{"id":"https://openalex.org/W4385490680","doi":"https://doi.org/10.1016/j.cancergen.2023.07.008","title":"Construction of a genomic instability-derived predictive prognostic signature for non-small cell lung cancer patients","display_name":"Construction of a genomic instability-derived predictive prognostic signature for non-small cell lung cancer patients","publication_year":2023,"publication_date":"2023-08-02","ids":{"openalex":"https://openalex.org/W4385490680","doi":"https://doi.org/10.1016/j.cancergen.2023.07.008","pmid":"https://pubmed.ncbi.nlm.nih.gov/37579716"},"language":"en","primary_location":{"id":"doi:10.1016/j.cancergen.2023.07.008","doi":"https://doi.org/10.1016/j.cancergen.2023.07.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cancergen.2023.07.008","pdf_url":null,"source":{"id":"https://openalex.org/S4210168666","display_name":"Cancer Genetics","issn_l":"2210-7762","issn":["2210-7762","2210-7770"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100318082","display_name":"Wei Li","orcid":"https://orcid.org/0000-0001-9931-5990","observed_orcids":["https://orcid.org/0000-0001-9931-5990"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210119554","display_name":"Yancheng First People's Hospital","ror":"https://ror.org/02rbkz523","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119554"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Li","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng City, Yancheng, Jiangsu 224006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng City, Yancheng, Jiangsu 224006, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210119554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013821799","display_name":"Huaman Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210153182","display_name":"Zigong First People's Hospital","ror":"https://ror.org/04khs3e04","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153182"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huaman Wu","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine, Zigong First People's Hospital, Ziliujing District, Zigong, Sichuan 643000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Zigong First People's Hospital, Ziliujing District, Zigong, Sichuan 643000, China","institution_ids":["https://openalex.org/I4210153182"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082943126","display_name":"Juan Xu","orcid":"https://orcid.org/0000-0002-1555-3009","observed_orcids":["https://orcid.org/0000-0002-1555-3009"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210119554","display_name":"Yancheng First People's Hospital","ror":"https://ror.org/02rbkz523","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119554"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juan Xu","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng City, Yancheng, Jiangsu 224006, China. Electronic address: xujuanycyy@163.com","Department of Pulmonary and Critical Care Medicine, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng City, Yancheng, Jiangsu 224006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng City, Yancheng, Jiangsu 224006, China. Electronic address: xujuanycyy@163.com","institution_ids":["https://openalex.org/I4210119554"]},{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Yancheng Clinical College of Xuzhou Medical University, The First People's Hospital of Yancheng City, Yancheng, Jiangsu 224006, China","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210119554"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082943126"],"corresponding_institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210119554"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":null,"fwci":1.2142,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79803867,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"278-279","issue":null,"first_page":"24","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.5673999786376953,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.3441999852657318,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9330000281333923},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.9599999785423279},{"id":"https://openalex.org/keywords/risk-prediction-score","display_name":"risk scoring","score":0.8460000157356262},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7350000143051147},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.9610000252723694},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.8849999904632568},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.796999990940094},{"id":"https://openalex.org/keywords/nomogram","display_name":"nomogram","score":0.6539999842643738},{"id":"https://openalex.org/keywords/foxm1","display_name":"FOXM1","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.7838945388793945},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6310155987739563},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5456774830818176},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5220115780830383},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5148491263389587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5084916353225708},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.4841083288192749},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.46295270323753357},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.447252094745636},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4312129616737366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4262763559818268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3241056799888611},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.25743240118026733},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1990051567554474},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18094795942306519},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.13921687006950378},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13871318101882935}],"mesh":[{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042822","descriptor_name":"Genomic Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cancergen.2023.07.008","doi":"https://doi.org/10.1016/j.cancergen.2023.07.008","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cancergen.2023.07.008","pdf_url":null,"source":{"id":"https://openalex.org/S4210168666","display_name":"Cancer Genetics","issn_l":"2210-7762","issn":["2210-7762","2210-7770"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Genetics","raw_type":"journal-article"},{"id":"pmid:37579716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37579716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W31514915","https://openalex.org/W1538833285","https://openalex.org/W1932059283","https://openalex.org/W1950656234","https://openalex.org/W1985987855","https://openalex.org/W2043251251","https://openalex.org/W2077180647","https://openalex.org/W2114361018","https://openalex.org/W2115845247","https://openalex.org/W2117692326","https://openalex.org/W2139317340","https://openalex.org/W2143193187","https://openalex.org/W2145403109","https://openalex.org/W2146512944","https://openalex.org/W2148115090","https://openalex.org/W2148390633","https://openalex.org/W2197921176","https://openalex.org/W2384318539","https://openalex.org/W2484023849","https://openalex.org/W2561459036","https://openalex.org/W2730083492","https://openalex.org/W2753630019","https://openalex.org/W2770171520","https://openalex.org/W2784371446","https://openalex.org/W2804105851","https://openalex.org/W2804711710","https://openalex.org/W2886186050","https://openalex.org/W2890410994","https://openalex.org/W2904973563","https://openalex.org/W2945863457","https://openalex.org/W2963015311","https://openalex.org/W2981223663","https://openalex.org/W2982293036","https://openalex.org/W2982651654","https://openalex.org/W2991691094","https://openalex.org/W2999238744","https://openalex.org/W3004984077","https://openalex.org/W3008526366","https://openalex.org/W3013724574","https://openalex.org/W3015580937","https://openalex.org/W3020626270","https://openalex.org/W3025039693","https://openalex.org/W3034345704","https://openalex.org/W3035480187","https://openalex.org/W3042383575","https://openalex.org/W3047133526","https://openalex.org/W3048896255","https://openalex.org/W3081954160","https://openalex.org/W3112174795","https://openalex.org/W3120414804","https://openalex.org/W3128646645","https://openalex.org/W3135370558","https://openalex.org/W3135634865","https://openalex.org/W3161649753","https://openalex.org/W3170858960","https://openalex.org/W3193724964","https://openalex.org/W3197199162","https://openalex.org/W3202724302","https://openalex.org/W4200507304","https://openalex.org/W4200520781","https://openalex.org/W4220915443","https://openalex.org/W4223517120","https://openalex.org/W4231495302","https://openalex.org/W4280576273","https://openalex.org/W4282919037","https://openalex.org/W4283797664","https://openalex.org/W4291008072","https://openalex.org/W4294541781","https://openalex.org/W4296167891","https://openalex.org/W6682022387","https://openalex.org/W6766287248"],"related_works":["https://openalex.org/W4297154151","https://openalex.org/W7122504221","https://openalex.org/W4392202663","https://openalex.org/W4206562766","https://openalex.org/W3149934417","https://openalex.org/W3211157226","https://openalex.org/W2947555199","https://openalex.org/W4405283253","https://openalex.org/W4296335956","https://openalex.org/W4381054139"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-03T00:00:00"}