{"id":"https://openalex.org/W4385488288","doi":"https://doi.org/10.1523/jneurosci.0161-22.2023","title":"Cognitive Flexibility Is Selectively Impaired by Radiation and Is Associated with Differential Recruitment of Adult-Born Neurons","display_name":"Cognitive Flexibility Is Selectively Impaired by Radiation and Is Associated with Differential Recruitment of Adult-Born Neurons","publication_year":2023,"publication_date":"2023-08-02","ids":{"openalex":"https://openalex.org/W4385488288","doi":"https://doi.org/10.1523/jneurosci.0161-22.2023","pmid":"https://pubmed.ncbi.nlm.nih.gov/37532464","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10451007"},"language":"en","primary_location":{"id":"doi:10.1523/jneurosci.0161-22.2023","doi":"https://doi.org/10.1523/jneurosci.0161-22.2023","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0161-22.2023","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1523/jneurosci.0161-22.2023","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024358177","display_name":"Evgeny M. Amelchenko","orcid":"https://orcid.org/0000-0002-4363-8747","observed_orcids":["https://orcid.org/0000-0002-4363-8747"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evgeny M. Amelchenko","raw_affiliation_strings":["Center for Developmental Genetics","Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","1Center for Developmental Genetics","2Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794"],"raw_orcid":"https://orcid.org/0000-0002-4363-8747","affiliations":[{"raw_affiliation_string":"Center for Developmental Genetics","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"1Center for Developmental Genetics","institution_ids":[]},{"raw_affiliation_string":"2Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044855028","display_name":"\u0414. \u0412. \u0411\u0435\u0437\u0440\u044f\u0434\u043d\u043e\u0432","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154072","display_name":"Institute of Normal Physiology named after P.K. Anokhin","ror":"https://ror.org/04kakt857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210154072"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitri V. Bezriadnov","raw_affiliation_strings":["P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","3P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","institution_ids":["https://openalex.org/I4210154072"]},{"raw_affiliation_string":"3P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","institution_ids":["https://openalex.org/I4210154072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092582381","display_name":"Olga A. Chekhov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olga A. Chekhov","raw_affiliation_strings":["Center for Developmental Genetics","Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","1Center for Developmental Genetics","2Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Developmental Genetics","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"1Center for Developmental Genetics","institution_ids":[]},{"raw_affiliation_string":"2Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034182205","display_name":"Anna Ivanova","orcid":"https://orcid.org/0000-0002-2454-1288","observed_orcids":["https://orcid.org/0000-0002-2454-1288"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210156060","display_name":"Institute of Higher Nervous Activity and Neurophysiology","ror":"https://ror.org/057n4xq60","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210115279","https://openalex.org/I4210156060"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Anna A. Ivanova","raw_affiliation_strings":["Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, 119234, Russian Federation","Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, 117485, Russian Federation","4Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, 117485, Russian Federation","5Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, 119234, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, 119234, Russian Federation","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, 117485, Russian Federation","institution_ids":["https://openalex.org/I4210156060"]},{"raw_affiliation_string":"4Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, 117485, Russian Federation","institution_ids":["https://openalex.org/I4210156060"]},{"raw_affiliation_string":"5Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, 119234, Russian Federation","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036000558","display_name":"Alexander V. Kedrov","orcid":"https://orcid.org/0000-0002-8581-4200","observed_orcids":["https://orcid.org/0000-0002-8581-4200"]},"institutions":[{"id":"https://openalex.org/I4210154072","display_name":"Institute of Normal Physiology named after P.K. Anokhin","ror":"https://ror.org/04kakt857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210154072"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander V. Kedrov","raw_affiliation_strings":["P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","3P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","institution_ids":["https://openalex.org/I4210154072"]},{"raw_affiliation_string":"3P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","institution_ids":["https://openalex.org/I4210154072"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007929999","display_name":"K. V. Anokhin","orcid":"https://orcid.org/0000-0003-4437-6002","observed_orcids":["https://orcid.org/0000-0003-4437-6002"]},"institutions":[{"id":"https://openalex.org/I19880235","display_name":"Lomonosov