{"id":"https://openalex.org/W4385347472","doi":"https://doi.org/10.3390/v15081635","title":"Expansion of Betatorquevirus and/or Gammatorquevirus in Patients with Severe Clinical Outcomes of the Liver Diseases","display_name":"Expansion of Betatorquevirus and/or Gammatorquevirus in Patients with Severe Clinical Outcomes of the Liver Diseases","publication_year":2023,"publication_date":"2023-07-27","ids":{"openalex":"https://openalex.org/W4385347472","doi":"https://doi.org/10.3390/v15081635","pmid":"https://pubmed.ncbi.nlm.nih.gov/37631978","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10457780"},"language":"en","primary_location":{"id":"doi:10.3390/v15081635","doi":"https://doi.org/10.3390/v15081635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15081635","pdf_url":"https://www.mdpi.com/1999-4915/15/8/1635/pdf?version=1690451641","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1999-4915/15/8/1635/pdf?version=1690451641","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061727903","display_name":"Xiaoan Zhang","orcid":"https://orcid.org/0000-0001-8042-3596","observed_orcids":["https://orcid.org/0000-0001-8042-3596"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]},{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Xiaoan Zhang","raw_affiliation_strings":["Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","School of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, China","Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA; School of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"School of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, China","institution_ids":["https://openalex.org/I167383011"]},{"raw_affiliation_string":"Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA; School of Clinical Medicine, Henan University of Science and Technology, Luoyang 471000, China","institution_ids":["https://openalex.org/I167383011","https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042039794","display_name":"William D. Park","orcid":"https://orcid.org/0009-0005-3499-0238","observed_orcids":["https://orcid.org/0009-0005-3499-0238"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William D. Park","raw_affiliation_strings":["Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA"],"raw_orcid":"https://orcid.org/0009-0005-3499-0238","affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044632408","display_name":"Marijn Thijssen","orcid":"https://orcid.org/0000-0003-1154-0021","observed_orcids":["https://orcid.org/0000-0003-1154-0021"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marijn Thijssen","raw_affiliation_strings":["Laboratory for Clinical and Epidemiological Virology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-1154-0021","affiliations":[{"raw_affiliation_string":"Laboratory for Clinical and Epidemiological Virology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102154772","display_name":"Yanjuan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanjuan Xu","raw_affiliation_strings":["Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012365482","display_name":"Longping V. Tse","orcid":"https://orcid.org/0000-0001-7582-8396","observed_orcids":["https://orcid.org/0000-0001-7582-8396"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Long Ping Victor Tse","raw_affiliation_strings":["Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074592383","display_name":"Mahmoud Reza Pourkarim","orcid":"https://orcid.org/0000-0003-4620-6453","observed_orcids":["https://orcid.org/0000-0003-4620-6453"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mahmoud Reza Pourkarim","raw_affiliation_strings":["Laboratory for Clinical and Epidemiological Virology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-4620-6453","affiliations":[{"raw_affiliation_string":"Laboratory for Clinical and Epidemiological Virology, Rega Institute, Department of Microbiology, Immunology and Transplantation, KU Leuven, 3000 Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058961190","display_name":"Rajeev Aurora","orcid":"https://orcid.org/0000-0002-6609-6055","observed_orcids":["https://orcid.org/0000-0002-6609-6055"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajeev Aurora","raw_affiliation_strings":["Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology & Immunology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067392420","display_name":"Xiaofeng Fan","orcid":"https://orcid.org/0000-0002-3201-5499","observed_orcids":["https://orcid.org/0000-0002-3201-5499"]},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaofeng Fan","raw_affiliation_strings":["Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA; Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, MO 63104, USA"],"raw_orcid":"https://orcid.org/0000-0002-3201-5499","affiliations":[{"raw_affiliation_string":"Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","institution_ids":["https://openalex.org/I47838141"]},{"raw_affiliation_string":"Division of Gastroenterology & Hepatology, Department of Internal Medicine, Saint Louis University School of Medicine, St. Louis, MO 63104, USA; Saint Louis