{"id":"https://openalex.org/W4385259555","doi":"https://doi.org/10.1158/1078-0432.c.6758646.v1","title":"Data from CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression","display_name":"Data from CDK4/6-MEK Inhibition in MPNSTs Causes Plasma Cell Infiltration, Sensitization to PD-L1 Blockade, and Tumor Regression","publication_year":2023,"publication_date":"2023-07-25","ids":{"openalex":"https://openalex.org/W4385259555","doi":"https://doi.org/10.1158/1078-0432.c.6758646.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6758646.v1","doi":"https://doi.org/10.1158/1078-0432.c.6758646.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6758646.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6758646.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015791875","display_name":"Jordan L. Kohlmeyer","orcid":"https://orcid.org/0000-0002-1859-5415","observed_orcids":["https://orcid.org/0000-0002-1859-5415"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan L. Kohlmeyer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1859-5415","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007676440","display_name":"Joshua J. Lingo","orcid":"https://orcid.org/0000-0002-4089-9052","observed_orcids":["https://orcid.org/0000-0002-4089-9052"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joshua J. Lingo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4089-9052","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017406323","display_name":"Courtney A. Kaemmer","orcid":"https://orcid.org/0000-0003-0018-3348","observed_orcids":["https://orcid.org/0000-0003-0018-3348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Courtney A. Kaemmer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0018-3348","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009683819","display_name":"Amanda Scherer","orcid":"https://orcid.org/0009-0001-4421-8613","observed_orcids":["https://orcid.org/0009-0001-4421-8613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda Scherer","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-4421-8613","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010768926","display_name":"Akshaya Warrier","orcid":"https://orcid.org/0000-0002-5892-5749","observed_orcids":["https://orcid.org/0000-0002-5892-5749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akshaya Warrier","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5892-5749","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088086063","display_name":"Ellen M. Voigt","orcid":"https://orcid.org/0000-0002-3013-2130","observed_orcids":["https://orcid.org/0000-0002-3013-2130"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ellen Voigt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3013-2130","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068761878","display_name":"Juan A. Raygoza Garay","orcid":"https://orcid.org/0000-0003-4296-4118","observed_orcids":["https://orcid.org/0000-0003-4296-4118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juan A. Raygoza Garay","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4296-4118","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045028741","display_name":"Gavin R. McGivney","orcid":"https://orcid.org/0000-0001-8544-9832","observed_orcids":["https://orcid.org/0000-0001-8544-9832"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gavin R. McGivney","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8544-9832","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018524674","display_name":"Qierra R. Brockman","orcid":"https://orcid.org/0000-0001-8562-4565","observed_orcids":["https://orcid.org/0000-0001-8562-4565"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qierra R. Brockman","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8562-4565","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012087578","display_name":"Amy Tang","orcid":"https://orcid.org/0000-0002-5772-2878","observed_orcids":["https://orcid.org/0000-0002-5772-2878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Tang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5772-2878","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076345776","display_name":"Ana Calizo","orcid":"https://orcid.org/0000-0002-2581-6378","observed_orcids":["https://orcid.org/0000-0002-2581-6378"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ana Calizo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2581-6378","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090607487","display_name":"Kai Pollard","orcid":"https://orcid.org/0000-0002-2778-8884","observed_orcids":["https://orcid.org/0000-0002-2778-8884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Pollard","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2778-8884","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011985957","display_name":"Xiaochun