{"id":"https://openalex.org/W4385185998","doi":"https://doi.org/10.1161/jaha.123.030802","title":"Transthyretin Cardiac Amyloidosis: Underrecognized in the Underrepresented","display_name":"Transthyretin Cardiac Amyloidosis: Underrecognized in the Underrepresented","publication_year":2023,"publication_date":"2023-07-24","ids":{"openalex":"https://openalex.org/W4385185998","doi":"https://doi.org/10.1161/jaha.123.030802","pmid":"https://pubmed.ncbi.nlm.nih.gov/37486081","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492987"},"language":"en","primary_location":{"id":"doi:10.1161/jaha.123.030802","doi":"https://doi.org/10.1161/jaha.123.030802","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.123.030802","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/JAHA.123.030802","source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/JAHA.123.030802","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082846779","display_name":"Douglas J. Leedy","orcid":"https://orcid.org/0000-0001-8510-0796","observed_orcids":["https://orcid.org/0000-0001-8510-0796"]},"institutions":[{"id":"https://openalex.org/I2801852214","display_name":"University of Washington Medical Center","ror":"https://ror.org/00wbzw723","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas J. Leedy","raw_affiliation_strings":["Division of Cardiology University of Washington Medical Center Seattle WA USA","Douglas J. Leedy https://orcid.org/0000-0001-8510-0796 , Division of Cardiology, , University of Washington Medical Center, , Seattle, , WA, , USA,"],"raw_orcid":"https://orcid.org/0000-0001-8510-0796","affiliations":[{"raw_affiliation_string":"Division of Cardiology University of Washington Medical Center Seattle WA USA","institution_ids":["https://openalex.org/I2801852214"]},{"raw_affiliation_string":"Douglas J. Leedy https://orcid.org/0000-0001-8510-0796 , Division of Cardiology, , University of Washington Medical Center, , Seattle, , WA, , USA,","institution_ids":["https://openalex.org/I2801852214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045641510","display_name":"Sarah A. M. Cuddy","orcid":"https://orcid.org/0000-0002-2124-2151","observed_orcids":["https://orcid.org/0000-0002-2124-2151"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A.M. Cuddy","raw_affiliation_strings":["Division of Cardiology Brigham and Women\u2019s Hospital Boston MA USA","Sarah A.M. Cuddy https://orcid.org/0000-0002-2124-2151 , Division of Cardiology, , Brigham and Women's Hospital, , Boston, , MA, , USA,"],"raw_orcid":"https://orcid.org/0000-0002-2124-2151","affiliations":[{"raw_affiliation_string":"Division of Cardiology Brigham and Women\u2019s Hospital Boston MA USA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Sarah A.M. Cuddy https://orcid.org/0000-0002-2124-2151 , Division of Cardiology, , Brigham and Women's Hospital, , Boston, , MA, , USA,","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020437483","display_name":"Richard Kar-Hang Cheng","orcid":"https://orcid.org/0000-0001-5994-5998","observed_orcids":["https://orcid.org/0000-0001-5994-5998"]},"institutions":[{"id":"https://openalex.org/I2801852214","display_name":"University of Washington Medical Center","ror":"https://ror.org/00wbzw723","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801852214"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard K. Cheng","raw_affiliation_strings":["Division of Cardiology University of Washington Medical Center Seattle WA USA"],"raw_orcid":"https://orcid.org/0000-0001-5994-5998","affiliations":[{"raw_affiliation_string":"Division of Cardiology University of Washington Medical Center Seattle WA USA","institution_ids":["https://openalex.org/I2801852214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020437483"],"corresponding_institution_ids":["https://openalex.org/I2801852214"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":{"value":3700,"currency":"USD","value_usd":3700},"fwci":null,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"15","first_page":"e030802","last_page":"e030802"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11638","display_name":"Cardiac tumors and thrombi","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transthyretin-amyloid-cardiomyopathy","display_name":"transthyretin amyloid cardiomyopathy","score":0.996999979019165},{"id":"https://openalex.org/keywords/heart-failure-with-preserved-ejection-fraction","display_name":"heart failure with preserved ejection fraction","score":0.9129999876022339},{"id":"https://openalex.org/keywords/transthyretin-stabilizers","display_name":"transthyretin stabilizers","score":0.8970000147819519},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.8539999723434448},{"id":"https://openalex.org/keywords/underrepresented-groups","display_name":"underrepresented