{"id":"https://openalex.org/W4385216504","doi":"https://doi.org/10.1016/j.tcsw.2023.100110","title":"Strain and temperature dependent aggregation of Candida auris is attenuated by inhibition of surface amyloid proteins","display_name":"Strain and temperature dependent aggregation of Candida auris is attenuated by inhibition of surface amyloid proteins","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4385216504","doi":"https://doi.org/10.1016/j.tcsw.2023.100110","pmid":"https://pubmed.ncbi.nlm.nih.gov/37559873","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10407437"},"language":"en","primary_location":{"id":"doi:10.1016/j.tcsw.2023.100110","doi":"https://doi.org/10.1016/j.tcsw.2023.100110","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tcsw.2023.100110","pdf_url":null,"source":{"id":"https://openalex.org/S2898553572","display_name":"The Cell Surface","issn_l":"2468-2330","issn":["2468-2330"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cell Surface","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.tcsw.2023.100110","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011380786","display_name":"Dhara Malavia","orcid":"https://orcid.org/0000-0001-8981-7372","observed_orcids":["https://orcid.org/0000-0001-8981-7372"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Dhara Malavia-Jones","raw_affiliation_strings":["MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803","https://openalex.org/I4387153154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080533196","display_name":"Rhys A. Farrer","orcid":"https://orcid.org/0000-0001-8456-7458","observed_orcids":["https://orcid.org/0000-0001-8456-7458","https://orcid.org/0000-0002-3710-9881"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rhys A. Farrer","raw_affiliation_strings":["MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803","https://openalex.org/I4387153154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040835246","display_name":"Mark H. T. Stappers","orcid":"https://orcid.org/0000-0003-4154-7160","observed_orcids":["https://orcid.org/0000-0003-4154-7160"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark H.T. Stappers","raw_affiliation_strings":["MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803","https://openalex.org/I4387153154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019475828","display_name":"Matt B. Edmondson","orcid":"https://orcid.org/0000-0002-9782-6751","observed_orcids":["https://orcid.org/0000-0002-9782-6751"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Matt B. Edmondson","raw_affiliation_strings":["MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803","https://openalex.org/I4387153154"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062892359","display_name":"Andrew M. Borman","orcid":"https://orcid.org/0000-0003-0585-5721","observed_orcids":["https://orcid.org/0000-0003-0585-5721","https://orcid.org/0000-0003-1563-0358"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2801253297","display_name":"Southmead Hospital","ror":"https://ror.org/05d576879","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801253297","https://openalex.org/I4405276282"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew M. Borman","raw_affiliation_strings":["MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK","UKHSA Mycology Reference Laboratory, National Infection Services, UKHSA South West Laboratory, Science Quarter, Southmead Hospital, Bristol BS10 5NB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803","https://openalex.org/I4387153154"]},{"raw_affiliation_string":"UKHSA Mycology Reference Laboratory, National Infection Services, UKHSA South West Laboratory, Science Quarter, Southmead Hospital, Bristol BS10 5NB, UK","institution_ids":["https://openalex.org/I2801253297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014003209","display_name":"Elizabeth M. Johnson","orcid":"https://orcid.org/0000-0003-3100-6969","observed_orcids":["https://orcid.org/0000-0003-3100-6969"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I2801253297","display_name":"Southmead Hospital","ror":"https://ror.org/05d576879","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801253297","https://openalex.org/I4405276282"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth M. Johnson","raw_affiliation_strings":["MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK","UKHSA Mycology Reference Laboratory, National Infection Services, UKHSA South West Laboratory, Science Quarter, Southmead Hospital, Bristol BS10 5NB, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803","https://openalex.org/I4387153154"]},{"raw_affiliation_string":"UKHSA Mycology Reference Laboratory, National Infection Services, UKHSA South West Laboratory, Science Quarter, Southmead Hospital, Bristol BS10 5NB, UK","institution_ids":["https://openalex.org/I2801253297"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017775850","display_name":"Peter N. Lipke","orcid":"https://orcid.org/0000-0003-1733-0690","observed_orcids":["https://orcid.org/0000-0003-1733-0690"]},"institutions":[{"id":"https://openalex.org/I174216632","display_name":"City