{"id":"https://openalex.org/W4385230751","doi":"https://doi.org/10.1111/ans.18629","title":"Palliative resection of the primary tumour improves survival in incurable metastatic colorectal cancer","display_name":"Palliative resection of the primary tumour improves survival in incurable metastatic colorectal cancer","publication_year":2023,"publication_date":"2023-07-25","ids":{"openalex":"https://openalex.org/W4385230751","doi":"https://doi.org/10.1111/ans.18629","pmid":"https://pubmed.ncbi.nlm.nih.gov/37489624"},"language":"en","primary_location":{"id":"doi:10.1111/ans.18629","doi":"https://doi.org/10.1111/ans.18629","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ans.18629","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ans.18629","source":{"id":"https://openalex.org/S40489520","display_name":"ANZ Journal of Surgery","issn_l":"1445-1433","issn":["1445-1433","1445-2197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ANZ Journal of Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ans.18629","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021743337","display_name":"Kamuran Inci","orcid":"https://orcid.org/0000-0003-4366-7254","observed_orcids":["https://orcid.org/0000-0003-4366-7254"]},"institutions":[{"id":"https://openalex.org/I2800527349","display_name":"Varberg Hospital","ror":"https://ror.org/02s0pza74","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2800527349"]},{"id":"https://openalex.org/I4405254354","display_name":"Region Halland","ror":"https://ror.org/01q8csw59","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4405254354"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Kamuran Inci","raw_affiliation_strings":["Department of Surgery, Region Halland, Varberg, Sweden","Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-4366-7254","affiliations":[{"raw_affiliation_string":"Department of Surgery, Region Halland, Varberg, Sweden","institution_ids":["https://openalex.org/I2800527349","https://openalex.org/I4405254354"]},{"raw_affiliation_string":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bengt Nilsson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800527349","display_name":"Varberg Hospital","ror":"https://ror.org/02s0pza74","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2800527349"]},{"id":"https://openalex.org/I4405254354","display_name":"Region Halland","ror":"https://ror.org/01q8csw59","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4405254354"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bengt Nilsson","raw_affiliation_strings":["Department of Surgery, Region Halland, Varberg, Sweden","Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Region Halland, Varberg, Sweden","institution_ids":["https://openalex.org/I2800527349","https://openalex.org/I4405254354"]},{"raw_affiliation_string":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042358106","display_name":"Klara Lyckenblad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800527349","display_name":"Varberg Hospital","ror":"https://ror.org/02s0pza74","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2800527349"]},{"id":"https://openalex.org/I4405254354","display_name":"Region Halland","ror":"https://ror.org/01q8csw59","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4405254354"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Klara Lyckenblad","raw_affiliation_strings":["Department of Surgery Region Halland  Varberg Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery Region Halland  Varberg Sweden","institution_ids":["https://openalex.org/I2800527349","https://openalex.org/I4405254354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030614505","display_name":"STEFAN LINDSKOG","orcid":"https://orcid.org/0000-0001-8055-5003","observed_orcids":["https://orcid.org/0000-0001-8055-5003"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Stefan Lindskog","raw_affiliation_strings":["Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden","Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Department of Surgery, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080787568","display_name":"Daniel Giglio","orcid":"https://orcid.org/0000-0002-1349-9336","observed_orcids":["https://orcid.org/0000-0002-1349-9336"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Daniel Giglio","raw_affiliation_strings":["Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden","Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":"https://orcid.org/0000-0002-1349-9336","affiliations":[{"raw_affiliation_string":"Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Department of Oncology, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021743337"],"corresponding_institution_ids":["https://openalex.org/I2800527349","https://openalex.org/I4405254354","https://openalex.org/I881427289"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":{"value":3550,"currency":"USD","value_usd":3550},"fwci":0.2406,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47422543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"93","issue":"11","first_page":"2680","last_page":"2685"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.7529000043869019,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.24279999732971191,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12064","display_name":"Intraperitoneal and Appendiceal Malignancies","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8870000243186951},{"id":"https://openalex.org/keywords/palliative-surgery","display_name":"palliative surgery","score":0.7459999918937683},{"id":"https://openalex.org/keywords/primary-tumor-resection","display_name":"primary tumor resection","score":0.9900000095367432},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9490000009536743},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9350000023841858},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.8579999804496765},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/carcinoembryonic-antigen","display_name":"carcinoembryonic antigen","score":0.9789999723434448},{"id":"https://openalex.org/keywords/left-sided-colorectal-cancer","display_name":"left-sided colorectal cancer","score":0.8690000176429749},{"id":"https://openalex.org/keywords/palliative-chemotherapy","display_name":"palliative