{"id":"https://openalex.org/W4385406334","doi":"https://doi.org/10.5858/arpa.2022-0482-oa","title":"Evaluation of Novel Targets, Including CC-Chemokine Receptor 4, in Adult T-Cell Acute Lymphoblastic Leukemia/Lymphoma: A Mayo Clinic Clinical and Pathologic Study","display_name":"Evaluation of Novel Targets, Including CC-Chemokine Receptor 4, in Adult T-Cell Acute Lymphoblastic Leukemia/Lymphoma: A Mayo Clinic Clinical and Pathologic Study","publication_year":2023,"publication_date":"2023-07-27","ids":{"openalex":"https://openalex.org/W4385406334","doi":"https://doi.org/10.5858/arpa.2022-0482-oa","pmid":"https://pubmed.ncbi.nlm.nih.gov/37522711"},"language":"en","primary_location":{"id":"doi:10.5858/arpa.2022-0482-oa","doi":"https://doi.org/10.5858/arpa.2022-0482-oa","is_oa":true,"landing_page_url":"https://doi.org/10.5858/arpa.2022-0482-oa","pdf_url":"https://meridian.allenpress.com/aplm/article-pdf/doi/10.5858/arpa.2022-0482-OA/3242697/10.5858_arpa.2022-0482-oa.pdf","source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://meridian.allenpress.com/aplm/article-pdf/doi/10.5858/arpa.2022-0482-OA/3242697/10.5858_arpa.2022-0482-oa.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000881706","display_name":"Sharad Khurana","orcid":"https://orcid.org/0000-0001-5483-7947","observed_orcids":["https://orcid.org/0000-0001-5483-7947"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharad Khurana","raw_affiliation_strings":["From the Division of Hematology/Oncology, University of Arizona Cancer Center, Tucson (Khurana)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology/Oncology, University of Arizona Cancer Center, Tucson (Khurana)","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031027678","display_name":"Michael G. Heckman","orcid":"https://orcid.org/0000-0003-3770-9331","observed_orcids":["https://orcid.org/0000-0003-3770-9331"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael G. Heckman","raw_affiliation_strings":["the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101720483","display_name":"Fiona E. Craig","orcid":"https://orcid.org/0009-0000-4575-5683","observed_orcids":["https://orcid.org/0009-0000-4575-5683"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fiona E. Craig","raw_affiliation_strings":["the Divisions of Hematopathology (Craig) and Hematology and Medical Oncology (Sproat), Mayo Clinic Arizona, Phoenix"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Hematopathology (Craig) and Hematology and Medical Oncology (Sproat), Mayo Clinic Arizona, Phoenix","institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112387332","display_name":"Jordan J. Cochuyt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan J. Cochuyt","raw_affiliation_strings":["the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072775789","display_name":"Patricia Theresa Greipp","orcid":"https://orcid.org/0000-0002-5536-9011","observed_orcids":["https://orcid.org/0000-0002-5536-9011"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Greipp","raw_affiliation_strings":["the Divisions of Laboratory Genetics (Greipp) and Hematology (Litzow), Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Laboratory Genetics (Greipp) and Hematology (Litzow), Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089383415","display_name":"Zaid Abdel Rahman","orcid":"https://orcid.org/0000-0003-2959-1177","observed_orcids":["https://orcid.org/0000-0003-2959-1177"]},"institutions":[{"id":"https://openalex.org/I4210130571","display_name":"Sanford Medical Center","ror":"https://ror.org/03byzcq48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210130571"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zaid Abdel Rahman","raw_affiliation_strings":["the Division of Hematology and Medical Oncology, Sanford Roger Maris Cancer Center, Fargo, North Dakota (Rahman)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Hematology and Medical Oncology, Sanford Roger Maris Cancer Center, Fargo, North Dakota (Rahman)","institution_ids":["https://openalex.org/I4210130571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111293822","display_name":"Lisa Z. Sproat","orcid":"https://orcid.org/0000-0002-6419-7581","observed_orcids":["https://orcid.org/0000-0002-6419-7581"]},"institutions":[{"id":"https://openalex.org/I4210125099","display_name":"Mayo Clinic in Arizona","ror":"https://ror.org/03jp40720","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099"]},{"id":"https://openalex.org/I4210127938","display_name":"Mayo Clinic Hospital","ror":"https://ror.org/03660jn93","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Z. Sproat","raw_affiliation_strings":["the Divisions of Hematopathology (Craig) and Hematology and Medical Oncology (Sproat), Mayo Clinic Arizona, Phoenix"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Hematopathology (Craig) and Hematology and Medical Oncology (Sproat), Mayo Clinic