{"id":"https://openalex.org/W4385348644","doi":"https://doi.org/10.3390/cancers15153826","title":"Polyphenol-Based Nanoparticles: A Promising Frontier for Enhanced Colorectal Cancer Treatment","display_name":"Polyphenol-Based Nanoparticles: A Promising Frontier for Enhanced Colorectal Cancer Treatment","publication_year":2023,"publication_date":"2023-07-27","ids":{"openalex":"https://openalex.org/W4385348644","doi":"https://doi.org/10.3390/cancers15153826","pmid":"https://pubmed.ncbi.nlm.nih.gov/37568642","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10416951"},"language":"en","primary_location":{"id":"doi:10.3390/cancers15153826","doi":"https://doi.org/10.3390/cancers15153826","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15153826","pdf_url":"https://www.mdpi.com/2072-6694/15/15/3826/pdf?version=1690516456","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/15/15/3826/pdf?version=1690516456","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092218635","display_name":"Hicham Wahnou","orcid":"https://orcid.org/0000-0003-1375-4111","observed_orcids":["https://orcid.org/0000-0003-1375-4111"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hicham Wahnou","raw_affiliation_strings":["Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P. 2693, Maarif, Casablanca 20100, Morocco","FSAC - Facult\u00e9 des Sciences A\u00efn Chock [Casablanca] (Universit\u00e9 Hassan II  Facult\u00e9 des Sciences - Ain Chock - BP 5366 - Maarif - Casablanca - Maroc)"],"raw_orcid":"https://orcid.org/0000-0003-1375-4111","affiliations":[{"raw_affiliation_string":"Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P. 2693, Maarif, Casablanca 20100, Morocco","institution_ids":["https://openalex.org/I99297268"]},{"raw_affiliation_string":"FSAC - Facult\u00e9 des Sciences A\u00efn Chock [Casablanca] (Universit\u00e9 Hassan II  Facult\u00e9 des Sciences - Ain Chock - BP 5366 - Maarif - Casablanca - Maroc)","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031642507","display_name":"Bertrand Liagre","orcid":"https://orcid.org/0000-0003-4148-2598","observed_orcids":["https://orcid.org/0000-0003-4148-2598"]},"institutions":[{"id":"https://openalex.org/I4405254737","display_name":"Laboratoire des Agroressources, Biomol\u00e9cules et Chimie pour l\u2019Innovation en Sant\u00e9","ror":"https://ror.org/0260bjh30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4405254737","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bertrand Liagre","raw_affiliation_strings":["Univ. Limoges, LABCiS, UR 22722, F-87000 Limoges, France","LABCiS - Laboratoire des Agroressources,  Biomol\u00e9cules et Chimie pour l'Innovation en Sant\u00e9 (Facult\u00e9 des Sciences et Techniques\r\n123 Avenue Albert Thomas\r\n87060 Limoges Cedex - France - France)"],"raw_orcid":"https://orcid.org/0000-0003-4148-2598","affiliations":[{"raw_affiliation_string":"Univ. Limoges, LABCiS, UR 22722, F-87000 Limoges, France","institution_ids":["https://openalex.org/I4405254737","https://openalex.org/I65806277"]},{"raw_affiliation_string":"LABCiS - Laboratoire des Agroressources,  Biomol\u00e9cules et Chimie pour l'Innovation en Sant\u00e9 (Facult\u00e9 des Sciences et Techniques\r\n123 Avenue Albert Thomas\r\n87060 Limoges Cedex - France - France)","institution_ids":["https://openalex.org/I4405254737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031469561","display_name":"Vincent Sol","orcid":"https://orcid.org/0000-0003-0175-0156","observed_orcids":["https://orcid.org/0000-0003-0175-0156"]},"institutions":[{"id":"https://openalex.org/I4405254737","display_name":"Laboratoire des Agroressources, Biomol\u00e9cules et Chimie pour l\u2019Innovation en Sant\u00e9","ror":"https://ror.org/0260bjh30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I4405254737","https://openalex.org/I65806277"]},{"id":"https://openalex.org/I65806277","display_name":"Universit\u00e9 de Limoges","ror":"https://ror.org/02cp04407","country_code":"FR","type":"education","lineage":["https://openalex.org/I65806277"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Vincent Sol","raw_affiliation_strings":["Univ. Limoges, LABCiS, UR 22722, F-87000 Limoges, France","LABCiS - Laboratoire des Agroressources,  Biomol\u00e9cules et Chimie pour l'Innovation en Sant\u00e9 (Facult\u00e9 des Sciences et Techniques\r\n123 Avenue Albert Thomas\r\n87060 Limoges Cedex - France - France)"],"raw_orcid":"https://orcid.org/0000-0003-0175-0156","affiliations":[{"raw_affiliation_string":"Univ. Limoges, LABCiS, UR 22722, F-87000 Limoges, France","institution_ids":["https://openalex.org/I4405254737","https://openalex.org/I65806277"]},{"raw_affiliation_string":"LABCiS - Laboratoire des Agroressources,  Biomol\u00e9cules et Chimie pour l'Innovation en Sant\u00e9 (Facult\u00e9 des Sciences et Techniques\r\n123 Avenue Albert Thomas\r\n87060 Limoges Cedex - France - France)","institution_ids":["https://openalex.org/I4405254737"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109887897","display_name":"Hicham El Attar","orcid":"https://orcid.org/0000-0002-1853-6335","observed_orcids":["https://orcid.org/0000-0002-1853-6335"]},"institutions":[{"id":"https://openalex.org/I4210125507","display_name":"Chouaib Doukkali University","ror":"https://ror.org/036kgyt43","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210125507"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hicham El Attar","raw_affiliation_strings":["Annasr Pathology Center, El Jadida 24000, Morocco","Facult\u00e9 des Sciences [El Jadida. Maroc] (Faculty of Sciences,  Route Ben Maachou, B.P. :20, 24.000 El Jadida, Maroc. - Maroc)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Annasr Pathology Center, El Jadida 24000, Morocco","institution_ids":["https://openalex.org/I4210125507"]},{"raw_affiliation_string":"Facult\u00e9 des Sciences [El Jadida. Maroc] (Faculty of Sciences,  Route Ben Maachou, B.P. :20, 24.000 El Jadida, Maroc. - Maroc)","institution_ids":["https://openalex.org/I4210125507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074619520","display_name":"R\u00fckset Attar","orcid":"https://orcid.org/0000-0001-8770-9562","observed_orcids":["https://orcid.org/0000-0001-8770-9562"]},"institutions":[{"id":"https://openalex.org/I100072489","display_name":"Yeditepe University","ror":"https://ror.org/025mx2575","country_code":"TR","type":"education","lineage":["https://openalex.org/I100072489"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Rukset Attar","raw_affiliation_strings":["Department of Obstetrics and Gynecology, Yeditepe University, Istanbul 34280, Turkey","Yeditepe University (\u0130n\u00f6n\u00fc Mah. Kay\u0131\u015fda\u011f\u0131 Cad. 26 A\u011fustos Yerle\u015fimi \r\nAtasehir, Istanbul, Turkey 34755\r\n\r\nE-mail  : info@yeditepe.edu.tr - Turquie)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynecology, Yeditepe University, Istanbul 34280, Turkey","institution_ids":["https://openalex.org/I100072489"]},{"raw_affiliation_string":"Yeditepe University (\u0130n\u00f6n\u00fc Mah. Kay\u0131\u015fda\u011f\u0131 Cad. 26 A\u011fustos Yerle\u015fimi \r\nAtasehir, Istanbul, Turkey 34755\r\n\r\nE-mail  : info@yeditepe.edu.tr - Turquie)","institution_ids":["https://openalex.org/I100072489"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081530669","display_name":"Mounia Oudghiri","orcid":"https://orcid.org/0000-0002-5815-1579","observed_orcids":["https://orcid.org/0000-0002-5815-1579"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Mounia Oudghiri","raw_affiliation_strings":["Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P. 2693, Maarif, Casablanca 20100, Morocco","LPGM - Laboratoire de Physiologie et G\u00e9n\u00e9tique Mol\u00e9culaire [Casablanca] (Universit\u00e9 Hassan II - A\u00efn Chock Facult\u00e9 des Sciences Casablanca - Maroc)"],"raw_orcid":"https://orcid.org/0000-0002-5815-1579","affiliations":[{"raw_affiliation_string":"Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P. 2693, Maarif, Casablanca 20100, Morocco","institution_ids":["https://openalex.org/I99297268"]},{"raw_affiliation_string":"LPGM - Laboratoire de Physiologie et G\u00e9n\u00e9tique Mol\u00e9culaire [Casablanca] (Universit\u00e9 Hassan II - A\u00efn Chock Facult\u00e9 des Sciences Casablanca - Maroc)","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074688010","display_name":"Rapha\u00ebl E. Duval","orcid":"https://orcid.org/0000-0003-4349-5595","observed_orcids":["https://orcid.org/0000-0003-4349-5595","https://orcid.org/0000-0002-9591-9057"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4387153710","display_name":"Laboratoire Lorrain de Chimie Mol\u00e9culaire","ror":"https://ror.org/020azc393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4387153710","https://openalex.org/I90183372"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Rapha\u00ebl Emmanuel Duval","raw_affiliation_strings":["Universit\u00e9 de Lorraine, CNRS, L2CM, F-54000 Nancy, France","L2CM - Laboratoire Lorrain de Chimie Mol\u00e9culaire (Universit\u00e9 de Lorraine, Boulevard des Aiguillettes, B.P. 70239, 54506 Vandoeuvre les Nancy Cedex, France - France)"],"raw_orcid":"https://orcid.org/0000-0003-4349-5595","affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lorraine, CNRS, L2CM, F-54000 