{"id":"https://openalex.org/W4385291386","doi":"https://doi.org/10.1038/s41598-023-39334-9","title":"Dietary polyphenols drive dose-dependent behavioral and molecular alterations to repeated morphine","display_name":"Dietary polyphenols drive dose-dependent behavioral and molecular alterations to repeated morphine","publication_year":2023,"publication_date":"2023-07-27","ids":{"openalex":"https://openalex.org/W4385291386","doi":"https://doi.org/10.1038/s41598-023-39334-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/37500710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10374644"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-023-39334-9","doi":"https://doi.org/10.1038/s41598-023-39334-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-39334-9","pdf_url":"https://www.nature.com/articles/s41598-023-39334-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41598-023-39334-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059785228","display_name":"Aya Osman","orcid":"https://orcid.org/0000-0002-2048-5039","observed_orcids":["https://orcid.org/0000-0002-2048-5039"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aya Osman","raw_affiliation_strings":["Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","The Seaver Center for Autism Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-2048-5039","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"The Seaver Center for Autism Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017674233","display_name":"Rebecca S. Hofford","orcid":"https://orcid.org/0000-0002-4381-4173","observed_orcids":["https://orcid.org/0000-0002-4381-4173"]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca S. Hofford","raw_affiliation_strings":["Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA","Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4381-4173","affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"raw_affiliation_string":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071250955","display_name":"Katherine R. Meckel","orcid":"https://orcid.org/0000-0001-8867-201X","observed_orcids":["https://orcid.org/0000-0001-8867-201X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine R. Meckel","raw_affiliation_strings":["Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-8867-201X","affiliations":[{"raw_affiliation_string":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003306338","display_name":"Yesha A. Dave","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yesha A. Dave","raw_affiliation_strings":["Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027851898","display_name":"Sharon M. Zeldin","orcid":"https://orcid.org/0000-0002-8971-2869","observed_orcids":["https://orcid.org/0000-0002-8971-2869"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon M. Zeldin","raw_affiliation_strings":["Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-8971-2869","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015170060","display_name":"Ava L. Shipman","orcid":"https://orcid.org/0000-0002-9244-2302","observed_orcids":["https://orcid.org/0000-0002-9244-2302"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ava L. Shipman","raw_affiliation_strings":["Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018193688","display_name":"Kelsey E. Lucerne","orcid":"https://orcid.org/0000-0001-5860-1245","observed_orcids":["https://orcid.org/0000-0001-5860-1245"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelsey E. Lucerne","raw_affiliation_strings":["Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-5860-1245","affiliations":[{"raw_affiliation_string":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076941033","display_name":"Kyle J. Trageser","orcid":"https://orcid.org/0000-0001-9161-0178","observed_orcids":["https://orcid.org/0000-0001-9161-0178"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle J Trageser","raw_affiliation_strings":["Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048865252","display_name":"Tatsunori Oguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatsunori Oguchi","raw_affiliation_strings":["Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA","institution_ids":["https://openalex.org/I4210116369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048364336","display_name":"Giulio Maria Pasinetti","orcid":"https://orcid.org/0000-0002-1524-5196","observed_orcids":["https://orcid.org/0000-0002-1524-5196"]},"institutions":[{"id":"https://openalex.org/I4210116369","display_name":"James J. Peters VA Medical Center","ror":"https://ror.org/02c8hpe74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210094901","https://openalex.org/I4210116369"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giulio M. Pasinetti","raw_affiliation_strings":["Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA","Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA","Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"Geriatric Research, Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, Bronx, NY, USA","institution_ids":["https://openalex.org/I4210116369"]},{"raw_affiliation_string":"Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039017085","display_name":"Drew D. Kiraly","orcid":"https://orcid.org/0000-0002-4818-5169","observed_orcids":["https://orcid.org/0000-0002-4818-5169"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Drew D. Kiraly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5039017085"],"corresponding_institution_ids":[],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":1.073,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.74236693,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"13","issue":"1","first_page":"12223","last_page":"12223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dietary-polyphenols","display_name":"dietary