{"id":"https://openalex.org/W4385397667","doi":"https://doi.org/10.1002/aoc.7173","title":"Molecular studies regarding colon cancer cell line (HCT116) treated by new ruthenium and palladium complexes","display_name":"Molecular studies regarding colon cancer cell line (HCT116) treated by new ruthenium and palladium complexes","publication_year":2023,"publication_date":"2023-07-30","ids":{"openalex":"https://openalex.org/W4385397667","doi":"https://doi.org/10.1002/aoc.7173"},"language":"en","primary_location":{"id":"doi:10.1002/aoc.7173","doi":"https://doi.org/10.1002/aoc.7173","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/aoc.7173","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aoc.7173","source":{"id":"https://openalex.org/S134627157","display_name":"Applied Organometallic Chemistry","issn_l":"0268-2605","issn":["0268-2605","1099-0739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Organometallic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aoc.7173","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017223757","display_name":"Magda F. Mohamed","orcid":"https://orcid.org/0000-0002-8616-9485","observed_orcids":["https://orcid.org/0000-0002-8616-9485"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]},{"id":"https://openalex.org/I4210099699","display_name":"University of Jeddah","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]}],"countries":["EG","SA"],"is_corresponding":true,"raw_author_name":"Magda F. Mohamed","raw_affiliation_strings":["Department of Chemistry (Biochemistry branch), Faculty of Science, Cairo University, Cairo, Egypt","Department of Chemistry, College of Science and Arts at Khulais, University of Jeddah, Jeddah, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0002-8616-9485","affiliations":[{"raw_affiliation_string":"Department of Chemistry (Biochemistry branch), Faculty of Science, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]},{"raw_affiliation_string":"Department of Chemistry, College of Science and Arts at Khulais, University of Jeddah, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I4210099699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092570815","display_name":"Alaa A. Kashmiry","orcid":"https://orcid.org/0000-0001-8248-6101","observed_orcids":["https://orcid.org/0000-0001-8248-6101"]},"institutions":[{"id":"https://openalex.org/I4210099699","display_name":"University of Jeddah","ror":"https://ror.org/015ya8798","country_code":"SA","type":"education","lineage":["https://openalex.org/I4210099699"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Alaa A. Kashmiry","raw_affiliation_strings":["Department of Chemistry, College of Science and Arts at Khulais, University of Jeddah, Jeddah, Saudi Arabia"],"raw_orcid":"https://orcid.org/0000-0001-8248-6101","affiliations":[{"raw_affiliation_string":"Department of Chemistry, College of Science and Arts at Khulais, University of Jeddah, Jeddah, Saudi Arabia","institution_ids":["https://openalex.org/I4210099699"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108016747","display_name":"Safaa S. Hassan","orcid":"https://orcid.org/0000-0003-1177-2375","observed_orcids":["https://orcid.org/0000-0003-1177-2375"]},"institutions":[{"id":"https://openalex.org/I145487455","display_name":"Cairo University","ror":"https://ror.org/03q21mh05","country_code":"EG","type":"education","lineage":["https://openalex.org/I145487455"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Safaa S. Hassan","raw_affiliation_strings":["Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-1177-2375","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt","institution_ids":["https://openalex.org/I145487455"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017223757","https://openalex.org/A5108016747"],"corresponding_institution_ids":["https://openalex.org/I145487455","https://openalex.org/I4210099699"],"apc_list":{"value":4020,"currency":"USD","value_usd":4020},"apc_paid":null,"fwci":0.3642,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57362748,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"37","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11746","display_name":"Inorganic and Organometallic Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10092","display_name":"Organometallic Complex Synthesis and Catalysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ruthenium-complexes","display_name":"ruthenium complexes","score":0.8809999823570251},{"id":"https://openalex.org/keywords/palladium-complexes","display_name":"palladium complexes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hct116-cells","display_name":"HCT116 cells","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7480000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8130000233650208},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cysteine-adducts","display_name":"cysteine adducts","score":0.6290000081062317},{"id":"https://openalex.org/keywords/anticancer-metal-complexes","display_name":"anticancer metal