Nancy, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4387153710","https://openalex.org/I90183372"]},{"raw_affiliation_string":"L2CM - Laboratoire Lorrain de Chimie Mol\u00e9culaire (Universit\u00e9 de Lorraine, Boulevard des Aiguillettes, B.P. 70239, 54506 Vandoeuvre les Nancy Cedex, France - France)","institution_ids":["https://openalex.org/I4387153710","https://openalex.org/I90183372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014726480","display_name":"Youness Limami","orcid":"https://orcid.org/0000-0002-8816-3001","observed_orcids":["https://orcid.org/0000-0002-8816-3001"]},"institutions":[{"id":"https://openalex.org/I4210145365","display_name":"Universit\u00e9 Hassan 1er","ror":"https://ror.org/03cdvht47","country_code":"MA","type":"education","lineage":["https://openalex.org/I4210145365"]},{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"Youness Limami","raw_affiliation_strings":["Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University of Settat, Settat 26000, Morocco","Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P. 2693, Maarif, Casablanca 20100, Morocco","FSAC - Facult\u00e9 des Sciences A\u00efn Chock [Casablanca] (Universit\u00e9 Hassan II  Facult\u00e9 des Sciences - Ain Chock - BP 5366 - Maarif - Casablanca - Maroc)","Laboratoire des Sciences et Technologies de la Sant\u00e9 [Settat, Maroc] (Route de Casablanca 14  - BP 539 - 26  000 Settat. - Maroc)"],"raw_orcid":"https://orcid.org/0000-0002-8816-3001","affiliations":[{"raw_affiliation_string":"Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University of Settat, Settat 26000, Morocco","institution_ids":["https://openalex.org/I4210145365"]},{"raw_affiliation_string":"Laboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P. 2693, Maarif, Casablanca 20100, Morocco","institution_ids":["https://openalex.org/I99297268"]},{"raw_affiliation_string":"FSAC - Facult\u00e9 des Sciences A\u00efn Chock [Casablanca] (Universit\u00e9 Hassan II  Facult\u00e9 des Sciences - Ain Chock - BP 5366 - Maarif - Casablanca - Maroc)","institution_ids":["https://openalex.org/I99297268"]},{"raw_affiliation_string":"Laboratoire des Sciences et Technologies de la Sant\u00e9 [Settat, Maroc] (Route de Casablanca 14  - BP 539 - 26  000 Settat. - Maroc)","institution_ids":["https://openalex.org/I4210145365"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5014726480","https://openalex.org/A5074688010"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210145365","https://openalex.org/I4387153710","https://openalex.org/I90183372","https://openalex.org/I99297268"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.9382,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.67491319,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"15","issue":"15","first_page":"3826","last_page":"3826"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8960000276565552},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nanoparticle-synthesis","display_name":"nanoparticle synthesis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dynamic-covalent-bonds","display_name":"dynamic covalent bonds","score":0.8479999899864197},{"id":"https://openalex.org/keywords/noncovalent-bonding","display_name":"noncovalent bonding","score":0.6990000009536743},{"id":"https://openalex.org/keywords/metal-phenolic-networks","display_name":"metal-phenolic networks","score":0.7820000052452087},{"id":"https://openalex.org/keywords/active-targeting","display_name":"active targeting","score":0.5929999947547913},{"id":"https://openalex.org/keywords/passive-targeting","display_name":"passive targeting","score":0.9879999756813049},{"id":"https://openalex.org/keywords/nanocarrier-drug-delivery","display_name":"nanocarrier drug delivery","score":0.6449999809265137},{"id":"https://openalex.org/keywords/micelles","display_name":"micelles","score":0.9769999980926514},{"id":"https://openalex.org/keywords/nanogels","display_name":"nanogels","score":0.9959999918937683},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":1.0},{"id":"https://openalex.org/keywords/nanoemulsions","display_name":"nanoemulsions","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gold-nanoparticles","display_name":"gold nanoparticles","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mesoporous-silica-nanoparticles","display_name":"mesoporous silica nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/metal-organic-frameworks","display_name":"metal-organic frameworks","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.7897155284881592},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6350852251052856},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6048685312271118},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4394637942314148},{"id":"https://openalex.org/C2777496208","wikidata":"https://www.wikidata.org/wiki/Q17156473","display_name":"Mesoporous