{"id":"https://openalex.org/W4385348554","doi":"https://doi.org/10.20996/1819-6446-2023-2904","title":"Association of polymorphic variants of CYP2C19, P2RY12, ITGB3, ITGA2 and eNOS3 genes with high residual platelet reactivity while taking clopidogrel and acetylsalicylic acid at different terms of myocardial infarction","display_name":"Association of polymorphic variants of CYP2C19, P2RY12, ITGB3, ITGA2 and eNOS3 genes with high residual platelet reactivity while taking clopidogrel and acetylsalicylic acid at different terms of myocardial infarction","publication_year":2023,"publication_date":"2023-07-27","ids":{"openalex":"https://openalex.org/W4385348554","doi":"https://doi.org/10.20996/1819-6446-2023-2904"},"language":"en","primary_location":{"id":"doi:10.20996/1819-6446-2023-2904","doi":"https://doi.org/10.20996/1819-6446-2023-2904","is_oa":true,"landing_page_url":"http://dx.doi.org/10.20996/1819-6446-2023-2904","pdf_url":"https://www.rpcardio.com/jour/article/download/2904/2432","source":{"id":"https://openalex.org/S2737589093","display_name":"Rational Pharmacotherapy in Cardiology","issn_l":"1819-6446","issn":["1819-6446","2225-3653"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312825","host_organization_name":"Stolichnaya Izdatelskaya Kompaniya","host_organization_lineage":["https://openalex.org/P4310312825"],"host_organization_lineage_names":["Stolichnaya Izdatelskaya Kompaniya"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rational Pharmacotherapy in Cardiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4385348554"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.rpcardio.com/jour/article/download/2904/2432","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000356005","display_name":"T. P. Pronko","orcid":"https://orcid.org/0000-0003-2126-5246","observed_orcids":["https://orcid.org/0000-0003-2126-5246"]},"institutions":[{"id":"https://openalex.org/I4210132691","display_name":"Grodno State Medical University","ror":"https://ror.org/039ryp971","country_code":"BY","type":"education","lineage":["https://openalex.org/I4210132691"]}],"countries":["BY"],"is_corresponding":false,"raw_author_name":"T. P. Pronko","raw_affiliation_strings":["Grodno State Medical University"],"raw_orcid":"https://orcid.org/0000-0003-2126-5246","affiliations":[{"raw_affiliation_string":"Grodno State Medical University","institution_ids":["https://openalex.org/I4210132691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031102026","display_name":"V. \u0410. Snezhitskiy","orcid":"https://orcid.org/0000-0002-1706-1243","observed_orcids":["https://orcid.org/0000-0002-1706-1243"]},"institutions":[{"id":"https://openalex.org/I4210132691","display_name":"Grodno State Medical University","ror":"https://ror.org/039ryp971","country_code":"BY","type":"education","lineage":["https://openalex.org/I4210132691"]}],"countries":["BY"],"is_corresponding":false,"raw_author_name":"V. A. Snezhitskiy","raw_affiliation_strings":["Grodno State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-1706-1243","affiliations":[{"raw_affiliation_string":"Grodno State Medical University","institution_ids":["https://openalex.org/I4210132691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044100616","display_name":"\u0422. \u041b. \u0421\u0442\u0435\u043f\u0443\u0440\u043e","orcid":"https://orcid.org/0000-0002-3337-4231","observed_orcids":["https://orcid.org/0000-0002-3337-4231"]},"institutions":[{"id":"https://openalex.org/I4210132691","display_name":"Grodno State Medical University","ror":"https://ror.org/039ryp971","country_code":"BY","type":"education","lineage":["https://openalex.org/I4210132691"]}],"countries":["BY"],"is_corresponding":false,"raw_author_name":"T. L. Stepuro","raw_affiliation_strings":["Grodno State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-3337-4231","affiliations":[{"raw_affiliation_string":"Grodno State Medical University","institution_ids":["https://openalex.org/I4210132691"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067553139","display_name":"Andrey V. Kapytski","orcid":"https://orcid.org/0000-0002-1862-4300","observed_orcids":["https://orcid.org/0000-0002-1862-4300"]},"institutions":[{"id":"https://openalex.org/I4210132691","display_name":"Grodno State Medical University","ror":"https://ror.org/039ryp971","country_code":"BY","type":"education","lineage":["https://openalex.org/I4210132691"]}],"countries":["BY"],"is_corresponding":false,"raw_author_name":"A. V. Kapytski","raw_affiliation_strings":["Grodno State Medical University"],"raw_orcid":"https://orcid.org/0000-0002-1862-4300","affiliations":[{"raw_affiliation_string":"Grodno State Medical University","institution_ids":["https://openalex.org/I4210132691"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210132691"],"apc_list":null,"apc_paid":null,"fwci":0.1759,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45138098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"3","first_page":"222","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11064","display_name":"Antiplatelet