{"id":"https://openalex.org/W4385437153","doi":"https://doi.org/10.1016/j.ecoenv.2023.115283","title":"Ticlopidine induces embryonic development toxicity and hepatotoxicity in zebrafish by upregulating the oxidative stress signaling pathway","display_name":"Ticlopidine induces embryonic development toxicity and hepatotoxicity in zebrafish by upregulating the oxidative stress signaling pathway","publication_year":2023,"publication_date":"2023-07-31","ids":{"openalex":"https://openalex.org/W4385437153","doi":"https://doi.org/10.1016/j.ecoenv.2023.115283","pmid":"https://pubmed.ncbi.nlm.nih.gov/37531924"},"language":"en","primary_location":{"id":"doi:10.1016/j.ecoenv.2023.115283","doi":"https://doi.org/10.1016/j.ecoenv.2023.115283","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2023.115283","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.ecoenv.2023.115283","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rong Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Xu","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103156939","display_name":"Pengxiang Xu","orcid":"https://orcid.org/0000-0002-2273-1504","observed_orcids":["https://orcid.org/0000-0002-2273-1504"]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengxiang Xu","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109494751","display_name":"Haiyan Wei","orcid":"https://orcid.org/0000-0003-3393-0792","observed_orcids":["https://orcid.org/0000-0003-3393-0792"]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyan Wei","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":"https://orcid.org/0000-0003-3393-0792","affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101482500","display_name":"Yong Huang","orcid":"https://orcid.org/0000-0002-7711-3770","observed_orcids":["https://orcid.org/0000-0002-7711-3770"]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I4210152154","display_name":"State Key Laboratory of Food Science and Technology","ror":"https://ror.org/04zgj7914","country_code":"CN","type":"facility","lineage":["https://openalex.org/I111599522","https://openalex.org/I141649914","https://openalex.org/I4210152154"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Huang","raw_affiliation_strings":["State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330029, Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330029, Jiangxi, PR China","institution_ids":["https://openalex.org/I141649914","https://openalex.org/I4210152154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027420507","display_name":"Xiaodan Zhu","orcid":"https://orcid.org/0000-0001-7080-1741","observed_orcids":["https://orcid.org/0000-0001-7080-1741"]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodan Zhu","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102202996","display_name":"Chuanming Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuanming Lin","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhimin Yan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhimin Yan","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010885254","display_name":"Liuyan Xin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liuyan Xin","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100381410","display_name":"Li Lin","orcid":"https://orcid.org/0000-0002-0132-5646","observed_orcids":["https://orcid.org/0000-0002-0132-5646"]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Li","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Weiming Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiming Lv","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuqin Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuqin Zeng","raw_affiliation_strings":["The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210133784"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019705695","display_name":"Guiyou Tian","orcid":"https://orcid.org/0000-0003-4478-4399","observed_orcids":["https://orcid.org/0000-0003-4478-4399"]},"institutions":[{"id":"https://openalex.org/I4210119042","display_name":"Gannan Normal University","ror":"https://ror.org/02jf7e446","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210119042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guiyou Tian","raw_affiliation_strings":["Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210119042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059435792","display_name":"Jinze Ma","orcid":"https://orcid.org/0000-0003-4652-614X","observed_orcids":["https://orcid.org/0000-0003-4652-614X"]},"institutions":[{"id":"https://openalex.org/I4210119042","display_name":"Gannan Normal University","ror":"https://ror.org/02jf7e446","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210119042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinze Ma","raw_affiliation_strings":["Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210119042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085511988","display_name":"Bo Cheng","orcid":"https://orcid.org/0000-0002-1236-8262","observed_orcids":["https://orcid.org/0000-0002-1236-8262"]},"institutions":[{"id":"https://openalex.org/I4210119042","display_name":"Gannan Normal University","ror":"https://ror.org/02jf7e446","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210119042"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Cheng","raw_affiliation_strings":["Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210119042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073933415","display_name":"Huiqiang Lu","orcid":"https://orcid.org/0000-0002-3987-6742","observed_orcids":["https://orcid.org/0000-0002-3987-6742"]},"institutions":[{"id":"https://openalex.org/I4210119042","display_name":"Gannan Normal University","ror":"https://ror.org/02jf7e446","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210119042"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiqiang Lu","raw_affiliation_strings":["Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China. Electronic address: luhq2@126.com","Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China. Electronic address: luhq2@126.com","institution_ids":["https://openalex.org/I4210119042"]},{"raw_affiliation_string":"Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou 341000 Jiangxi, PR China","institution_ids":["https://openalex.org/I4210119042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031012348","display_name":"Yijian Chen","orcid":"https://orcid.org/0000-0002-5757-684X","observed_orcids":["https://orcid.org/0000-0002-5757-684X","https://orcid.org/0000-0002-2555-6668"]},"institutions":[{"id":"https://openalex.org/I4210113195","display_name":"Gannan Medical University","ror":"https://ror.org/01tjgw469","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210113195"]},{"id":"https://openalex.org/I4210133784","display_name":"First Affiliated Hospital of Gannan Medical University","ror":"https://ror.org/040gnq226","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210133784"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yijian Chen","raw_affiliation_strings":["The First Af\ufb01liated Hospital of Gannan Medical University, Ganzhou 341000, China; The Endemic Disease (Thalassemia) Clinical Research Center of Jiangxi Province, Ganzhou 341000, China. Electronic address: chenyj2005@163.com","The Endemic Disease (Thalassemia) Clinical Research Center of Jiangxi Province, Ganzhou 341000, China","The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China"],"raw_orcid":"https://orcid.org/0000-0002-5757-684X","affiliations":[{"raw_affiliation_string":"The First Af\ufb01liated Hospital of Gannan Medical University, Ganzhou 341000, China; The Endemic Disease (Thalassemia) Clinical Research Center of Jiangxi Province, Ganzhou 341000, China. Electronic address: chenyj2005@163.com","institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210133784"]},{"raw_affiliation_string":"The Endemic Disease (Thalassemia) Clinical Research Center of Jiangxi Province, Ganzhou 341000, China","institution_ids":[]},{"raw_affiliation_string":"The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China","institution_ids":["https://openalex.org/I4210133784"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031012348","https://openalex.org/A5073933415"],"corresponding_institution_ids":["https://openalex.org/I4210113195","https://openalex.org/I4210119042","https://openalex.org/I4210133784"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":2.7044,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.89974002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"262","issue":null,"first_page":"115283","last_page":"115283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.035999998450279236,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ticlopidine","display_name":"ticlopidine","score":1.0},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7990000247955322},{"id":"https://openalex.org/keywords/zebrafish-larvae","display_name":"zebrafish larvae","score":0.8579999804496765},{"id":"https://openalex.org/keywords/swim-bladder-development","display_name":"swim bladder development","score":0.8339999914169312},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.5590000152587891},{"id":"https://openalex.org/keywords/hepatocyte-proliferation","display_name":"hepatocyte proliferation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.9200000166893005},{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.6880000233650208},{"id":"https://openalex.org/keywords/liver-metabolism","display_name":"hepatic metabolism","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2778905298","wikidata":"https://www.wikidata.org/wiki/Q420571","display_name":"Ticlopidine","level":4,"score":0.8242393136024475},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6778324842453003},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.6704806089401245},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.5459651947021484},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.5088103413581848},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.499769926071167},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4054924249649048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4041229486465454},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3858310580253601},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36439335346221924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22825947403907776},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18804717063903809},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ecoenv.2023.115283","doi":"https://doi.org/10.1016/j.ecoenv.2023.115283","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2023.115283","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},{"id":"pmid:37531924","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37531924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and environmental safety","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5e54dc7634554164b99373770d7632ff","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5e54dc7634554164b99373770d7632ff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ecotoxicology and Environmental Safety, Vol 262, Iss , Pp 115283- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.ecoenv.2023.115283","doi":"https://doi.org/10.1016/j.ecoenv.2023.115283","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ecoenv.2023.115283","pdf_url":null,"source":{"id":"https://openalex.org/S13733787","display_name":"Ecotoxicology and Environmental Safety","issn_l":"0147-6513","issn":["0147-6513","1090-2414"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ecotoxicology and Environmental