groups","score":0.7440000176429749},{"id":"https://openalex.org/keywords/underdiagnosis","display_name":"underdiagnosis","score":0.7009999752044678},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.8230000138282776},{"id":"https://openalex.org/keywords/heart-failure-hospitalization","display_name":"heart failure hospitalization","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.9584256410598755},{"id":"https://openalex.org/C2777607188","wikidata":"https://www.wikidata.org/wiki/Q5038315","display_name":"Cardiac amyloidosis","level":3,"score":0.7024469375610352},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.6773020625114441},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5158616900444031},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.38401278853416443},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3811070919036865}],"mesh":[{"descriptor_ui":"D000091202","descriptor_name":"Health Disparate Minority and Vulnerable Populations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011228","descriptor_name":"Prealbumin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019683","descriptor_name":"Penetrance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/jaha.123.030802","doi":"https://doi.org/10.1161/jaha.123.030802","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.123.030802","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/JAHA.123.030802","source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10492987","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10492987","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10492987/pdf/JAH3-12-e030802.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Am Heart Assoc","raw_type":"Text"},{"id":"pmid:37486081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37486081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"Editorial"},{"id":"pmh:oai:doaj.org/article:ab9618e47a4748f4933dd88d4937bc82","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ab9618e47a4748f4933dd88d4937bc82","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 15 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1161/jaha.123.030802","doi":"https://doi.org/10.1161/jaha.123.030802","is_oa":true,"landing_page_url":"https://doi.org/10.1161/jaha.123.030802","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/JAHA.123.030802","source":{"id":"https://openalex.org/S2489920150","display_name":"Journal of the American Heart Association","issn_l":"2047-9980","issn":["2047-9980"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Heart Association","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000902362","display_name":"Personalized Exercise Training to Improve Functional Capacity in Transthyretin Cardiac Amyloidosis","funder_award_id":"K23HL166686","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385185998.pdf","grobid_xml":"https://content.openalex.org/works/W4385185998.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W2162772358","https://openalex.org/W2314304229","https://openalex.org/W2575846051","https://openalex.org/W2888036721","https://openalex.org/W2979730941","https://openalex.org/W3006028248","https://openalex.org/W3028686367","https://openalex.org/W3163032277","https://openalex.org/W3174416962","https://openalex.org/W3193293922","https://openalex.org/W4295570938","https://openalex.org/W4317761849","https://openalex.org/W4385185772"],"related_works":["https://openalex.org/W4391067717","https://openalex.org/W2948364217","https://openalex.org/W4289878937","https://openalex.org/W7117683958","https://openalex.org/W4386897733","https://openalex.org/W4411693050","https://openalex.org/W7207903268","https://openalex.org/W4385564607","https://openalex.org/W7135200912","https://openalex.org/W3119935845"],"abstract_inverted_index":{"ver":[0],"the":[1,55,81],"past":[2],"decade,":[3],"transthyretin":[4,63],"cardiac":[5],"amyloidosis":[6],"(ATTR-CM)":[7],"has":[8,50],"rapidly":[9],"emerged":[10],"as":[11,34,46,48,62,73],"an":[12],"increasingly":[13],"diagnosed":[14],"cause":[15],"of":[16,54,57,69,85,87],"heart":[17],"failure":[18],"(HF)":[19],"among":[20],"older":[21],"adults,":[22],"predominantly":[23],"those":[24],"with":[25,27],"HF":[26,78],"preserved":[28],"ejection":[29],"fraction.Although":[30],"still":[31],"frequently":[32],"classified":[33],"a":[35],"rare":[36],"disease,":[37],"there":[38],"is":[39,44,71],"mounting":[40],"evidence":[41],"that":[42],"ATTR-CM":[43,70],"not":[45],"\"rare\"":[47],"it":[49],"been":[51],"historically":[52],"described.Because":[53],"development":[56],"effective":[58],"disease-modifying":[59],"therapies,":[60],"such":[61],"stabilizers,":[64],"early":[65],"and":[66,89],"accurate":[67],"identification":[68],"essential,":[72],"these":[74],"treatments":[75],"can":[76],"reduce":[77],"hospitalizations,":[79],"slow":[80],"decline":[82],"in":[83],"loss":[84],"quality":[86],"life,":[88],"extend":[90],"survival.":[91]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-25T00:00:00"}