silica","level":4,"score":0.4275307059288025},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4114401638507843},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.35646766424179077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3458145260810852},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.33922797441482544},{"id":"https://openalex.org/C82776694","wikidata":"https://www.wikidata.org/wiki/Q380049","display_name":"Mesoporous material","level":3,"score":0.21787497401237488},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19952189922332764},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1493133008480072},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.10050606727600098},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3390/cancers15153826","doi":"https://doi.org/10.3390/cancers15153826","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15153826","pdf_url":"https://www.mdpi.com/2072-6694/15/15/3826/pdf?version=1690516456","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10416951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10416951","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10416951/pdf/cancers-15-03826.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:37568642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37568642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-04196379v1","doi":null,"is_oa":false,"landing_page_url":"https://unilim.hal.science/hal-04196379","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, 2023, 15 (15), pp.3826. ⟨10.3390/cancers15153826⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.yeditepe.edu.tr:20.500.11831/9397","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/20.500.11831/9397","pdf_url":null,"source":{"id":"https://openalex.org/S7407055288","display_name":"Yeditepe University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus, WOS","raw_type":"Journal"}],"best_oa_location":{"id":"doi:10.3390/cancers15153826","doi":"https://doi.org/10.3390/cancers15153826","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15153826","pdf_url":"https://www.mdpi.com/2072-6694/15/15/3826/pdf?version=1690516456","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385348644.pdf","grobid_xml":"https://content.openalex.org/works/W4385348644.grobid-xml"},"referenced_works_count":117,"referenced_works":["https://openalex.org/W180956902","https://openalex.org/W1485777439","https://openalex.org/W1573363574","https://openalex.org/W1976595844","https://openalex.org/W1985671683","https://openalex.org/W1988481670","https://openalex.org/W1997581155","https://openalex.org/W1998934929","https://openalex.org/W1999467305","https://openalex.org/W2001997510","https://openalex.org/W2011820088","https://openalex.org/W2012856926","https://openalex.org/W2012867962","https://openalex.org/W2027091780","https://openalex.org/W2034913332","https://openalex.org/W2037048276","https://openalex.org/W2047101821","https://openalex.org/W2051376250","https://openalex.org/W2058153177","https://openalex.org/W2058559717","https://openalex.org/W2068684928","https://openalex.org/W2072005992","https://openalex.org/W2072198924","https://openalex.org/W2092184047","https://openalex.org/W2098860797","https://openalex.org/W2137634849","https://openalex.org/W2139695381","https://openalex.org/W2154105741","https://openalex.org/W2154621970","https://openalex.org/W2163014902","https://openalex.org/W2166566484","https://openalex.org/W2171147985","https://openalex.org/W2206146039","https://openalex.org/W2252628274","https://openalex.org/W2283564633","https://openalex.org/W2318061512","https://openalex.org/W2324415512","https://openalex.org/W2410631057","https://openalex.org/W2412452823","https://openalex.org/W2414365196","https://openalex.org/W2482902162","https://openalex.org/W2564841767","https://openalex.org/W2570175298","https://openalex.org/W2593056983","https://openalex.org/W2599460167","https://openalex.org/W2604124458","https://openalex.org/W2762367768","https://openalex.org/W2764273853","https://openalex.org/W2767337915","https://openalex.org/W2769578776","https://openalex.org/W2784773935","https://openalex.org/W2785922969","https://openalex.org/W2786031287","https://openalex.org/W2799529459","https://openalex.org/W2809162864","https://openalex.org/W2887877482","https://openalex.org/W2890931579","https://openalex.org/W2893450414","https://openalex.org/W2895188628","https://openalex.org/W2898976917","https://openalex.org/W2899114650","https://openalex.org/W2