{"id":"https://openalex.org/W4385264393","doi":"https://doi.org/10.1097/aci.0000000000000932","title":"Ocular involvement in allergic drug reactions","display_name":"Ocular involvement in allergic drug reactions","publication_year":2023,"publication_date":"2023-07-26","ids":{"openalex":"https://openalex.org/W4385264393","doi":"https://doi.org/10.1097/aci.0000000000000932","pmid":"https://pubmed.ncbi.nlm.nih.gov/37493235"},"language":"en","primary_location":{"id":"doi:10.1097/aci.0000000000000932","doi":"https://doi.org/10.1097/aci.0000000000000932","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aci.0000000000000932","pdf_url":null,"source":{"id":"https://openalex.org/S13845130","display_name":"Current Opinion in Allergy and Clinical Immunology","issn_l":"1473-6322","issn":["1473-6322","1528-4050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Allergy & Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007903529","display_name":"Edward Fernandez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Fernandez","raw_affiliation_strings":["Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080985934","display_name":"Elizabeth Jane Phillips","orcid":"https://orcid.org/0000-0002-7623-3383","observed_orcids":["https://orcid.org/0000-0002-7623-3383"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Elizabeth Phillips","raw_affiliation_strings":["Center for Drug Safety and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee","Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Drug Safety and Immunology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043884041","display_name":"Hajirah N. Saeed","orcid":"https://orcid.org/0000-0002-7385-6534","observed_orcids":["https://orcid.org/0000-0002-7385-6534"]},"institutions":[{"id":"https://openalex.org/I1304196042","display_name":"Loyola University Medical Center","ror":"https://ror.org/05xcyt367","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1304196042","https://openalex.org/I1304269903"]},{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]},{"id":"https://openalex.org/I4210159390","display_name":"Loyola Medicine","ror":"https://ror.org/04azs9g49","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210159390"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hajirah N. Saeed","raw_affiliation_strings":["Department of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, Illinois","Department of Ophthalmology, Loyola University Medical Center, Maywood, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Illinois Eye and Ear Infirmary, University of Illinois Chicago, Chicago, Illinois","institution_ids":["https://openalex.org/I39422238"]},{"raw_affiliation_string":"Department of Ophthalmology, Loyola University Medical Center, Maywood, IL, USA","institution_ids":["https://openalex.org/I1304196042","https://openalex.org/I4210159390"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080985934"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"],"apc_list":null,"apc_paid":null,"fwci":0.0505,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.08937198,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"23","issue":"5","first_page":"397","last_page":"408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.09589999914169312,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.06870000064373016,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-drug-reactions","display_name":"allergic drug reactions","score":0.843999981880188},{"id":"https://openalex.org/keywords/ocular-toxicity","display_name":"ocular toxicity","score":0.828000009059906},{"id":"https://openalex.org/keywords/immune-mediated-adverse-drug-reactions","display_name":"immune-mediated adverse drug reactions","score":0.8880000114440918},{"id":"https://openalex.org/keywords/hypersensitivity-mechanisms","display_name":"hypersensitivity mechanisms","score":0.7900000214576721},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ocular-immune-privilege","display_name":"ocular immune privilege","score":0.9679999947547913},{"id":"https://openalex.org/keywords/visual-function-preservation","display_name":"vision preservation","score":0.5},{"id":"https://openalex.org/keywords/ophthalmology","display_name":"ophthalmology","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9203202724456787},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5833299160003662},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4670746624469757},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4380495548248291},{"id":"https://openalex.org/C2780870513","wikidata":"https://www.wikidata.org/wiki/Q471521","display_name":"Allergic conjunctivitis","level":3,"score":0.42236876487731934},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2628972828388214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24411463737487793},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.2202620506286621},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000081028","descriptor_name":"Toxic Optic Neuropathy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005123","descriptor_name":"Eye","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/aci.0000000000000932","doi":"https://doi.org/10.1097/aci.0000000000000932","is_oa":false,"landing_page_url":"https://doi.org/10.1097/aci.0000000000000932","pdf_url":null,"source":{"id":"https://openalex.org/S13845130","display_name":"Current Opinion in Allergy and Clinical Immunology","issn_l":"1473-6322","issn":["1473-6322","1528-4050"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Allergy & Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:37493235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37493235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in allergy and clinical immunology","raw_type":"Review"},{"id":"pmh:oai:alma.61MUN_INST:11195551820007891","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Ocular-involvement-in-allergic-drug-reactions/991005884842507891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5970016102","display_name":"Genetic