{"id":"https://openalex.org/W4385068898","doi":"https://doi.org/10.3390/cancers15143695","title":"Generation of Orthotopic Patient-Derived Xenografts in Humanized Mice for Evaluation of Emerging Targeted Therapies and Immunotherapy Combinations for Melanoma","display_name":"Generation of Orthotopic Patient-Derived Xenografts in Humanized Mice for Evaluation of Emerging Targeted Therapies and Immunotherapy Combinations for Melanoma","publication_year":2023,"publication_date":"2023-07-20","ids":{"openalex":"https://openalex.org/W4385068898","doi":"https://doi.org/10.3390/cancers15143695","pmid":"https://pubmed.ncbi.nlm.nih.gov/37509357","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10377652"},"language":"en","primary_location":{"id":"doi:10.3390/cancers15143695","doi":"https://doi.org/10.3390/cancers15143695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15143695","pdf_url":"https://www.mdpi.com/2072-6694/15/14/3695/pdf?version=1689906507","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/15/14/3695/pdf?version=1689906507","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007111794","display_name":"Chi Wing Yan","orcid":"https://orcid.org/0000-0002-8658-7302","observed_orcids":["https://orcid.org/0000-0002-8658-7302"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi Yan","raw_affiliation_strings":["Department of Pharmacology , Vanderbilt University , Nashville TN","Department of Veterans Affairs , Tennessee Valley Healthcare System , Nashville","Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA","Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA"],"raw_orcid":"https://orcid.org/0000-0002-8658-7302","affiliations":[{"raw_affiliation_string":"Department of Pharmacology , Vanderbilt University , Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Veterans Affairs , Tennessee Valley Healthcare System , Nashville","institution_ids":["https://openalex.org/I4210101790"]},{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I4210101790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037844360","display_name":"Caroline A. Nebhan","orcid":"https://orcid.org/0000-0002-9402-7284","observed_orcids":["https://orcid.org/0000-0002-9402-7284"]},"institutions":[{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Ann Nebhan","raw_affiliation_strings":["Department of Veterans Affairs , Tennessee Valley Healthcare System , Nashville","Division of Hematology & Oncology , Vanderbilt University Medical Center , Nashville TN","Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA","Division of Hematology & Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs , Tennessee Valley Healthcare System , Nashville","institution_ids":["https://openalex.org/I4210101790"]},{"raw_affiliation_string":"Division of Hematology & Oncology , Vanderbilt University Medical Center , Nashville TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I4210101790"]},{"raw_affiliation_string":"Division of Hematology & Oncology, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076757523","display_name":"Nabil Saleh","orcid":"https://orcid.org/0000-0002-3694-0681","observed_orcids":["https://orcid.org/0000-0002-3694-0681"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nabil Saleh","raw_affiliation_strings":["Department of Pharmacology , Vanderbilt University , Nashville TN","Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA"],"raw_orcid":"https://orcid.org/0000-0002-3694-0681","affiliations":[{"raw_affiliation_string":"Department of Pharmacology , Vanderbilt University , Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001839705","display_name":"Rebecca L. Shattuck-Brandt","orcid":"https://orcid.org/0000-0003-2163-3221","observed_orcids":["https://orcid.org/0000-0003-2163-3221"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Lynn Shattuck-Brandt","raw_affiliation_strings":["Department of Pharmacology , Vanderbilt University , Nashville TN","Department of Veterans Affairs , Tennessee Valley Healthcare System , Nashville","Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA","Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology , Vanderbilt University , Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Veterans Affairs , Tennessee Valley Healthcare System , Nashville","institution_ids":["https://openalex.org/I4210101790"]},{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I4210101790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059563188","display_name":"Sheau\u2010Chiann Chen","orcid":"https://orcid.org/0000-0002-5574-1434","observed_orcids":["https://orcid.org/0000-0002-5574-1434"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheau-Chiann Chen","raw_affiliation_strings":["Department of Biostatistics , Vanderbilt University Medical Center , Nashville TN","Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics , Vanderbilt University Medical Center , Nashville TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013233073","display_name":"Gregory Dan Ayers","orcid":"https://orcid.org/0000-0002-0892-350X","observed_orcids":["https://orcid.org/0000-0002-0892-350X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Dan Ayers","raw_affiliation_strings":["Department of Biostatistics , Vanderbilt University Medical Center , Nashville TN","Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics , Vanderbilt University Medical Center , Nashville TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082473453","display_name":"Vivian Lee Weiss","orcid":"https://orcid.org/0000-0003-0874-3207","observed_orcids":["https://orcid.org/0000-0003-0874-3207"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivian Weiss","raw_affiliation_strings":["Department of Pathology, Microbiology and Immunology , Vanderbilt University Medical Center , Nashville , TN","Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology , Vanderbilt University Medical Center , Nashville , TN","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010542605","display_name":"Ann J. Richmond","orcid":"https://orcid.org/0000-0002-9580-900X","observed_orcids":["https://orcid.org/0000-0002-9580-900X"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4210101790","display_name":"VA Tennessee Valley Healthcare System","ror":"https://ror.org/01c9rqr26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210101790","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ann Richmond","raw_affiliation_strings":["Department of Pharmacology , Vanderbilt University , Nashville TN","Department of Veterans Affairs , Tennessee Valley Healthcare System , Nashville","Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA","Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA"],"raw_orcid":"https://orcid.org/0000-0002-9580-900X","affiliations":[{"raw_affiliation_string":"Department of Pharmacology , Vanderbilt University , Nashville TN","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Veterans Affairs , Tennessee Valley Healthcare System , Nashville","institution_ids":["https://openalex.org/I4210101790"]},{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA","institution_ids":["https://openalex.org/I4210101790"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060947046","display_name":"Anna E. Vilgelm","orcid":"https://orcid.org/0000-0002-4446-913X","observed_orcids":["https://orcid.org/0000-0002-4446-913X"]},"institutions":[{"id":"https://openalex.org/I2799885155","display_name":"The Ohio State University Comprehensive Cancer Center \u2013 Arthur G. James Cancer Hospital and Richard J. Solove Research Institute","ror":"https://ror.org/028t46f04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799885155","https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I4405282248","display_name":"Pelotonia","ror":"https://ror.org/05jcvqz82","country_code":"US","type":"funder","lineage":["https://openalex.org/I4405282248"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Anna E. Vilgelm","raw_affiliation_strings":["Department of Pathology , Ohio State University , Columbus OH","Pelotonia Institute for Immuno-Oncology , The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute , Columbus OH","Department of Pathology, Ohio State University, Columbus, OH 43210, USA","Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center\u2014Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH 43210, USA"],"raw_orcid":"https://orcid.org/0000-0002-4446-913X","affiliations":[{"raw_affiliation_string":"Department of Pathology , Ohio State University , Columbus OH","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Pelotonia Institute for Immuno-Oncology , The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute , Columbus OH","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I4405282248"]},{"raw_affiliation_string":"Department of Pathology, Ohio State University, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Pelotonia Institute for Immuno-Oncology, The Ohio State University Comprehensive Cancer Center\u2014Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH 43210, USA","institution_ids":["https://openalex.org/I2799885155","https://openalex.org/I4405282248"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010542605","https://openalex.org/A5060947046"],"corresponding_institution_ids":["https://openalex.org/I200719446","https://openalex.org/I2799885155","https://openalex.org/I4210101790","https://openalex.org/I4405282248","https://openalex.org/I52357470"],"apc_list":{"value":2600,"currency":"CHF","value_usd":2892},"apc_paid":{"value":2600,"currency":"CHF","value_usd":2892},"fwci":1.8296,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.86911521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"15","issue":"14","first_page":"3695","last_page":"3695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.8833000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.032499998807907104,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.968999981880188},{"id":"https://openalex.org/keywords/humanized-mouse-model","display_name":"humanized mice","score":0.9229999780654907},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9900000095367432},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/immune-mediated-toxicity","display_name":"immune-mediated toxicity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/rigosertib","display_name":"rigosertib","score":0.7440000176429749},{"id":"https://openalex.org/keywords/anti-pd-1-therapy","display_name":"anti-PD-1 therapy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-resistance","display_name":"immune checkpoint inhibitor resistance","score":0.49399998784065247},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9419999718666077},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8040000200271606},{"id":"https://openalex.org/keywords/immunoediting","display_name":"immunoediting","score":0.8379999995231628},{"id":"https://openalex.org/keywords/chimerism","display_name":"chimerism","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2776156784","wikidata":"https://www.wikidata.org/wiki/Q3491954","display_name":"Humanized mouse","level":3,"score":0.8716076612472534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7313104867935181},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6148532032966614},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5891414284706116},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5869032144546509},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5864141583442688},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.52463299036026},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4202231466770172}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers15143695","doi":"https://doi.org/10.3390/cancers15143695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15143695","pdf_url":"https://www.mdpi.com/2072-6694/15/14/3695/pdf?version=1689906507","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"doi:10.20944/preprints202307.0566.v1","doi":"https://doi.org/10.20944/preprints202307.0566.