Zhang","orcid":"https://orcid.org/0000-0002-6107-1182","observed_orcids":["https://orcid.org/0000-0002-6107-1182"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaochun Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6107-1182","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036526586","display_name":"Angela C. Hirbe","orcid":"https://orcid.org/0000-0003-1719-0771","observed_orcids":["https://orcid.org/0000-0003-1719-0771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Angela C. Hirbe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1719-0771","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075174884","display_name":"Christine A. Pratilas","orcid":"https://orcid.org/0000-0002-7116-0605","observed_orcids":["https://orcid.org/0000-0002-7116-0605"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine A. Pratilas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7116-0605","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046926172","display_name":"Mariah Leidinger","orcid":"https://orcid.org/0009-0001-6469-334X","observed_orcids":["https://orcid.org/0009-0001-6469-334X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariah Leidinger","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-6469-334X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015683610","display_name":"Patrick John Breheny","orcid":"https://orcid.org/0000-0002-0650-1119","observed_orcids":["https://orcid.org/0000-0002-0650-1119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Breheny","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0650-1119","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052737968","display_name":"Michael S. Chimenti","orcid":"https://orcid.org/0000-0002-4433-9976","observed_orcids":["https://orcid.org/0000-0002-4433-9976"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael S. Chimenti","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4433-9976","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026306257","display_name":"Jessica C. Sieren","orcid":"https://orcid.org/0000-0002-1109-7886","observed_orcids":["https://orcid.org/0000-0002-1109-7886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica C. Sieren","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1109-7886","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074549728","display_name":"Varun Monga","orcid":"https://orcid.org/0000-0002-1185-5448","observed_orcids":["https://orcid.org/0000-0002-1185-5448"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Varun Monga","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1185-5448","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035007884","display_name":"Munir R. Tanas","orcid":"https://orcid.org/0000-0002-6779-2642","observed_orcids":["https://orcid.org/0000-0002-6779-2642"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Munir R. Tanas","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6779-2642","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073793359","display_name":"David Kyle Meyerholz","orcid":"https://orcid.org/0000-0003-1552-3253","observed_orcids":["https://orcid.org/0000-0003-1552-3253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David K. Meyerholz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1552-3253","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061379662","display_name":"Benjamin W. Darbro","orcid":"https://orcid.org/0000-0001-9279-356X","observed_orcids":["https://orcid.org/0000-0001-9279-356X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin W. Darbro","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9279-356X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011523086","display_name":"Rebecca D. Dodd","orcid":"https://orcid.org/0000-0001-7295-1882","observed_orcids":["https://orcid.org/0000-0001-7295-1882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca D. Dodd","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7295-1882","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5088413933","display_name":"Dawn E. Quelle","orcid":"https://orcid.org/0000-0001-8776-0122","observed_orcids":["https://orcid.org/0000-0001-8776-0122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dawn E. Quelle","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8776-0122","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.08219999819993973,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.03959999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/malignant-peripheral-nerve-sheath-tumor","display_name":"malignant peripheral nerve sheath tumor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cdk4-6-inhibition","display_name":"CDK4/6 inhibition","score":0.9520000219345093},{"id":"https://openalex.org/keywords/mek-inhibition","display_name":"MEK inhibition","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pd-l1-blockade","display_name":"PD-L1 blockade","score":0.9300000071525574},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9300000071525574},{"id":"https://openalex.org/keywords/plasma-cell-infiltration","display_name":"plasma