{"id":"https://openalex.org/W4385225554","doi":"https://doi.org/10.21203/rs.3.rs-3117826/v1","title":"Normalization of Gene Expression for Acute Leukemia Studies: Selecting a Set of Endogenous Genes Control","display_name":"Normalization of Gene Expression for Acute Leukemia Studies: Selecting a Set of Endogenous Genes Control","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4385225554","doi":"https://doi.org/10.21203/rs.3.rs-3117826/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-3117826/v1","doi":"https://doi.org/10.21203/rs.3.rs-3117826/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3117826/v1","pdf_url":"https://www.researchsquare.com/article/rs-3117826/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3117826/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059931486","display_name":"Fl\u00e1via Melo Cunha de Pinho Pessoa","orcid":"https://orcid.org/0000-0002-8432-4760","observed_orcids":["https://orcid.org/0000-0002-8432-4760"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fl\u00e1via Melo Cunha de Pinho Pessoa","raw_affiliation_strings":["Federal University of Cear\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Cear\u00e1","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012998655","display_name":"Vit\u00f3ria Beatriz de Jesus Viana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Vit\u00f3ria Beatriz de Jesus Viana","raw_affiliation_strings":["Federal University of Par\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Par\u00e1","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076160452","display_name":"Marcelo Braga de Oliveira","orcid":"https://orcid.org/0000-0002-5114-6099","observed_orcids":["https://orcid.org/0000-0002-5114-6099"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo Braga Oliveira","raw_affiliation_strings":["Federal University of Par\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Par\u00e1","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044939438","display_name":"Rodrigo Monteiro Ribeiro","orcid":"https://orcid.org/0009-0007-0794-4337","observed_orcids":["https://orcid.org/0009-0007-0794-4337"]},"institutions":[{"id":"https://openalex.org/I4210165349","display_name":"Hospital Geral de Fortaleza","ror":"https://ror.org/05megpp22","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210165349"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rodrigo Monteiro Ribeiro","raw_affiliation_strings":["Fortaleza General Hospital (HGF)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortaleza General Hospital (HGF)","institution_ids":["https://openalex.org/I4210165349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090364647","display_name":"Deivide de Sousa Oliveira","orcid":"https://orcid.org/0000-0001-8630-3739","observed_orcids":["https://orcid.org/0000-0001-8630-3739"]},"institutions":[{"id":"https://openalex.org/I4210165349","display_name":"Hospital Geral de Fortaleza","ror":"https://ror.org/05megpp22","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210165349"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Deivide Sousa Oliveira","raw_affiliation_strings":["Fortaleza General Hospital (HGF)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fortaleza General Hospital (HGF)","institution_ids":["https://openalex.org/I4210165349"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076156820","display_name":"Germison Silva Lopes","orcid":"https://orcid.org/0000-0002-7125-5620","observed_orcids":["https://orcid.org/0000-0002-7125-5620"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Germison Silva Lopes","raw_affiliation_strings":["C\u00e9sar Cals General Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C\u00e9sar Cals General Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080960242","display_name":"Manoel Odorico Moraes Filho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Manoel Odorico Moraes Filho","raw_affiliation_strings":["Federal University of Cear\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Cear\u00e1","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020764857","display_name":"Maria Elisabete Amaral de Moraes","orcid":"https://orcid.org/0000-0002-6826-8930","observed_orcids":["https://orcid.org/0000-0002-6826-8930","https://orcid.org/0000-0002-8449-6677"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Elisabete Amaral Moraes","raw_affiliation_strings":["Federal University of Cear\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Cear\u00e1","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006136258","display_name":"Raquel Carvalho Montenegro","orcid":"https://orcid.org/0000-0002-3861-293X","observed_orcids":["https://orcid.org/0000-0002-3861-293X"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Raquel Carvalho Montenegro","raw_affiliation_strings":["Federal University of Cear\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Cear\u00e1","institution_ids":["https://openalex.org/I243754102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039089774","display_name":"Fabiano Cordeiro Moreira","orcid":"https://orcid.org/0000-0002-2799-3546","observed_orcids":["https://orcid.org/0000-0002-2799-3546"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fabiano Cordeiro Moreira","raw_affiliation_strings":["Federal University of Par\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Par\u00e1","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058996435","display_name":"Andr\u00e9 Salim