Therapy and Cardiovascular Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2c19","display_name":"CYP2C19","score":0.8119999766349792},{"id":"https://openalex.org/keywords/p2y12-receptor","display_name":"P2Y12 receptor","score":0.8840000033378601},{"id":"https://openalex.org/keywords/integrin-beta3","display_name":"CD61","score":0.9779999852180481},{"id":"https://openalex.org/keywords/itga2","display_name":"ITGA2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/clopidogrel","display_name":"clopidogrel","score":0.718999981880188},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.953000009059906},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.6779999732971191},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/clopidogrel-resistance","display_name":"clopidogrel resistance","score":0.6549999713897705},{"id":"https://openalex.org/keywords/antiplatelet-therapy","display_name":"antiplatelet therapy","score":0.6179999709129333}],"concepts":[{"id":"https://openalex.org/C140840227","wikidata":"https://www.wikidata.org/wiki/Q3737532","display_name":"CYP2C19","level":4,"score":0.7275894284248352},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6357042789459229},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5906487107276917},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.5789294838905334},{"id":"https://openalex.org/C2777849778","wikidata":"https://www.wikidata.org/wiki/Q410237","display_name":"Clopidogrel","level":3,"score":0.5668511390686035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5438365340232849},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4996187686920166},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.45860323309898376},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.442960262298584},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.42487776279449463},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.3633999824523926},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3145419955253601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.272773802280426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1739460825920105}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.20996/1819-6446-2023-2904","doi":"https://doi.org/10.20996/1819-6446-2023-2904","is_oa":true,"landing_page_url":"http://dx.doi.org/10.20996/1819-6446-2023-2904","pdf_url":"https://www.rpcardio.com/jour/article/download/2904/2432","source":{"id":"https://openalex.org/S2737589093","display_name":"Rational Pharmacotherapy in Cardiology","issn_l":"1819-6446","issn":["1819-6446","2225-3653"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312825","host_organization_name":"Stolichnaya Izdatelskaya Kompaniya","host_organization_lineage":["https://openalex.org/P4310312825"],"host_organization_lineage_names":["Stolichnaya Izdatelskaya Kompaniya"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rational Pharmacotherapy in Cardiology","raw_type":"journal-article"},{"id":"pmh:https://cyberleninka.ru/article/n/assotsiatsiya-polimorfnyh-variantov-genov-cyp2c19-p2ry12-itgb3-itga2-i-enos3-s-vysokoy-ostatochnoy-reaktivnostyu-trombotsitov-na","doi":null,"is_oa":false,"landing_page_url":"https://cyberleninka.ru/article/n/assotsiatsiya-polimorfnyh-variantov-genov-cyp2c19-p2ry12-itgb3-itga2-i-enos3-s-vysokoy-ostatochnoy-reaktivnostyu-trombotsitov-na","pdf_url":null,"source":{"id":"https://openalex.org/S4306401404","display_name":"CyberLeninK (CyberLeninka)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:abfa8d81f0554ebe8f8ee003fbfd2ff6","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/abfa8d81f0554ebe8f8ee003fbfd2ff6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"\u0420\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u0442\u0435\u0440\u0430\u043f\u0438\u044f \u0432 \u043a\u0430\u0440\u0434\u0438\u043e\u043b\u043e\u0433\u0438\u0438, Vol 19, Iss 3, Pp 222-229 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.20996/1819-6446-2023-2904","doi":"https://doi.org/10.20996/1819-6446-2023-2904","is_oa":true,"landing_page_url":"http://dx.doi.org/10.20996/1819-6446-2023-2904","pdf_url":"https://www.rpcardio.com/jour/article/download/2904/2432","source":{"id":"https://openalex.org/S2737589093","display_name":"Rational Pharmacotherapy in Cardiology","issn_l":"1819-6446","issn":["1819-6446","2225-3653"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310312825","host_organization_name":"Stolichnaya Izdatelskaya Kompaniya","host_organization_lineage":["https://openalex.org/P4310312825"],"host_organization_lineage_names":["Stolichnaya Izdatelskaya Kompaniya"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rational Pharmacotherapy in Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385348554.pdf","grobid_xml":"https://content.openalex.org/works/W4385348554.