cell infiltration","score":0.8140000104904175},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.6959999799728394},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6340000033378601},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.765999972820282},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7408294677734375},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.5842106938362122},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.5019805431365967},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.43020322918891907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42829692363739014},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3666674792766571},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3384387493133545},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.33254849910736084},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.32981908321380615},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26908114552497864},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21471458673477173},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6758646.v1","doi":"https://doi.org/10.1158/1078-0432.c.6758646.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6758646.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6758646.v1","doi":"https://doi.org/10.1158/1078-0432.c.6758646.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6758646.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4383302142","https://openalex.org/W4311194872","https://openalex.org/W7172126328","https://openalex.org/W4402966554","https://openalex.org/W7130706502","https://openalex.org/W6964619956"],"abstract_inverted_index":{"AbstractPurpose:":[0],"Malignant":[1],"peripheral":[2],"nerve":[3],"sheath":[4],"tumors":[5,158,171],"(MPNST)":[6],"are":[7],"lethal,":[8],"Ras-driven":[9],"sarcomas":[10],"that":[11,159],"lack":[12],"effective":[13],"therapies.":[14],"We":[15],"investigated":[16],"effects":[17],"of":[18,55,98,117,131,140,235],"targeting":[19],"cyclin-dependent":[20],"kinases":[21],"4":[22,130],"and":[23,40,50,57,69,88,100,113,151,164,181,215,248],"6":[24],"(CDK4/6),":[25],"MEK,":[26],"and/or":[27],"programmed":[28],"death-ligand":[29],"1":[30],"(PD-L1)":[31],"in":[32,62,129,219,239],"preclinical":[33,227],"MPNST":[34,63,94,118,133,240],"models.":[35],"Experimental":[36],"Design:":[37],"Patient-matched":[38],"MPNSTs":[39,143,191],"precursor":[41],"lesions":[42],"were":[43],"examined":[44],"by":[45],"FISH,":[46],"RNA":[47],"sequencing,":[48],"IHC,":[49],"Connectivity-Map":[51],"analyses.":[52],"Antitumor":[53],"activity":[54,218],"CDK4/6":[56,87,99],"MEK":[58,89,101],"inhibitors":[59,102],"was":[60],"measured":[61],"cell":[64,111,184],"lines,":[65],"patient-derived":[66],"xenografts":[67],"(PDX),":[68],"de":[70,141],"novo":[71,142],"mouse":[72],"MPNSTs,":[73,220],"with":[74,176,198],"the":[75,105],"latter":[76],"used":[77],"to":[78,155,192],"determine":[79],"anti\u2013PD-L1":[80,193,224],"response.":[81],"Results:":[82],"Patient":[83],"tumor":[84,108,127,145,149,183,203],"analyses":[85],"identified":[86],"as":[90,241],"actionable":[91],"targets":[92],"for":[93,232],"therapy.":[95,225],"Low-dose":[96],"combinations":[97],"synergistically":[103],"reactivated":[104],"retinoblastoma":[106],"(RB1)":[107],"suppressor,":[109],"induced":[110],"death,":[112],"decreased":[114],"clonogenic":[115],"survival":[116,153],"cells.":[119],"In":[120,135],"immune-deficient":[121],"mice,":[122,137],"dual":[123],"CDK4/6-MEK":[124,188,206],"inhibition":[125,189,207],"slowed":[126],"growth":[128],"5":[132],"PDXs.":[134],"immunocompetent":[136],"combination":[138],"therapy":[139],"caused":[144],"regression,":[146],"delayed":[147],"resistant":[148],"outgrowth,":[150],"improved":[152,249],"relative":[154],"monotherapies.":[156],"Drug-sensitive":[157],"regressed":[160],"contained":[161],"plasma":[162,211],"cells":[163],"increased":[165,182],"cytotoxic":[166],"T":[167],"cells,":[168],"whereas":[169],"drug-resistant":[170],"adopted":[172],"an":[173],"immunosuppressive":[174],"microenvironment":[175],"elevated":[177],"MHC":[178],"II-low":[179],"macrophages":[180],"PD-L1":[185],"expression.":[186],"Excitingly,":[187],"sensitized":[190],"immune":[194,213],"checkpoint":[195],"blockade":[196],"(ICB)":[197],"some":[199],"mice":[200],"showing":[201],"complete":[202],"regression.":[204],"Conclusions:":[205],"induces":[208],"a":[209],"novel":[210],"cell-associated":[212],"response":[214],"extended":[216],"antitumor":[217,246],"which":[221],"dramatically":[222],"enhances":[223],"These":[226],"findings":[228],"provide":[229],"strong":[230],"rationale":[231],"clinical":[233],"translation":[234],"CDK4/6-MEK-ICB":[236],"targeted":[237],"therapies":[238],"they":[242],"may":[243],"yield":[244],"sustained":[245],"responses":[247],"patient":[250],"outcomes.":[251]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-07-26T00:00:00"}