polyphenols","score":0.9929999709129333},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.890999972820282},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9399999976158142},{"id":"https://openalex.org/keywords/locomotor-sensitization","display_name":"locomotor sensitization","score":0.9129999876022339},{"id":"https://openalex.org/keywords/conditioned-place-preference","display_name":"conditioned place preference","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8970000147819519},{"id":"https://openalex.org/keywords/sirt1","display_name":"SIRT1","score":0.8460000157356262},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"histone deacetylase","score":0.9210000038146973},{"id":"https://openalex.org/keywords/polyphenol-metabolites","display_name":"polyphenol metabolites","score":0.902999997138977},{"id":"https://openalex.org/keywords/prebiotics","display_name":"prebiotics","score":0.7210000157356262},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.796999990940094},{"id":"https://openalex.org/keywords/behavioral-resilience","display_name":"behavioral resilience","score":0.5860000252723694},{"id":"https://openalex.org/keywords/synaptic-function","display_name":"synaptic function","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.6673809885978699},{"id":"https://openalex.org/C2776552330","wikidata":"https://www.wikidata.org/wiki/Q1476178","display_name":"Nucleus accumbens","level":3,"score":0.6426424980163574},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6029573678970337},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.5980997085571289},{"id":"https://openalex.org/C35124327","wikidata":"https://www.wikidata.org/wiki/Q5159285","display_name":"Conditioned place preference","level":3,"score":0.581193745136261},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5152969360351562},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4824729263782501},{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.4669203758239746},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32244765758514404},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26285994052886963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21164345741271973},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1614166498184204},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.15672600269317627},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.1341908872127533},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009714","descriptor_name":"Nucleus Accumbens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/s41598-023-39334-9","doi":"https://doi.org/10.1038/s41598-023-39334-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-39334-9","pdf_url":"https://www.nature.com/articles/s41598-023-39334-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"doi:10.1101/2022.06.14.496180","doi":"https://doi.org/10.1101/2022.06.14.496180","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2022.06.14.496180","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2022/06/19/2022.06.14.496180.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10374644","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10374644","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10374644/pdf/41598_2023_Article_39334.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:37500710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37500710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e71a359cf4a54496baafc4762ebbdb74","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e71a359cf4a54496baafc4762ebbdb74","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41598-023-39334-9","doi":"https://doi.org/10.1038/s41598-023-39334-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-023-39334-9","pdf_url":"https://www.nature.com/articles/s41598-023-39334-9.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2475325919","display_name":"Dissecting the role of granulocyte-colony stimulating factor in cocaine-mediated behavioral plasticity","funder_award_id":"K08DA044308","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G2620606246","display_name":"Dissecting the role of the gut microbiome on striatal chromatin conformation and drug-seeking behavior","funder_award_id":"F99NS124187","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5002497260","display_name":"Pasinetti:  Overall; Dietary Botanicals in the Preservation of Cognitive and Psychological Resilience (Pasinetti)","funder_award_id":"P50AT008661","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G6203974929","display_name":"Targeting the host metabolome to reverse drug-induced epigenetic changes","funder_award_id":"DP1DA051551","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G9000864103","display_name":"Defining the role of short-chain fatty acids in adolescent opioid reinforcement and epigenetic regulation","funder_award_id":"K01DA050906","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320313731","display_name":"Beatrice and Samuel A. Seaver Foundation","ror":"https://ror.org/0177kw895"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385291386.pdf","grobid_xml":"https://content.openalex.org/works/W4385291386.