Arizona, Phoenix","institution_ids":["https://openalex.org/I4210125099","https://openalex.org/I4210127938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Litzow","raw_affiliation_strings":["the Divisions of Laboratory Genetics (Greipp) and Hematology (Litzow), Mayo Clinic, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Divisions of Laboratory Genetics (Greipp) and Hematology (Litzow), Mayo Clinic, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035051206","display_name":"James M. Foran","orcid":"https://orcid.org/0000-0003-1673-1708","observed_orcids":["https://orcid.org/0000-0003-1673-1708"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James M. Foran","raw_affiliation_strings":["the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville","institution_ids":["https://openalex.org/I4210146710"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049552841","display_name":"Liuyan Jiang","orcid":"https://orcid.org/0000-0002-9851-985X","observed_orcids":["https://orcid.org/0000-0002-9851-985X"]},"institutions":[{"id":"https://openalex.org/I4210146710","display_name":"Mayo Clinic in Florida","ror":"https://ror.org/03zzw1w08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4210146710"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liuyan (Jennifer) Jiang","raw_affiliation_strings":["the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Departments of Biomedical Statistics and Informatics (Heckman, Cochuyt) and Laboratory Medicine and Pathology (Jiang), and the Division of Hematology and Medical Oncology (Foran), Mayo Clinic Florida, Jacksonville","institution_ids":["https://openalex.org/I4210146710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035051206"],"corresponding_institution_ids":["https://openalex.org/I4210146710"],"apc_list":null,"apc_paid":null,"fwci":0.932,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72880981,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"148","issue":"4","first_page":"471","last_page":"475"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.875},{"id":"https://openalex.org/keywords/t-lymphoblastic-lymphoma","display_name":"T-cell lymphoblastic lymphoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ccr4","display_name":"CCR4","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cd47","display_name":"CD47","score":0.8289999961853027},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cd38","display_name":"CD38","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cd123","display_name":"CD123","score":1.0},{"id":"https://openalex.org/keywords/bcl6","display_name":"BCL6","score":0.7929999828338623},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.5640000104904175},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6570000052452087},{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5922825336456299},{"id":"https://openalex.org/C2775866117","wikidata":"https://www.wikidata.org/wiki/Q21102300","display_name":"CCR4","level":5,"score":0.5557270050048828},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.553739070892334},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.5378173589706421},{"id":"https://openalex.org/C128879288","wikidata":"https://www.wikidata.org/wiki/Q5009764","display_name":"CC chemokine receptors","level":5,"score":0.47350627183914185},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.4538978934288025},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42851364612579346},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4175618588924408},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38487082719802856},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34749430418014526},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3400741517543793},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3209031820297241},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.3093518614768982},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.11497184634208679}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051928","descriptor_name":"CD47 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053650","descriptor_name":"Interleukin-3 Receptor alpha Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D054218","descriptor_name":"Precursor T-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D054218","descriptor_name":"Precursor T-Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D054398","descriptor_name":"Receptors, CCR4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5858/arpa.2022-0482-oa","doi":"https://doi.org/10.5858/arpa.2022-0482-oa","is_oa":true,"landing_page_url":"https://doi.org/10.5858/arpa.2022-0482-oa","pdf_url":"https://meridian.allenpress.com/aplm/article-pdf/doi/10.5858/arpa.2022-0482-OA/3242697/10.5858_arpa.2022-0482-oa.pdf","source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},{"id":"pmid:37522711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37522711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of pathology & laboratory medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.5858/arpa.2022-0482-oa","doi":"https://doi.org/10.5858/arpa.2022-0482-oa","is_oa":true,"landing_page_url":"https://doi.org/10.5858/arpa.2022-0482-oa","pdf_url":"https://meridian.allenpress.com/aplm/article-pdf/doi/10.5858/arpa.2022-0482-OA/3242697/10.5858_arpa.2022-0482-oa.pdf","source":{"id":"https://openalex.org/S139062638","display_name":"Archives of Pathology & Laboratory Medicine","issn_l":"0003-9985","issn":["0003-9985","1543-2165"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Pathology & Laboratory Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385406334.pdf","grobid_xml":"https://content.openalex.org/works/W4385406334.