risk and long-term outcomes associated with Drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in survivors","funder_award_id":"R01HG010863","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000875372","display_name":"Immune-mediated adverse drug reactions to HIV and TB treatments in South Africa: predict, prevent and improve long-term outcomes (IMARI SA study)","funder_award_id":"R01AI152183","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000908289","display_name":"NATIENS: A Phase III Randomized Double Blinded Study to Determine the Mechanisms and Optimal Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis","funder_award_id":"U01AI154659","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W20383355","https://openalex.org/W60551495","https://openalex.org/W1972965443","https://openalex.org/W1974882706","https://openalex.org/W1989533996","https://openalex.org/W1990843593","https://openalex.org/W1993362219","https://openalex.org/W1994236211","https://openalex.org/W1994286102","https://openalex.org/W2002537493","https://openalex.org/W2009600071","https://openalex.org/W2019221616","https://openalex.org/W2024629488","https://openalex.org/W2026240335","https://openalex.org/W2027866275","https://openalex.org/W2031301975","https://openalex.org/W2034770000","https://openalex.org/W2040700547","https://openalex.org/W2042651481","https://openalex.org/W2054935459","https://openalex.org/W2057606496","https://openalex.org/W2059846081","https://openalex.org/W2062356301","https://openalex.org/W2068119665","https://openalex.org/W2071108721","https://openalex.org/W2074305158","https://openalex.org/W2079442841","https://openalex.org/W2083704008","https://openalex.org/W2085402521","https://openalex.org/W2088315838","https://openalex.org/W2095312392","https://openalex.org/W2101763884","https://openalex.org/W2108813293","https://openalex.org/W2109467564","https://openalex.org/W2109696646","https://openalex.org/W2116366533","https://openalex.org/W2125544442","https://openalex.org/W2141779237","https://openalex.org/W2155111125","https://openalex.org/W2156990229","https://openalex.org/W2167280120","https://openalex.org/W2193435616","https://openalex.org/W2261479492","https://openalex.org/W2263975793","https://openalex.org/W2294989188","https://openalex.org/W2316331981","https://openalex.org/W2320992818","https://openalex.org/W2326932338","https://openalex.org/W2330827278","https://openalex.org/W2335651231","https://openalex.org/W2364588516","https://openalex.org/W2415836965","https://openalex.org/W2467925070","https://openalex.org/W2507863689","https://openalex.org/W2509999533","https://openalex.org/W2511306180","https://openalex.org/W2586373514","https://openalex.org/W2609303274","https://openalex.org/W2616423891","https://openalex.org/W2660763961","https://openalex.org/W2765971926","https://openalex.org/W2772067453","https://openalex.org/W2802987970","https://openalex.org/W2804042527","https://openalex.org/W2808727261","https://openalex.org/W2810996417","https://openalex.org/W2841316572","https://openalex.org/W2903686952","https://openalex.org/W2907876292","https://openalex.org/W2912028213","https://openalex.org/W2918950605","https://openalex.org/W2945590213","https://openalex.org/W2961317638","https://openalex.org/W2973122049","https://openalex.org/W2989926876","https://openalex.org/W3006321193","https://openalex.org/W3008393877","https://openalex.org/W3015497943","https://openalex.org/W3027076398","https://openalex.org/W3081059877","https://openalex.org/W3082756308","https://openalex.org/W3093862226","https://openalex.org/W3125862927","https://openalex.org/W3140478808","https://openalex.org/W3167007076","https://openalex.org/W3174921438","https://openalex.org/W3177512260","https://openalex.org/W3184233504","https://openalex.org/W3195102101","https://openalex.org/W3198765778","https://openalex.org/W4205091237","https://openalex.org/W4213316974","https://openalex.org/W4309511016","https://openalex.org/W4310290807","https://openalex.org/W4319459976"],"related_works":["https://openalex.org/W1973642117","https://openalex.org/W2035549101","https://openalex.org/W2155584447","https://openalex.org/W3126948490","https://openalex.org/W2089471795","https://openalex.org/W2024192783","https://openalex.org/W4379880475","https://openalex.org/W4249684403","https://openalex.org/W2790467239","https://openalex.org/W2014055353"],"abstract_inverted_index":{"PURPOSE":[0],"OF":[1],"REVIEW:":[2],"Many":[3],"systemic":[4],"medications":[5,29],"have":[6],"been":[7],"observed":[8],"to":[9,20,51,56,100,119],"cause":[10],"ocular":[11,32,57,71,81,90],"toxicity.":[12,58],"A":[13],"subset":[14],"of":[15,69,80,88,98,109],"these":[16,99],"reactions":[17,44,74],"is":[18,116],"thought":[19],"involve":[21],"immunomodulation":[22],"or":[23],"a":[24],"hypersensitivity":[25,53],"reaction.":[26],"As":[27],"new":[28],"are":[30,35],"developed,":[31],"adverse":[33,72,91],"effects":[34],"becoming":[36],"increasingly":[37],"prevalent.":[38],"Herein":[39],"we":[40],"review":[41],"immune-mediated":[42,70,89],"drug":[43,73,92],"affecting":[45],"they":[46],"eye":[47],"with":[48],"special":[49],"attention":[50],"the":[52,86],"mechanisms":[54,66],"leading":[55],"RECENT":[59],"FINDINGS:":[60],"Recent":[61],"work":[62],"has":[63],"focused":[64],"on":[65],"and":[67,78,104,114,122],"risk":[68],"including":[75],"genetic":[76],"susceptibility":[77],"loss":[79],"immune":[82],"privilege.":[83],"SUMMARY:":[84],"Given":[85],"consequences":[87],"reactions,":[93],"clinicians":[94],"must":[95],"be":[96],"aware":[97],"facilitate":[101],"early":[102],"recognition":[103],"management.":[105],"The":[106],"prompt":[107],"involvement":[108],"an":[110],"ophthalmologist":[111],"for":[112],"diagnosis":[113],"management":[115],"often":[117],"essential":[118],"preserve":[120],"vision":[121],"avoid":[123],"long-term":[124],"morbidity.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-07-27T00:00:00"}