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W630533930","https://openalex.org/W994855498","https://openalex.org/W1566831845","https://openalex.org/W1910180380","https://openalex.org/W1966907480","https://openalex.org/W1970753300","https://openalex.org/W1982160170","https://openalex.org/W1988709930","https://openalex.org/W1998268055","https://openalex.org/W2016977901","https://openalex.org/W2026848854","https://openalex.org/W2028914189","https://openalex.org/W2029860792","https://openalex.org/W2066848874","https://openalex.org/W2070050178","https://openalex.org/W2072970694","https://openalex.org/W2074542118","https://openalex.org/W2075527287","https://openalex.org/W2080585999","https://openalex.org/W2081128169","https://openalex.org/W2087090598","https://openalex.org/W2087330696","https://openalex.org/W2091492780","https://openalex.org/W2095076671","https://openalex.org/W2096361448","https://openalex.org/W2099456560","https://openalex.org/W2108647075","https://openalex.org/W2131026689","https://openalex.org/W2131123075","https://openalex.org/W2143847963","https://openalex.org/W2150254599","https://openalex.org/W2157107905","https://openalex.org/W2159482845","https://openalex.org/W2170416289","https://openalex.org/W2345356016","https://openalex.org/W2345672368","https://openalex.org/W2462345027","https://openalex.org/W2474954343","https://openalex.org/W2496974376","https://openalex.org/W2536503303","https://openalex.org/W2561750639","https://openalex.org/W2562627217","https://openalex.org/W2767693656","https://openalex.org/W2770846762","https://openalex.org/W2789606537","https://openalex.org/W2794098750","https://openalex.org/W2794480084","https://openalex.org/W2796649808","https://openalex.org/W2810800768","https://openalex.org/W2899457671","https://openalex.org/W2901009338","https://openalex.org/W2920630434","https://openalex.org/W2922011958","https://openalex.org/W2935024989","https://openalex.org/W2944545583","https://openalex.org/W2944567251","https://openalex.org/W2946372752","https://openalex.org/W2949583997","https://openalex.org/W2954606580","https://openalex.org/W2956671755","https://openalex.org/W2957585395","https://openalex.org/W2969718750","https://openalex.org/W2978643617","https://openalex.org/W2984988230","https://openalex.org/W2987906885","https://openalex.org/W3003982683","https://openalex.org/W3030441098","https://openalex.org/W3114511050","https://openalex.org/W3126130527","https://openalex.org/W3136987255","https://openalex.org/W3165393001","https://openalex.org/W3170802752","https://openalex.org/W3174200503","https://openalex.org/W4200215135","https://openalex.org/W4207009607","https://openalex.org/W4231877095","https://openalex.org/W4294216483","https://openalex.org/W4307425304"],"related_works":["https://openalex.org/W4283030811","https://openalex.org/W2516911978","https://openalex.org/W7169665881","https://openalex.org/W3092191481","https://openalex.org/W4410934443","https://openalex.org/W4380367675","https://openalex.org/W2604945962","https://openalex.org/W4365812448","https://openalex.org/W2037352574","https://openalex.org/W2030883738"],"abstract_inverted_index":{"Abstract":[0],"Opioid":[1],"Use":[2],"Disorder":[3],"(OUD)":[4],"is":[5],"a":[6,52,142],"neuropsychiatric":[7,71],"condition":[8],"associated":[9],"with":[10,51],"tremendous":[11],"medical":[12],"and":[13,38,46,64,82,104,172,181,195,213,237,242],"social":[14],"consequences.":[15],"Despite":[16],"this":[17],"burden,":[18],"current":[19],"pharmacotherapies":[20],"for":[21,27,100,161,246],"OUD":[22,41],"are":[23,42,176],"ineffective":[24],"or":[25],"intolerable":[26],"many":[28],"patients.":[29],"As":[30],"such,":[31],"interventions":[32],"aimed":[33],"at":[34,117,125],"promoting":[35],"overall":[36],"health":[37],"resilience":[39,63],"against":[40],"of":[43,70,77,115,135,208,216],"immense":[44],"clinical":[45],"societal":[47],"interest.":[48],"Recently,":[49],"treatment":[50,79,111,190],"Bioactive":[53],"Dietary":[54],"Polyphenol":[55],"Preparation":[56],"(BDPP)":[57],"was":[58],"shown":[59],"to":[60,85,164,240],"promote":[61],"behavioral":[62,81,222,236],"adaptive":[65],"neuroplasticity":[66],"in":[67,198,220],"multiple":[68],"models":[69],"disease.":[72],"Here,":[73],"we":[74,131,205],"assessed":[75],"effects":[76,234],"BDPP":[78,92,151],"on":[80,235],"molecular":[83],"responses":[84,95,239],"repeated":[86],"morphine":[87,121,159,202,241],"treatment.":[88],"We":[89,167],"find":[90],"that":[91,229],"pre-treatment":[93,152],"alters":[94],"across":[96],"the":[97,136,179,199,209,214,244],"dose":[98,119,127,143,149,201],"range":[99],"both":[101],"locomotor":[102],"sensitization":[103],"conditioned":[105],"place":[106],"preference.":[107],"Most":[108],"notably,":[109],"polyphenol":[110,145,189,218],"consistently":[112],"reduced":[113],"formation":[114],"preference":[116],"low":[118,200],"(5mg/kg)":[120],"but":[122],"enhanced":[123],"it":[124],"high":[126,148],"(15mg/kg).":[128],"In":[129],"parallel,":[130],"performed":[132],"transcriptomic":[133],"profiling":[134],"nucleus":[137],"accumbens,":[138],"which":[139],"again":[140],"showed":[141],"x":[144],"interaction.":[146],"At":[147],"morphine,":[150],"potentiated":[153],"gene":[154],"expression":[155],"changes":[156],"induced":[157],"by":[158,178],"particularly":[160,197],"genes":[162],"related":[163],"synaptic":[165],"function.":[166],"also":[168],"profiled":[169],"microbiome":[170,180,193],"composition":[171,194],"function,":[173,196],"as":[174,184],"polyphenols":[175,230],"metabolized":[177],"can":[182],"act":[183],"prebiotics.":[185],"The":[186],"profile":[187],"revealed":[188],"markedly":[191],"altered":[192],"group.":[203],"Finally,":[204],"investigated":[206],"involvement":[207],"SIRT1":[210],"histone":[211],"deacetylase,":[212],"role":[215],"specific":[217],"metabolites":[219],"these":[221,226],"phenotypes.":[223],"Taken":[224],"together,":[225],"results":[227],"demonstrate":[228],"have":[231],"robust":[232],"dose-dependent":[233],"physiological":[238],"lay":[243],"foundation":[245],"future":[247],"translational":[248],"work.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-07-27T00:00:00"}