University of New York","ror":"https://ror.org/00453a208","country_code":"US","type":"education","lineage":["https://openalex.org/I174216632"]},{"id":"https://openalex.org/I83041322","display_name":"Brooklyn College","ror":"https://ror.org/019k4jq75","country_code":"US","type":"education","lineage":["https://openalex.org/I83041322"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter N. Lipke","raw_affiliation_strings":["Biology Department, Brooklyn College of City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biology Department, Brooklyn College of City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA","institution_ids":["https://openalex.org/I174216632","https://openalex.org/I83041322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008227126","display_name":"Neil A. R. Gow","orcid":"https://orcid.org/0000-0002-2776-5850","observed_orcids":["https://orcid.org/0000-0002-2776-5850"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]},{"id":"https://openalex.org/I4387153154","display_name":"MRC Centre for Medical Mycology","ror":"https://ror.org/00vbzva31","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803","https://openalex.org/I4210087105","https://openalex.org/I4387153154","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Neil A.R. Gow","raw_affiliation_strings":["MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK"],"raw_orcid":"https://orcid.org/0000-0002-2776-5850","affiliations":[{"raw_affiliation_string":"MRC Centre for Medical Mycology, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK","institution_ids":["https://openalex.org/I23923803","https://openalex.org/I4387153154"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008227126","https://openalex.org/A5011380786"],"corresponding_institution_ids":["https://openalex.org/I23923803","https://openalex.org/I4387153154"],"apc_list":{"value":2280,"currency":"USD","value_usd":2280},"apc_paid":{"value":2280,"currency":"USD","value_usd":2280},"fwci":5.8226,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.97422695,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"10","issue":null,"first_page":"100110","last_page":"100110"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.20469999313354492,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-auris","display_name":"Candida auris","score":1.0},{"id":"https://openalex.org/keywords/cell-aggregation","display_name":"cell aggregation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/thioflavin-t","display_name":"thioflavin T","score":0.9739999771118164},{"id":"https://openalex.org/keywords/extracellular-matrix-production","display_name":"extracellular matrix synthesis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/chitin-synthase","display_name":"chitin synthase","score":0.8970000147819519},{"id":"https://openalex.org/keywords/chitinase","display_name":"chitinase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/gpi-anchored-proteins","display_name":"GPI-anchored proteins","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cell-surface-proteins","display_name":"cell surface proteins","score":0.5289999842643738},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.6129999756813049},{"id":"https://openalex.org/keywords/strain-differences","display_name":"strain differences","score":0.5929999947547913},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.6190000176429749},{"id":"https://openalex.org/keywords/cell-isolation","display_name":"cell isolation","score":0.4860000014305115},{"id":"https://openalex.org/keywords/cell-surface-hydrophobicity","display_name":"cell surface hydrophobicity","score":0.6880000233650208},{"id":"https://openalex.org/keywords/surface-charge","display_name":"surface charge","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2909786013","wikidata":"https://www.wikidata.org/wiki/Q26816853","display_name":"Candida auris","level":3,"score":0.8423442840576172},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5508227944374084},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5494871735572815},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.5479032397270203},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5238770842552185},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.4516054391860962},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3371862769126892},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32140570878982544},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.23498597741127014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23391154408454895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15489310026168823},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12094110250473022},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.09408432245254517},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.05869483947753906},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.tcsw.2023.100110","doi":"https://doi.org/10.1016/j.tcsw.2023.100110","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tcsw.2023.100110","pdf_url":null,"source":{"id":"https://openalex.org/S2898553572","display_name":"The Cell Surface","issn_l":"2468-2330","issn":["2468-2330"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cell Surface","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.4456806","doi":"https://doi.org/10.2139/ssrn.4456806","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.4456806","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"doi:10.1101/2023.05.09.540062","doi":"https://doi.org/10.1101/2023.05.09.540062","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.05.09.540062","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/05/09/2023.05.09.540062.