{"id":"https://openalex.org/W4385514652","doi":"https://doi.org/10.1089/thy.2023.0070","title":"GlycA as a Novel Biomarker of Systemic Inflammation in Hypothyroidism","display_name":"GlycA as a Novel Biomarker of Systemic Inflammation in Hypothyroidism","publication_year":2023,"publication_date":"2023-08-03","ids":{"openalex":"https://openalex.org/W4385514652","doi":"https://doi.org/10.1089/thy.2023.0070","pmid":"https://pubmed.ncbi.nlm.nih.gov/37534852"},"language":"en","primary_location":{"id":"doi:10.1089/thy.2023.0070","doi":"https://doi.org/10.1089/thy.2023.0070","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.2023.0070","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid\u00ae","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075222714","display_name":"Sarah Galv\u00e3o","orcid":"https://orcid.org/0000-0003-4181-5567","observed_orcids":["https://orcid.org/0000-0003-4181-5567"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Sarah Galvao","raw_affiliation_strings":["Post-Graduate Program in Endocrinology, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-4181-5567","affiliations":[{"raw_affiliation_string":"Post-Graduate Program in Endocrinology, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014251117","display_name":"Isabela M. Bense\u00f1or","orcid":"https://orcid.org/0000-0002-6723-5678","observed_orcids":["https://orcid.org/0000-0002-6723-5678"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Isabela M. Bensenor","raw_affiliation_strings":["Center for Clinical and Epidemiological Research, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical and Epidemiological Research, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008531984","display_name":"Michael Joseph Blaha","orcid":"https://orcid.org/0000-0001-5138-9683","observed_orcids":["https://orcid.org/0000-0001-5138-9683"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Blaha","raw_affiliation_strings":["Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Steven Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven Jones","raw_affiliation_strings":["Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054876477","display_name":"Peter Paul Toth","orcid":"https://orcid.org/0000-0001-5810-5460","observed_orcids":["https://orcid.org/0000-0001-5810-5460"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I4210120111","display_name":"CGH Medical Center","ror":"https://ror.org/02vajn858","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210120111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter P. Toth","raw_affiliation_strings":["Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, Maryland, USA","Department of Preventive Cardiology, CGH Medical Center, Sterling, Illinois, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, Maryland, USA","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Preventive Cardiology, CGH Medical Center, Sterling, Illinois, USA","institution_ids":["https://openalex.org/I4210120111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053901502","display_name":"Raul Dias Santos","orcid":"https://orcid.org/0000-0002-9860-6582","observed_orcids":["https://orcid.org/0000-0002-9860-6582"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]},{"id":"https://openalex.org/I4405258467","display_name":"Instituto do Cora\u00e7\u00e3o - HCFMUSP","ror":"https://ror.org/00q3jak84","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210145268","https://openalex.org/I4405258467"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raul D. Santos","raw_affiliation_strings":["Lipid Clinic Heart Institute (InCor), University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lipid Clinic Heart Institute (InCor), University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374","https://openalex.org/I4405258467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005626241","display_name":"M\u00e1rcio Sommer Bittencourt","orcid":"https://orcid.org/0000-0002-3711-1754","observed_orcids":["https://orcid.org/0000-0002-3711-1754"]},"institutions":[{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcio Bittencourt","raw_affiliation_strings":["Department of Medicine, Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023008381","display_name":"Paulo A. Lotufo","orcid":"https://orcid.org/0000-0002-4856-8450","observed_orcids":["https://orcid.org/0000-0002-4856-8450"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo A. Lotufo","raw_affiliation_strings":["Center for Clinical and Epidemiological Research, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Clinical and Epidemiological Research, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009338517","display_name":"Patr\u00edcia de F\u00e1tima dos Santos Teixeira","orcid":"https://orcid.org/0000-0001-8859-6387","observed_orcids":["https://orcid.org/0000-0001-8859-6387","https://orcid.org/0000-0002-1215-7190"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Patr\u00edcia de F\u00e1tima dos Santos