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1718583592","https://openalex.org/W1905228037","https://openalex.org/W2029040162","https://openalex.org/W2029838980","https://openalex.org/W2064718641","https://openalex.org/W2066865770","https://openalex.org/W2082149672","https://openalex.org/W2140392018","https://openalex.org/W2170393845","https://openalex.org/W2181840159","https://openalex.org/W2201896712","https://openalex.org/W2336778042","https://openalex.org/W2465625103","https://openalex.org/W2577894874","https://openalex.org/W2584285506","https://openalex.org/W2621019317","https://openalex.org/W2624881000","https://openalex.org/W2756571957","https://openalex.org/W2770225442","https://openalex.org/W2808518834","https://openalex.org/W2885342807","https://openalex.org/W2915031645","https://openalex.org/W2953154232","https://openalex.org/W2989513909","https://openalex.org/W3004480632","https://openalex.org/W3028697220","https://openalex.org/W3171063154","https://openalex.org/W4281716109","https://openalex.org/W4284887194","https://openalex.org/W4292075202","https://openalex.org/W4306999976"],"related_works":["https://openalex.org/W205995199","https://openalex.org/W2624881000","https://openalex.org/W3016684723","https://openalex.org/W2885923307","https://openalex.org/W2577894874","https://openalex.org/W2391683938","https://openalex.org/W3166095980","https://openalex.org/W2063469101","https://openalex.org/W2748238204","https://openalex.org/W4401234848"],"abstract_inverted_index":{"Aim.":[0],"Study":[1],"of":[2,5,8,35,68,123,148,155,158,166,169,175,194,203,211,218,238,245,265,267,270,297,307,313,318,342,352,356,369,374,397,405],"the":[3,73,80,93,101,109,117,136,140,250,311,323,330,335,345,375],"association":[4,317,355],"polymorphic":[6],"variants":[7],"CYP2C19":[9,94,131,183,271,284,324,376,385],"(G681A),":[10],"P2RY12":[11,102,224,275,336,380],"(H1/H2),":[12],"ITGB3":[13,110,346],"(T1565C),":[14],"ITGA2":[15,273,286,378,387],"(C807T),":[16],"eNOS3":[17,252],"(T786C)":[18,119,362],"genes":[19,278,289,383,390],"with":[20,47,322,334,344,360,393],"high":[21],"residual":[22],"platelet":[23],"reactivity":[24],"(HRPR)":[25],"to":[26,125,135,177,187,213,228,240,256,299,310,320,358,400],"clopidogrel":[27,126,178,214,321],"and":[28,40,55,66,70,162,283,384],"acetylsalicylic":[29],"acid":[30],"(ASA)":[31],"at":[32],"different":[33],"terms":[34],"myocardial":[36],"infarction":[37],"(MI).":[38],"Material":[39],"methods.":[41],"The":[42,121,173,209,236,316,354],"study":[43],"included":[44],"400":[45],"patients":[46],"MI":[48,195,204,219,246,308],"aged":[49],"31-74":[50],"years,":[51],"317":[52],"(79,3%)":[53],"men":[54],"83":[56],"(20,7%)":[57],"women.":[58],"Platelet":[59],"aggregation":[60],"performed":[61],"on":[62,92,100,108,116,152,163,191,200,215,242,304,339,349,366,402],"days":[63,153,164,192,201,216,243,305,340,350,367,403],"1-2,":[64],"12-14":[65,154],"28-30":[67,165,202,306,404],"MI,":[69,156,167,343],"genotyping":[71],"by":[72],"polymerase":[74],"chain":[75],"reaction":[76],"were":[77,86,391],"analyzed":[78],"using":[79],"STATISTICA":[81],"10.0":[82],"program.":[83],"Results.":[84],"Differences":[85],"found":[87,328,365],"in":[88,129,181,222,249],"ADP-test":[89,97,105],"1-3":[90],"depending":[91,99,107,115],"(G681A)":[95,325],"polymorphism,":[96,104,112],"1":[98,114],"(H1/H2)":[103,337],"2":[106],"(T1565C)":[111,347],"ASPI-test":[113],"eNOS":[118,277,288,361,382,389],"polymorphism.":[120],"risk":[122,174,210,237,296,396],"HRPR":[124,176,212,239,298,319,357,399],"is":[127,179,220,247],"higher":[128,180,221,248,295,395],"681A":[130],"allele":[132,253,258,372],"carriers":[133,138,185,226,231,254,259],"compared":[134,186,227,255,309],"G681":[137],"throughout":[139],"entire":[141,331],"observation":[142,332],"period:":[143],"initially":[144],"odds":[145],"ratio":[146],"(OR)":[147],"1,8":[149],"(1,14-2,88),":[150],"p=0,012,":[151],"OR":[157,168],"1,7":[159],"(1,08-2,68),":[160],"p=0,023":[161],"2,3":[170],"(1,42-3,81),":[171],"p=0,0008.":[172],"AA":[182],"genotype":[184,189],"GG":[188],"carriers,":[190],"1-2":[193,217,244,341,368],"(OR":[196,205,232,260,279,290],"6,5":[197],"(1,16-36,4),":[198],"p=0,033),":[199],"7,8":[206],"(1,26-48,0),":[207],"p=0,027).":[208],"H2":[223],"locus":[225,230],"H1":[229],"1,5":[233],"(1,02-2,22),":[234],"p=0,039).":[235],"ASA":[241,359],"786C":[251],"T786":[257],"1,4":[261],"(1,02-1,96),":[262],"p=0,036).":[263],"Carriers":[264],"haplotypes":[266,373],"minor":[268],"alleles":[269],"+":[272,274,276,285,287,377,379,381,386,388],"3,9":[280],"(1,13-13,65),":[281],"p=0,032)":[282],"5,1":[291],"(1,7214,96),":[292],"p=0,0032)":[293],"have":[294],"dual":[300],"antiplatelet":[301],"therapy":[302],"(DAPT)":[303],"rest":[312],"patients.":[314],"Conclusion.":[315],"polymorphism":[326,338,348,363],"was":[327,364],"during":[329],"period,":[333],"10-12":[351],"MI.":[353,370,406],"Minor":[371],"associated":[392],"a":[394],"developing":[398],"DAPT":[401]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-29T00:00:00"}