University Liver Center, Saint Louis University School of Medicine, St. Louis, MO 63104, USA","institution_ids":["https://openalex.org/I47838141"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067392420"],"corresponding_institution_ids":["https://openalex.org/I47838141"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":0.7982,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71764872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"15","issue":"8","first_page":"1635","last_page":"1635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.3061999976634979,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.3061999976634979,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12025","display_name":"Hepatitis Viruses Studies and Epidemiology","score":0.22599999606609344,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.1509999930858612,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anelloviruses","display_name":"anelloviruses","score":0.8019999861717224},{"id":"https://openalex.org/keywords/viral-metagenomics","display_name":"viral metagenomics","score":0.5809999704360962},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.6880000233650208},{"id":"https://openalex.org/keywords/acute-liver-failure","display_name":"acute liver failure","score":0.9919999837875366},{"id":"https://openalex.org/keywords/liver-transplantation","display_name":"liver transplantation","score":1.0},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.8650000095367432},{"id":"https://openalex.org/keywords/viral-diversity","display_name":"viral diversity","score":0.48399999737739563},{"id":"https://openalex.org/keywords/clinical-outcome-prediction","display_name":"clinical outcome prediction","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5977071523666382},{"id":"https://openalex.org/C2779609443","wikidata":"https://www.wikidata.org/wiki/Q1368191","display_name":"Liver transplantation","level":3,"score":0.5942385792732239},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.555791974067688},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5419341921806335},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.5092664957046509},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4958206117153168},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.4735616445541382},{"id":"https://openalex.org/C2910427207","wikidata":"https://www.wikidata.org/wiki/Q4735279","display_name":"Torque teno virus","level":4,"score":0.45128825306892395},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.44367340207099915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.435889333486557},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.35764968395233154},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.2983296513557434},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08497345447540283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010406","descriptor_name":"Penicillins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016031","descriptor_name":"Liver Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017114","descriptor_name":"Liver Failure, Acute","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049811","descriptor_name":"Anelloviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049811","descriptor_name":"Anelloviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049811","descriptor_name":"Anelloviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049811","descriptor_name":"Anelloviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.3390/v15081635","doi":"https://doi.org/10.3390/v15081635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15081635","pdf_url":"https://www.mdpi.com/1999-4915/15/8/1635/pdf?version=1690451641","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},{"id":"pmid:37631978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37631978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:20.500.12942/728340","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/20.500.12942/728340","pdf_url":"https://lirias.kuleuven.be/retrieve/c46c8810-dd04-4b0f-b1ab-8b3c7aca2796","source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses-Basel, vol. 15 (8), Art.No. ARTN 1635","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10457780","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10457780","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10457780/pdf/viruses-15-01635.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:9dfad877ae114cb2aa5fc1e746a70829","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9dfad877ae114cb2aa5fc1e746a70829","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Viruses, Vol 15, Iss 8, p 1635 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/v15081635","doi":"https://doi.org/10.3390/v15081635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/v15081635","pdf_url":"https://www.mdpi.com/1999-4915/15/8/1635/pdf?version=1690451641","source":{"id":"https://openalex.org/S55776271","display_name":"Viruses","issn_l":"1999-4915","issn":["1999-4915"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Viruses","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G4985829091","display_name":"Viral Categorization and Discovery in Acute Liver Failure with Unknown Etiology","funder_award_id":"R21AI117128","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000056221","display_name":null,"funder_award_id":"AI117128","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G991201336","display_name":null,"funder_award_id":"AI117128","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320312021","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385347472.pdf","grobid_xml":"https://content.openalex.org/works/W4385347472.