{"id":"https://openalex.org/W4385406841","doi":"https://doi.org/10.1007/s11010-023-04805-0","title":"Molecular mechanisms underlying cyclophosphamide-induced cognitive impairment and strategies for neuroprotection in preclinical models","display_name":"Molecular mechanisms underlying cyclophosphamide-induced cognitive impairment and strategies for neuroprotection in preclinical models","publication_year":2023,"publication_date":"2023-07-31","ids":{"openalex":"https://openalex.org/W4385406841","doi":"https://doi.org/10.1007/s11010-023-04805-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/37522975","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/11339103"},"language":"en","primary_location":{"id":"doi:10.1007/s11010-023-04805-0","doi":"https://doi.org/10.1007/s11010-023-04805-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11010-023-04805-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11010-023-04805-0.pdf","source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s11010-023-04805-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085108865","display_name":"Kamilia M. Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Kamilia M. Ibrahim","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046359043","display_name":"Samar F. Darwish","orcid":"https://orcid.org/0000-0002-4238-7069","observed_orcids":["https://orcid.org/0000-0002-4238-7069"]},"institutions":[{"id":"https://openalex.org/I4210151980","display_name":"Badr University in Cairo","ror":"https://ror.org/04tbvjc27","country_code":"EG","type":"education","lineage":["https://openalex.org/I4210151980"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Samar F. Darwish","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo, 11829, Egypt","institution_ids":["https://openalex.org/I4210151980"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059058890","display_name":"Eman M. Mantawy","orcid":"https://orcid.org/0000-0001-8375-9618","observed_orcids":["https://orcid.org/0000-0001-8375-9618"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Eman M. Mantawy","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt","Preclinical and Translational Research Center, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Preclinical and Translational Research Center, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044499133","display_name":"Ebtehal El\u2010Demerdash","orcid":"https://orcid.org/0000-0003-2951-4892","observed_orcids":["https://orcid.org/0000-0003-2951-4892"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Ebtehal El-demerdash","raw_affiliation_strings":["Department of Pharmacology & Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. ebtehal_dm@yahoo.com","Preclinical and Translational Research Center, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, Egypt. ebtehal_dm@yahoo.com","Preclinical and Translational Research Center, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. ebtehal_dm@yahoo.com","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Preclinical and Translational Research Center, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, Egypt. ebtehal_dm@yahoo.com","institution_ids":["https://openalex.org/I107720978"]},{"raw_affiliation_string":"Preclinical and Translational Research Center, Faculty of Pharmacy, Ain Shams University, Abasia, Cairo, Egypt","institution_ids":["https://openalex.org/I107720978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044499133"],"corresponding_institution_ids":["https://openalex.org/I107720978"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":{"value":3590,"currency":"USD","value_usd":3590},"fwci":2.2414,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.92043315,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"479","issue":"8","first_page":"1873","last_page":"1893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemotherapy-induced-cognitive-impairment","display_name":"chemotherapy-induced cognitive impairment","score":0.8479999899864197},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8870000243186951},{"id":"https://openalex.org/keywords/oxidative-brain-damage","display_name":"brain oxidative damage","score":0.9089999794960022},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":1.0},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/neurotransmitter-imbalance","display_name":"neurotransmitter imbalance","score":0.871999979019165},{"id":"https://openalex.org/keywords/neurotrophic-factors","display_name":"neurotrophic factors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neuroprotective-agents","display_name":"neuroprotective agents","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cancer-patients","display_name":"cancer