Teixeira","raw_affiliation_strings":["Post-Graduate Program in Endocrinology, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Post-Graduate Program in Endocrinology, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5009338517"],"corresponding_institution_ids":["https://openalex.org/I122140584"],"apc_list":null,"apc_paid":null,"fwci":0.8133,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.74699227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"33","issue":"10","first_page":"1171","last_page":"1181"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glyca","display_name":"GlycA","score":0.7360000014305115},{"id":"https://openalex.org/keywords/systemic-inflammation","display_name":"systemic inflammation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.9959999918937683},{"id":"https://openalex.org/keywords/levothyroxine","display_name":"levothyroxine","score":0.8980000019073486},{"id":"https://openalex.org/keywords/thyroid-stimulating-hormone","display_name":"thyroid-stimulating hormone","score":0.8149999976158142},{"id":"https://openalex.org/keywords/anti-thyroid-peroxidase-antibodies","display_name":"thyroid peroxidase antibodies","score":0.7170000076293945},{"id":"https://openalex.org/keywords/undiagnosed-hypothyroidism","display_name":"undiagnosed hypothyroidism","score":0.824999988079071},{"id":"https://openalex.org/keywords/cardiovascular-risk-markers","display_name":"cardiovascular risk markers","score":0.527999997138977},{"id":"https://openalex.org/keywords/elsa-brasil-cohort","display_name":"ELSA-Brasil cohort","score":0.8119999766349792},{"id":"https://openalex.org/keywords/magnetic-resonance-spectroscopy","display_name":"magnetic resonance spectroscopy","score":0.7440000176429749},{"id":"https://openalex.org/keywords/glycoprotein-biomarkers","display_name":"glycoprotein biomarkers","score":0.6470000147819519},{"id":"https://openalex.org/keywords/autoimmune-thyroid-disease","display_name":"autoimmune thyroid disease","score":0.5249999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8199430704116821},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.6814452409744263},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6387401819229126},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6324089765548706},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.6157947778701782},{"id":"https://openalex.org/C2775883008","wikidata":"https://www.wikidata.org/wiki/Q773449","display_name":"Levothyroxine","level":3,"score":0.4766203463077545},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.46657595038414},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4470616281032562},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.42273199558258057},{"id":"https://openalex.org/C2778840127","wikidata":"https://www.wikidata.org/wiki/Q712838","display_name":"Thyroid function tests","level":3,"score":0.4202728867530823},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3690217137336731},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3594498038291931},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3424355983734131},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/thy.2023.0070","doi":"https://doi.org/10.1089/thy.2023.0070","is_oa":false,"landing_page_url":"https://doi.org/10.1089/thy.2023.0070","pdf_url":null,"source":{"id":"https://openalex.org/S27569427","display_name":"Thyroid","issn_l":"1050-7256","issn":["1050-7256","1557-9077"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid\u00ae","raw_type":"journal-article"},{"id":"pmid:37534852","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37534852","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thyroid : official journal of the American Thyroid Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1544436674","https://openalex.org/W1747119434","https://openalex.org/W1840058780","https://openalex.org/W1969336260","https://openalex.org/W1993655330","https://openalex.org/W2000973805","https://openalex.org/W2014538668","https://openalex.org/W2033152833","https://openalex.org/W2045199633","https://openalex.org/W2047898666","https://openalex.org/W2081220240","https://openalex.org/W2088339673","https://openalex.org/W2091655302","https://openalex.org/W2099111117","https://openalex.org/W2104342488","https://openalex.org/W2105216713","https://openalex.org/W2115819915","https://openalex.org/W2128219988","https://openalex.org/W2140936682","https://openalex.org/W2157769976","https://openalex.org/W2159087408","https://openalex.org/W2161444360","https://openalex.org/W2169531519","https://openalex.org/W2265212715","https://openalex.org/W2337946759","https://openalex.org/W2381728735","https://openalex.org/W2427069358","https://openalex.org/W2556512023","https://openalex.org/W2567513353","https://openalex.org/W2756429786","https://openalex.org/W2767172593","https://openalex.org/W2791328791","https://openalex.org/W2797362459","https://openalex.org/W2800239085","https://openalex.org/W2887012516","https://openalex.org/W2891009351","