{"id":"https://openalex.org/W4385480774","doi":"https://doi.org/10.1016/j.jacbts.2023.04.009","title":"An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3","display_name":"An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3","publication_year":2023,"publication_date":"2023-08-02","ids":{"openalex":"https://openalex.org/W4385480774","doi":"https://doi.org/10.1016/j.jacbts.2023.04.009","pmid":"https://pubmed.ncbi.nlm.nih.gov/37791314","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10544073"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacbts.2023.04.009","doi":"https://doi.org/10.1016/j.jacbts.2023.04.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacbts.2023.04.009","pdf_url":null,"source":{"id":"https://openalex.org/S2898156683","display_name":"JACC Basic to Translational Science","issn_l":"2452-302X","issn":["2452-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Basic to Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.jacbts.2023.04.009","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014350987","display_name":"Andrea D. Thompson","orcid":"https://orcid.org/0000-0001-8798-2024","observed_orcids":["https://orcid.org/0000-0001-8798-2024"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrea D. Thompson","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083907789","display_name":"Marcus J. Wagner","orcid":"https://orcid.org/0000-0001-9068-6920","observed_orcids":["https://orcid.org/0000-0001-9068-6920"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus J. Wagner","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103922840","display_name":"Juliani Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juliani Rodriguez","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003947259","display_name":"Alok Malhotra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alok Malhotra","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054083366","display_name":"Steve Vander Roest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Vander Roest","raw_affiliation_strings":["Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025898697","display_name":"Ulla Lilienthal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ulla Lilienthal","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040066574","display_name":"Hao Shao","orcid":"https://orcid.org/0000-0003-4437-5536","observed_orcids":["https://orcid.org/0000-0003-4437-5536"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Shao","raw_affiliation_strings":["Institute for Neurodegenerative Diseases and Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Neurodegenerative Diseases and Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104151210","display_name":"Mathav Vignesh","orcid":"https://orcid.org/0009-0008-5618-4407","observed_orcids":["https://orcid.org/0009-0008-5618-4407"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathav Vignesh","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111478508","display_name":"Keely Weber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keely Weber","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061747547","display_name":"Jaime M. Yob","orcid":"https://orcid.org/0000-0002-7206-6215","observed_orcids":["https://orcid.org/0000-0002-7206-6215"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaime M. Yob","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028158963","display_name":"Benjamin L. Prosser","orcid":"https://orcid.org/0000-0003-3696-9131","observed_orcids":["https://orcid.org/0000-0003-3696-9131"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin L. Prosser","raw_affiliation_strings":["Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075632907","display_name":"Adam S. Helms","orcid":"https://orcid.org/0000-0002-0234-6430","observed_orcids":["https://orcid.org/0000-0002-0234-6430"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam S. Helms","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067529915","display_name":"Jason E. Gestwicki","orcid":"https://orcid.org/0000-0002-6125-3154","observed_orcids":["https://orcid.org/0000-0002-6125-3154"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason E. Gestwicki","raw_affiliation_strings":["Institute for Neurodegenerative Diseases and Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Neurodegenerative Diseases and Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071223660","display_name":"David Ginsburg","orcid":"https://orcid.org/0000-0002-6436-8942","observed_orcids":["https://orcid.org/0000-0002-6436-8942"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Ginsburg","raw_affiliation_strings":["Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA","Howard Hughes Medical Institute, Chevy Chase, Maryland, USA","The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Chevy