{"id":"https://openalex.org/W4385201650","doi":"https://doi.org/10.3390/biomedicines11072071","title":"Dietary Supplementation with 20-Hydroxyecdysone Ameliorates Hepatic Steatosis and Reduces White Adipose Tissue Mass in Ovariectomized Rats Fed a High-Fat, High-Fructose Diet","display_name":"Dietary Supplementation with 20-Hydroxyecdysone Ameliorates Hepatic Steatosis and Reduces White Adipose Tissue Mass in Ovariectomized Rats Fed a High-Fat, High-Fructose Diet","publication_year":2023,"publication_date":"2023-07-23","ids":{"openalex":"https://openalex.org/W4385201650","doi":"https://doi.org/10.3390/biomedicines11072071","pmid":"https://pubmed.ncbi.nlm.nih.gov/37509710","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10377470"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines11072071","doi":"https://doi.org/10.3390/biomedicines11072071","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11072071","pdf_url":"https://www.mdpi.com/2227-9059/11/7/2071/pdf?version=1690107871","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/11/7/2071/pdf?version=1690107871","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008122516","display_name":"Jariya Buniam","orcid":"https://orcid.org/0000-0001-5066-9552","observed_orcids":["https://orcid.org/0000-0001-5066-9552"]},"institutions":[{"id":"https://openalex.org/I4405255716","display_name":"Chulabhorn Royal Academy","ror":"https://ror.org/03b5p6e80","country_code":"TH","type":"education","lineage":["https://openalex.org/I4405255716"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Jariya Buniam","raw_affiliation_strings":["Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok 10210, Thailand"],"raw_orcid":"https://orcid.org/0000-0001-5066-9552","affiliations":[{"raw_affiliation_string":"Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok 10210, Thailand","institution_ids":["https://openalex.org/I4405255716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027292290","display_name":"Piyachat Chansela","orcid":"https://orcid.org/0009-0009-9478-7847","observed_orcids":["https://orcid.org/0009-0009-9478-7847"]},"institutions":[{"id":"https://openalex.org/I4401726974","display_name":"Phramongkutklao College of Medicine","ror":"https://ror.org/04md5yc36","country_code":"TH","type":"education","lineage":["https://openalex.org/I4401726974"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Piyachat Chansela","raw_affiliation_strings":["Department of Anatomy, Phramongkutklao College of Medicine, Bangkok 10400, Thailand"],"raw_orcid":"https://orcid.org/0009-0009-9478-7847","affiliations":[{"raw_affiliation_string":"Department of Anatomy, Phramongkutklao College of Medicine, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I4401726974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028594909","display_name":"Jittima Weerachayaphorn","orcid":"https://orcid.org/0000-0001-9686-7749","observed_orcids":["https://orcid.org/0000-0001-9686-7749"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Jittima Weerachayaphorn","raw_affiliation_strings":["Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050452139","display_name":"Vitoon Saengsirisuwan","orcid":"https://orcid.org/0000-0001-7798-3680","observed_orcids":["https://orcid.org/0000-0001-7798-3680"]},"institutions":[{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Vitoon Saengsirisuwan","raw_affiliation_strings":["Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand","institution_ids":["https://openalex.org/I25399158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050452139"],"corresponding_institution_ids":["https://openalex.org/I25399158"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2447},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2447},"fwci":1.209,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77447803,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"11","issue":"7","first_page":"2071","last_page":"2071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.028699999675154686,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/20-hydroxyecdysone","display_name":"20-hydroxyecdysone","score":1.0},{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9980000257492065},{"id":"https://openalex.org/keywords/white-adipose-tissue","display_name":"white adipose tissue","score":0.8190000057220459},{"id":"https://openalex.org/keywords/high-fat-high-fructose-diet","display_name":"high-fat