{"id":"https://openalex.org/W4385397695","doi":"https://doi.org/10.1111/cbdd.14306","title":"Neuroprotective potential of saroglitazar in 6\u2010OHDA induced Parkinson's disease in rats","display_name":"Neuroprotective potential of saroglitazar in 6\u2010OHDA induced Parkinson's disease in rats","publication_year":2023,"publication_date":"2023-07-30","ids":{"openalex":"https://openalex.org/W4385397695","doi":"https://doi.org/10.1111/cbdd.14306","pmid":"https://pubmed.ncbi.nlm.nih.gov/37518817"},"language":"en","primary_location":{"id":"doi:10.1111/cbdd.14306","doi":"https://doi.org/10.1111/cbdd.14306","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cbdd.14306","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cbdd.14306","source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology & Drug Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cbdd.14306","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Rohit Bhatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Rohit Bhatt","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084089145","display_name":"Devendra J. Vaishnav","orcid":"https://orcid.org/0000-0001-5704-0693","observed_orcids":["https://orcid.org/0000-0001-5704-0693"]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Devendra Vaishnav","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071342718","display_name":"Vishal Airao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vishal Airao","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010630540","display_name":"Tejas Sharma","orcid":"https://orcid.org/0000-0001-9218-2558","observed_orcids":["https://orcid.org/0000-0001-9218-2558"]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Tejas Sharma","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018148019","display_name":"Mahesh Rachamalla","orcid":"https://orcid.org/0000-0002-0091-9207","observed_orcids":["https://orcid.org/0000-0002-0091-9207"]},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mahesh Rachamalla","raw_affiliation_strings":["Department of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084231903","display_name":"Shalini Mani","orcid":"https://orcid.org/0000-0003-2500-6962","observed_orcids":["https://orcid.org/0000-0003-2500-6962"]},"institutions":[{"id":"https://openalex.org/I154970844","display_name":"Jaypee Institute of Information Technology","ror":"https://ror.org/05sttyy11","country_code":"IN","type":"education","lineage":["https://openalex.org/I154970844"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shalini Mani","raw_affiliation_strings":["Department of Biotechnology, Centre for Emerging Disease, Jaypee Institute of Information Technology, Noida, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Centre for Emerging Disease, Jaypee Institute of Information Technology, Noida, India","institution_ids":["https://openalex.org/I154970844"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012983370","display_name":"Ashish Kumar Gupta","orcid":"https://orcid.org/0000-0001-7070-3308","observed_orcids":["https://orcid.org/0000-0001-7070-3308"]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Ashish Kumar Gupta","raw_affiliation_strings":["Department of Biophysics, All India Institute of Medical Science (AIIMS), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biophysics, All India Institute of Medical Science (AIIMS), New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086198572","display_name":"Vijay Jagdish Upadhye","orcid":"https://orcid.org/0000-0002-8821-1720","observed_orcids":["https://orcid.org/0000-0002-8821-1720"]},"institutions":[{"id":"https://openalex.org/I9694494","display_name":"Parul University","ror":"https://ror.org/024v3fg07","country_code":"IN","type":"education","lineage":["https://openalex.org/I9694494"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Vijay Upadhye","raw_affiliation_strings":["Centre of Research for Development (CR4D) and Department of Microbiology, Parul University, Vadodara, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre of Research for Development (CR4D) and Department of Microbiology, Parul University, Vadodara, India","institution_ids":["https://openalex.org/I9694494"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054173631","display_name":"Saurabh Kumar Jha","orcid":"https://orcid.org/0000-0002-7437-0755","observed_orcids":["https://orcid.org/0000-0002-7437-0755"]},"institutions":[{"id":"https://openalex.org/I74885063","display_name":"Sharda University","ror":"https://ror.org/03b6ffh07","country_code":"IN","type":"education","lineage":["https://openalex.org/I74885063"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saurabh Kumar Jha","raw_affiliation_strings":["Department of Biotechnology School of Engineering & Technology (SET), Sharda University Greater Noida India"],"raw_orcid":"https://orcid.org/0000-0002-7437-0755","affiliations":[{"raw_affiliation_string":"Department of Biotechnology School of Engineering & Technology (SET), Sharda University Greater Noida India","institution_ids":["https://openalex.org/I74885063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006548312","display_name":"Niraj Kumar Jha","orcid":"https://orcid.org/0000-0001-9486-4069","observed_orcids":["https://orcid.org/0000-0001-9486-4069"]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]},{"id":"https://openalex.org/I110360157","display_name":"Lovely Professional University","ror":"https://ror.org/00et6q107","country_code":"IN","type":"education","lineage":["https://openalex.org/I110360157"]},{"id":"https://openalex.org/I3132702812","display_name":"Uttaranchal University","ror":"https://ror.org/00ba6pg24","country_code":"IN","type":"education","lineage":["https://openalex.org/I3132702812"]},{"id":"https://openalex.org/I74885063","display_name":"Sharda