{"id":"https://openalex.org/W4385380716","doi":"https://doi.org/10.7554/elife.108128.3","title":"Systematic characterisation of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry","display_name":"Systematic characterisation of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry","publication_year":2026,"publication_date":"2026-06-25","ids":{"openalex":"https://openalex.org/W4385380716","doi":"https://doi.org/10.7554/elife.108128.3"},"language":"en","primary_location":{"id":"doi:10.7554/elife.108128.3","doi":"https://doi.org/10.7554/elife.108128.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108128.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.108128.3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100729491","display_name":"Hao Jiang","orcid":"https://orcid.org/0000-0003-4123-4930","observed_orcids":["https://orcid.org/0000-0003-4123-4930"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hao Jiang","raw_affiliation_strings":["Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-4123-4930","affiliations":[{"raw_affiliation_string":"Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053405833","display_name":"Jimena Druker","orcid":"https://orcid.org/0009-0009-3661-231X","observed_orcids":["https://orcid.org/0009-0009-3661-231X"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jimena Druker","raw_affiliation_strings":["Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James W. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James W. Wilson","raw_affiliation_strings":["Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012730233","display_name":"Dalila Bensaddek","orcid":"https://orcid.org/0000-0002-5995-770X","observed_orcids":["https://orcid.org/0000-0002-5995-770X"]},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Dalila Bensaddek","raw_affiliation_strings":["Bioscience core lab, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioscience core lab, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087159664","display_name":"Jason R. Swedlow","orcid":"https://orcid.org/0000-0002-2198-1958","observed_orcids":["https://orcid.org/0000-0002-2198-1958"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jason R. Swedlow","raw_affiliation_strings":["Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2198-1958","affiliations":[{"raw_affiliation_string":"Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002686348","display_name":"S\u00f3nia Rocha","orcid":"https://orcid.org/0000-0002-2413-4981","observed_orcids":["https://orcid.org/0000-0002-2413-4981"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sonia Rocha","raw_affiliation_strings":["Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-2413-4981","affiliations":[{"raw_affiliation_string":"Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014112981","display_name":"Angus I. Lamond","orcid":"https://orcid.org/0000-0001-6204-6045","observed_orcids":["https://orcid.org/0000-0001-6204-6045"]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Angus I. Lamond","raw_affiliation_strings":["Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0001-6204-6045","affiliations":[{"raw_affiliation_string":"Division of Molecular, Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom","institution_ids":["https://openalex.org/I177639307"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014112981"],"corresponding_institution_ids":["https://openalex.org/I177639307"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":4.077,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.92200171,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7387999892234802,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.7387999892234802,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.07599999755620956,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proline-hydroxylation","display_name":"proline hydroxylation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/prolyl-hydroxylase","display_name":"prolyl hydroxylase","score":0.8040000200271606},{"id":"https://openalex.org/keywords/fg-4592","display_name":"FG-4592","score":0.8399999737739563},{"id":"https://openalex.org/keywords/roxadustat","display_name":"roxadustat","score":0.8090000152587891},{"id":"https://openalex.org/keywords/mg132","display_name":"MG132","score":0.8759999871253967},{"id":"https://openalex.org/keywords/repo-man","display_name":"Repo-Man","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cdca2","display_name":"CDCA2","score":0.996999979019165},{"id":"https://openalex.org/keywords/mitotic-progression","display_name":"mitotic progression","score":0.8360000252723694},{"id":"https://openalex.org/keywords/rna-metabolism","display_name":"RNA metabolism","score":0.5479999780654907},{"id":"https://openalex.org/keywords/mrna-splicing","display_name":"mRNA