899780982","https://openalex.org/W2901027643","https://openalex.org/W2909091922","https://openalex.org/W2909290882","https://openalex.org/W2910346583","https://openalex.org/W2911499655","https://openalex.org/W2921639857","https://openalex.org/W2958502160","https://openalex.org/W2962839931","https://openalex.org/W2969036666","https://openalex.org/W2969819865","https://openalex.org/W2976406483","https://openalex.org/W2981613907","https://openalex.org/W2984769886","https://openalex.org/W2995145725","https://openalex.org/W3010283440","https://openalex.org/W3012136225","https://openalex.org/W3020846278","https://openalex.org/W3033264701","https://openalex.org/W3081020835","https://openalex.org/W3084189893","https://openalex.org/W3100427629","https://openalex.org/W3128646645","https://openalex.org/W3133917975","https://openalex.org/W3134531697","https://openalex.org/W3153073177","https://openalex.org/W3174442355","https://openalex.org/W3174475154","https://openalex.org/W3176005990","https://openalex.org/W3184450599","https://openalex.org/W3191218765","https://openalex.org/W3195651305","https://openalex.org/W3211848238","https://openalex.org/W3212557134","https://openalex.org/W4206012887","https://openalex.org/W4206662285","https://openalex.org/W4214896027","https://openalex.org/W4220737221","https://openalex.org/W4221048820","https://openalex.org/W4224292454","https://openalex.org/W4226478213","https://openalex.org/W4229080685","https://openalex.org/W4281606197","https://openalex.org/W4281644203","https://openalex.org/W4293769622","https://openalex.org/W4295080856","https://openalex.org/W4296526294","https://openalex.org/W4297243533","https://openalex.org/W4308507339","https://openalex.org/W4363674006","https://openalex.org/W4378471210","https://openalex.org/W4380363632","https://openalex.org/W4381429335","https://openalex.org/W4382051786","https://openalex.org/W6607371174","https://openalex.org/W6755735514"],"related_works":["https://openalex.org/W3118611490","https://openalex.org/W4403617748","https://openalex.org/W4381855701","https://openalex.org/W2547438882","https://openalex.org/W4312139131","https://openalex.org/W7164035720","https://openalex.org/W4405475650","https://openalex.org/W7160384018","https://openalex.org/W4391160547","https://openalex.org/W4399388975"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1],"(CRC)":[2],"poses":[3],"a":[4,45],"significant":[5],"challenge":[6],"in":[7,41],"healthcare,":[8],"necessitating":[9],"the":[10,35,48,91,107,138,150,168],"exploration":[11],"of":[12,50,73,75,95,111,140,171,178],"novel":[13,38],"therapeutic":[14,30,39],"strategies.":[15],"Natural":[16],"compounds":[17],"such":[18,119],"as":[19,28,120],"polyphenols":[20,96,112,144],"with":[21],"inherent":[22],"anticancer":[23,93,109,174],"properties":[24,110],"have":[25],"gained":[26],"attention":[27],"potential":[29,139],"agents.":[31],"This":[32,104],"review":[33,88,134,163],"highlights":[34,149],"need":[36,151],"for":[37,145,152,181],"approaches":[40],"CRC,":[42],"followed":[43],"by":[44,136],"discussion":[46],"on":[47],"synthesis":[49,54],"polyphenols-based":[51,179],"nanoparticles.":[52],"Various":[53],"techniques,":[55],"including":[56],"dynamic":[57],"covalent":[58],"bonding,":[59,61],"non-covalent":[60],"polymerization,":[62],"chemical":[63],"conjugation,":[64],"reduction,":[65],"and":[66,80,97,113,130,148,159,176],"metal-polyphenol":[67],"networks,":[68],"are":[69,84],"explored.":[70],"The":[71,87,133],"mechanisms":[72,170],"action":[74],"these":[76],"nanoparticles,":[77,126,129],"encompassing":[78],"passive":[79],"active":[81],"targeting":[82],"mechanisms,":[83],"also":[85],"discussed.":[86],"further":[89],"examines":[90],"intrinsic":[92,173],"activity":[94],"their":[98,157],"enhancement":[99,177],"through":[100],"nano-based":[101,116],"delivery":[102,117],"systems.":[103],"section":[105],"explores":[106],"natural":[108],"investigates":[114],"different":[115],"systems,":[118],"micelles,":[121],"nanogels,":[122],"liposomes,":[123],"nanoemulsions,":[124],"gold":[125],"mesoporous":[127],"silica":[128],"metal-organic":[131],"frameworks.":[132],"concludes":[135],"emphasizing":[137],"nanoparticle-based":[141],"strategies":[142],"utilizing":[143],"CRC":[146,182],"treatment":[147],"future":[153],"research":[154],"to":[155],"optimize":[156],"efficacy":[158],"safety.":[160],"Overall,":[161],"this":[162],"provides":[164],"valuable":[165],"insights":[166],"into":[167],"synthesis,":[169],"action,":[172],"activity,":[175],"nanoparticles":[180],"treatment.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":25},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-07-29T00:00:00"}