University","ror":"https://ror.org/03b6ffh07","country_code":"IN","type":"education","lineage":["https://openalex.org/I74885063"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Niraj Kumar Jha","raw_affiliation_strings":["Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, India","Department of Biotechnology School of Engineering & Technology (SET), Sharda University Greater Noida India","Department of Biotechnology, School of Applied & Life Sciences (SALS) Uttaranchal University Dehradun India","School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India"],"raw_orcid":"https://orcid.org/0000-0001-9486-4069","affiliations":[{"raw_affiliation_string":"Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, India","institution_ids":["https://openalex.org/I101407740"]},{"raw_affiliation_string":"Department of Biotechnology School of Engineering & Technology (SET), Sharda University Greater Noida India","institution_ids":["https://openalex.org/I74885063"]},{"raw_affiliation_string":"Department of Biotechnology, School of Applied & Life Sciences (SALS) Uttaranchal University Dehradun India","institution_ids":["https://openalex.org/I3132702812"]},{"raw_affiliation_string":"School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, India","institution_ids":["https://openalex.org/I110360157"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103237928","display_name":"Sachin K. Parmar","orcid":"https://orcid.org/0000-0002-3818-0663","observed_orcids":["https://orcid.org/0000-0002-3818-0663"]},"institutions":[{"id":"https://openalex.org/I197181853","display_name":"Saurashtra University","ror":"https://ror.org/0250jpt55","country_code":"IN","type":"education","lineage":["https://openalex.org/I197181853"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Sachin Parmar","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India"],"raw_orcid":"https://orcid.org/0000-0002-3818-0663","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, India","institution_ids":["https://openalex.org/I197181853"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5006548312","https://openalex.org/A5103237928"],"corresponding_institution_ids":["https://openalex.org/I101407740","https://openalex.org/I110360157","https://openalex.org/I197181853","https://openalex.org/I3132702812","https://openalex.org/I74885063"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":null,"fwci":0.9505,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.71172821,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"102","issue":"5","first_page":"955","last_page":"971"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saroglitazar","display_name":"saroglitazar","score":0.9890000224113464},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.906000018119812},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.972000002861023},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8149999976158142},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9909999966621399},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9909999966621399},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.8830000162124634},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.9549999833106995},{"id":"https://openalex.org/keywords/dopamine-turnover","display_name":"dopamine turnover","score":0.7710000276565552},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.5049999952316284},{"id":"https://openalex.org/keywords/ppar-activation","display_name":"PPAR activation","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.8054838180541992},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.7796844244003296},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.632836103439331},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6170417666435242},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.587949812412262},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5380991697311401},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.4549117386341095},{"id":"https://openalex.org/C165069038","wikidata":"https://www.wikidata.org/wiki/Q420930","display_name":"Glutathione reductase","level":5,"score":0.42246949672698975},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4087519347667694},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.38176167011260986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3563983142375946},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3376903235912323},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32681548595428467},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31848952174186707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30940893292427063},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.14622634649276733},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.04819634556770325}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016627","descriptor_name":"Oxidopamine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047493","descriptor_name":"PPAR alpha","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059290","descriptor_name":"Dopaminergic Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/cbdd.14306","doi":"https://doi.org/10.1111/cbdd.14306","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cbdd.14306","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cbdd.14306","source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology & Drug Design","raw_type":"journal-article"},{"id":"pmid:37518817","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37518817","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical biology & drug design","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/cbdd.14306","doi":"https://doi.org/10.1111/cbdd.14306","is_oa":true,"landing_page_url":"https://doi.org/10.1111/cbdd.14306","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/cbdd.14306","source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology & Drug Design","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322007","display_name":"Ministry of Environment","ror":"https://ror.org/04xmt0833"},{"id":"https://openalex.org/F4320324763","display_name":"Ministry of Environment, Forest and Climate Change","ror":"https://ror.org/023wx0t90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385397695.pdf","grobid_xml":"https://content.openalex.org/works/W4385397695.