{"id":"https://openalex.org/W4385406971","doi":"https://doi.org/10.1111/jocd.15934","title":"Stratum corneum compliance enhances tactile sensitivity through increasing skin deformation: A study protocol for a randomized controlled trial","display_name":"Stratum corneum compliance enhances tactile sensitivity through increasing skin deformation: A study protocol for a randomized controlled trial","publication_year":2023,"publication_date":"2023-07-31","ids":{"openalex":"https://openalex.org/W4385406971","doi":"https://doi.org/10.1111/jocd.15934","pmid":"https://pubmed.ncbi.nlm.nih.gov/37522513"},"language":"en","primary_location":{"id":"doi:10.1111/jocd.15934","doi":"https://doi.org/10.1111/jocd.15934","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jocd.15934","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.15934","source":{"id":"https://openalex.org/S169297576","display_name":"Journal of Cosmetic Dermatology","issn_l":"1473-2130","issn":["1473-2130","1473-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cosmetic Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.15934","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079648028","display_name":"Saito Sakaguchi","orcid":"https://orcid.org/0000-0003-1514-9468","observed_orcids":["https://orcid.org/0000-0003-1514-9468"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]},{"id":"https://openalex.org/I4210123820","display_name":"Shiseido Group (Japan)","ror":"https://ror.org/03da3g825","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210123820"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Saito Sakaguchi","raw_affiliation_strings":["Graduate School of Information Sciences, Tohoku University, Sendai, Japan","MIRAI Technology Institute, Shiseido Co., Ltd., Yokohama, Japan"],"raw_orcid":"https://orcid.org/0000-0003-1514-9468","affiliations":[{"raw_affiliation_string":"Graduate School of Information Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"MIRAI Technology Institute, Shiseido Co., Ltd., Yokohama, Japan","institution_ids":["https://openalex.org/I4210123820"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024966100","display_name":"Kaoru Saito","orcid":"https://orcid.org/0000-0002-7912-4860","observed_orcids":["https://orcid.org/0000-0002-7912-4860"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kaoru Saito","raw_affiliation_strings":["Graduate School of Information Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Information Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029691594","display_name":"Naomi Arakawa","orcid":"https://orcid.org/0000-0003-0536-1262","observed_orcids":["https://orcid.org/0000-0003-0536-1262"]},"institutions":[{"id":"https://openalex.org/I4210123820","display_name":"Shiseido Group (Japan)","ror":"https://ror.org/03da3g825","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210123820"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naomi Arakawa","raw_affiliation_strings":["MIRAI Technology Institute, Shiseido Co., Ltd., Yokohama, Japan"],"raw_orcid":"https://orcid.org/0000-0003-0536-1262","affiliations":[{"raw_affiliation_string":"MIRAI Technology Institute, Shiseido Co., Ltd., Yokohama, Japan","institution_ids":["https://openalex.org/I4210123820"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003204631","display_name":"Masashi Konyo","orcid":"https://orcid.org/0000-0002-6826-9722","observed_orcids":["https://orcid.org/0000-0002-6826-9722"]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Konyo","raw_affiliation_strings":["Graduate School of Information Sciences, Tohoku University, Sendai, Japan"],"raw_orcid":"https://orcid.org/0000-0002-6826-9722","affiliations":[{"raw_affiliation_string":"Graduate School of Information Sciences, Tohoku University, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079648028"],"corresponding_institution_ids":["https://openalex.org/I201537933","https://openalex.org/I4210123820"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":0.9459,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.68436766,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"23","issue":"1","first_page":"296","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stratum-corneum","display_name":"stratum corneum","score":0.8920000195503235},{"id":"https://openalex.org/keywords/skin-compliance","display_name":"skin