Chase, Maryland, USA","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"The Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083767342","display_name":"Sharlene M. Day","orcid":"https://orcid.org/0000-0001-9802-7188","observed_orcids":["https://orcid.org/0000-0001-9802-7188"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharlene M. Day","raw_affiliation_strings":["Department of Internal Medicine, Division of Cardiovascular Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Division of Cardiovascular Medicine and Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014350987"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":{"value":4530,"currency":"USD","value_usd":4530},"apc_paid":{"value":4530,"currency":"USD","value_usd":4530},"fwci":0.2661,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.43476267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"9","first_page":"1198","last_page":"1211"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.04619999974966049,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mybpc3","display_name":"MYBPC3","score":0.9789999723434448},{"id":"https://openalex.org/keywords/familial-hypertrophic-cardiomyopathy","display_name":"familial hypertrophic cardiomyopathy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8299999833106995},{"id":"https://openalex.org/keywords/bag3","display_name":"BAG3","score":0.9909999966621399},{"id":"https://openalex.org/keywords/allosteric-modulators","display_name":"allosteric modulators","score":0.8479999899864197},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.9150000214576721}],"concepts":[{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.659830629825592},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.562056303024292},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.5587810277938843},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5528509020805359},{"id":"https://openalex.org/C99089365","wikidata":"https://www.wikidata.org/wiki/Q18034356","display_name":"BAG3","level":4,"score":0.5198271870613098},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.47852978110313416},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.47721630334854126},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.4677826166152954},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37884166836738586},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2954671382904053},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.08550134301185608},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.jacbts.2023.04.009","doi":"https://doi.org/10.1016/j.jacbts.2023.04.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacbts.2023.04.009","pdf_url":null,"source":{"id":"https://openalex.org/S2898156683","display_name":"JACC Basic to Translational Science","issn_l":"2452-302X","issn":["2452-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Basic to Translational Science","raw_type":"journal-article"},{"id":"doi:10.1101/2022.10.08.511444","doi":"https://doi.org/10.1101/2022.10.08.511444","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.10.08.511444","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/10/08/2022.10.08.511444.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10544073","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10544073","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10544073/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC Basic Transl Sci","raw_type":"Text"},{"id":"pmid:37791314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37791314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC. Basic to translational science","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt86m4174b","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/86m4174b","pdf_url":"https://escholarship.org/content/qt86m4174b/qt86m4174b.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC: Basic to Translational Science, vol 8, iss 9","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:e054c56a7a6a40a997ed586ff5af5d30","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e054c56a7a6a40a997ed586ff5af5d30","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC: Basic to Translational Science, Vol 8, Iss 9, Pp 1198-1211 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jacbts.2023.04.009","doi":"https://doi.org/10.1016/j.jacbts.2023.04.009","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacbts.2023.04.009","pdf_url":null,"source":{"id":"https://openalex.org/S2898156683","display_name":"JACC Basic to Translational Science","issn_l":"2452-302X","issn":["2452-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Basic to Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3549828030","display_name":null,"funder_award_id":"NIH T32","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4741184760","display_name":"The Molecular Genetics of