complexes","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8613131642341614},{"id":"https://openalex.org/C555196967","wikidata":"https://www.wikidata.org/wiki/Q1086","display_name":"Ruthenium","level":3,"score":0.7434372901916504},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6608598828315735},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6357592344284058},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.625281035900116},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5900370478630066},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5265434384346008},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.5234224796295166},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4791000187397003},{"id":"https://openalex.org/C502130503","wikidata":"https://www.wikidata.org/wiki/Q1089","display_name":"Palladium","level":3,"score":0.4719480872154236},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.41307157278060913},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3400469720363617},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3042182922363281},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2816696763038635},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1289622187614441},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/aoc.7173","doi":"https://doi.org/10.1002/aoc.7173","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/aoc.7173","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aoc.7173","source":{"id":"https://openalex.org/S134627157","display_name":"Applied Organometallic Chemistry","issn_l":"0268-2605","issn":["0268-2605","1099-0739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Organometallic Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/aoc.7173","doi":"https://doi.org/10.1002/aoc.7173","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1002/aoc.7173","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aoc.7173","source":{"id":"https://openalex.org/S134627157","display_name":"Applied Organometallic Chemistry","issn_l":"0268-2605","issn":["0268-2605","1099-0739"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Organometallic Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385397667.pdf","grobid_xml":"https://content.openalex.org/works/W4385397667.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1696360195","https://openalex.org/W1946042492","https://openalex.org/W1972086638","https://openalex.org/W1974693247","https://openalex.org/W1986633321","https://openalex.org/W2012338094","https://openalex.org/W2020462222","https://openalex.org/W2020721942","https://openalex.org/W2024161779","https://openalex.org/W2025057122","https://openalex.org/W2042390732","https://openalex.org/W2048419851","https://openalex.org/W2051685805","https://openalex.org/W2055280031","https://openalex.org/W2058591356","https://openalex.org/W2060161215","https://openalex.org/W2062204233","https://openalex.org/W2064158450","https://openalex.org/W2064586647","https://openalex.org/W2066825427","https://openalex.org/W2067366063","https://openalex.org/W2078034063","https://openalex.org/W2082698680","https://openalex.org/W2089359919","https://openalex.org/W2096327894","https://openalex.org/W2100840379","https://openalex.org/W2106076920","https://openalex.org/W2111865926","https://openalex.org/W2124504411","https://openalex.org/W2128485976","https://openalex.org/W2134979684","https://openalex.org/W2155027112","https://openalex.org/W2231229367","https://openalex.org/W2336942638","https://openalex.org/W2548586861","https://openalex.org/W2604012372","https://openalex.org/W2609003861","https://openalex.org/W2621340052","https://openalex.org/W2728738366","https://openalex.org/W2770421661","https://openalex.org/W2781905544","https://openalex.org/W2890030066","https://openalex.org/W2897071158","https://openalex.org/W2979534618","https://openalex.org/W2985579317","https://openalex.org/W3001169245","https://openalex.org/W3211230854","https://openalex.org/W4283640217","https://openalex.org/W4283729696","https://openalex.org/W4319789967"],"related_works":["https://openalex.org/W3216180852","https://openalex.org/W4313238390","https://openalex.org/W3092685729","https://openalex.org/W2589680909","https://openalex.org/W3200195271","https://openalex.org/W2904621468","https://openalex.org/W3037470412","https://openalex.org/W4361248540","https://openalex.org/W4320017602","https://openalex.org/W1907373472"],"abstract_inverted_index":{"Ru(H2dtpa)":[0,134],"(H2O)":[1,135],"and":[2,7,41,49,68,125,136,142,170],"Pd":[3,137],"(DME)Cl2":[4,138],"were":[5,10,71,93,127,140],"prepared,":[6],"their":[8,50],"structures":[9],"confirmed":[11],"by":[12],"different":[13,62],"structural":[14],"tools.":[15],"[Ru(H4dtpa)":[16],"(cysteine)]":[17],"Cl":[18],"was":[19,56],"separated":[20],"as":[21],"a":[22,74,128],"model":[23],"for":[24,45,58],"the":[25,42,46,100],"interaction":[26],"of":[27,102,167],"Ru":[28],"(III)":[29],"complex":[30,48],"containing":[31],"DTPA":[32],"ligand":[33],"with":[34],"its":[35],"corresponding":[36],"most":[37],"active":[38],"amino":[39],"acid":[40],"geometrical":[43],"parameters":[44],"ternary":[47],"constituent":[51],"ligands":[52],"are":[53],"evaluated.":[54],"Cytotoxicity":[55],"examined":[57],"both":[59,83,133],"complexes":[60,84,106,139,168],"against":[61,73,146],"cancer":[63,112],"cell":[64,78,114,119],"lines":[65],"(HCT116,":[66],"A549":[67],"Mcf7).":[69],"They":[70],"tested":[72],"normal":[75],"human":[76,110],"lung":[77],"line":[79],"(W138).":[80],"In":[81],"addition,":[82],"ensured":[85],"cytocidal,":[86],"not":[87],"cytostatic":[88],"effect.":[89],"Several":[90],"molecular":[91,129],"tools":[92],"utilized":[94],"in":[95,149,157],"order":[96],"to":[97,108,164],"figure":[98],"out":[99],"mechanism":[101],"action":[103],"that":[104,131],"two":[105],"followed":[107],"inhibit":[109],"colon":[111,147],"(HCT116)":[113],"line.":[115],"Gene":[116],"expression":[117],"analysis,":[118,124],"cycle":[120],"assay,":[121],"genomic":[122],"DNA":[123],"apoptosis":[126],"techniques":[130],"proved":[132],"promising":[141],"effective":[143],"chemotherapeutic":[144],"agents":[145],"carcinoma":[148],"this":[150],"current":[151],"study.":[152],"So,":[153],"authors":[154],"recommended":[155],"more":[156],"vivo":[158],"future":[159],"studies":[160],"should":[161],"be":[162,175],"done":[163],"make":[165],"sure":[166],"bioactivity":[169],"safety":[171],"before":[172],"they":[173],"would":[174],"used":[176],"commercially.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-07-31T00:00:00"}