Moscow State University","ror":"https://ror.org/010pmpe69","country_code":"RU","type":"education","lineage":["https://openalex.org/I19880235"]},{"id":"https://openalex.org/I4210154072","display_name":"Institute of Normal Physiology named after P.K. Anokhin","ror":"https://ror.org/04kakt857","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210110862","https://openalex.org/I4210154072"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Konstantin V. Anokhin","raw_affiliation_strings":["Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, 119234, Russian Federation","P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","3P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","5Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, 119234, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, 119234, Russian Federation","institution_ids":["https://openalex.org/I19880235"]},{"raw_affiliation_string":"P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","institution_ids":["https://openalex.org/I4210154072"]},{"raw_affiliation_string":"3P.K. Anokhin Research Institute of Normal Physiology, Moscow, 125315, Russian Federation","institution_ids":["https://openalex.org/I4210154072"]},{"raw_affiliation_string":"5Institute for Advanced Brain Studies, Lomonosov Moscow State University, Moscow, 119234, Russian Federation","institution_ids":["https://openalex.org/I19880235"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058683356","display_name":"Alexander A. Lazutkin","orcid":"https://orcid.org/0000-0001-7598-4399","observed_orcids":["https://orcid.org/0000-0001-7598-4399"]},"institutions":[{"id":"https://openalex.org/I4210156060","display_name":"Institute of Higher Nervous Activity and Neurophysiology","ror":"https://ror.org/057n4xq60","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210115279","https://openalex.org/I4210156060"]},{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["RU","US"],"is_corresponding":false,"raw_author_name":"Alexander A. Lazutkin","raw_affiliation_strings":["Center for Developmental Genetics grigori.enikolopov@stonybrookmedicine.edu lazutkin.a.a@gmail.com","Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, 117485, Russian Federation","1Center for Developmental Genetics","2Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","4Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, 117485, Russian Federation"],"raw_orcid":"https://orcid.org/0000-0001-7598-4399","affiliations":[{"raw_affiliation_string":"Center for Developmental Genetics grigori.enikolopov@stonybrookmedicine.edu lazutkin.a.a@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, 117485, Russian Federation","institution_ids":["https://openalex.org/I4210156060"]},{"raw_affiliation_string":"1Center for Developmental Genetics","institution_ids":[]},{"raw_affiliation_string":"2Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"4Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, 117485, Russian Federation","institution_ids":["https://openalex.org/I4210156060"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033022509","display_name":"Grigori Enikolopov","orcid":"https://orcid.org/0000-0001-8178-8917","observed_orcids":["https://orcid.org/0000-0001-8178-8917"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grigori Enikolopov","raw_affiliation_strings":["Center for Developmental Genetics grigori.enikolopov@stonybrookmedicine.edu lazutkin.a.a@gmail.com","Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","1Center for Developmental Genetics","2Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Developmental Genetics grigori.enikolopov@stonybrookmedicine.edu lazutkin.a.a@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]},{"raw_affiliation_string":"1Center for Developmental Genetics","institution_ids":[]},{"raw_affiliation_string":"2Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794","institution_ids":["https://openalex.org/I59553526"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1621,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.73275862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"43","issue":"34","first_page":"6061","last_page":"6083"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.26829999685287476,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.08919999748468399,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognitive-flexibility","display_name":"cognitive flexibility","score":0.765999972820282},{"id":"https://openalex.org/keywords/gamma-radiation","display_name":"gamma radiation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/hippocampal-neurogenesis","display_name":"hippocampal neurogenesis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/adult-neurogenesis","display_name":"adult neurogenesis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/spatial-learning-and-memory","display_name":"spatial learning and memory","score":0.8270000219345093},{"id":"https://openalex.org/keywords/search-strategies","display_name":"search strategies","score":0.5600000023841858},{"id":"https://openalex.org/keywords/radiation-induced-cognitive-deficits","display_name":"radiation-induced cognitive deficits","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C66102695","wikidata":"https://www.wikidata.org/wiki/Q5141208","display_name":"Cognitive