese-superoxide-dismutase","display_name":"manganese superoxide dismutase","score":0.9440000057220459},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cancer-prognosis","display_name":"cancer prognosis","score":0.503000020980835},{"id":"https://openalex.org/keywords/lovo-cells","display_name":"LoVo cells","score":0.7269999980926514},{"id":"https://openalex.org/keywords/redox-homeostasis","display_name":"redox homeostasis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/patient-survival","display_name":"patient survival","score":0.40799999237060547},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8599649667739868},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6344019770622253},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.5444856286048889},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5090898871421814},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5080876350402832},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4436103105545044},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.43178120255470276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40610089898109436},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37325096130371094},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34769177436828613},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3230232000350952},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2498679757118225},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17081210017204285},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051416","descriptor_name":"Focal Adhesion Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051416","descriptor_name":"Focal Adhesion Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12967-023-04341-x","doi":"https://doi.org/10.1186/s12967-023-04341-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-023-04341-x","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-023-04341-x","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10398918","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10398918","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10398918/pdf/12967_2023_Article_4341.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmid:37533102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37533102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:inserm-04264493v1","doi":null,"is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-04264493","pdf_url":"https://inserm.hal.science/inserm-04264493v1/file/Revised%20article%20Bastin%20et%20al%20avec%20figures_depot%20HAL.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, 2023, 21 (1), pp.522. &#x27E8;10.1186/s12967-023-04341-x&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:08da4395fe2b4e27ba67cb17740e7c9b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/08da4395fe2b4e27ba67cb17740e7c9b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12967-023-04341-x","doi":"https://doi.org/10.1186/s12967-023-04341-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-023-04341-x","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-023-04341-x","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8967602103","display_name":null,"funder_award_id":"FDM202006011237","funder_id":"https://openalex.org/F4320321589","funder_display_name":"Fondation pour la Recherche M\u00e9dicale"}],"funders":[{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385514801.pdf","grobid_xml":"https://content.openalex.org/works/W4385514801.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1590512020","https://openalex.org/W1934094702","https://openalex.org/W1969524738","https://openalex.org/W1986375111","https://openalex.org/W1994409023","https://openalex.org/W2013851984","https://openalex.org/W2016163301","https://openalex.org/W2027988626","https://openalex.org/W2044423100","https://openalex.org/W2066560754","https://openalex.org/W2073331259","https://openalex.org/W2102409753","https://openalex.org/W2117692326","https://openalex.org/W2130410032","https://openalex.org/W2141901922","https://openalex.org/W2147954704","https://openalex.org/W2148332345","https://openalex.org/W2153459372","https://openalex.org/W2154941270","https://openalex.org/W2157999222","https://openalex.org/W2160298454","https://openalex.org/W2171065062","https://openalex.org/W2346247884","https://openalex.org/W2398800029","https://openalex.org/W2496616613","https://openalex.org/W2517334795","https://openalex.org/W2518704790","https://openalex.org/W2622622183","https://openalex.org/W2765794440","https://openalex.org/W2771952185","https://openalex.org/W2781642641","https://openalex.org/W2802833332","https://openalex.org/W2806313922","https://openalex.org/W2970045605","https://openalex.org/W2999738634","https://openalex.org/W3003593776","https://openalex.org/W3011404380","https://openalex.org/W3033521417","https