patients","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9147448539733887},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5747640132904053},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5017795562744141},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.501349925994873},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4627537727355957},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4494738280773163},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38520389795303345},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3510652780532837},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18668994307518005},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10236987471580505}],"mesh":[{"descriptor_ui":"D000066829","descriptor_name":"Neuroprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1007/s11010-023-04805-0","doi":"https://doi.org/10.1007/s11010-023-04805-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11010-023-04805-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11010-023-04805-0.pdf","source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11339103","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11339103","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11339103/pdf/11010_2023_Article_4805.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biochem","raw_type":"Text"},{"id":"pmid:37522975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37522975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biochemistry","raw_type":"Journal Article"},{"id":"doi:10.60692/ey3d0-cpx21","doi":"https://doi.org/10.60692/ey3d0-cpx21","is_oa":true,"landing_page_url":"https://doi.org/10.60692/ey3d0-cpx21","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/qyvd0-6n938","doi":"https://doi.org/10.60692/qyvd0-6n938","is_oa":true,"landing_page_url":"https://doi.org/10.60692/qyvd0-6n938","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1007/s11010-023-04805-0","doi":"https://doi.org/10.1007/s11010-023-04805-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11010-023-04805-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s11010-023-04805-0.pdf","source":{"id":"https://openalex.org/S11742566","display_name":"Molecular and Cellular Biochemistry","issn_l":"0300-8177","issn":["0300-8177","1573-4919"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biochemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321119","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385406841.pdf","grobid_xml":"https://content.openalex.org/works/W4385406841.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W1562273961","https://openalex.org/W1766732272","https://openalex.org/W1965658052","https://openalex.org/W1971027103","https://openalex.org/W1977962377","https://openalex.org/W1980538374","https://openalex.org/W1996160766","https://openalex.org/W2026844934","https://openalex.org/W2028545235","https://openalex.org/W2033023829","https://openalex.org/W2045465386","https://openalex.org/W2045662629","https://openalex.org/W2054087224","https://openalex.org/W2062508862","https://openalex.org/W2070423606","https://openalex.org/W2075218700","https://openalex.org/W2082909557","https://openalex.org/W2094682461","https://openalex.org/W2154122162","https://openalex.org/W2158738222","https://openalex.org/W2168711831","https://openalex.org/W2218632706","https://openalex.org/W2221985609","https://openalex.org/W2228569760","https://openalex.org/W2252903124","https://openalex.org/W2266543467","https://openalex.org/W2276241585","https://openalex.org/W2294030378","https://openalex.org/W2294386056","https://openalex.org/W2348389929","https://openalex.org/W2419409011","https://openalex.org/W2467060560","https://openalex.org/W2510835175","https://openalex.org/W2519413740","https://openalex.org/W2519786994","https://openalex.org/W2521392361","https://openalex.org/W2569150154","https://openalex.org/W2589764628","https://openalex.org/W2603079770","https://openalex.org/W2621656000","https://openalex.org/W2624853583","https://openalex.org/W2734842194","https://openalex.org/W2738316055","https://openalex.org/W2742200852","https://openalex.org/W2761503357","https://openalex.org/W2768768130","https://openalex.org/W2769631482","https://openalex.org/W2769876766","https://openalex.org/W2771359783","https://openalex.org/W2774293483","https://openalex.org/W2785091318","https://openalex.org/W2802176353","https://openalex.org/W2802684976","https://openalex.org/W2803481743","https://openalex.org/W2809397958","https://openalex.org/W2884134082","https://openalex.org/W2891890452","https://openalex.org/W2899158325","https://openalex.org/W2907590035","https://openalex.org/W2907961170","https://openalex.org/W2913006758","https://openalex.org/W2937346106","https://openalex.org/W2939689822","https://openalex.org/W2944386491","https://openalex.org/W2951206969","https://openalex.org/W2954782052","https://openalex.org/W2973222161","https://openalex.org/W2978605903","https://openalex.org/W2981241390","https://openalex.org/W2995569529","https://openalex.org/W2998183474","https://openalex.org/W3000667365","https://openalex.org/W3010