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W67736822","https://openalex.org/W146759131","https://openalex.org/W149565960","https://openalex.org/W588501357","https://openalex.org/W826091804","https://openalex.org/W1150141001","https://openalex.org/W1408977967","https://openalex.org/W1503832746","https://openalex.org/W1545899030","https://openalex.org/W1556802048","https://openalex.org/W1567614586","https://openalex.org/W1588570886","https://openalex.org/W1608114173","https://openalex.org/W1775749144","https://openalex.org/W1965026439","https://openalex.org/W1977258406","https://openalex.org/W1978997879","https://openalex.org/W1979766264","https://openalex.org/W1983310681","https://openalex.org/W1991715802","https://openalex.org/W1995334846","https://openalex.org/W1996877995","https://openalex.org/W1999228896","https://openalex.org/W2006221702","https://openalex.org/W2007819558","https://openalex.org/W2008081488","https://openalex.org/W2019511637","https://openalex.org/W2022222693","https://openalex.org/W2029246446","https://openalex.org/W2031852956","https://openalex.org/W2054685711","https://openalex.org/W2055207613","https://openalex.org/W2055279192","https://openalex.org/W2057451803","https://openalex.org/W2059045481","https://openalex.org/W2059395745","https://openalex.org/W2069217287","https://openalex.org/W2073092594","https://openalex.org/W2082302366","https://openalex.org/W2087853632","https://openalex.org/W2088318694","https://openalex.org/W2097830904","https://openalex.org/W2113716558","https://openalex.org/W2114918609","https://openalex.org/W2128457767","https://openalex.org/W2136445578","https://openalex.org/W2163815564","https://openalex.org/W2465564629","https://openalex.org/W2507986424","https://openalex.org/W2768977224","https://openalex.org/W2809397958","https://openalex.org/W2889197740","https://openalex.org/W2893325662","https://openalex.org/W2906486676","https://openalex.org/W2914778832","https://openalex.org/W2988223062","https://openalex.org/W3014772574","https://openalex.org/W4211044101"],"related_works":["https://openalex.org/W4312428114","https://openalex.org/W2059045481","https://openalex.org/W4377965242","https://openalex.org/W7120659113","https://openalex.org/W4302762778","https://openalex.org/W2075192772","https://openalex.org/W2016322897","https://openalex.org/W2074164779","https://openalex.org/W2001269125","https://openalex.org/W1991715802"],"abstract_inverted_index":{"Parkinson's":[0],"disease":[1],"(PD)":[2],"is":[3],"a":[4],"neurodegenerative":[5],"disorder":[6],"that":[7],"affects":[8],"2%-3%":[9],"of":[10,16,46,88,98,103,118,131,141,167,201,205,210],"the":[11],"population":[12],"worldwide.":[13],"Clinical":[14],"presentation":[15],"PD":[17,127,173,211],"includes":[18],"motor":[19],"and":[20,36,55,70,78,90,96,135,152,155,165,182,188,219],"non-motor":[21],"symptoms.":[22],"The":[23],"interplay":[24],"between":[25],"pathogenic":[26],"factors":[27],"such":[28,62],"as":[29,63],"increased":[30],"oxidative":[31,54,160],"stress,":[32,161],"neuroinflammation,":[33,162],"mitochondrial":[34,84,163],"dysfunction":[35,164],"apoptosis":[37,95,136,166],"are":[38],"responsible":[39],"for":[40,216],"neurodegeneration":[41],"in":[42,50,107,115,126,137,170,174,185,191,198,207],"PD.":[43,142,202],"Intrastriatal":[44],"administration":[45],"6-hydroxy":[47],"dopamine":[48,109,183],"(6-OHDA)":[49],"rat":[51,186,199,208],"brain":[52],"provoked":[53],"nitrosative":[56],"stress":[57],"by":[58,94,128,158],"decreasing":[59],"endogenous":[60],"antioxidants":[61],"superoxide":[64],"dismutase,":[65],"catalase,":[66],"glutathione,":[67],"glutathione":[68,71],"peroxidase":[69],"reductase.":[72],"Consequently,":[73],"interleukin-6,":[74],"tumour":[75],"necrosis-\u03b1,":[76],"interferon-\u03b3":[77],"cyclooxygenase-2":[79],"mediated":[80],"neuroinflammation":[81,134],"leads":[82],"to":[83,213],"dysfunction,":[85],"involving":[86],"inhibition":[87],"complex-II":[89],"IV":[91],"activities,":[92],"followed":[93],"degeneration":[97],"striatal":[99,179],"dopaminergic":[100,104,168],"neurons.":[101],"Degeneration":[102],"neurons":[105],"resulted":[106],"reduced":[108],"turnover,":[110],"consequently":[111],"induced":[112,172],"behavioural":[113,189],"abnormalities":[114],"rats.":[116,175,192],"Activation":[117],"peroxisome":[119],"proliferator-activated":[120],"receptors":[121,154],"(PPARs)":[122],"have":[123],"protective":[124],"role":[125],"modulating":[129],"response":[130],"antioxidant":[132],"enzymes,":[133],"various":[138],"animal":[139],"models":[140],"Saroglitazar":[143],"(SG)":[144],"being":[145],"dual":[146],"PPAR-\u03b1/\u03b3":[147],"agonist":[148],"activates":[149],"both":[150],"PPAR-\u03b1":[151],"PPAR-\u03b3":[153],"provide":[156],"neuroprotection":[157],"reducing":[159],"cells":[169],"6-OHDA":[171],"Thereby,":[176],"SG":[177,194,206],"restored":[178],"histopathological":[180],"damage":[181],"concentration":[184],"striatum,":[187],"alterations":[190],"Thus,":[193],"proved":[195],"neuroprotective":[196],"effects":[197],"model":[200,209],"Potential":[203],"benefits":[204],"advocates":[212],"consider":[214],"it":[215],"further":[217],"preclinical":[218],"clinical":[220],"evaluation.":[221]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-07-31T00:00:00"}