compliance","score":0.9810000061988831},{"id":"https://openalex.org/keywords/tactile-sensitivity","display_name":"tactile sensitivity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/skin-hydration","display_name":"skin hydration","score":0.8190000057220459},{"id":"https://openalex.org/keywords/moisturizing-cream","display_name":"moisturizing cream","score":0.972000002861023},{"id":"https://openalex.org/keywords/tactile-discrimination","display_name":"tactile discrimination","score":0.8899999856948853},{"id":"https://openalex.org/keywords/skin-deformation","display_name":"skin deformation","score":0.796999990940094},{"id":"https://openalex.org/keywords/skin-extensibility","display_name":"skin extensibility","score":0.9520000219345093},{"id":"https://openalex.org/keywords/elastic-modulus","display_name":"elastic modulus","score":0.7039999961853027},{"id":"https://openalex.org/keywords/tactile-perception","display_name":"tactile perception","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.9905049800872803},{"id":"https://openalex.org/C130093455","wikidata":"https://www.wikidata.org/wiki/Q173253","display_name":"Sensation","level":2,"score":0.4758464992046356},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4631269574165344},{"id":"https://openalex.org/C95150158","wikidata":"https://www.wikidata.org/wiki/Q7833972","display_name":"Transepidermal water loss","level":3,"score":0.45601728558540344},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.4517298936843872},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4044203758239746},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3639296293258667},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1851496398448944},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12893041968345642},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.10265049338340759},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09144985675811768},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004548","descriptor_name":"Elasticity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017592","descriptor_name":"Skin Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jocd.15934","doi":"https://doi.org/10.1111/jocd.15934","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jocd.15934","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.15934","source":{"id":"https://openalex.org/S169297576","display_name":"Journal of Cosmetic Dermatology","issn_l":"1473-2130","issn":["1473-2130","1473-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cosmetic Dermatology","raw_type":"journal-article"},{"id":"pmid:37522513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37522513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cosmetic dermatology","raw_type":"Clinical Trial Protocol"}],"best_oa_location":{"id":"doi:10.1111/jocd.15934","doi":"https://doi.org/10.1111/jocd.15934","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jocd.15934","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocd.15934","source":{"id":"https://openalex.org/S169297576","display_name":"Journal of Cosmetic Dermatology","issn_l":"1473-2130","issn":["1473-2130","1473-2165"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cosmetic Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385406971.pdf"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W610199707","https://openalex.org/W1504784767","https://openalex.org/W1588530204","https://openalex.org/W1964477575","https://openalex.org/W1965640126","https://openalex.org/W1965682728","https://openalex.org/W1967465908","https://openalex.org/W1969694130","https://openalex.org/W2005589641","https://openalex.org/W2008594606","https://openalex.org/W2057731241","https://openalex.org/W2058443261","https://openalex.org/W2064129579","https://openalex.org/W2071133211","https://openalex.org/W2079458882","https://openalex.org/W2092511662","https://openalex.org/W2092610649","https://openalex.org/W2096551885","https://openalex.org/W2105007212","https://openalex.org/W2110713905","https://openalex.org/W2111193324","https://openalex.org/W2122105736","https://openalex.org/W2127794676","https://openalex.org/W2132125247","https://openalex.org/W2134222224","https://openalex.org/W2136398741","https://openalex.org/W2141331305","https://openalex.org/W2148384915","https://openalex.org/W2150383989","https://openalex.org/W2152966241","https://openalex.org/W2169288745","https