{"id":"https://openalex.org/W4385286459","doi":"https://doi.org/10.18632/aging.204904","title":"Non-SMC condensin I complex subunit D2 (NCAPD2) reveals its prognostic and immunologic features in human cancers","display_name":"Non-SMC condensin I complex subunit D2 (NCAPD2) reveals its prognostic and immunologic features in human cancers","publication_year":2023,"publication_date":"2023-07-26","ids":{"openalex":"https://openalex.org/W4385286459","doi":"https://doi.org/10.18632/aging.204904","pmid":"https://pubmed.ncbi.nlm.nih.gov/37498296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10415567"},"language":"en","primary_location":{"id":"doi:10.18632/aging.204904","doi":"https://doi.org/10.18632/aging.204904","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.204904","pdf_url":"https://www.aging-us.com/article/204904/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.aging-us.com/article/204904/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006124360","display_name":"Xiaoying Dong","orcid":"https://orcid.org/0000-0001-8871-6721","observed_orcids":["https://orcid.org/0000-0001-8871-6721"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoying Dong","raw_affiliation_strings":["Department of Infectious Disease, Shengjing Hospital of China Medical University, Shenyang 110004, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Shengjing Hospital of China Medical University, Shenyang 110004, People\u2019s Republic of China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070937593","display_name":"Ting Liu","orcid":"https://orcid.org/0000-0002-8030-018X","observed_orcids":["https://orcid.org/0000-0002-8030-018X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210150338","display_name":"Beijing Ditan Hospital","ror":"https://ror.org/05kkkes98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Liu","raw_affiliation_strings":["Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Chaoyang 100015, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Chaoyang 100015, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062372664","display_name":"Zhizhao Li","orcid":"https://orcid.org/0000-0003-2142-1878","observed_orcids":["https://orcid.org/0000-0003-2142-1878"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210150338","display_name":"Beijing Ditan Hospital","ror":"https://ror.org/05kkkes98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210150338"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhizhao Li","raw_affiliation_strings":["Department of Cardiovascular, Beijing Ditan Hospital, Capital Medical University, Chaoyang 100015, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular, Beijing Ditan Hospital, Capital Medical University, Chaoyang 100015, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210150338"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103278714","display_name":"Yongzhen Zhai","orcid":"https://orcid.org/0000-0002-7665-9683","observed_orcids":["https://orcid.org/0000-0002-7665-9683"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]},{"id":"https://openalex.org/I91656880","display_name":"China Medical University","ror":"https://ror.org/032d4f246","country_code":"CN","type":"education","lineage":["https://openalex.org/I91656880"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongzhen Zhai","raw_affiliation_strings":["Department of Infectious Disease, Shengjing Hospital of China Medical University, Shenyang 110004, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease, Shengjing Hospital of China Medical University, Shenyang 110004, People\u2019s Republic of China","institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5103278714"],"corresponding_institution_ids":["https://openalex.org/I2800370534","https://openalex.org/I91656880"],"apc_list":null,"apc_paid":null,"fwci":1.6999,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.85727094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"15","issue":"14","first_page":"7237","last_page":"7257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3513000011444092,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.3513000011444092,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.1704999953508377,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.16750000417232513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pan-cancer","display_name":"pan-cancer","score":0.6299999952316284},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8830000162124634},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8669999837875366},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.7689999938011169},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"immune checkpoint","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.9539999961853027},{"id":"https://openalex.org/keywords/microsatellite-instability","display_name":"microsatellite instability","score":0.9890000224113464},{"id":"https://openalex.org/keywords/rna-methylation","display_name":"RNA