Khayat","orcid":"https://orcid.org/0000-0002-3451-6369","observed_orcids":["https://orcid.org/0000-0002-3451-6369"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Salim Khayat","raw_affiliation_strings":["Federal University of Par\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Par\u00e1","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026940372","display_name":"Caroline Aquino Moreira-Nunes","orcid":"https://orcid.org/0000-0001-5845-3481","observed_orcids":["https://orcid.org/0000-0001-5845-3481"]},"institutions":[{"id":"https://openalex.org/I243754102","display_name":"Universidade Federal do Cear\u00e1","ror":"https://ror.org/03srtnf24","country_code":"BR","type":"education","lineage":["https://openalex.org/I243754102"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Caroline Aquino Moreira-Nunes","raw_affiliation_strings":["Federal University of Cear\u00e1"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal University of Cear\u00e1","institution_ids":["https://openalex.org/I243754102"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026940372"],"corresponding_institution_ids":["https://openalex.org/I243754102"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reference-genes","display_name":"reference genes","score":0.8859999775886536},{"id":"https://openalex.org/keywords/endogenous-control-genes","display_name":"endogenous control genes","score":0.7760000228881836},{"id":"https://openalex.org/keywords/gene-expression-normalization","display_name":"gene expression normalization","score":0.9620000123977661},{"id":"https://openalex.org/keywords/acute-leukemia","display_name":"acute leukemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/reference-gene-stability","display_name":"reference gene stability","score":0.8399999737739563},{"id":"https://openalex.org/keywords/beta-actin","display_name":"beta-actin","score":0.8529999852180481},{"id":"https://openalex.org/keywords/abl","display_name":"ABL","score":0.9620000123977661},{"id":"https://openalex.org/keywords/tata-binding-protein","display_name":"TATA-binding protein","score":0.8550000190734863},{"id":"https://openalex.org/keywords/rplp0","display_name":"RPLP0","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase","display_name":"glyceraldehyde-3-phosphate dehydrogenase","score":0.996999979019165},{"id":"https://openalex.org/keywords/hypoxanthine-guanine-phosphoribosyltransferase","display_name":"hypoxanthine-guanine phosphoribosyltransferase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/normfinder","display_name":"NormFinder","score":0.7089999914169312},{"id":"https://openalex.org/keywords/genorm","display_name":"geNorm","score":0.8560000061988831},{"id":"https://openalex.org/keywords/peripheral-blood","display_name":"peripheral blood","score":0.7670000195503235},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":1.0}],"concepts":[{"id":"https://openalex.org/C2779148672","wikidata":"https://www.wikidata.org/wiki/Q25326537","display_name":"Reference genes","level":4,"score":0.9297447800636292},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6913663148880005},{"id":"https://openalex.org/C134792803","wikidata":"https://www.wikidata.org/wiki/Q424886","display_name":"Glyceraldehyde 3-phosphate dehydrogenase","level":4,"score":0.6250933408737183},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.589160144329071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5565532445907593},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5462242960929871},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.50526362657547},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.47042012214660645},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46646130084991455},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4624820649623871},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.44476988911628723},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4411279559135437},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.42714235186576843},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34760111570358276},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1807231605052948},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07764327526092529},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06617337465286255},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-3117826/v1","doi":"https://doi.org/10.21203/rs.3.rs-3117826/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3117826/v1","pdf_url":"https://www.researchsquare.com/article/rs-3117826/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3117826/v1","doi":"https://doi.org/10.21203/rs.3.rs-3117826/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3117826/v1","pdf_url":"https://www.researchsquare.com/article/rs-3117826/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320323202","display_name":"Funda\u00e7\u00e3o Cearense de Apoio ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/007pgtp80"},{"id":"https://openalex.org/F4320324376","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818"},{"id":"https://openalex.org/F4320334115","display_name":"Pr\u00f3-Reitoria de Pesquisa e P\u00f3s-Gradua\u00e7\u00e3o, Universidade Federal do