{"id":"https://openalex.org/W4385201657","doi":"https://doi.org/10.3390/gels9070587","title":"Microemulsion-Based Keratin\u2013Chitosan Gel for Improvement of Skin Permeation/Retention and Activity of Curcumin","display_name":"Microemulsion-Based Keratin\u2013Chitosan Gel for Improvement of Skin Permeation/Retention and Activity of Curcumin","publication_year":2023,"publication_date":"2023-07-21","ids":{"openalex":"https://openalex.org/W4385201657","doi":"https://doi.org/10.3390/gels9070587","pmid":"https://pubmed.ncbi.nlm.nih.gov/37504466","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10379975"},"language":"en","primary_location":{"id":"doi:10.3390/gels9070587","doi":"https://doi.org/10.3390/gels9070587","is_oa":true,"landing_page_url":"https://doi.org/10.3390/gels9070587","pdf_url":"https://www.mdpi.com/2310-2861/9/7/587/pdf?version=1690192628","source":{"id":"https://openalex.org/S2737559645","display_name":"Gels","issn_l":"2310-2861","issn":["2310-2861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2310-2861/9/7/587/pdf?version=1690192628","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013748072","display_name":"Jiangxiu Niu","orcid":"https://orcid.org/0000-0002-6708-0127","observed_orcids":["https://orcid.org/0000-0002-6708-0127"]},"institutions":[{"id":"https://openalex.org/I4210117164","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117164"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiangxiu Niu","raw_affiliation_strings":["College of Food and Drug, Luoyang Normal University, Luoyang 471934, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Drug, Luoyang Normal University, Luoyang 471934, China","institution_ids":["https://openalex.org/I4210117164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067251474","display_name":"Ming Yuan","orcid":"https://orcid.org/0000-0003-4208-3628","observed_orcids":["https://orcid.org/0000-0003-4208-3628","https://orcid.org/0000-0003-2935-3320"]},"institutions":[{"id":"https://openalex.org/I4210117164","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117164"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Yuan","raw_affiliation_strings":["College of Food and Drug, Luoyang Normal University, Luoyang 471934, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Drug, Luoyang Normal University, Luoyang 471934, China","institution_ids":["https://openalex.org/I4210117164"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Panpan Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117164","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117164"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panpan Gao","raw_affiliation_strings":["College of Food and Drug, Luoyang Normal University, Luoyang 471934, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Drug, Luoyang Normal University, Luoyang 471934, China","institution_ids":["https://openalex.org/I4210117164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115597318","display_name":"Liye Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117164","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117164"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liye Wang","raw_affiliation_strings":["College of Food and Drug, Luoyang Normal University, Luoyang 471934, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Drug, Luoyang Normal University, Luoyang 471934, China","institution_ids":["https://openalex.org/I4210117164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022918609","display_name":"Yueheng Qi","orcid":"https://orcid.org/0000-0001-8837-0767","observed_orcids":["https://orcid.org/0000-0001-8837-0767"]},"institutions":[{"id":"https://openalex.org/I4210117164","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117164"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yueheng Qi","raw_affiliation_strings":["College of Food and Drug, Luoyang Normal University, Luoyang 471934, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Drug, Luoyang Normal University, Luoyang 471934, China","institution_ids":["https://openalex.org/I4210117164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100373485","display_name":"Jingjing Chen","orcid":"https://orcid.org/0000-0002-5800-6064","observed_orcids":["https://orcid.org/0000-0002-5800-6064"]},"institutions":[{"id":"https://openalex.org/I4210117164","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117164"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Chen","raw_affiliation_strings":["College of Food and Drug, Luoyang Normal University, Luoyang 471934, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Drug, Luoyang Normal University, Luoyang 471934, China","institution_ids":["https://openalex.org/I4210117164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113147736","display_name":"Kaiyue Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117164","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117164"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaiyue Bai","raw_affiliation_strings":["College of Food and Drug, Luoyang Normal University, Luoyang 471934, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Drug, Luoyang Normal University, Luoyang 