chemotherapy","score":0.9539999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9818304777145386},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.694206714630127},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5487488508224487},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.42999985814094543},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.42575934529304504},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4232063591480255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3971310257911682},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.3578813076019287},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.32205358147621155},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26640257239341736}],"mesh":[{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012004","descriptor_name":"Rectal Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/ans.18629","doi":"https://doi.org/10.1111/ans.18629","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ans.18629","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ans.18629","source":{"id":"https://openalex.org/S40489520","display_name":"ANZ Journal of Surgery","issn_l":"1445-1433","issn":["1445-1433","1445-2197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ANZ Journal of Surgery","raw_type":"journal-article"},{"id":"pmid:37489624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37489624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ANZ journal of surgery","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/ans.18629","doi":"https://doi.org/10.1111/ans.18629","is_oa":true,"landing_page_url":"https://doi.org/10.1111/ans.18629","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/ans.18629","source":{"id":"https://openalex.org/S40489520","display_name":"ANZ Journal of Surgery","issn_l":"1445-1433","issn":["1445-1433","1445-2197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ANZ Journal of Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G8414598210","display_name":null,"funder_award_id":"RFD009","funder_id":"https://openalex.org/F4320326009","funder_display_name":"Region Halland"}],"funders":[{"id":"https://openalex.org/F4320323421","display_name":"G\u00f6teborgs Universitet","ror":"https://ror.org/01tm6cn81"},{"id":"https://openalex.org/F4320326009","display_name":"Region Halland","ror":"https://ror.org/01q8csw59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385230751.pdf","grobid_xml":"https://content.openalex.org/works/W4385230751.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1969827599","https://openalex.org/W1986030136","https://openalex.org/W2025145463","https://openalex.org/W2032341267","https://openalex.org/W2076886613","https://openalex.org/W2086981332","https://openalex.org/W2113029107","https://openalex.org/W2118971132","https://openalex.org/W2157463323","https://openalex.org/W2158981462","https://openalex.org/W2163875836","https://openalex.org/W2277975170","https://openalex.org/W2294243512","https://openalex.org/W2461057589","https://openalex.org/W2531319683","https://openalex.org/W2613762037","https://openalex.org/W2744084279","https://openalex.org/W2790124447","https://openalex.org/W2810705969","https://openalex.org/W2866982694","https://openalex.org/W2889646458","https://openalex.org/W2912909642","https://openalex.org/W2914899520","https://openalex.org/W2926443132","https://openalex.org/W2939215161","https://openalex.org/W2995971344","https://openalex.org/W3000166603","https://openalex.org/W3049692526","https://openalex.org/W3104370917","https://openalex.org/W3111631690","https://openalex.org/W3128475185","https://openalex.org/W3202442063","https://openalex.org/W4220757622","https://openalex.org/W4232388779"],"related_works":["https://openalex.org/W2215781426","https://openalex.org/W2886631114","https://openalex.org/W1986030136","https://openalex.org/W2589928042","https://openalex.org/W2810705969","https://openalex.org/W2156226733","https://openalex.org/W2470085345","https://openalex.org/W3104370917","https://openalex.org/W2584763111","https://openalex.org/W2807670400"],"abstract_inverted_index":{"BACKGROUND:":[0],"Studies":[1],"show":[2],"conflicting":[3],"results":[4],"on":[5,33,196],"whether":[6],"primary":[7],"tumour":[8],"resection":[9],"(PTR)":[10],"in":[11,37,54,131,146,202],"metastatic":[12,112],"colorectal":[13],"cancer":[14],"(mCRC)":[15],"prolongs":[16],"survival.":[17],"The":[18,68,82],"aim":[19],"of":[20,31],"this":[21,42],"study":[22,188],"was":[23,85,95,129,142,156,208],"to":[24,76,87,97,210],"analyse":[25],"prognostic":[26,215],"factors":[27,46,78,99,216],"and":[28,50,66,71,117,140,165,177,198],"the":[29,147,162,171],"effects":[30],"PTR":[32,49,105,136,141,163,191,207],"overall":[34],"survival":[35],"(OS)":[36],"mCRC":[38,56,59,133,212],"patients.":[39],"METHODS:":[40],"In":[41],"population-based":[43],"cohort":[44],"study,":[45],"associated":[47,79,182,217],"with":[48,58,61,80,183,214,218],"OS":[51,128,155,197],"were":[52,74,180],"assessed":[53],"188":[55],"patients":[57,124,134,203,213],"treated":[60],"palliative":[62,132,211],"chemotherapy":[63],"between":[64],"2008":[65],"2019.":[67],"Chi-square":[69],"test":[70,84],"Mann-Whitney":[72],"U-test":[73],"used":[75,86,96],"assess":[77],"PTR.":[81,127],"log-rank":[83],"compare":[88],"Kaplan-Meier":[89],"estimates":[90],"for":[91,161,170,205],"OS.":[92,101],"Cox":[93,148],"regression":[94,149],"identify":[98],"predicting":[100],"RESULTS:":[102],"Patients":[103],"undergoing":[104,126,135],"had":[106,120,192],"significantly":[107,181],"better":[108,219],"performance":[109,175],"status,":[110],"fewer":[111],"sites,":[113],"lower":[114],"CEA":[115],"levels,":[116],"more":[118],"often":[119],"left-sided":[121],"CRC":[122],"than":[123],"not":[125],"longer":[130],"(P":[137,151],"<":[138,152],"0.01)":[139],"an":[143],"independent":[144],"variable":[145],"analysis":[150],"0.05).":[153],"Median":[154],"22.9":[157],"\u00b1":[158,167],"1.9":[159],"months":[160,169],"group":[164],"14.5":[166],"1.5":[168],"non-operated":[172],"group.":[173],"Poor":[174],"status":[176],"liver":[178],"metastases":[179],"poor":[184],"prognosis.":[185,220],"CONCLUSION:":[186],"This":[187],"shows":[189],"that":[190],"a":[193],"positive":[194],"effect":[195],"may":[199],"be":[200],"considered":[201],"suitable":[204],"surgery.":[206],"offered":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-07-26T00:00:00"}