{"id":"https://openalex.org/W4385286994","doi":"https://doi.org/10.1158/1078-0432.23781526","title":"Figure S6 from Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma","display_name":"Figure S6 from Combined CDK4/6 and ERK1/2 Inhibition Enhances Antitumor Activity in NF1-Associated Plexiform Neurofibroma","publication_year":2023,"publication_date":"2023-07-26","ids":{"openalex":"https://openalex.org/W4385286994","doi":"https://doi.org/10.1158/1078-0432.23781526"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.23781526","doi":"https://doi.org/10.1158/1078-0432.23781526","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.23781526","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S6_from_Combined_CDK4_6_and_ERK1_2_Inhibition_Enhances_Antitumor_Activity_in_NF1-Associated_Plexiform_Neurofibroma/23781526/1/files/41715202.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S6_from_Combined_CDK4_6_and_ERK1_2_Inhibition_Enhances_Antitumor_Activity_in_NF1-Associated_Plexiform_Neurofibroma/23781526/1/files/41715202.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002388430","display_name":"Alyssa C. Flint","orcid":"https://orcid.org/0000-0001-5698-9776","observed_orcids":["https://orcid.org/0000-0001-5698-9776"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alyssa C. Flint","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5698-9776","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001582911","display_name":"Dana K. Mitchell","orcid":"https://orcid.org/0000-0002-1022-1072","observed_orcids":["https://orcid.org/0000-0002-1022-1072"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dana K. Mitchell","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1022-1072","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067366916","display_name":"Steven P. Angus","orcid":"https://orcid.org/0000-0002-7655-657X","observed_orcids":["https://orcid.org/0000-0002-7655-657X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven P. Angus","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7655-657X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084429604","display_name":"Abbi E. Smith","orcid":"https://orcid.org/0000-0002-4402-8959","observed_orcids":["https://orcid.org/0000-0002-4402-8959"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abbi E. Smith","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4402-8959","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011940249","display_name":"Waylan Bessler","orcid":"https://orcid.org/0000-0003-0685-9206","observed_orcids":["https://orcid.org/0000-0003-0685-9206"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waylan Bessler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0685-9206","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049617151","display_name":"Li Jiang","orcid":"https://orcid.org/0009-0003-6488-1927","observed_orcids":["https://orcid.org/0009-0003-6488-1927"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Jiang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0003-6488-1927","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058070935","display_name":"Henry Elmer Mang","orcid":"https://orcid.org/0000-0002-2496-1442","observed_orcids":["https://orcid.org/0000-0002-2496-1442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henry Mang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2496-1442","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767812","display_name":"Xiaohong Li","orcid":"https://orcid.org/0009-0000-2728-0565","observed_orcids":["https://orcid.org/0009-0000-2728-0565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaohong Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-2728-0565","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020630997","display_name":"Qingbo Lu","orcid":"https://orcid.org/0009-0005-6786-9100","observed_orcids":["https://orcid.org/0009-0005-6786-9100","https://orcid.org/0009-0009-4283-0735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qingbo Lu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-6786-9100","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081742889","display_name":"Brooke Rodriguez","orcid":"https://orcid.org/0009-0005-6313-3681","observed_orcids":["https://orcid.org/0009-0005-6313-3681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brooke Rodriguez","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-6313-3681","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061385868","display_name":"George Earl Sandusky","orcid":"https://orcid.org/0000-0003-0769-057X","observed_orcids":["https://orcid.org/0000-0003-0769-057X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"George E. Sandusky","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0769-057X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112540473","display_name":"Andi R. Masters","orcid":"https://orcid.org/0000-0002-9570-8786","observed_orcids":["https://orcid.org/0000-0002-9570-8786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andi R. Masters","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9570-8786","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012408594","display_name":"Chi Zhang","orcid":"https://orcid.org/0000-0001-9553-0925","observed_orcids":["https://orcid.org/0000-0001-9553-0925"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chi Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9553-0925","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040167145","display_name":"Pengtao Dang","orcid":"https://orcid.org/0009-0005-0144-0432","observed_orcids":["https://orcid.org/0009-0005-0144-0432","https://orcid.org/0009-0000-3178-2090"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pengtao Dang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-0144-0432","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078591052","display_name":"Jenna