471934, China","institution_ids":["https://openalex.org/I4210117164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110917619","display_name":"Yanli Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117164","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117164"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanli Fan","raw_affiliation_strings":["College of Food and Drug, Luoyang Normal University, Luoyang 471934, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Drug, Luoyang Normal University, Luoyang 471934, China","institution_ids":["https://openalex.org/I4210117164"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100654385","display_name":"Xianming Liu","orcid":"https://orcid.org/0000-0001-7426-3450","observed_orcids":["https://orcid.org/0000-0001-7426-3450"]},"institutions":[{"id":"https://openalex.org/I4210117164","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210117164"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xianming Liu","raw_affiliation_strings":["College of Food and Drug, Luoyang Normal University, Luoyang 471934, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Food and Drug, Luoyang Normal University, Luoyang 471934, China","institution_ids":["https://openalex.org/I4210117164"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100654385","https://openalex.org/A5115597318"],"corresponding_institution_ids":["https://openalex.org/I4210117164"],"apc_list":{"value":1800,"currency":"CHF","value_usd":2002},"apc_paid":{"value":1800,"currency":"CHF","value_usd":2002},"fwci":3.3321,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.9351176,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"9","issue":"7","first_page":"587","last_page":"587"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":1.0},{"id":"https://openalex.org/keywords/microemulsions","display_name":"microemulsions","score":0.9890000224113464},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.9610000252723694},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.9869999885559082},{"id":"https://openalex.org/keywords/skin-retention","display_name":"skin retention","score":0.8939999938011169},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.7210000157356262},{"id":"https://openalex.org/keywords/bioadhesion","display_name":"bioadhesion","score":0.9300000071525574},{"id":"https://openalex.org/keywords/analgesic-activity","display_name":"analgesic activity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":1.0},{"id":"https://openalex.org/keywords/skin-irritation","display_name":"skin irritation","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.7560806274414062},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7033069133758545},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.6640571355819702},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.566164493560791},{"id":"https://openalex.org/C190119865","wikidata":"https://www.wikidata.org/wiki/Q338019","display_name":"Microemulsion","level":3,"score":0.5582352876663208},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5574969053268433},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4943389892578125},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.49419525265693665},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.47023269534111023},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3000611662864685},{"id":"https://openalex.org/C58226133","wikidata":"https://www.wikidata.org/wiki/Q1324199","display_name":"Pulmonary surfactant","level":2,"score":0.22889292240142822},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1302087903022766},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11491590738296509},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/gels9070587","doi":"https://doi.org/10.3390/gels9070587","is_oa":true,"landing_page_url":"https://doi.org/10.3390/gels9070587","pdf_url":"https://www.mdpi.com/2310-2861/9/7/587/pdf?version=1690192628","source":{"id":"https://openalex.org/S2737559645","display_name":"Gels","issn_l":"2310-2861","issn":["2310-2861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10379975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10379975","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10379975/pdf/gels-09-00587.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels","raw_type":"Text"},{"id":"pmid:37504466","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37504466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:319a0e23762f44229eeeff94354b7d33","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/319a0e23762f44229eeeff94354b7d33","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gels, Vol 9, Iss 7, p 587 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/gels9070587","doi":"https://doi.org/10.3390/gels9070587","is_oa":true,"landing_page_url":"https://doi.org/10.3390/gels9070587","pdf_url":"https://www.mdpi.com/2310-2861/9/7/587/pdf?version=1690192628","source":{"id":"https://openalex.org/S2737559645","display_name":"Gels","issn_l":"2310-2861","issn":["2310-2861"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gels","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329217","display_name":"Luoyang Normal University","ror":"https://ror.org/029man787"},{"id":"https://openalex.org/F4320336593","display_name":"Henan Provincial Science and Technology Research Project","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385201657.pdf","grobid_xml":"https://content.openalex.org/works/W4385201657.