high-fructose diet","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8429999947547913},{"id":"https://openalex.org/keywords/acetyl-coa-carboxylase","display_name":"acetyl-CoA carboxylase","score":0.9539999961853027},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.996999979019165},{"id":"https://openalex.org/keywords/carnitine-palmitoyltransferase-1","display_name":"carnitine palmitoyltransferase 1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/srebp-1","display_name":"SREBP1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8155843019485474},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.788826584815979},{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.7332528829574585},{"id":"https://openalex.org/C2776175330","wikidata":"https://www.wikidata.org/wiki/Q1365091","display_name":"Steatosis","level":2,"score":0.7242501974105835},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6788641810417175},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.6013453006744385},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5954445600509644},{"id":"https://openalex.org/C48289651","wikidata":"https://www.wikidata.org/wiki/Q106916817","display_name":"Fatty acid synthase","level":3,"score":0.5182123780250549},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.467842698097229},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4626849889755249},{"id":"https://openalex.org/C82714985","wikidata":"https://www.wikidata.org/wiki/Q306213","display_name":"Beta oxidation","level":3,"score":0.443510502576828},{"id":"https://openalex.org/C2778435403","wikidata":"https://www.wikidata.org/wiki/Q243309","display_name":"Carnitine","level":2,"score":0.44202932715415955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42948171496391296},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.40993088483810425},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.1995115578174591},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.11380895972251892},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.07478383183479309}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines11072071","doi":"https://doi.org/10.3390/biomedicines11072071","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11072071","pdf_url":"https://www.mdpi.com/2227-9059/11/7/2071/pdf?version=1690107871","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10377470","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10377470","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10377470/pdf/biomedicines-11-02071.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmid:37509710","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37509710","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:4bc56ec6828843fabb50699cb4634e70","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4bc56ec6828843fabb50699cb4634e70","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 11, Iss 7, p 2071 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines11072071","doi":"https://doi.org/10.3390/biomedicines11072071","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines11072071","pdf_url":"https://www.mdpi.com/2227-9059/11/7/2071/pdf?version=1690107871","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G510058617","display_name":null,"funder_award_id":"640200017397000","funder_id":"https://openalex.org/F4320316404","funder_display_name":"Chulabhorn Royal Academy"}],"funders":[{"id":"https://openalex.org/F4320316404","display_name":"Chulabhorn Royal Academy","ror":"https://ror.org/03b5p6e80"},{"id":"https://openalex.org/F4320322401","display_name":"Mahidol University","ror":"https://ror.org/01znkr924"},{"id":"https://openalex.org/F4320335210","display_name":"Faculty of Science, Mahidol University","ror":"https://ror.org/01znkr924"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385201650.pdf","grobid_xml":"https://content.openalex.org/works/W4385201650.