://openalex.org/W3041426930","https://openalex.org/W3128646645","https://openalex.org/W4212834395","https://openalex.org/W4285740101"],"related_works":["https://openalex.org/W6976868851","https://openalex.org/W3089448988","https://openalex.org/W2373353311","https://openalex.org/W4404867146","https://openalex.org/W7162506836","https://openalex.org/W7198977670","https://openalex.org/W4377029214","https://openalex.org/W2041018780","https://openalex.org/W2767467112","https://openalex.org/W7099214085"],"abstract_inverted_index":{"BACKGROUND:":[0],"Colorectal":[1],"cancer":[2,78],"(CRC)":[3],"can":[4],"be":[5,35,366],"classified":[6],"into":[7],"four":[8],"molecular":[9],"subtypes":[10],"(CMS)":[11],"among":[12],"which":[13,275,334],"CMS1":[14,129],"is":[15,201,207,225,293,304],"associated":[16,208,305],"with":[17,209,306,361,368],"the":[18,23,27,41,70,89,92,95,154,177,215,289,296,318,343],"best":[19],"prognosis,":[20],"while":[21],"CMS4,":[22],"mesenchymal":[24,162],"subtype,":[25],"has":[26,46],"worst":[28],"outcome.":[29],"Although":[30],"mitochondria":[31],"are":[32],"considered":[33],"to":[34,75,87,113,128,152,187,267,331],"hubs":[36],"of":[37,43,73,83,94,98,146,156,179,241,283,291,328,347,356],"numerous":[38],"signaling":[39],"pathways,":[40],"study":[42,85],"mitochondrial":[44,147,248,357],"metabolism":[45],"been":[47],"neglected":[48],"for":[49,193,214,342],"many":[50],"years.":[51],"Mitochondrial":[52],"Complex":[53],"I":[54],"(CI)":[55],"plays":[56],"a":[57,246,268,353],"dual":[58],"role,":[59],"both":[60,258],"in":[61,77,100,121,183,203,219,234,295,359,373],"energy":[62],"and":[63,109,118,123,130,136,161,168,190,206,299,317,339],"reactive":[64],"oxygen":[65],"species":[66],"(ROS)":[67],"production.":[68],"However,":[69],"possible":[71],"contribution":[72],"CI":[74,90,115,181,200,235,292,302,316,329,358],"tumorigenesis":[76],"remains":[79],"unclear.":[80],"The":[81],"purpose":[82],"this":[84],"was":[86],"investigate":[88],"under":[91],"prism":[93],"CMS":[96,188],"classification":[97,189],"CRC":[99,184,284],"ex":[101],"vivo":[102],"models.":[103],"METHODS:":[104],"Biochemical":[105],"dosages,":[106],"bioenergetics":[107],"analysis":[108],"western-blot":[110],"were":[111,138,150,171],"used":[112],"characterize":[114],"expression,":[116],"function":[117],"redox":[119],"balance":[120],"LoVo":[122],"MDST8":[124,337],"cell":[125],"lines,":[126],"belonging":[127],"CMS4":[131,204,260,297,348],"subgroups,":[132],"respectively.":[133],"Cell":[134],"proliferation":[135],"migration":[137,338],"assessed":[139,176],"by":[140,173,239],"xCELLigence":[141],"technology.":[142],"Overproduction":[143],"or":[144,255,370],"scavenging":[145,256],"ROS":[148],"(mtROS)":[149],"performed":[151],"analyze":[153],"effect":[155],"mtROS":[157,223,257],"on":[158],"proliferation,":[159],"migration,":[160],"markers.":[163],"Focal":[164],"adhesion":[165,271],"kinase":[166,272],"(FAK)":[167,273],"its":[169],"activation":[170],"analyzed":[172],"immunofluorescence.":[174],"We":[175,197,212,251,324],"distribution":[178],"two":[180],"scores":[182],"cohorts":[185,282],"according":[186],"their":[191,278],"relevance":[192],"patient":[194],"survival.":[195],"RESULTS:":[196],"found":[198],"that":[199,218,253,288,300,326,364],"downregulated":[202,294],"cells":[205],"elevated":[210],"mtROS.":[211],"establish":[213],"first":[216],"time":[217],"these":[220],"migrating":[221],"cells,":[222],"production":[224],"maintained":[226],"at":[227],"optimal":[228],"levels":[229],"not":[230],"only":[231],"through":[232],"changes":[233],"activity":[236],"but":[237],"also":[238,265],"inactivation/acetylation":[240],"superoxide":[242],"dismutase":[243],"2":[244],"(SOD2),":[245],"major":[247],"antioxidant":[249],"enzyme.":[250],"show":[252],"promoting":[254],"mitigate":[259],"cells'":[261],"migration.":[262],"Our":[263],"results":[264],"point":[266],"mtROS-mediated":[269],"focal":[270],"activation,":[274],"likely":[276,335],"sustains":[277],"migratory":[279],"phenotype.":[280],"Using":[281],"patients,":[285],"we":[286],"document":[287],"expression":[290,303],"subgroup,":[298],"low":[301],"poor":[307],"prognosis.":[308],"Patients'":[309],"datasets":[310],"reveal":[311,352],"an":[312],"inverse":[313],"correlation":[314],"between":[315],"epithelial-mesenchymal":[319],"transition":[320],"(EMT)":[321],"pathway.":[322],"CONCLUSION:":[323],"showed":[325],"inhibition":[327],"contributes":[330],"heighten":[332],"mtROS,":[333],"foster":[336],"might":[340],"account":[341],"specific":[344],"EMT":[345],"signature":[346],"tumors.":[349],"These":[350],"data":[351],"novel":[354],"role":[355],"CRC,":[360],"biological":[362],"consequences":[363],"may":[365],"targeted":[367],"anti-":[369],"pro-oxidant":[371],"drugs":[372],"clinical":[374],"practice.":[375]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-08-04T00:00:00"}