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1006649906","https://openalex.org/W1804724315","https://openalex.org/W1972328324","https://openalex.org/W1994263032","https://openalex.org/W2002979002","https://openalex.org/W2062906923","https://openalex.org/W2297123046","https://openalex.org/W2317256715","https://openalex.org/W2335491934","https://openalex.org/W2604242669","https://openalex.org/W2742350697","https://openalex.org/W2750841772","https://openalex.org/W2762783789","https://openalex.org/W2791923263","https://openalex.org/W2795948895","https://openalex.org/W2808315564","https://openalex.org/W2897462389","https://openalex.org/W2899728692","https://openalex.org/W2901219029","https://openalex.org/W2903341150","https://openalex.org/W2910337726","https://openalex.org/W2910942945","https://openalex.org/W2926145108","https://openalex.org/W2988902422","https://openalex.org/W2995535906","https://openalex.org/W3012660851","https://openalex.org/W3021622981","https://openalex.org/W3041383164","https://openalex.org/W3047270306","https://openalex.org/W3080685786","https://openalex.org/W3090811637","https://openalex.org/W3092844446","https://openalex.org/W3102957332","https://openalex.org/W3112110665","https://openalex.org/W3120387451","https://openalex.org/W3128581473","https://openalex.org/W3132436559","https://openalex.org/W3132759751","https://openalex.org/W3134945026","https://openalex.org/W3158233760","https://openalex.org/W3158717406","https://openalex.org/W3162075640","https://openalex.org/W3195484783","https://openalex.org/W3209856045","https://openalex.org/W3211849155","https://openalex.org/W3213411891","https://openalex.org/W3216735993","https://openalex.org/W3216766345","https://openalex.org/W4200276026","https://openalex.org/W4200276476","https://openalex.org/W4200353977","https://openalex.org/W4214916829","https://openalex.org/W4220655407","https://openalex.org/W4220758450","https://openalex.org/W4220777330","https://openalex.org/W4220782584","https://openalex.org/W4280648481","https://openalex.org/W4294869815","https://openalex.org/W4296261074","https://openalex.org/W4301182790","https://openalex.org/W4311541023","https://openalex.org/W4321369272"],"related_works":["https://openalex.org/W4378515035","https://openalex.org/W4321369272","https://openalex.org/W7212081174","https://openalex.org/W2897131400","https://openalex.org/W3102957332","https://openalex.org/W4321461694","https://openalex.org/W3147021725","https://openalex.org/W4391023039","https://openalex.org/W2089059559","https://openalex.org/W4407945929"],"abstract_inverted_index":{"Curcumin":[0],"(Cur)":[1],"is":[2],"a":[3,8,212,237],"kind":[4],"of":[5,10,46,50,111,232],"polyphenol":[6],"with":[7],"variety":[9],"topical":[11,48,142,241],"pharmacological":[12],"properties":[13],"including":[14],"antioxidant,":[15],"analgesic":[16,194],"and":[17,25,58,87,102,108,120,134,149,167,195,230,234],"anti-inflammatory":[18,196],"activities.":[19,197],"However,":[20],"its":[21,30,78],"low":[22],"water":[23],"solubility":[24],"poor":[26],"skin":[27,85,147,161,170,214,228],"bioavailability":[28],"limit":[29],"effectiveness.":[31],"In":[32,177,198],"the":[33,44,47,62,68,95,112,154,164,183,200,221,227],"current":[34],"study,":[35],"we":[36],"aimed":[37],"to":[38,66,243],"develop":[39],"microemulsion-based":[40],"keratin\u2013chitosan":[41,63],"gel":[42,65,74,98,114,128,156,185,202,224],"for":[43,77,141,240],"improvement":[45],"activity":[49],"Cur.":[51],"The":[52,71,91,105,126,144],"curcumin-loaded":[53,190],"microemulsion":[54,191],"(CME)":[55],"was":[56,75,139,186],"formulated":[57,72],"then":[59],"loaded":[60],"into":[61],"(KCS)":[64],"form":[67],"CME-KCS":[69,73,97,113,127,155,184,201,223],"gel.":[70],"evaluated":[76],"characterization,":[79],"in":[80,83,88,145,159,193],"vitro":[81,84,146,160],"release,":[82,137],"permeation":[86,148],"vivo":[89,178],"activity.":[90],"results":[92,180],"showed":[93,129,152],"that":[94,153,182,220],"developed":[96,222],"had":[99,157],"an":[100],"orange-yellow":[101],"gel-like":[103],"appearance.":[104],"particle":[106],"size":[107],"zeta":[109],"potential":[110],"were":[115],"186.45":[116],"\u00b1":[117,122,174],"0.75":[118],"nm":[119],"9.42":[121],"0.86":[123],"mV,":[124],"respectively.":[125],"desirable":[130],"viscoelasticity,":[131],"spreadability,":[132],"bioadhesion":[133],"controlled":[135],"drug":[136,171],"which":[138],"suitable":[140],"application.":[143],"retention":[150,172,231],"study":[151],"better":[158],"penetration":[162,229],"than":[163,189],"Cur":[165,233],"solution":[166],"achieved":[168],"maximum":[169],"(3.75":[173],"0.24":[175],"\u03bcg/cm2).":[176],"experimental":[179],"confirmed":[181],"more":[187],"effective":[188],"(Cur-ME)":[192],"addition,":[199],"did":[203],"not":[204],"cause":[205],"any":[206],"erythema":[207],"or":[208],"edema":[209],"based":[210],"on":[211],"mice":[213],"irritation":[215],"test.":[216],"These":[217],"findings":[218],"indicated":[219],"could":[225,235],"improve":[226],"become":[236],"promising":[238],"formulation":[239],"delivery":[242],"treat":[244],"local":[245],"diseases.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-25T00:00:00"}