splicing","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.8836638331413269},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8521331548690796},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.8058459758758545},{"id":"https://openalex.org/C2779815552","wikidata":"https://www.wikidata.org/wiki/Q484583","display_name":"Proline","level":3,"score":0.7679115533828735},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6196268200874329},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5740177035331726},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5525720119476318},{"id":"https://openalex.org/C116817701","wikidata":"https://www.wikidata.org/wiki/Q5955221","display_name":"Hydrophilic interaction chromatography","level":3,"score":0.540818452835083},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5147454738616943},{"id":"https://openalex.org/C179998833","wikidata":"https://www.wikidata.org/wiki/Q381233","display_name":"High-performance liquid chromatography","level":2,"score":0.3031182289123535},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.258301317691803},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12170189619064331}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.7554/elife.108128.3","doi":"https://doi.org/10.7554/elife.108128.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108128.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/2023.07.28.550951","doi":"https://doi.org/10.1101/2023.07.28.550951","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.07.28.550951","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/28/2023.07.28.550951.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.108128.3","doi":"https://doi.org/10.7554/elife.108128.3","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108128.3","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2440704980","display_name":"The interplay between the oxygen sensors PHDs and the cell cycle","funder_award_id":"206293/Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3030879768","display_name":null,"funder_award_id":"10.35802/206293","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3353615744","display_name":null,"funder_award_id":"EP/Y010655/1","funder_id":"https://openalex.org/F4320314731","funder_display_name":"UK Research and Innovation"},{"id":"https://openalex.org/G339059223","display_name":null,"funder_award_id":"Z/17/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3790753261","display_name":"Molecular Analysis of Nuclear Bodies and RNP Trafficking Pathways in the Cell Nucleus","funder_award_id":"BB/V010948/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G6568315177","display_name":null,"funder_award_id":"APP3732","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314731","display_name":"UK Research and Innovation","ror":"https://ror.org/001aqnf71"},{"id":"https://openalex.org/F4320332167","display_name":"Directorate for Biological Sciences","ror":"https://ror.org/001xhss06"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4385380716.pdf"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1123798321","https://openalex.org/W1436172216","https://openalex.org/W1484952182","https://openalex.org/W1749022239","https://openalex.org/W1967550539","https://openalex.org/W1979760206","https://openalex.org/W1984148608","https://openalex.org/W1988377666","https://openalex.org/W1991674420","https://openalex.org/W1992848590","https://openalex.org/W1995638700","https://openalex.org/W1996286498","https://openalex.org/W2005868568","https://openalex.org/W2006189460","https://openalex.org/W2013743510","https://openalex.org/W2014562678","https://openalex.org/W2015466408","https://openalex.org/W2029099008","https://openalex.org/W2029268001","https://openalex.org/W2040031153","https://openalex.org/W2042044881","https://openalex.org/W2042624112","https://openalex.org/W2044036144","https://openalex.org/W2045123283","https://openalex.org/W2054212408","https://openalex.org/W2070623737","https://openalex.org/W2071555141","https://openalex.org/W2075394689","https://openalex.org/W2080752012","https://openalex.org/W2083344986","https://openalex.org/W2089141914","https://openalex.org/W2093509030","https://openalex.org/W2106485251","https://openalex.org/W2116715687","https://openalex.org/W2123721271","https://openalex.org/W2132261610","https://openalex.org/W2132500972","https://openalex.org/W2139196828","https://openalex.org/W2144625075","https://openalex.org/W2147718842","https://openalex.org/W2150126834","https://openalex.org/W2165923048","https://openalex.org/W2178456244","https://openalex.org/W2274830107","https://openalex.org/W2343251287","https://openalex.org/W2507518506","https://openalex.org/W2530505699","https://openalex.org/W2544360569","https://openalex.org/W2552001782","https://openalex.org/W2588464