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1517358866","https://openalex.org/W1581851846","https://openalex.org/W1940806157","https://openalex.org/W1961739599","https://openalex.org/W1967460756","https://openalex.org/W1977207984","https://openalex.org/W2006964323","https://openalex.org/W2013865699","https://openalex.org/W2018071147","https://openalex.org/W2019374954","https://openalex.org/W2022122839","https://openalex.org/W2029214471","https://openalex.org/W2038125044","https://openalex.org/W2039305636","https://openalex.org/W2048668276","https://openalex.org/W2057902197","https://openalex.org/W2062560800","https://openalex.org/W2069042667","https://openalex.org/W2074203821","https://openalex.org/W2082930819","https://openalex.org/W2089563896","https://openalex.org/W2091930065","https://openalex.org/W2107130601","https://openalex.org/W2112291880","https://openalex.org/W2123609879","https://openalex.org/W2150551377","https://openalex.org/W2155070507","https://openalex.org/W2155658630","https://openalex.org/W2160814840","https://openalex.org/W2204688218","https://openalex.org/W2283091934","https://openalex.org/W2324319567","https://openalex.org/W2324378908","https://openalex.org/W2529829375","https://openalex.org/W2547866881","https://openalex.org/W2554921668","https://openalex.org/W2610204288","https://openalex.org/W2617130129","https://openalex.org/W2739174192","https://openalex.org/W2776765985","https://openalex.org/W2781240994","https://openalex.org/W2804191277","https://openalex.org/W2810423511","https://openalex.org/W2889096616","https://openalex.org/W2897544177","https://openalex.org/W2916463536","https://openalex.org/W2924788077","https://openalex.org/W3004644667","https://openalex.org/W3015579983","https://openalex.org/W3022084469","https://openalex.org/W3109665518","https://openalex.org/W3157948752","https://openalex.org/W3172379734","https://openalex.org/W3216031004","https://openalex.org/W4200161106","https://openalex.org/W4214513422","https://openalex.org/W4220750547","https://openalex.org/W4281476729","https://openalex.org/W4296803763","https://openalex.org/W4312179065"],"related_works":["https://openalex.org/W4213434662","https://openalex.org/W3022084469","https://openalex.org/W4363649832","https://openalex.org/W7155706671","https://openalex.org/W4416725440","https://openalex.org/W4410435061","https://openalex.org/W7203820972","https://openalex.org/W2096850461","https://openalex.org/W4407129999","https://openalex.org/W3214566793"],"abstract_inverted_index":{"Metabolic":[0],"dysfunction-associated":[1],"fatty":[2,148],"liver":[3,106,153],"disease":[4],"(MAFLD)":[5],"is":[6,60,64],"defined":[7],"as":[8],"hepatic":[9,124,160],"steatosis":[10],"in":[11,69,104,151,180],"combination":[12],"with":[13,97,182],"overweight,":[14],"diabetes,":[15],"or":[16,58,198],"other":[17],"metabolic":[18],"risk":[19],"factors.":[20],"MAFLD":[21,56,87,196],"affects":[22,99],"a":[23,65,114,192],"significant":[24],"number":[25],"of":[26,53,110,135,147,162,169],"the":[27,51,105,133,145,152],"global":[28],"population":[29],"and":[30,34,48,72,79,102,107,127,139,154,165],"imposes":[31],"substantial":[32],"clinical":[33],"economic":[35],"burdens.":[36],"With":[37],"no":[38],"approved":[39],"pharmacotherapy,":[40],"current":[41],"treatment":[42,57],"options":[43],"are":[44],"limited":[45],"to":[46,76,92],"diet":[47,117],"exercise.":[49],"Therefore,":[50,81],"development":[52],"medicines":[54],"for":[55,86,195],"prevention":[59,197],"necessary.":[61],"20-Hydroxyecdysone":[62],"(20E)":[63],"natural":[66],"steroid":[67],"found":[68,120],"edible":[70],"plants":[71],"has":[73],"been":[74],"shown":[75],"improve":[77],"metabolism":[78],"dyslipidemia.":[80],"it":[82],"may":[83,190],"be":[84],"useful":[85],"treatment.":[88,199],"Here,":[89],"we":[90],"aimed":[91],"determine":[93],"how":[94],"dietary":[95],"supplementation":[96],"20E":[98,122,131,158,176,189],"fat":[100,129],"accumulation":[101],"lipogenesis":[103],"adipose":[108,155,167],"tissue":[109],"ovariectomized":[111],"rats":[112,181],"fed":[113],"high-fat,":[115],"high-fructose":[116],"(OHFFD).":[118],"We":[119],"that":[121,188],"reduced":[123,166],"triglyceride":[125],"content":[126],"visceral":[128],"deposition.":[130],"increased":[132,159],"phosphorylation":[134],"AMP-activated":[136],"protein":[137],"kinase":[138],"acetyl":[140],"CoA":[141],"carboxylase":[142],"while":[143],"reducing":[144],"expression":[146,161,168],"acid":[149],"synthase":[150],"tissue.":[156],"Additionally,":[157],"carnitine":[163],"palmitoyltransferase-1":[164],"sterol":[170],"regulatory":[171],"element-binding":[172],"protein-1.":[173],"In":[174],"conclusion,":[175],"demonstrated":[177],"beneficial":[178],"effects":[179],"OHFFD-induced":[183],"MAFLD.":[184],"These":[185],"findings":[186],"suggest":[187],"represent":[191],"promising":[193],"option":[194]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-07-25T00:00:00"}