Par\u00e1","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385225554.pdf","grobid_xml":"https://content.openalex.org/works/W4385225554.grobid-xml"},"referenced_works_count":89,"referenced_works":["https://openalex.org/W1572270798","https://openalex.org/W1572867882","https://openalex.org/W1577577364","https://openalex.org/W1894380633","https://openalex.org/W1953379078","https://openalex.org/W1963740134","https://openalex.org/W1967946848","https://openalex.org/W1970843634","https://openalex.org/W1971025107","https://openalex.org/W1979518586","https://openalex.org/W1979822119","https://openalex.org/W1979975126","https://openalex.org/W1982060052","https://openalex.org/W1986080495","https://openalex.org/W1989310128","https://openalex.org/W1989457658","https://openalex.org/W1991814173","https://openalex.org/W2000944914","https://openalex.org/W2002904896","https://openalex.org/W2008083733","https://openalex.org/W2009467250","https://openalex.org/W2009638710","https://openalex.org/W2012977035","https://openalex.org/W2014066134","https://openalex.org/W2014368589","https://openalex.org/W2022440848","https://openalex.org/W2027776732","https://openalex.org/W2043586699","https://openalex.org/W2046424438","https://openalex.org/W2049619530","https://openalex.org/W2052799891","https://openalex.org/W2056220590","https://openalex.org/W2059491580","https://openalex.org/W2070068513","https://openalex.org/W2073869597","https://openalex.org/W2084397515","https://openalex.org/W2088556112","https://openalex.org/W2098161480","https://openalex.org/W2099050424","https://openalex.org/W2099249565","https://openalex.org/W2099824652","https://openalex.org/W2103712182","https://openalex.org/W2105423509","https://openalex.org/W2107277218","https://openalex.org/W2110885661","https://openalex.org/W2112982595","https://openalex.org/W2115093096","https://openalex.org/W2115894077","https://openalex.org/W2124308944","https://openalex.org/W2124615737","https://openalex.org/W2126482035","https://openalex.org/W2126835198","https://openalex.org/W2127535576","https://openalex.org/W2128443399","https://openalex.org/W2129717778","https://openalex.org/W2133900563","https://openalex.org/W2133950005","https://openalex.org/W2135035785","https://openalex.org/W2138581811","https://openalex.org/W2139016888","https://openalex.org/W2149896049","https://openalex.org/W2151354028","https://openalex.org/W2152544605","https://openalex.org/W2152813678","https://openalex.org/W2156384838","https://openalex.org/W2156683104","https://openalex.org/W2157157037","https://openalex.org/W2158003869","https://openalex.org/W2166642834","https://openalex.org/W2168420558","https://openalex.org/W2271925893","https://openalex.org/W2277711614","https://openalex.org/W2336183819","https://openalex.org/W2395717214","https://openalex.org/W2465137285","https://openalex.org/W2594411204","https://openalex.org/W2754132491","https://openalex.org/W2759385754","https://openalex.org/W2767334499","https://openalex.org/W2915325169","https://openalex.org/W2945894038","https://openalex.org/W2966069078","https://openalex.org/W3027517636","https://openalex.org/W3028145661","https://openalex.org/W3197498361","https://openalex.org/W4200363889","https://openalex.org/W4211063020","https://openalex.org/W4231297009","https://openalex.org/W4291824965"],"related_works":["https://openalex.org/W4391174219","https://openalex.org/W4387748192","https://openalex.org/W2126385616","https://openalex.org/W2347368448","https://openalex.org/W4390499369","https://openalex.org/W3008630173","https://openalex.org/W2271925893","https://openalex.org/W1984301590","https://openalex.org/W2593637774","https://openalex.org/W7096092074"],"abstract_inverted_index":{"Abstract":[0],"Reference":[1],"genes":[2,48,74,126],"are":[3,17],"used":[4,50],"as":[5,51,131,163],"internal":[6],"reaction":[7],"control":[8],"for":[9,14,38,58,161,165],"gene":[10,37,169],"expression":[11,170],"analysis":[12,40,59,93,167],"and":[13,20,67,87,108,113,124,143,174,190],"this":[15,91,154],"they":[16,137],"considered":[18],"reliable":[19],"must":[21],"meet":[22],"several":[23],"important":[24],"criteria.":[25],"In":[26],"view":[27],"of":[28,31,41,47,60,71,82,168],"the":[29,34,39,56,100,117,122,157,166,186],"absence":[30],"studies":[32],"regarding":[33],"best":[35],"reference":[36,73,133],"acute":[42,181],"leukemia":[43],"patients,":[44],"a":[45,139],"panel":[46],"commonly":[49],"endogenous":[52,101,159],"was":[53,75,95],"selected":[54],"from":[55,178],"literature":[57],"stability:":[61],"GAPDH,":[62],"ABL,":[63,106,188],"HPRT1,":[64],"RPLP0,":[65],"ACTB":[66],"TBP.":[68],"The":[69],"stability":[70],"candidate":[72],"analyzed":[76,118],"according":[77],"to":[78,97],"four":[79],"statistical":[80],"methods":[81],"assessment,":[83],"namely,":[84],"NormFinder,":[85],"GeNorm":[86],"R":[88],"software.":[89],"From":[90],"study\u2019s":[92],"it":[94],"possible":[96],"identify":[98],"that":[99,136],"set":[102,160],"composed":[103,184],"by":[104,185],"ACTB,":[105,187],"TBP":[107,189],"RPLPO":[109,191],"demonstrated":[110],"good":[111,132],"performances":[112],"stable":[114],"expressions":[115],"between":[116,146],"groups.":[119],"Besides":[120],"that,":[121],"GAPDH":[123],"HPRT":[125],"could":[127],"not":[128],"be":[129],"classified":[130],"genes,":[134],"considering":[135],"presented":[138],"high":[140],"standard":[141],"deviation":[142],"great":[144],"variability":[145],"groups,":[147],"indicating":[148],"low":[149],"stability.":[150],"Given":[151],"these":[152],"findings,":[153],"study":[155],"suggests":[156],"main":[158],"use":[162],"control/reference":[164],"in":[171],"peripheral":[172],"blood":[173],"bone":[175],"marrow":[176],"samples":[177],"patients":[179],"with":[180],"leukemias,":[182],"is":[183],"genes.":[192]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-07-25T00:00:00"}