Hemostasis","funder_award_id":"R35HL135793","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6971475997","display_name":null,"funder_award_id":"HL007853","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G839474415","display_name":null,"funder_award_id":"HL135793","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000858524","display_name":"Pathogenic mechanisms of myosin binding protein C missense variants within hypertrophic cardiomyopathy","funder_award_id":"K08HL163328","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000864271","display_name":"Training in Muscle Biology and Muscle Disease","funder_award_id":"T32AR053461","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000892101","display_name":"Molecular Chaperones and Small Molecules","funder_award_id":"R01NS059690","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G9000914334","display_name":"Multidisciplinary Cardiovascular Research Training","funder_award_id":"T32HL007853","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320309056","display_name":"Alnylam Pharmaceuticals","ror":"https://ror.org/00thr3w71"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320309652","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291"},{"id":"https://openalex.org/F4320310160","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320320929","display_name":"Universiteit Leiden","ror":"https://ror.org/027bh9e22"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W1501063278","https://openalex.org/W1507317369","https://openalex.org/W1540912658","https://openalex.org/W1565234800","https://openalex.org/W1594617739","https://openalex.org/W1750064119","https://openalex.org/W1775327385","https://openalex.org/W1827307662","https://openalex.org/W1861243942","https://openalex.org/W1906645663","https://openalex.org/W1954317670","https://openalex.org/W1965787735","https://openalex.org/W1970102552","https://openalex.org/W1970288681","https://openalex.org/W1972250530","https://openalex.org/W1974256456","https://openalex.org/W1980087135","https://openalex.org/W1993218631","https://openalex.org/W1993551445","https://openalex.org/W1995885857","https://openalex.org/W1996000832","https://openalex.org/W1997609921","https://openalex.org/W1999746307","https://openalex.org/W2007573706","https://openalex.org/W2008744347","https://openalex.org/W2009296843","https://openalex.org/W2012520981","https://openalex.org/W2014573616","https://openalex.org/W2014922787","https://openalex.org/W2032025341","https://openalex.org/W2039367486","https://openalex.org/W2042778705","https://openalex.org/W2043620628","https://openalex.org/W2046110995","https://openalex.org/W2050162178","https://openalex.org/W2053503219","https://openalex.org/W2053691011","https://openalex.org/W2059010449","https://openalex.org/W2062886087","https://openalex.org/W2068273299","https://openalex.org/W2070301080","https://openalex.org/W2070536183","https://openalex.org/W2078741614","https://openalex.org/W2080045669","https://openalex.org/W2086614100","https://openalex.org/W2088255158","https://openalex.org/W2090710197","https://openalex.org/W2096038757","https://openalex.org/W2117807601","https://openalex.org/W2121229923","https://openalex.org/W2124762989","https://openalex.org/W2126842426","https://openalex.org/W2131062132","https://openalex.org/W2144335262","https://openalex.org/W2148011038","https://openalex.org/W2148584610","https://openalex.org/W2148947476","https://openalex.org/W2151433089","https://openalex.org/W2152091753","https://openalex.org/W2156739666","https://openalex.org/W2161347773","https://openalex.org/W2162066969","https://openalex.org/W2164832091","https://openalex.org/W2168268910","https://openalex.org/W2170573493","https://openalex.org/W2191152768","https://openalex.org/W2262506123","https://openalex.org/W2277697424","https://openalex.org/W2284855986","https://openalex.org/W2299864672","https://openalex.org/W2311476251","https://openalex.org/W2319589010","https://openalex.org/W2336853363","https://openalex.org/W2430196186","https://openalex.org/W2493771271","https://openalex.org/W2517515998","https://openalex.org/W2520421952","https://openalex.org/W2616299533","https://openalex.org/W2728458405","https://openalex.org/W2737293726","https://openalex.org/W2737729179","https://openalex.org/W2763622914","https://openalex.org/W2765508828","https://openalex.org/W2769672674","https://openalex.org/W2770310323","https://openalex.org/W2770502839","https://openalex.org/W2786095341","https://openalex.org/W2805332892","https://openalex.org/W2810408353","https://openalex.org/W2810892605","https://openalex.org/W2890477831","https://openalex.org/W2895168260","https://openalex.org/W2900980188","https://openalex.org/W2901710420","https://openalex.org/W2904408019","https://openalex.org/W2942611143","https://openalex.org/W2951957494