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10407437","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10407437","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Surf","raw_type":"Text"},{"id":"pmid:37559873","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37559873","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell surface (Amsterdam, Netherlands)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:474986532a0e407591e01236194ffe25","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/474986532a0e407591e01236194ffe25","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Cell Surface, Vol 10, Iss , Pp 100110- (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.tcsw.2023.100110","doi":"https://doi.org/10.1016/j.tcsw.2023.100110","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.tcsw.2023.100110","pdf_url":null,"source":{"id":"https://openalex.org/S2898553572","display_name":"The Cell Surface","issn_l":"2468-2330","issn":["2468-2330"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Cell Surface","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1082060630","display_name":null,"funder_award_id":"225303/Z/22/Z","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G2643330585","display_name":"MRC Centre for Medical Mycology","funder_award_id":"MR/N006364/2","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3042134689","display_name":"Targeting a new kingdom: the nature and significance of Type VI secretion system-mediated anti-fungal activity","funder_award_id":"215599","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G3945503679","display_name":"Mechanistic insights into fungal pathogenicity and drug resistance using a novel lineage of Cryptococcus","funder_award_id":"225303/Z/22/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G467776361","display_name":"Making and breaking the cell walls of fungal pathogens.","funder_award_id":"101873","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G513848445","display_name":"From \u2018molecular pattern\u2019 to ligand structure and function \u2013 the origins of antifungal immunity","funder_award_id":"224323","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G5257130269","display_name":"IMPACT OF FUNGAL ADAPTATION UPON HOST RECOGNITION AND PATHOGENESIS","funder_award_id":"MR/M026663/2","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7975206854","display_name":"IMPACT OF FUNGAL ADAPTATION UPON HOST RECOGNITION AND PATHOGENESIS","funder_award_id":"MR/M026663/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8071514546","display_name":"Medical Research Council Centre for Medical Mycology","funder_award_id":"MR/V033417/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8303135053","display_name":"Genetic and chemical validation of sugar nucleotide biosynthesis as a target against Candida albicans","funder_award_id":"200208","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320336039","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639"},{"id":"https://openalex.org/F4320336903","display_name":"NIHR Leicester Biomedical Research Centre","ror":"https://ror.org/05xqxa525"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385216504.pdf","grobid_xml":"https://content.openalex.org/works/W4385216504.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W152757858","https://openalex.org/W1558671359","https://openalex.org/W1582560245","https://openalex.org/W1821298691","https://openalex.org/W1967864456","https://openalex.org/W1981427275","https://openalex.org/W1981832826","https://openalex.org/W1987095367","https://openalex.org/W1997437177","https://openalex.org/W2002379595","https://openalex.org/W2018475805","https://openalex.org/W2028042667","https://openalex.org/W2038138901","https://openalex.org/W2047067218","https://openalex.org/W2056848681","https://openalex.org/W2066976786","https://openalex.org/W2067631595","https://openalex.org/W2074079723","https://openalex.org/W2085808820","https://openalex.org/W2094201044","https://openalex.org/W2095680943","https://openalex.org/W2101131499","https://openalex.org/W2102387530","https://openalex.org/W2105033070","https://openalex.org/W2106053424","https://openalex.org/W2108234281","https://openalex.org/W2108344673","https://openalex.org/W2110335151","https://openalex.org/W2115011276","https://openalex.org/W2118142980","https://openalex.org/W2119180969","https://openalex.org/W2124380402","https://openalex.org/W2126597545","https://openalex.org/W2127616142","https://openalex.org/W2127988357","https://openalex.org/W2131846