K. Koenig","orcid":"https://orcid.org/0000-0001-6952-955X","observed_orcids":["https://orcid.org/0000-0001-6952-955X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jenna Koenig","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6952-955X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047612906","display_name":"Gary L. Johnson","orcid":"https://orcid.org/0000-0003-2867-0551","observed_orcids":["https://orcid.org/0000-0003-2867-0551"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary L. Johnson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2867-0551","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014196571","display_name":"Weihua Shen","orcid":"https://orcid.org/0009-0002-5249-5175","observed_orcids":["https://orcid.org/0009-0002-5249-5175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weihua Shen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-5249-5175","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080535835","display_name":"Jiangang Liu","orcid":"https://orcid.org/0000-0002-2800-077X","observed_orcids":["https://orcid.org/0000-0002-2800-077X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiangang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2800-077X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078360952","display_name":"Amit Aggarwal","orcid":"https://orcid.org/0000-0003-4800-4046","observed_orcids":["https://orcid.org/0000-0003-4800-4046"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amit Aggarwal","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4800-4046","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071061160","display_name":"Gregory P. Donoho","orcid":"https://orcid.org/0009-0007-8865-5093","observed_orcids":["https://orcid.org/0009-0007-8865-5093"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory P. Donoho","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-8865-5093","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079993897","display_name":"Melinda D. Willard","orcid":"https://orcid.org/0000-0002-2937-962X","observed_orcids":["https://orcid.org/0000-0002-2937-962X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melinda D. Willard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2937-962X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003086261","display_name":"Shripad V. Bhagwat","orcid":"https://orcid.org/0009-0001-1231-9735","observed_orcids":["https://orcid.org/0009-0001-1231-9735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shripad V. Bhagwat","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-1231-9735","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056688749","display_name":"D. Wade Clapp","orcid":"https://orcid.org/0000-0001-9465-0917","observed_orcids":["https://orcid.org/0000-0001-9465-0917"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D. Wade Clapp","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9465-0917","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5062014907","display_name":"Steven D. Rhodes","orcid":"https://orcid.org/0000-0002-6551-8631","observed_orcids":["https://orcid.org/0000-0002-6551-8631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven D. Rhodes","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6551-8631","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdk4-6-inhibition","display_name":"CDK4/6 inhibition","score":0.8339999914169312},{"id":"https://openalex.org/keywords/erk1-2-inhibition","display_name":"ERK1/2 inhibition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nf1-associated-plexiform-neurofibroma","display_name":"NF1-associated plexiform neurofibroma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7950000166893005},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5576008558273315},{"id":"https://openalex.org/C2910078708","wikidata":"https://www.wikidata.org/wiki/Q1418735","display_name":"Plexiform neurofibroma","level":4,"score":0.44989484548568726},{"id":"https://openalex.org/C2777831590","wikidata":"https://www.wikidata.org/wiki/Q1418735","display_name":"Neurofibroma","level":3,"score":0.41092756390571594},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3348765969276428},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17109471559524536},{"id":"https://openalex.org/C2778984943","wikidata":"https://www.wikidata.org/wiki/Q847605","display_name":"Neurofibromatosis","level":2,"score":0.128431499004364}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.23781526","doi":"https://doi.org/10.1158/1078-0432.23781526","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.23781526","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S6_from_Combined_CDK4_6_and_ERK1_2_Inhibition_Enhances_Antitumor_Activity_in_NF1-Associated_Plexiform_Neurofibroma/23781526/1/files/41715202.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.23781526","doi":"https://doi.org/10.1158/1078-0432.23781526","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.23781526","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Figure_S6_from_Combined_CDK4_6_and_ERK1_2_Inhibition_Enhances_Antitumor_Activity_in_NF1-Associated_Plexiform_Neurofibroma/23781526/1/files/41715202.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385286994.pdf","grobid_xml":"https://content.openalex.org/works/W4385286994.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4386380229","https://openalex.org/W4402817478","https://openalex.org/W4402790180","https://openalex.org/W4402817481","https://openalex.org/W4402799356","https://openalex.org/W4392561796","https://openalex.org/W4402798929"],"abstract_inverted_index":{"Caspase":[0],"Glo":[1],"3/7":[2],"Assay":[3]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-27T00:00:00"}