https://openalex.org/W2907659012","https://openalex.org/W2912469576","https://openalex.org/W2946664098","https://openalex.org/W2971614705","https://openalex.org/W3002771111","https://openalex.org/W3014435347","https://openalex.org/W3099456611","https://openalex.org/W3111141110","https://openalex.org/W3112332718","https://openalex.org/W3136042714","https://openalex.org/W3160161394","https://openalex.org/W3169976372","https://openalex.org/W4211165806","https://openalex.org/W4280515411","https://openalex.org/W4295078505","https://openalex.org/W4381144811"],"related_works":["https://openalex.org/W2921025266","https://openalex.org/W1506939397","https://openalex.org/W7120636066","https://openalex.org/W4390601041","https://openalex.org/W2019313425","https://openalex.org/W2964216737","https://openalex.org/W2979484257","https://openalex.org/W5968707","https://openalex.org/W6949674866","https://openalex.org/W1968502070"],"abstract_inverted_index":{"Background:":[0],"GlycA":[1,21,66,195,205,232,282,302,322,352],"is":[2],"a":[3,47],"novel":[4],"glycoprotein":[5],"biomarker":[6],"of":[7,20,36,124,215,263,281,301,321],"systemic":[8,360],"inflammation":[9,361],"and":[10,65,83,94,106,143,164,194,257,288,303,335,348],"cardiovascular":[11,365],"risk.":[12,366],"Our":[13],"objective":[14],"was":[15,98,126,217,305],"to":[16,40,187,240,285,317],"assess":[17],"the":[18,54,131,165,189,260],"levels":[19,35,67,196,233,280,300,320],"in":[22,175,236,238,283,308,325],"individuals":[23,79],"with":[24,38,62,80,108,135,177,271,276,330,344,358],"hypothyroidism.":[25],"We":[26,45,58,77],"also":[27,274],"explored":[28],"whether":[29],"levothyroxine":[30],"(LT4)-treated":[31],"patients":[32,176],"had":[33,278,350],"different":[34],"GlycA,":[37],"attention":[39],"thyrotropin":[41],"(TSH)":[42],"levels.":[43],"Methods:":[44],"performed":[46,159,174,186],"cross-sectional":[48],"analysis,":[49],"using":[50,69,85],"baseline":[51],"data":[52],"from":[53],"ELSA-Brasil":[55],"cohort":[56],"study.":[57],"included":[59],"only":[60,225,269],"participants":[61],"serum":[63,96],"TSH":[64,97,110,129,136],"measurements,":[68],"magnetic":[70],"resonance":[71],"spectroscopy":[72],"(":[73,119],"n":[74,120],"=":[75,121,294,340],"4745).":[76],"excluded":[78],"endogenous":[81],"hyperthyroidism":[82],"those":[84,107,116,144,222,264,270,275],"drugs":[86],"impacting":[87],"thyroid":[88],"function.":[89],"Participants":[90],"not":[91,251,268],"taking":[92],"LT4":[93,118],"whose":[95],"0.4\u20134.0":[99],"mIU/L":[100,138],"were":[101,139,151,158,173,185,228,234,323],"classified":[102],"as":[103,111,128,200,202],"euthyroid":[104],"(EU)":[105],"elevated":[109],"undiagnosed":[112],"hypothyroidism":[113],"(UH).":[114],"For":[115],"on":[117,223],"345),":[122],"adequacy":[123],"treatment":[125],"defined":[127],"within":[130],"reference":[132],"range.":[133],"Those":[134],"<0.4":[137],"considered":[140,152],"over-treated":[141],"(OT),":[142],">4.0":[145],"mIU/L,":[146],"under-treated":[147],"(UT).":[148],"Both":[149],"(UT+OT)":[150],"inadequately":[153],"treated":[154,230],"(IT).":[155],"Group":[156],"comparisons":[157],"by":[160],"Kruskal-Wallis,":[161],"adjusted":[162],"Chi-square,":[163],"post":[166],"hoc":[167],"Dunn":[168],"test.":[169],"Additional":[170],"subgroup":[171,261],"analysis":[172,262,310],"circulating":[178],"thyroperoxidase":[179],"antibodies":[180],"(TPO-Ab+).":[181],"Respective":[182],"multivariable":[183,309],"analyses":[184],"evaluate":[188],"relationship":[190],"between":[191,253,298],"thyroid-related":[192],"variables":[193],"(Generalized":[197],"Linear":[198],"Model),":[199],"well":[201],"an":[203],"abnormal":[204],"(>400":[206],"\u03bcmol/L;":[207],"Logistic":[208],"Binary":[209],"Regression).":[210],"Results:":[211],"The":[212],"prevalence":[213],"rate":[214],"UH":[216,254],"9.8%":[218],"(467/4745)":[219],"and,":[220,362],"among":[221],"LT4,":[224],"61.7%":[226],"(213/345)":[227],"adequately":[229],"(AT).":[231],"higher":[235,279,299,351],"IT":[237,304],"comparison":[239,284],"EU":[241],"(429":[242],"vs.":[243,290],"410":[244],"\u03bcmol/L,":[245,292,333,338],"p":[246,293,339],"<":[247],"0.01)":[248],"but":[249,273],"did":[250],"differ":[252],"(413":[255],"\u03bcmol/L)":[256],"euthyroidism.":[258],"However,":[259],"TPO-Ab+":[265],"showed":[266],"that":[267],"IT,":[272,345],"UH,":[277],"euthyroidism":[286],"(423":[287,337],"424":[289],"402":[291],"0.04).":[295],"This":[296],"association":[297],"maintained":[306],"even":[307],"(odds":[311],"ratio":[312],"1.53,":[313],"confidence":[314],"interval":[315],"1.03":[316],"2.31)":[318],"Lower":[319],"detected":[324],"AT":[326],"(405":[327],"\u03bcmol/L,)":[328],"compared":[329],"OT":[331,347],"(432":[332],"0.04)":[334],"UT":[336],"0.02).":[341],"Conclusions:":[342],"Patients":[343],"both":[346],"UT,":[349],"levels,":[353],"which":[354],"may":[355],"be":[356],"associated":[357],"low-grade":[359],"possibly,":[363],"increased":[364]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-04T00:00:00"}