628","https://openalex.org/W2133416815","https://openalex.org/W2141816565","https://openalex.org/W2149855980","https://openalex.org/W2164762330","https://openalex.org/W2165823335","https://openalex.org/W2168696662","https://openalex.org/W2169594819","https://openalex.org/W2514801655","https://openalex.org/W2536287248","https://openalex.org/W2572527541","https://openalex.org/W2619093518","https://openalex.org/W2624308185","https://openalex.org/W2770387075","https://openalex.org/W2794692961","https://openalex.org/W2811231377","https://openalex.org/W2885246726","https://openalex.org/W2900853140","https://openalex.org/W2903177545","https://openalex.org/W2922422721","https://openalex.org/W2950095546","https://openalex.org/W2951867871","https://openalex.org/W2953431223","https://openalex.org/W2956528092","https://openalex.org/W3004023244","https://openalex.org/W3016937378","https://openalex.org/W3020256411","https://openalex.org/W3031864352","https://openalex.org/W3037529309","https://openalex.org/W3130607038","https://openalex.org/W3132382281","https://openalex.org/W3154722708","https://openalex.org/W3157351997","https://openalex.org/W3192245350","https://openalex.org/W3199548440","https://openalex.org/W4225337568","https://openalex.org/W4226498213","https://openalex.org/W4232655037","https://openalex.org/W4306878780","https://openalex.org/W4324020291","https://openalex.org/W4392639057","https://openalex.org/W6793473994"],"related_works":["https://openalex.org/W4392639057","https://openalex.org/W4385344302","https://openalex.org/W4322576973","https://openalex.org/W4324020291","https://openalex.org/W2947537849","https://openalex.org/W4398230340","https://openalex.org/W3037529309","https://openalex.org/W4403769442","https://openalex.org/W4225337568","https://openalex.org/W2892374734"],"abstract_inverted_index":{"ABSTRACT":[0],"Candida":[1],"auris":[2,255,279],"is":[3,223],"a":[4,13,75,224],"multi-drug":[5],"resistant":[6,23],"human":[7,17],"fungal":[8],"pathogen":[9],"that":[10,41,221,231],"has":[11,54],"become":[12],"global":[14],"threat":[15],"to":[16,20,34,161,213,237,240],"health":[18],"due":[19],"its":[21],"drug":[22],"phenotype,":[24],"persistence":[25],"in":[26,58,98,112,129,134,145,150,199,235,264],"the":[27,44,113,118,123,184,200,211,238],"hospital":[28],"environment":[29],"and":[30,79,108,115,138,158,170,181,227,244,274],"propensity":[31],"for":[32,156,159],"patient":[33,35],"spread.":[36],"Isolates":[37],"display":[38],"variable":[39],"aggregation":[40,157,169,222],"may":[42,232],"affect":[43],"relative":[45],"virulence":[46],"of":[47,51,72,81,92,105,117,122,203,277,290],"strains.":[48,100],"Therefore,":[49],"dissection":[50],"this":[52],"phenotype":[53,78],"gained":[55],"substantial":[56],"interest":[57],"recent":[59],"years.":[60],"We":[61],"studied":[62],"eight":[63],"clinical":[64],"isolates":[65,258],"from":[66],"four":[67,71,80],"different":[68],"clades":[69],"(I-IV);":[70],"which":[73,82],"had":[74],"strongly":[76,272],"aggregating":[77,135,140,273],"did":[83,142,282],"not.":[84],"Genome":[85,192],"analysis":[86,193],"identified":[87,103,270],"polymorphisms":[88],"associated":[89],"with":[90,183,210,285],"loss":[91],"cell":[93,132,151,245,265],"surface":[94,147,152,246,286],"proteins":[95,205],"were":[96,164,174,269],"enriched":[97],"weakly-aggregating":[99,275],"Additionally,":[101],"we":[102],"down-regulation":[104],"chitin":[106],"synthase":[107],"chitinase":[109],"genes":[110,209],"involved":[111],"synthesis":[114],"dissolution":[116],"chitinous":[119],"septum.":[120],"Characterisation":[121],"cells":[124],"revealed":[125],"no":[126],"ultrastructural":[127],"defects":[128,263],"cytokinesis":[130],"or":[131,149,288],"separation":[133],"isolates.":[136],"Strongly":[137],"weakly":[139],"strains":[141,276],"not":[143,166,260,283],"differ":[144],"net":[146],"charge":[148,287],"hydrophobicity.":[153],"The":[154,249],"capacity":[155],"adhesion":[160],"polystyrene":[162],"microspheres":[163],"also":[165],"correlated.":[167],"However,":[168],"extracellular":[171,242],"matrix":[172,243],"formation":[173],"all":[175],"increased":[176],"at":[177],"higher":[178],"growth":[179],"temperatures,":[180],"treatment":[182],"amyloid":[185,215,250],"protein":[186],"inhibitor":[187,251],"Thioflavin-T":[188,252],"markedly":[189],"attenuated":[190],"aggregation.":[191,256],"further":[194],"indicated":[195],"strain":[196,226],"specific":[197],"differences":[198,268],"genome":[201],"content":[202],"GPI-anchored":[204],"including":[206],"those":[207],"encoding":[208],"potential":[212],"form":[214,241],"proteins.":[216],"Collectively":[217],"our":[218],"data":[219],"suggests":[220],"complex":[225],"temperature":[228],"dependent":[229],"phenomenon":[230],"be":[233],"linked":[234],"part":[236],"ability":[239],"amyloids.":[247],"HIGHLIGHTS":[248],"inhibited":[253],"C.":[254,278],"Aggregating":[257],"do":[259],"exhibit":[261],"any":[262],"separation.":[266],"Genomic":[267],"between":[271],".":[280],"Aggregation":[281],"correlate":[284],"hydrophobicity":[289],"yeast":[291],"cells.":[292]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2023-07-25T00:00:00"}