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1967519901","https://openalex.org/W1985734999","https://openalex.org/W2000042664","https://openalex.org/W2014051912","https://openalex.org/W2023645032","https://openalex.org/W2028127573","https://openalex.org/W2040412593","https://openalex.org/W2044638517","https://openalex.org/W2068458133","https://openalex.org/W2071976711","https://openalex.org/W2088856850","https://openalex.org/W2109173831","https://openalex.org/W2120902911","https://openalex.org/W2147618390","https://openalex.org/W2152207030","https://openalex.org/W2170747616","https://openalex.org/W2292351551","https://openalex.org/W2529965014","https://openalex.org/W2559325775","https://openalex.org/W2610517983","https://openalex.org/W2736894590","https://openalex.org/W2891286508","https://openalex.org/W2929477060","https://openalex.org/W2936155984","https://openalex.org/W2967923425","https://openalex.org/W2990427812","https://openalex.org/W3010486552","https://openalex.org/W3011245150","https://openalex.org/W3020657060","https://openalex.org/W3041927911","https://openalex.org/W3088217668","https://openalex.org/W3118724893","https://openalex.org/W3137062742","https://openalex.org/W3137252420","https://openalex.org/W3151578668","https://openalex.org/W3184084815","https://openalex.org/W3187716974","https://openalex.org/W3187785654","https://openalex.org/W3202085543","https://openalex.org/W4212948393","https://openalex.org/W4251751280","https://openalex.org/W4254687493","https://openalex.org/W4280581573"],"related_works":["https://openalex.org/W4212948393","https://openalex.org/W2969459590","https://openalex.org/W3184084815","https://openalex.org/W7221322348","https://openalex.org/W3119477738","https://openalex.org/W2594267540","https://openalex.org/W4406119030","https://openalex.org/W7062327345","https://openalex.org/W4396928868","https://openalex.org/W4328104244"],"abstract_inverted_index":{"Anellovirus":[0],"(AV)":[1],"is":[2],"a":[3,22,124,194],"ubiquitous":[4],"virus":[5],"in":[6,175,213],"the":[7,26,33,96,99,134,206,209,214],"human":[8],"population.":[9],"Individuals":[10],"can":[11],"be":[12,170,199],"infected":[13],"with":[14,47,56,123,143,153],"multiple":[15],"AV":[16,104,135,210],"genera":[17],"and":[18,39,69,92,112,148,189],"species":[19],"to":[20,204],"form":[21],"heterogeneous":[23],"repertoire,":[24],"termed":[25],"anellome.":[27],"Using":[28],"advanced":[29],"methods,":[30],"we":[31],"examined":[32],"anellomes":[34,52],"from":[35],"12":[36],"paired":[37,90,187],"serum":[38,91,188],"liver":[40,93,145,149,180,190,217],"samples,":[41],"as":[42,44,179],"well":[43],"2701":[45],"subjects":[46],"different":[48],"clinical":[49,173],"diagnoses.":[50],"Overall,":[51],"are":[53],"remarkably":[54],"individualized,":[55],"significant":[57],"among-group":[58],"differences":[59],"(Kruskal\u2013Wallis":[60],"test":[61],"p":[62,70,159],"=":[63,71,160],"6.6":[64],"\u00d7":[65,73,162,164],"10\u2212162":[66,74],"for":[67,75,89,201],"richness":[68],"7.48":[72],"Shannon":[76],"entropy).":[77],"High":[78],"dissimilarity":[79],"scores":[80],"(beta":[81],"diversity)":[82],"were":[83],"observed":[84],"between":[85,186],"patient":[86,155],"groups,":[87],"except":[88],"samples.":[94],"At":[95],"population":[97],"level,":[98],"relative":[100],"abundance":[101],"of":[102,172,184,208,216],"combinational":[103],"genus":[105],"Betatorquevirus":[106],"(torque":[107,114],"teno":[108,115],"mini":[109],"viruses,":[110,117],"TTMV),":[111],"Gammatorquevirus":[113],"midi":[116],"TTMDV)":[118],"exhibited":[119],"an":[120],"exponential":[121],"distribution":[122],"low":[125],"bound":[126],"point":[127],"at":[128],"32%.":[129],"Defined":[130],"by":[131],"this":[132],"value,":[133],"TTMV/TTMDV-expanded":[136,211],"anellome":[137,167,185,212],"was":[138],"significantly":[139],"enriched":[140],"among":[141],"patients":[142],"acute":[144],"failure":[146],"(31.7%)":[147],"transplantation":[150],"(40.7%),":[151],"compared":[152],"other":[154],"groups":[156],"(\u03c72":[157],"test:":[158],"4.1":[161],"10\u22128\u20133.2":[163],"10\u22123).":[165],"Therefore,":[166],"heterogeneity":[168],"may":[169],"predictive":[171],"outcomes":[174,215],"certain":[176],"diseases,":[177],"such":[178],"disease.":[181,218],"The":[182],"consistency":[183],"samples":[191],"indicates":[192],"that":[193],"liquid":[195],"biopsy":[196],"approach":[197],"would":[198],"suitable":[200],"longitudinal":[202],"studies":[203],"clarify":[205],"causality":[207]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2023-07-29T00:00:00"}