311908","https://openalex.org/W3013669021","https://openalex.org/W3019023480","https://openalex.org/W3023435860","https://openalex.org/W3024065332","https://openalex.org/W3032267617","https://openalex.org/W3033829306","https://openalex.org/W3038503389","https://openalex.org/W3042581723","https://openalex.org/W3043449577","https://openalex.org/W3086041334","https://openalex.org/W3090639455","https://openalex.org/W3090668231","https://openalex.org/W3094620060","https://openalex.org/W3106125810","https://openalex.org/W3114836680","https://openalex.org/W3120304846","https://openalex.org/W3129723783","https://openalex.org/W3136789394","https://openalex.org/W3137948826","https://openalex.org/W3167444500","https://openalex.org/W3170415045","https://openalex.org/W3170588962","https://openalex.org/W3171144340","https://openalex.org/W3194553885","https://openalex.org/W3200707411","https://openalex.org/W3209255096","https://openalex.org/W3210141429","https://openalex.org/W3214108279","https://openalex.org/W4205765008","https://openalex.org/W4210785929","https://openalex.org/W4214925106","https://openalex.org/W4221095599","https://openalex.org/W4255230143","https://openalex.org/W4280531878","https://openalex.org/W4281653050","https://openalex.org/W4281676404","https://openalex.org/W4281806947","https://openalex.org/W4286008242","https://openalex.org/W4288758478","https://openalex.org/W4292634012","https://openalex.org/W4296168170","https://openalex.org/W4296667436","https://openalex.org/W4297260157","https://openalex.org/W4310211651","https://openalex.org/W4313332607","https://openalex.org/W4313455215","https://openalex.org/W4319869602","https://openalex.org/W4323858390"],"related_works":["https://openalex.org/W4414205070","https://openalex.org/W2973222161","https://openalex.org/W2944386491","https://openalex.org/W4417274645","https://openalex.org/W4413939483","https://openalex.org/W3112802637","https://openalex.org/W3024065332","https://openalex.org/W7108913069","https://openalex.org/W7160373116","https://openalex.org/W7201890298"],"abstract_inverted_index":{"Cyclophosphamide":[0],"has":[1,125,155],"drastically":[2],"enhanced":[3],"the":[4,61,80,94,139,146,152,162,184,194,203,215],"expectancy":[5],"and":[6,42,85,112,219],"quality":[7,216],"of":[8,10,58,79,82,122,135,141,151,165,183,187,217,221],"life":[9,218],"cancer":[11,222],"patients.":[12],"However,":[13],"it":[14],"is":[15,133,172],"accompanied":[16],"by":[17,30],"diverse":[18],"neurological":[19,211],"complications":[20],"which":[21],"are":[22],"considered":[23],"a":[24,55,173],"dose-limiting":[25],"adverse":[26],"effect.":[27],"Neurotoxicity":[28],"caused":[29],"cyclophosphamide":[31,166],"can":[32],"manifest":[33],"in":[34,118,128,145,167],"numerous":[35],"manners":[36],"including":[37,66],"anxiety,":[38],"depression,":[39],"motor":[40],"dysfunction":[41],"cognitive":[43],"deficits.":[44],"This":[45],"review":[46,90,192],"article":[47],"offers":[48],"an":[49],"overview":[50],"on":[51,60,93,161],"cyclophosphamide-induced":[52,199],"neurotoxicity,":[53],"providing":[54],"unified":[56],"point":[57],"view":[59],"possible":[62],"underlying":[63],"molecular":[64,195],"mechanisms":[65,196],"oxidative":[67],"brain":[68,83],"damage,":[69],"neuroinflammation,":[70],"apoptotic":[71],"neuronal":[72],"cell":[73],"death":[74],"as":[75,77,106,108],"well":[76,107],"disruption":[78],"balance":[81],"neurotransmitters":[84],"neurotrophic":[86],"factors.":[87],"Besides,":[88],"this":[89,191,210],"sheds":[91],"light":[92],"promising":[95,116],"protective":[96,153,205],"agents":[97,124,154],"that":[98],"have":[99],"been":[100,126,156],"investigated":[101],"using":[102],"preclinical":[103],"animal":[104],"models":[105],"their":[109],"biological":[110],"targets":[111],"protection":[113],"mechanisms.":[114],"Despite":[115],"results":[117],"experimental":[119],"models,":[120],"none":[121,150],"these":[123,188],"studied":[127],"clinical":[129,147,179],"trials.":[130],"Thus,":[131],"there":[132,171],"lack":[134],"evidence":[136],"to":[137],"advocate":[138],"use":[140],"any":[142],"neuroprotective":[143],"agent":[144],"setting.":[148],"Furthermore,":[149],"evaluated":[157],"for":[158,176,181,198,208],"its":[159],"effect":[160],"anticancer":[163],"activity":[164],"tumor-bearing":[168],"animals.":[169],"Therefore,":[170],"great":[174],"necessity":[175],"adequate":[177],"well-designed":[178],"studies":[180],"evaluation":[182],"therapeutic":[185],"values":[186],"candidates.":[189],"Conclusively,":[190],"summarizes":[193],"accounting":[197],"neurotoxicity":[200],"together":[201],"with":[202,225],"potential":[204],"strategies":[206],"seeking":[207],"downgrading":[209],"complication,":[212],"thus":[213],"enhancing":[214],"well-being":[220],"patients":[223],"treated":[224],"cyclophosphamide.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":31},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-01T00:00:00"}