flexibility","level":3,"score":0.7195768356323242},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.7024345993995667},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.612881600856781},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6119872331619263},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5813761949539185},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5812554955482483},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.5721663236618042},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.5518039464950562},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.5266333222389221},{"id":"https://openalex.org/C12515866","wikidata":"https://www.wikidata.org/wiki/Q50628021","display_name":"Water maze","level":3,"score":0.49493950605392456},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4643424451351166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3951592743396759},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18061107397079468},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1523/jneurosci.0161-22.2023","doi":"https://doi.org/10.1523/jneurosci.0161-22.2023","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0161-22.2023","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10451007","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10451007","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10451007/pdf/zns6061.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:37532464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37532464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1523/jneurosci.0161-22.2023","doi":"https://doi.org/10.1523/jneurosci.0161-22.2023","is_oa":true,"landing_page_url":"https://doi.org/10.1523/jneurosci.0161-22.2023","pdf_url":null,"source":{"id":"https://openalex.org/S5555990","display_name":"Journal of Neuroscience","issn_l":"0270-6474","issn":["0270-6474","1529-2401"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319739","host_organization_name":"Society for Neuroscience","host_organization_lineage":["https://openalex.org/P4310319739"],"host_organization_lineage_names":["Society for Neuroscience"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2531653244","display_name":null,"funder_award_id":"19-15-00247","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G2920505873","display_name":"Nitric oxide-mediated changes in glymphatic and CSF systems in aging and Alzheimer\u2019s disease","funder_award_id":"RF1AG057705","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3553338279","display_name":null,"funder_award_id":"075\u201015\u20102020\u2010801","funder_id":"https://openalex.org/F4320327494","funder_display_name":"Ministry of Science and Higher Education of the Russian Federation"},{"id":"https://openalex.org/G4769768948","display_name":null,"funder_award_id":"17-15-01426","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G4869243411","display_name":null,"funder_award_id":"R01 AG057705-01","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8736011256","display_name":null,"funder_award_id":"20-15-00283","funder_id":"https://openalex.org/F4320324099","funder_display_name":"Russian Science Foundation"},{"id":"https://openalex.org/G9000894660","display_name":"Endogenous barcoding to determine complex dynamics of adult neurogenesis in aging and Alzheimer's disease","funder_award_id":"R01AG076937","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320324099","display_name":"Russian Science Foundation","ror":"https://ror.org/03y2gwe85"},{"id":"https://openalex.org/F4320327494","display_name":"Ministry of Science and Higher Education of the Russian Federation","ror":null},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1043077372","https://openalex.org/W1522291623","https://openalex.org/W1904016355","https://openalex.org/W1968139840","https://openalex.org/W1981279518","https://openalex.org/W1982528484","https://openalex.org/W1986428552","https://openalex.org/W1996714226","https://openalex.org/W1996771718","https://openalex.org/W2000809528","https://openalex.org/W2001682194","https://openalex.org/W2011580597","https://openalex.org/W2018934769","https://openalex.org/W2029929966","https://openalex.org/W2031531997","https://openalex.org/W2044110964","https://openalex.org/W2051173215","https://openalex.org/W2060011143","https://openalex.org/W2060152950","https://openalex.org/W2069785065","https://openalex.org/W2069930429","https://openalex.org/W2071181288","https://openalex.org/W2088269525","https://openalex.org/W2090833066","https://openalex.org/W2092064202","https://openalex.org/W2098137179","https://openalex.org/W2099250398","https://openalex.org/W2103272211","https://openalex.org/W2103524361","https://openalex.org/W2104118481","https://openalex.org/W2105089471","https://openalex.org/W2108461283","https://openalex.org/W2117609242","https://openalex.org/W2118454691","https://openalex.org/W2120417084","https://openalex.org/W2130169724","https://openalex.org/W2136863044","https://openalex.org/W2145725821","https://openalex.org/W2145884075","https://openalex.org/W2146316688","https://openalex.org/W2149901479","https://openalex.org/W2156159177","https://openalex.org/W2161423713","https://openalex.org/W2163239886","https://openalex.org/W2166514604","https://openalex.org/W2237075569","https://openalex.org/W2273912701","https://openalex.org/W2275815036","https://openalex.org/W2405293310","https://openalex.org/W2547225283","https://openalex.org/W2610621727","https://openalex.org/W2789329186","https://openalex.org/W2792193428","https://openalex.org/W2794318307","https://openalex.org/W2796418566","https://openalex.org/W2801769333","https://openalex.org/W2909938262","https://openalex.org/W2910883336","https://openalex.org/W2917971697","https://openalex.org/W2964520925","https://openalex.org/W2969807555","https://openalex.org/W2970838824","https://openalex.org/W2972076745","https://openalex.org/W2976971804","https://openalex.org/W2993849398","https://openalex.org/W3036638316","https://openalex.org/W3129495705","https://openalex.org/W3137889466","https://openalex.org/W3139426294","https://openalex.org/W3178483553","https://openalex.org/W3183684673","https://openalex.org/W3199460728","https://openalex.org/W3216640891","https://openalex.org/W4231546346","https://openalex.org/W4231909405","https://openalex.org/W4283728561","https://openalex.org/W4283829975"],"related_works":["https://openalex.org/W2059425846","https://openalex.org/W3003575519","https://openalex.org/W4405461332","https://openalex.org/W2099250398","https://openalex.org/W2114242740","https://openalex.org/W2084839712","https://openalex.org/W2130958619","https://openalex.org/W2018934769","https://openalex.org/W2055301723","https://openalex.org/W2792193428"],"abstract_inverted_index":{"Exposure":[0,251],"to":[1,70,73,116,153,252,264,266,300,308,318,323],"elevated":[2],"doses":[3],"of":[4,21,27,102,109,121,187,212,219,231,245,274,276,285,288,304,336,344],"ionizing":[5],"radiation,":[6],"such":[7],"as":[8],"those":[9],"in":[10,134,158,166,340,355],"therapeutic":[11],"procedures,":[12],"catastrophic":[13],"accidents,":[14],"or":[15,42,118,171,367],"space":[16],"exploration,":[17],"increases":[18],"the":[19,50,67,87,100,107,159,167,229,242,262,360],"risk":[20],"cognitive":[22,29,234,256,259,279,361],"dysfunction.":[23],"The":[24,271],"full":[25,272],"range":[26,273],"radiation-induced":[28],"deficits":[30],"is":[31,96,281],"unknown,":[32,282],"partly":[33,283],"because":[34,284],"commonly":[35],"used":[36,346],"tests":[37],"may":[38,43],"be":[39,45,353],"insufficiently":[40],"sensitive":[41],"not":[44,175],"adequately":[46],"tuned":[47],"for":[48,241,358],"assessing":[49,359],"fine":[51],"behavioral":[52,85,226,296],"features":[53],"affected":[54],"by":[55,216,364],"radiation.":[56],"Here,":[57,291],"we":[58,292],"asked":[59],"whether":[60],"\u03b3-radiation":[61,232],"might":[62],"affect":[63,255],"learning,":[64,145,194,330],"memory,":[65,332],"and":[66,98,106,139,142,149,161,209,236,258,269,306,333],"overall":[68],"ability":[69,263],"adapt":[71,265],"behavior":[72],"cope":[74],"with":[75],"a":[76,83,286,294,310],"challenging":[77],"environment":[78],"(cognitive/behavioral":[79],"flexibility).":[80],"We":[81,112,202,313],"developed":[82,293],"new":[84,225,246,295,350],"assay,":[86],"context":[88],"discrimination":[89],"Morris":[90],"water":[91],"maze":[92],"(cdMWM)":[93],"task,":[94],"which":[95],"hippocampus-dependent":[97],"requires":[99],"integration":[101],"various":[103,302],"contextual":[104],"cues":[105,305],"adjustment":[108],"search":[110,147,191,347],"strategies.":[111,348],"exposed":[113,152,317],"male":[114],"mice":[115,299],"1":[117],"5":[119,154],"Gy":[120,155],"\u03b3":[122],"rays":[123],"and,":[124,195],"at":[125],"different":[126],"time":[127],"points":[128],"after":[129,178,198,207],"irradiation,":[130,179,199],"trained":[131],"them":[132],"consecutively":[133],"spatial":[135,160],"MWM,":[136,138],"reversal":[137,162],"cdMWM":[140,168,220],"tasks,":[141],"assessed":[143],"their":[144],"navigational":[146],"strategies,":[148],"memory.":[150],"Mice":[151],"performed":[156],"successfully":[157,324],"MWM":[163],"tasks;":[164],"however,":[165],"task":[169,297,351],"6":[170,196],"8":[172],"weeks":[173,197],"(but":[174],"3":[176],"weeks)":[177],"they":[180],"demonstrated":[181],"transient":[182],"learning":[183],"deficit,":[184],"decreased":[185],"use":[186,335],"efficient":[188,337],"spatially":[189],"precise":[190],"strategies":[192,307],"during":[193],"memory":[200],"deficit.":[201],"also":[203],"observed":[204],"impaired":[205],"neurogenesis":[206],"irradiation":[208,277],"selective":[210],"activation":[211],"12-week-old":[213],"newborn":[214],"neurons":[215],"specific":[217],"components":[218],"training":[221],"paradigm.":[222],"Thus,":[223],"our":[224],"paradigm":[227],"reveals":[228],"effects":[230],"on":[233,278],"flexibility":[235,260,280],"indicates":[237],"an":[238],"extended":[239],"timeframe":[240],"functional":[243],"maturation":[244],"hippocampal":[247],"neurons.":[248],"SIGNIFICANCE":[249],"STATEMENT":[250],"radiation":[253],"can":[254],"performance":[257],"\u2014":[261],"changed":[267],"circumstances":[268,341],"demands.":[270],"consequences":[275],"lack":[287],"suitable":[289],"models.":[290],"requiring":[298,342],"combine":[301],"types":[303],"find":[309],"correct":[311],"solution.":[312],"show":[314,328],"that":[315],"animals":[316],"\u03b3-radiation,":[319],"despite":[320],"being":[321],"able":[322],"solve":[325],"standard":[326],"problems,":[327],"delayed":[329],"deficient":[331],"diminished":[334],"navigation":[338],"patterns":[339],"adjustments":[343],"previously":[345],"This":[349],"could":[352],"applied":[354],"other":[356],"settings":[357],"changes":[362],"induced":[363],"aging,":[365],"trauma,":[366],"disease.":[368]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-03T00:00:00"}