","https://openalex.org/W2978515721","https://openalex.org/W2990846635","https://openalex.org/W2992949002","https://openalex.org/W2997876005","https://openalex.org/W3015815374","https://openalex.org/W3081376436","https://openalex.org/W3121184362","https://openalex.org/W3122115907","https://openalex.org/W3126512595","https://openalex.org/W3160729499","https://openalex.org/W3161142831","https://openalex.org/W3193503263","https://openalex.org/W3198896771","https://openalex.org/W3210406208","https://openalex.org/W3216383239","https://openalex.org/W4286247406"],"related_works":["https://openalex.org/W2805332892","https://openalex.org/W2538440170","https://openalex.org/W4389021950","https://openalex.org/W4200294421","https://openalex.org/W4378648980","https://openalex.org/W4205732089","https://openalex.org/W2885678423","https://openalex.org/W4378649703","https://openalex.org/W2885286391","https://openalex.org/W2997876005"],"abstract_inverted_index":{"Structured":[0],"Abstract":[1],"Objective":[2],"We":[3,72,207,294],"aim":[4],"to":[5,45,77,178,280,288,304],"identify":[6,78,305],"regulators":[7,283],"of":[8,30,49,53,87,130,194,212,235,251,284,311,346],"myosin":[9,19,112],"binding":[10,20],"protein":[11,14,21,59,69,197,221,271,286,335],"C3":[12,22],"(MyBP-C)":[13],"homeostasis.":[15],"Background":[16],"Variants":[17],"in":[18,38,89,248,302],"(":[23],"MYBPC3":[24,39,263,274],")":[25],"account":[26],"for":[27,159,359],"approximately":[28],"50%":[29],"familial":[31],"hypertrophic":[32],"cardiomyopathy":[33,256],"(HCM).":[34],"Most":[35],"pathogenic":[36,262],"variants":[37,42,264],"are":[40],"truncating":[41],"that":[43,56,66,80,121,209,240,265,320,329,350],"lead":[44],"reduced":[46,322],"total":[47,267],"levels":[48,86,172,310],"MyBP-C":[50,58,88,124,171,180,220,236,269,285,312,323,347],"protein.":[51],"Elucidation":[52],"the":[54,229,249,282,330],"pathways":[55],"regulate":[57],"homeostasis":[60,287],"could":[61,353],"uncover":[62,289],"new":[63,356],"therapeutic":[64,291,357],"strategies":[65],"restore":[67],"normal":[68],"levels.":[70,125,149,181,222,324],"Method":[71],"developed":[73,295],"a":[74,100,128,151,156,233,298,343,355],"high-throughput":[75,299],"screen":[76,158,227,301],"compounds":[79,138,163,175,306],"can":[81],"increase":[82,179],"or":[83,144],"decrease":[84],"steady-state":[85,309],"an":[90,191],"induced":[91],"pluripotent":[92],"stem":[93],"cell":[94],"cardiomyocyte":[95],"(iPSC-CM)":[96],"model":[97],"derived":[98],"from":[99],"patient":[101],"with":[102,203,216],"HCM.":[103,252,360],"To":[104],"normalize":[105],"results,":[106],"we":[107,136,185],"also":[108],"monitored":[109],"effects":[110],"on":[111,118,187],"heavy":[113],"chain":[114],"(MYH)":[115],"and":[116,165,173,296,318,338],"focused":[117,186],"those":[119],"molecules":[120],"selectively":[122],"modulated":[123],"Results":[126],"Screening":[127],"library":[129],"2,426":[131],"known":[132],"biologically":[133],"active":[134],"compounds,":[135,316],"identified":[137,228],"which":[139,189,307],"either":[140],"decreased":[141],"(241/2426,":[142],"9.9%)":[143],"increased":[145],"(29/2426,":[146],"1.2%)":[147],"MyBP-C/MYH":[148],"After":[150],"rigorous":[152],"validation":[153],"process,":[154],"including":[155],"counter":[157],"cellular":[160],"toxicity,":[161],"two":[162,315],"(JG98":[164],"parthenolide)":[166],"were":[167,176],"confirmed":[168,177],"as":[169,232],"decreasing":[170],"no":[174],"For":[182],"further":[183],"studies,":[184],"JG98,":[188],"is":[190,258,278,342],"allosteric":[192],"modulator":[193],"heat":[195,333],"shock":[196,334],"70":[198,336],"(Hsp70),":[199],"inhibiting":[200],"its":[201,339],"interaction":[202],"BAG":[204],"domain":[205],"co-chaperones.":[206],"found":[208],"genetic":[210],"reduction":[211],"BAG3":[213,341],"phenocopies":[214],"treatment":[215,250],"JG98":[217,317],"by":[218,261,273],"reducing":[219],"Conclusion":[223],"An":[224],"unbiased":[225],"compound":[226],"Hsp70-BAG3":[230],"complex":[231,331],"regulator":[234,345],"stability.":[237],"Thus,":[238],"approaches":[239],"stimulate":[241],"this":[242,351],"complex\u2019s":[243],"function":[244],"may":[245],"be":[246,354],"beneficial":[247],"Highlights":[253],"-":[254,276,293,325],"Hypertrophic":[255],"(HCM)":[257],"commonly":[259],"caused":[260],"reduce":[266],"wild-type":[268],"(the":[270],"encoded":[272],").":[275],"It":[277],"critical":[279],"understand":[281],"novel":[290],"strategies.":[292],"executed":[297],"chemical":[300],"iPSC-CMs":[303],"alter":[308],"protein,":[313],"revealing":[314],"parthenolide,":[319],"significantly":[321],"Validation":[326],"studies":[327],"suggest":[328],"between":[332],"(Hsp70)":[337],"co-chaperone":[340],"dynamic":[344],"stability,":[348],"suggesting":[349],"axis":[352],"target":[358]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-08-03T00:00:00"}