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W40825427","https://openalex.org/W97158386","https://openalex.org/W1486523341","https://openalex.org/W1511263879","https://openalex.org/W1552117335","https://openalex.org/W1977380325","https://openalex.org/W1996098672","https://openalex.org/W2008009748","https://openalex.org/W2019307823","https://openalex.org/W2025321364","https://openalex.org/W2048591984","https://openalex.org/W2050627986","https://openalex.org/W2075001839","https://openalex.org/W2075028813","https://openalex.org/W2078201723","https://openalex.org/W2085533078","https://openalex.org/W2103384599","https://openalex.org/W2110220145","https://openalex.org/W2129741568","https://openalex.org/W2141795335","https://openalex.org/W2153633245","https://openalex.org/W2154295451","https://openalex.org/W2164739672","https://openalex.org/W2781552270","https://openalex.org/W2799443762","https://openalex.org/W2890864006","https://openalex.org/W2898159047","https://openalex.org/W2899385931","https://openalex.org/W2905627019","https://openalex.org/W2911317946","https://openalex.org/W2916618543","https://openalex.org/W2945544174","https://openalex.org/W4255725272","https://openalex.org/W4283381496","https://openalex.org/W4308294973"],"related_works":["https://openalex.org/W2984802906","https://openalex.org/W7128625126","https://openalex.org/W2368549915","https://openalex.org/W2097087749","https://openalex.org/W2979864991","https://openalex.org/W2279238067","https://openalex.org/W1967553819","https://openalex.org/W1906100218","https://openalex.org/W3016092294","https://openalex.org/W2336493943"],"abstract_inverted_index":{"CONTEXT.\u2014:":[0],"Unlike":[1],"B-cell":[2],"acute":[3],"lymphoblastic":[4],"leukemia/lymphoma":[5],"(ALL/LBL),":[6],"there":[7],"have":[8],"been":[9],"few":[10],"therapeutic":[11,34],"advances":[12],"in":[13,36,82,84,109,121,137,152,182,194,199],"T-cell":[14],"ALL":[15],"(T-ALL)/LBL,":[16],"an":[17],"aggressive":[18],"ALL/LBL":[19],"subtype.":[20],"OBJECTIVE.\u2014:":[21],"To":[22],"perform":[23],"a":[24,122,196],"focused":[25],"tissue":[26,63],"array":[27],"study":[28],"to":[29],"elucidate":[30],"tumor":[31,62],"markers":[32],"of":[33,44,47,80,86,94,107,111,125,143,173,190,202],"potential":[35,129],"T-ALL/LBL.":[37],"DESIGN.\u2014:":[38],"Using":[39],"immunohistochemistry,":[40],"we":[41],"evaluated":[42],"expression":[43,79,93,106],"leukemic":[45],"antigens":[46],"interest,":[48],"specifically":[49],"CC-chemokine":[50],"receptor":[51],"4":[52,110],"(CCR4),":[53],"among":[54,159],"others,":[55],"on":[56],"available":[57],"remnant":[58],"diagnostic":[59],"material,":[60],"including":[61],"slides":[64],"obtained":[65],"from":[66],"formalin-fixed,":[67],"paraffin-embedded":[68],"preserved":[69],"tissues.":[70],"RESULTS.\u2014:":[71],"Our":[72],"analysis":[73],"identified,":[74],"for":[75],"the":[76,105,138,188],"first":[77],"time,":[78],"CCR4":[81,132,163],"T-ALL/LBL":[83,126],"11":[85],"27":[87],"cases":[88,113],"(40.7%)":[89],"and":[90,97,117,154,170,180,184],"confirmed":[91],"common":[92,136],"BCL2,":[95,178],"CD38,":[96,179],"CD47,":[98,177],"as":[99],"reported":[100],"previously.":[101],"We":[102],"also":[103],"identified":[104],"CD123":[108,181],"26":[112],"(15.4%),":[114],"whereas":[115],"BCL6":[116],"PDL1":[118],"were":[119,157],"expressed":[120],"small":[123],"number":[124],"cases.":[127,164],"The":[128],"novel":[130,203],"target":[131],"was":[133],"significantly":[134],"more":[135],"Pre/Pro-T":[139],"immunophenotypic":[140],"subtype,":[141],"6":[142],"9":[144],"(66.7%,":[145],"P":[146],"=":[147],".01).":[148],"No":[149],"additional":[150],"differences":[151],"clinical":[153,171,192],"epidemiologic":[155],"variables":[156],"noted":[158],"positive":[160],"or":[161],"negative":[162],"CONCLUSIONS.\u2014:":[165],"These":[166],"findings":[167],"support":[168],"preclinical":[169],"testing":[172],"therapies":[174],"targeting":[175],"CCR4,":[176],"T-ALL/LBL,":[183,195],"may":[185],"help":[186],"guide":[187],"development":[189],"targeted":[191],"trials":[193],"rare":[197],"disease":[198],"urgent":[200],"need":[201],"therapies.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-08-01T00:00:00"}