://openalex.org/W2185994763","https://openalex.org/W2195928948","https://openalex.org/W2490009378","https://openalex.org/W2772883394","https://openalex.org/W2787116938","https://openalex.org/W2793538173","https://openalex.org/W2803070037","https://openalex.org/W2952050834","https://openalex.org/W2954428149","https://openalex.org/W2971176260","https://openalex.org/W2997952934","https://openalex.org/W3003800554","https://openalex.org/W3082649036","https://openalex.org/W4205490020","https://openalex.org/W4242593198","https://openalex.org/W4300612139","https://openalex.org/W4323359686"],"related_works":["https://openalex.org/W368943992","https://openalex.org/W4388530014","https://openalex.org/W4323359686","https://openalex.org/W4408738926","https://openalex.org/W4283752398","https://openalex.org/W2014111779","https://openalex.org/W4386993445","https://openalex.org/W1969694130","https://openalex.org/W6906821401","https://openalex.org/W2057731241"],"abstract_inverted_index":{"BACKGROUND:":[0],"Tactile":[1,144,199],"sensation":[2,186],"plays":[3,305],"a":[4,31,122,130,191,291,306],"crucial":[5,307],"role":[6,308],"in":[7,84,95,171,203,219,268,288,293,309],"object":[8],"manipulation,":[9],"communication,":[10],"and":[11,63,91,153,162,263,282],"even":[12],"emotional":[13],"well-being.":[14],"It":[15],"has":[16],"been":[17],"reported":[18],"that":[19,29,120,136,312],"the":[20,45,48,51,70,73,82,96,99,169,172,210,236,246,254,260,265,275,300],"deformability":[21],"of":[22,47,54,72,98,164,228,238,245,257,259,299],"skin":[23,27,61,89,211,239,289,314],"(also":[24],"described":[25],"as":[26],"compliance)":[28],"shows":[30],"large":[32],"mechanical":[33,159],"response":[34,160,269],"to":[35,60,113,126,141,177,209,235,250,270],"stimuli":[36],"is":[37,283],"associated":[38],"with":[39],"high":[40],"tactile":[41,77,85,185,196,229,271,280,294,310],"sensitivity.":[42],"However,":[43],"although":[44],"compliance":[46,97,298],"stratum":[49,74,100,173,247,261,276,302],"corneum,":[50],"outermost":[52],"layer":[53,304],"skin,":[55],"can":[56],"change":[57,216],"daily":[58],"due":[59,249],"care":[62],"environmental":[64],"factors,":[65],"few":[66],"studies":[67],"have":[68],"quantified":[69],"effect":[71],"corneum":[75,174,248,262,277,303],"on":[76],"sensation.":[78],"AIMS:":[79],"We":[80],"investigated":[81],"changes":[83],"sensitivity":[86,200,281],"resulting":[87],"from":[88,168],"hydration":[90,179],"identified":[92],"corresponding":[93],"alterations":[94],"corneum.":[101],"METHODS:":[102],"A":[103],"randomized":[104],"controlled":[105],"trial":[106],"was":[107,147,201,217,232],"conducted.":[108],"Participants":[109],"were":[110,175,187],"randomly":[111],"assigned":[112],"an":[114,286],"intervention":[115],"group":[116,132],"(n":[117,133],"=":[118,134],"20)":[119],"had":[121,137,206],"moisturizing":[123],"cream":[124,170,207,251],"applied":[125,140,208],"their":[127,142],"cheeks":[128],"or":[129],"control":[131],"19)":[135],"Milli-Q":[138,223],"water":[139,157,243],"cheeks.":[143],"discrimination":[145,227],"performance":[146],"assessed":[148],"using":[149,190],"psychophysical":[150],"techniques":[151],"before":[152],"after":[154],"application.":[155],"The":[156,225,241,297],"content,":[158],"characteristics,":[161],"penetration":[163],"PEG/PPG-17/4":[165],"dimethyl":[166],"ether":[167],"evaluated":[176],"identify":[178],"effects.":[180],"Skin":[181],"deformations":[182],"occurring":[183],"during":[184],"measured":[188],"concurrently":[189],"suction":[192],"device":[193],"employed":[194],"for":[195],"stimulation.":[197],"RESULTS:":[198],"increased":[202,264],"participants":[204,220],"who":[205,221],"surface,":[212],"while":[213],"no":[214],"significant":[215],"observed":[218],"received":[222],"water.":[224],"improved":[226],"stimulus":[230],"intensity":[231,295],"directly":[233],"related":[234],"magnitude":[237],"displacement.":[240],"higher":[242],"content":[244],"application":[252],"decreased":[253],"dynamic":[255],"modulus":[256],"elasticity":[258],"skin's":[266],"extensibility":[267],"stimuli.":[272],"CONCLUSIONS:":[273],"Hydrating":[274],"significantly":[278],"enhances":[279],"accompanied":[284],"by":[285],"increase":[287],"extensibility,":[290],"factor":[292],"perception.":[296],"thin":[301],"experiences":[311],"involve":[313],"stretching.":[315]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-01T00:00:00"}