methylation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/drug-sensitivity","display_name":"drug sensitivity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.781000018119812},{"id":"https://openalex.org/keywords/promoter-methylation","display_name":"promoter methylation","score":0.6830000281333923},{"id":"https://openalex.org/keywords/gene-overexpression","display_name":"gene overexpression","score":0.6370000243186951},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.75},{"id":"https://openalex.org/keywords/adrenocortical-carcinoma","display_name":"adrenocortical carcinoma","score":0.7749999761581421},{"id":"https://openalex.org/keywords/uterine-corpus-endometrial-carcinoma","display_name":"uterine corpus endometrial carcinoma","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6269835233688354},{"id":"https://openalex.org/C158163496","wikidata":"https://www.wikidata.org/wiki/Q5937310","display_name":"Human Protein Atlas","level":4,"score":0.5846771597862244},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5824344158172607},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5137194395065308},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4669163227081299},{"id":"https://openalex.org/C2779767149","wikidata":"https://www.wikidata.org/wiki/Q488212","display_name":"Microsatellite instability","level":5,"score":0.43462345004081726},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.434379518032074},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.4199652671813965},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.41344892978668213},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32401686906814575},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24597346782684326},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2073485553264618},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.17097654938697815},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15365543961524963},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.0},{"id":"https://openalex.org/C61320498","wikidata":"https://www.wikidata.org/wiki/Q265193","display_name":"Microsatellite","level":4,"score":0.0},{"id":"https://openalex.org/C6856738","wikidata":"https://www.wikidata.org/wiki/Q331672","display_name":"Protein expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000075223","descriptor_name":"Poly-ADP-Ribose Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000096142","descriptor_name":"Cutaneous Malignant Melanoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.18632/aging.204904","doi":"https://doi.org/10.18632/aging.204904","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.204904","pdf_url":"https://www.aging-us.com/article/204904/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10415567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10415567","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10415567/pdf/aging-15-204904.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging (Albany NY)","raw_type":"Text"},{"id":"pmid:37498296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37498296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.18632/aging.204904","doi":"https://doi.org/10.18632/aging.204904","is_oa":true,"landing_page_url":"https://doi.org/10.18632/aging.204904","pdf_url":"https://www.aging-us.com/article/204904/pdf","source":{"id":"https://openalex.org/S4210231119","display_name":"Aging","issn_l":"1945-4589","issn":["1945-4589"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316297","host_organization_name":"Impact Journals LLC","host_organization_lineage":["https://openalex.org/P4310316297"],"host_organization_lineage_names":["Impact Journals LLC"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3887308073","display_name":null,"funder_award_id":"M1417","funder_id":"https://openalex.org/F4320336313","funder_display_name":"Shengjing Hospital"},{"id":"https://openalex.org/G8379350071","display_name":null,"funder_award_id":"2023-MS-189","funder_id":"https://openalex.org/F4320323086","funder_display_name":"Natural Science Foundation of Liaoning Province"}],"funders":[{"id":"https://openalex.org/F4320323086","display_name":"Natural Science Foundation of Liaoning Province","ror":null},{"id":"https://openalex.org/F4320336313","display_name":"Shengjing Hospital","ror":"https://ror.org/0202bj006"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385286459.pdf","grobid_xml":"https://content.openalex.org/works/W4385286459.