Safety","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W240506283","https://openalex.org/W1121521847","https://openalex.org/W1204829567","https://openalex.org/W1968362444","https://openalex.org/W1976599392","https://openalex.org/W1990529846","https://openalex.org/W2032787294","https://openalex.org/W2048553024","https://openalex.org/W2053661494","https://openalex.org/W2061220034","https://openalex.org/W2107528246","https://openalex.org/W2119624946","https://openalex.org/W2138635268","https://openalex.org/W2157103022","https://openalex.org/W2430858641","https://openalex.org/W2521662433","https://openalex.org/W2561450689","https://openalex.org/W2605862990","https://openalex.org/W2624854612","https://openalex.org/W2729854624","https://openalex.org/W2764036437","https://openalex.org/W2773825076","https://openalex.org/W2777218045","https://openalex.org/W2789430508","https://openalex.org/W2793289663","https://openalex.org/W2795923929","https://openalex.org/W2801928995","https://openalex.org/W2885626252","https://openalex.org/W2888213344","https://openalex.org/W2889111495","https://openalex.org/W2891980308","https://openalex.org/W2897364906","https://openalex.org/W2937074474","https://openalex.org/W2949540526","https://openalex.org/W2953777803","https://openalex.org/W2988624326","https://openalex.org/W2989982111","https://openalex.org/W2991280175","https://openalex.org/W2998650632","https://openalex.org/W3002488938","https://openalex.org/W3024085885","https://openalex.org/W3037800437","https://openalex.org/W3044400259","https://openalex.org/W3112191948","https://openalex.org/W3116894279","https://openalex.org/W3122988712","https://openalex.org/W3131190077","https://openalex.org/W3160044598","https://openalex.org/W3177726718","https://openalex.org/W4205112020","https://openalex.org/W4205789062","https://openalex.org/W4220710246","https://openalex.org/W4247878364","https://openalex.org/W4280617650","https://openalex.org/W4281675921","https://openalex.org/W4306175189","https://openalex.org/W4306955939","https://openalex.org/W4367053317","https://openalex.org/W6795168224"],"related_works":["https://openalex.org/W4205112020","https://openalex.org/W4386481419","https://openalex.org/W1204829567","https://openalex.org/W4205751268","https://openalex.org/W2052104207","https://openalex.org/W2945671263","https://openalex.org/W4309289628","https://openalex.org/W2738674325","https://openalex.org/W7168265375","https://openalex.org/W7221437623"],"abstract_inverted_index":{"Ticlopidine":[0,199],"exerts":[1],"its":[2,84],"anti-platelet":[3],"effects":[4],"mainly":[5],"by":[6,255,287],"antagonizing":[7],"platelet":[8],"p2y12":[9],"receptors.":[10],"Previously,":[11],"a":[12,73,276,298],"few":[13],"studies":[14],"have":[15],"shown":[16],"that":[17],"ticlopidine":[18,66,82,103,118,245,288],"can":[19,42,50],"induce":[20],"liver":[21,47,128,162,187,190,238,251],"injury,":[22],"but":[23],"the":[24,61,79,137,212,226,281],"exact":[25],"mechanism":[26],"of":[27,65,81,102,117,136,143,179,237,257,290],"hepatotoxicity":[28,80,285],"remains":[29],"unclear.":[30],"Oxidative":[31],"stress,":[32],"metabolic":[33,177],"disorders,":[34],"hepatocyte":[35,209],"apoptosis,":[36],"lipid":[37],"peroxidation,":[38],"and":[39,83,99,133,147,156,169,174,183,189,197,204,207,235,250,267,284],"inflammatory":[40],"responses":[41],"all":[43],"lead":[44],"to":[45,58,76,94,114,263,279],"hepatic":[46],"damage,":[48],"which":[49],"cause":[51],"hepatotoxicity.":[52,268],"In":[53,243,269],"this":[54,270],"study,":[55,271],"in":[56,107,127,161,192,221,225,253,295],"order":[57],"deeply":[59],"explore":[60],"potential":[62],"molecular":[63],"mechanisms":[64],"-induced":[67],"hepatotoxicity,":[68],"we":[69,217,272],"used":[70,273],"zebrafish":[71,90,110,123,145,181,195,254,274],"as":[72,275],"model":[74,277],"organism":[75,278],"comprehensively":[77],"evaluate":[78],"associated":[85],"mechanism.":[86],"Three":[87],"days":[88],"post-fertilization,":[89],"larvae":[91,124,146,182,196],"were":[92,111],"exposed":[93,112],"varying":[95],"concentrations":[96],"(1.5,":[97],"1.75":[98],"2":[100],"\u03bcg/mL)":[101],"for":[104,119,301],"72":[105],"h,":[106],"contrast,":[108],"adult":[109],"exposure":[113],"4":[115],"\u03bcg/mL":[116],"28":[120],"days.":[121],"Ticlopidine-exposed":[122],"showed":[125,240],"changes":[126,224],"morphology,":[129],"shortened":[130,228],"body":[131,229],"length,":[132,230],"delayed":[134,231],"development":[135,249],"swim":[138,232],"bladder":[139,233],"development.":[140],"Liver":[141],"tissues":[142,239],"ticlopidine-exposed":[144,180,194],"adults":[148,184],"stained":[149],"with":[150],"Hematoxylin":[151],"&":[152],"Eosin":[153],"revealed":[154],"vacuolization":[155],"increased":[157],"cellular":[158],"interstitial":[159],"spaces":[160],"tissues.":[163],"Furthermore,":[164],"using":[165,215],"Oil":[166],"Red":[167],"O":[168],"periodic":[170],"acid-Schiff":[171],"staining":[172],"methods":[173],"evaluating":[175],"different":[176],"enzymes":[178],"suggested":[185],"abnormal":[186],"metabolism":[188],"injury":[191],"both":[193],"adults.":[198],"also":[200],"significantly":[201],"elevated":[202],"inflammation":[203],"oxidative":[205,258,291],"stress":[206,259,292],"reduced":[208],"proliferation.":[210],"During":[211],"rescue":[213],"intervention":[214],"N-acetylcysteine,":[216],"observed":[218],"significant":[219,241],"improvement":[220],"ticlopidine-induced":[222],"morphological":[223],"liver,":[227],"development,":[234],"proliferation":[236,252],"improvement.":[242],"conclusion,":[244],"might":[246],"inhibit":[247],"normal":[248],"upregulation":[256,289],"levels,":[260],"thus":[261],"leading":[262],"embryonic":[264],"developmental":[265,282],"toxicity":[266,283],"elucidate":[280],"induced":[286],"signaling":[293],"pathway":[294],"zebrafish,":[296],"providing":[297],"theoretical":[299],"basis":[300],"clinical":[302],"application.":[303]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-08-01T00:00:00"}