299","https://openalex.org/W2613663785","https://openalex.org/W2775824694","https://openalex.org/W2785201697","https://openalex.org/W2795473923","https://openalex.org/W2796440706","https://openalex.org/W2900884817","https://openalex.org/W2940577902","https://openalex.org/W2944545583","https://openalex.org/W2953689825","https://openalex.org/W2954852328","https://openalex.org/W2962680130","https://openalex.org/W2964088814","https://openalex.org/W2969810690","https://openalex.org/W2972038063","https://openalex.org/W3005045932","https://openalex.org/W3082670149","https://openalex.org/W3095583226","https://openalex.org/W3162036156","https://openalex.org/W3208691473","https://openalex.org/W4299583305","https://openalex.org/W4391836539","https://openalex.org/W4395684789","https://openalex.org/W4407022565","https://openalex.org/W4409290622","https://openalex.org/W4410155593"],"related_works":["https://openalex.org/W4413414676","https://openalex.org/W2150126834","https://openalex.org/W3000550016","https://openalex.org/W2795885981","https://openalex.org/W4406820569","https://openalex.org/W2382955972","https://openalex.org/W3156335044","https://openalex.org/W4205124514","https://openalex.org/W2934050112","https://openalex.org/W2071795070"],"abstract_inverted_index":{"Abstract":[0],"We":[1,191,266],"have":[2,44],"developed":[3],"a":[4,17,68,73,197,287],"robust":[5],"workflow":[6],"for":[7,244,302],"the":[8,53,62,120,159,162,172,181,188,238,258,276],"identification":[9,211],"of":[10,19,75,90,110,161,183,199,212,249,289,296],"proline":[11,79,97,111,136,213,232],"hydroxylation":[12,80,98,214,233,295],"sites":[13,99,215,234],"in":[14,83,132,142,202,216,228,247,275,305],"proteins,":[15],"using":[16,193],"combination":[18,198,288],"hydrophilic":[20,127],"interaction":[21],"chromatography":[22],"(HILIC)":[23],"enrichment":[24,243],"and":[25,34,77,85,93,122,144,180,204,253,274,291],"high-resolution":[26],"nano-Liquid":[27],"Chromatography-Mass":[28],"Spectrometry":[29],"(LC-MS)":[30],"together":[31],"with":[32,51,61,67,100,149],"refining":[33],"filtering":[35],"parameters":[36,170],"during":[37],"data":[38,46],"analysis.":[39],"Using":[40],"this":[41],"approach,":[42],"we":[43,156,285],"combined":[45],"from":[47],"cell":[48,254],"lines":[49],"treated":[50],"either":[52,150],"prolyl":[54],"hydroxylase":[55],"(PHD)":[56],"inhibitor,":[57,240],"Roxadustat":[58],"(FG-4592),":[59],"or":[60,66,152],"proteasome":[63],"inhibitor":[64],"MG-132,":[65],"DMSO":[69],"control,":[70],"to":[71,187],"identify":[72],"total":[74],"4,993":[76],"3,247":[78],"sites,":[81],"respectively,":[82],"HEK293":[84,121],"RCC4":[86,123],"cells.":[87],"A":[88],"subset":[89],"1,954":[91],"(HEK293)":[92],"1,253":[94],"(RCC4)":[95],"non-collagen":[96],"high":[101],"confidence":[102],"were":[103,114,117,130,235],"inhibited":[104,236],"by":[105,237,279],"FG-4592":[106],"treatment.":[107],"Features":[108],"characteristic":[109,140],"hydroxylated":[112,135,271],"peptides":[113,133,195],"identified,":[115],"which":[116,138,229],"consistent":[118],"between":[119],"datasets.":[124],"The":[125],"more":[126],"HILIC":[128],"fractions":[129],"enriched":[131],"containing":[134],"residues,":[137],"showed":[139,242],"differences":[141],"charge":[143],"mass":[145],"distribution,":[146],"as":[147],"compared":[148],"unmodified,":[151],"oxidised":[153],"peptides.":[154],"Furthermore,":[155],"discovered":[157],"that":[158,196,268,294],"intensity":[160],"diagnostic":[163],"hydroxyproline":[164],"immonium":[165],"ion":[166],"was":[167],"dependent":[168],"upon":[169],"including":[171,257],"MS":[173,206],"collision":[174],"energy":[175],"setting,":[176],"parent":[177],"peptide":[178],"concentration":[179],"sequence":[182],"amino":[184],"acids":[185],"adjacent":[186],"modified":[189],"proline.":[190],"show":[192,267],"synthetic":[194],"retention":[200],"time":[201],"LC":[203],"optimised":[205],"parameter":[207],"settings":[208],"allows":[209],"reliable":[210],"peptides,":[217],"even":[218],"when":[219],"multiple":[220],"prolines":[221],"residues":[222],"are":[223],"present.":[224],"Focussing":[225],"on":[226],"proteins":[227,245],"newly":[230],"identified":[231],"pan-PHD":[239],"FG-4592,":[241],"involved":[246],"metabolism":[248],"RNA,":[250],"mRNA":[251],"splicing":[252],"cycle":[255],"regulation,":[256],"protein":[259],"phosphatase":[260],"1":[261,283],"regulatory":[262],"subunit,":[263],"Repo-Man":[264,269,297],"(CDCA2).":[265],"is":[270,300],"at":[272,298],"P604":[273,299],"accompanying":[277],"study":[278],"Druker":[280],"et":[281],"al.":[282],",":[284],"present":[286],"cellular":[290],"biochemical":[292],"evidence":[293],"important":[301],"its":[303],"function":[304],"controlling":[306],"mitotic":[307],"progression.":[308]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-07-30T00:00:00"}