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1595782100","https://openalex.org/W1831033366","https://openalex.org/W1940241680","https://openalex.org/W1968713873","https://openalex.org/W2035618305","https://openalex.org/W2049553585","https://openalex.org/W2104885590","https://openalex.org/W2107429737","https://openalex.org/W2130430382","https://openalex.org/W2149968536","https://openalex.org/W2274715327","https://openalex.org/W2320042023","https://openalex.org/W2460092097","https://openalex.org/W2557048067","https://openalex.org/W2560367415","https://openalex.org/W2577573386","https://openalex.org/W2606495925","https://openalex.org/W2622499649","https://openalex.org/W2635951006","https://openalex.org/W2752236919","https://openalex.org/W2765224588","https://openalex.org/W2797675588","https://openalex.org/W2912321830","https://openalex.org/W2944814492","https://openalex.org/W2980091963","https://openalex.org/W2995761893","https://openalex.org/W3013239365","https://openalex.org/W3047400464","https://openalex.org/W3101572072","https://openalex.org/W3128646645","https://openalex.org/W3178354761","https://openalex.org/W3182626601","https://openalex.org/W3205620579","https://openalex.org/W4206965224","https://openalex.org/W4221078247","https://openalex.org/W4312096896"],"related_works":["https://openalex.org/W4296581839","https://openalex.org/W4318156537","https://openalex.org/W4387038028","https://openalex.org/W4411847781","https://openalex.org/W4408387745","https://openalex.org/W4318192687","https://openalex.org/W6939917929","https://openalex.org/W6920728184","https://openalex.org/W4401179875","https://openalex.org/W7165857219"],"abstract_inverted_index":{"Non-SMC":[0],"condensin":[1],"I":[2],"complex":[3],"subunit":[4],"D2":[5],"(NCAPD2)":[6],"is":[7],"overexpressed":[8,154],"in":[9,23,49,71,155,176,179,194,200,207,245,264,288,300,323,339],"some":[10,165],"malignant":[11],"tumors.":[12,290,302],"However,":[13],"there":[14],"are":[15],"few":[16],"studies":[17],"on":[18,59,134],"the":[19,27,83,129,161,253,324],"function":[20],"of":[21,87,131,164,197,256,271],"NCAPD2":[22,43,68,93,132,152,171,182,198,236,272,291,309,320,331],"pan-cancer.":[24],"We":[25,55,126],"used":[26],"Cancer":[28],"Genome":[29],"Atlas":[30,37],"(TCGA),":[31],"Genotype-Tissue":[32],"Expression":[33],"(GTEx),":[34],"Human":[35],"Protein":[36],"(HPA),":[38],"and":[39,45,52,62,75,95,117,137,158,191,204,231,259,262,284,329],"UALCAN":[40],"to":[41,66,81,308],"analyze":[42],"expression":[44,70,94,133,173,183,270],"promoter":[46],"methylation":[47,115,286],"levels":[48],"33":[50],"tumors":[51,157],"normal":[53,64,180],"samples.":[54],"performed":[56,80],"immunohistochemistry":[57],"(IHC)":[58],"liver":[60,219],"cancer":[61],"corresponding":[63],"tissues":[65],"examine":[67],"protein":[69,172,310],"LIHC.":[72,195,246],"Kaplan-Meier":[73],"survival":[74,206,254],"univariate":[76],"regression":[77,244],"analyses":[78],"were":[79,311],"explore":[82],"pan-cancer":[84],"clinical":[85,96,162,189],"significance":[86],"NCAPD2.":[88,147],"Moreover,":[89],"correlative":[90],"analysis":[91,142,149,317],"between":[92],"characteristics,":[97],"immune":[98,101,103,277,280],"cell":[99,213,278],"infiltration,":[100,279],"checkpoints,":[102,281],"regulators,":[104,116],"tumor":[105],"mutation":[106],"burden":[107],"(TMB),":[108],"microsatellite":[109],"instability":[110],"(MSI),":[111],"ribonucleic":[112],"acid":[113],"(RNA)":[114],"drug":[118],"sensitivity":[119,314],"was":[120,144,153,174,184,237,266,273],"conducted":[121,145],"using":[122,146],"data":[123],"from":[124],"TCGA.":[125],"also":[127],"investigated":[128],"effects":[130],"immunotherapy":[135,298],"efficacy":[136],"prognosis.":[138],"Gene":[139],"set":[140],"enrichment":[141],"(GSEA)":[143],"Bioinformatic":[148],"showed":[150,318],"that":[151,170,252,319],"most":[156,340],"correlated":[159,275],"with":[160,186,276],"characteristics":[163],"cancers.":[166,341],"IHC":[167],"results":[168],"demonstrated":[169,251],"higher":[175],"LIHC":[177,265],"than":[178],"liver.":[181],"linked":[185],"T":[187],"stage,":[188,190],"histologic":[192],"grade":[193,217],"Overexpression":[196],"resulted":[199],"poor":[201],"overall":[202],"survival,":[203],"disease-specific":[205],"adrenocortical":[208],"carcinoma,":[209,214,221],"kidney":[210],"renal":[211],"papillary":[212],"brain":[215],"lower":[216],"glioma,":[218],"hepatocellular":[220],"lung":[222],"adenocarcinoma,":[223,226],"mesothelioma,":[224],"pancreatic":[225],"sarcoma,":[227],"skin":[228],"cutaneous":[229],"melanoma,":[230],"uterine":[232],"corpus":[233],"endometrial":[234],"carcinoma.":[235],"considered":[238],"an":[239],"independent":[240],"biomarker":[241],"by":[242,313],"Cox":[243],"The":[247,269],"time":[248],"ROC":[249],"curve":[250],"rate":[255],"1-,":[257],"3-,":[258],"5-year":[260],"OS":[261],"DSS":[263],"above":[267],"0.6.":[268],"significantly":[274],"TMB,":[282],"MSI,":[283],"RNA":[285],"regulators":[287],"several":[289],"had":[292],"a":[293,335],"high":[294],"predictive":[295],"value":[296],"for":[297],"efficiency":[299],"certain":[301],"In":[303],"our":[304],"study,":[305],"drugs":[306],"sensitive":[307],"screened":[312],"analysis.":[315],"GSEA":[316],"mainly":[321],"participated":[322],"G2M":[325],"checkpoint,":[326],"mitotic":[327],"spindle,":[328],"KRAS-signaling.":[330],"may":[332],"act":[333],"as":[334],"prognostic":[336],"molecular":[337],"marker":[338]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-07-27T00:00:00"}