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202307.0566.v1","pdf_url":"https://www.preprints.org/manuscript/202307.0566/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10377652","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10377652","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmid:37509357","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37509357","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/cancers15143695","doi":"https://doi.org/10.3390/cancers15143695","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers15143695","pdf_url":"https://www.mdpi.com/2072-6694/15/14/3695/pdf?version=1689906507","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1188393146","display_name":null,"funder_award_id":"CA 116021","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1243813451","display_name":null,"funder_award_id":"CA 34590","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1280513408","display_name":null,"funder_award_id":"5P30CA68485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1300984159","display_name":null,"funder_award_id":"P30 CA 68485","funder_id":"https://openalex.org/F4320309601","funder_display_name":"Vanderbilt-Ingram Cancer Center"},{"id":"https://openalex.org/G1388609297","display_name":null,"funder_award_id":"S10OD023475","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G153582612","display_name":null,"funder_award_id":"P30 CA 68485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1683023738","display_name":null,"funder_award_id":"5101BX000196-04","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2006259475","display_name":null,"funder_award_id":"5P30 CA68485-19","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2367676916","display_name":null,"funder_award_id":"P30 CA68485","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G2600212515","display_name":null,"funder_award_id":"W81XWH2210019","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G268010445","display_name":"Leica Bond RX","funder_award_id":"1s10od023475-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2761330696","display_name":null,"funder_award_id":"CA233770","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3152736877","display_name":null,"funder_award_id":"S10 OD023475-01A1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3428023363","display_name":null,"funder_award_id":"R37 CA233770-01","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G3433274139","display_name":null,"funder_award_id":"P30 CA68485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G3572849318","display_name":"New Strategies for Treatment of NRAS Mutant Melanoma after Progression on Immune Checkpoint Inhibitors","funder_award_id":"R01CA116021","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G359867969","display_name":null,"funder_award_id":"IK6 BX005225","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G36614667","display_name":null,"funder_award_id":"CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4334524930","display_name":null,"funder_award_id":"CA233770","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4513176822","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4923790243","display_name":null,"funder_award_id":"CA116021","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5562593068","display_name":null,"funder_award_id":"CA34590","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5841998288","display_name":"Training Program in Stem Cell and Regenerative Developmental Biology","funder_award_id":"T32HD007502","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G5853943267","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320309151","funder_display_name":"Vanderbilt University"},{"id":"https://openalex.org/G6188970379","display_name":"Chemokine Signals in the Premetastatic Niche Inhibit Metastasis","funder_award_id":"R01CA034590","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6537411040","display_name":null,"funder_award_id":"5101BX000196-04","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6983782547","display_name":null,"funder_award_id":"I01 BX000196","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G7096016949","display_name":"HARNESSING INNATE IMMUNITY TO IMPROVE METASTATIC BREAST CANCER THERAPY. THE ASSISTANT SECRETARY OF DEFENSE FOR HEALTH AFFAIRS THROUGH THE BREAST CANCER RESEARCH PROGRAM, ENDORSED BY THE DEPARTMENT OF DEFENSE. THE ASSISTANT SECRETARY OF DEFENSE FOR HEALTH AFFAIRS THROUGH THE BREAST CANCER RESEARCH PROGRAM, ENDORSED BY THE DEPARTMENT OF THE ARMY.","funder_award_id":"W81XWH2210019","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G8113317439","display_name":null,"funder_award_id":"CA116021-S1","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G818418256","display_name":null,"funder_award_id":"5101BX000196-04)","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G8516375048","display_name":null,"funder_award_id":"CA016058","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000006939","display_name":"VOLT (Vanderbilt Oncology Training Program)","funder_award_id":"T32CA217834","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000081609","display_name":null,"funder_award_id":"CA68485","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000130502","display_name":null,"funder_award_id":"5P30 CA68485\u201019","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000266250","display_name":null,"funder_award_id":"CA016058","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000270150","display_name":null,"funder_award_id":"CA116021-S1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000285544","display_name":null,"funder_award_id":"CA116021","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000312249","display_name":null,"funder_award_id":"CA34590","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000887552","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA016058","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000917025","display_name":"Combining senescence-inducing and senolytic agents to improve melanoma therapy","funder_award_id":"R37CA233770","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G946322834","display_name":null,"funder_award_id":"CA116021-S1","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320308296","display_name":"Melanoma Research Alliance","ror":"https://ror.org/025ck6r46"},{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320309601","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/05dq2gs74"},{"id":"https://openalex.org/F4320316230","display_name":"Pelotonia","ror":"https://ror.org/05jcvqz82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385068898.pdf","grobid_xml":"https://content.openalex.org/works/W4385068898.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1506338229","https://openalex.org/W1904795858","https://openalex.org/W1911261107","https://openalex.org/W1922733886","https://openalex.org/W1952297410","https://openalex.org/W1968520204","https://openalex.org/W2003466425","https://openalex.org/W2053696072","https://openalex.org/W2113591516","https://openalex.org/W2139132031","https://openalex.org/W2151536540","https://openalex.org/W2162755712","https://openalex.org/W2166045197","https://openalex.org/W2332292689","https://openalex.org/W2333987865","https://openalex.org/W2415744702","https://openalex.org/W2557596611","https://openalex.org/W2564136012","https://openalex.org/W2578178300","https://openalex.org/W2588026635","https://openalex.org/W2602014586","https://openalex.org/W2605630275","https://openalex.org/W2755992118","https://openalex.org/W2770694551","https://openalex.org/W2774358746","https://openalex.org/W2806295244","https://openalex.org/W2888417599","https://openalex.org/W2892246393","https://openalex.org/W2914850591","https://openalex.org/W2946366053","https://openalex.org/W2967855006","https://openalex.org/W2983138989","https://openalex.org/W3000368668","https://openalex.org/W3014641112","https://openalex.org/W3029206054","https://openalex.org/W3068973665","https://openalex.org/W3083944072","https://openalex.org/W3084043355","https://openalex.org/W3089088060","https://openalex.org/W3092002669","https://openalex.org/W3104704485","https://openalex.org/W3106575506","https://openalex.org/W3112619797","https://openalex.org/W3141524818","https://openalex.org/W3171259716","https://openalex.org/W3217126890","https://openalex.org/W4205955455","https://openalex.org/W4226258201","https://openalex.org/W4295484467","https://openalex.org/W4296736732","https://openalex.org/W4385068898"],"related_works":["https://openalex.org/W4386568573","https://openalex.org/W1991648826","https://openalex.org/W2739698264","https://openalex.org/W2593489585","https://openalex.org/W2504967839","https://openalex.org/W4386608797","https://openalex.org/W2886325188","https://openalex.org/W2797031998","https://openalex.org/W2886222285","https://openalex.org/W2397690754"],"abstract_inverted_index":{"Current":[0],"methodologies":[1],"for":[2,23,59],"developing":[3],"PDX":[4,25,31,40,49,137,146,172,179],"in":[5,8,27,35,44,81,131,174],"humanized":[6,28,45,57,72,175,186],"mice":[7,58,73,176,187],"preclinical":[9,60],"trials":[10,115],"with":[11,74,91,145,151],"immune-based":[12],"therapies":[13],"are":[14,32,41,50],"limited":[15,152],"by":[16,169],"GVHD.":[17],"Here,":[18],"we":[19],"compared":[20],"two":[21],"approaches":[22],"establishing":[24,171],"tumors":[26,147,150,173,180],"mice:":[29],"(1)":[30],"first":[33,64,170],"established":[34,43,48,148],"immune-deficient":[36],"mice;":[37,46],"or":[38],"(2)":[39],"initially":[42],"then":[47],"transplanted":[51],"to":[52,141,164,188],"a":[53,182],"larger":[54,183],"cohort":[55,184],"of":[56,70,77,98,109,185],"trials.":[61],"With":[62],"the":[63,82,92,117],"approach,":[65,94],"there":[66],"was":[67,96,112,143],"rapid":[68],"wasting":[69],"PDX-bearing":[71],"high":[75],"levels":[76],"activated":[78],"T":[79,128,154],"cells":[80],"circulation":[83],"and":[84,101,107,133,135],"organs,":[85],"indicating":[86],"immune-mediated":[87],"toxicity.":[88],"In":[89],"contrast,":[90],"second":[93,118],"toxicity":[95],"less":[97],"an":[99],"issue":[100],"long-term":[102],"human":[103,110],"melanoma":[104],"tumor":[105,138],"growth":[106],"maintenance":[108],"chimerism":[111],"achieved.":[113],"Preclinical":[114],"from":[116,149],"approach":[119],"revealed":[120],"that":[121,160],"rigosertib,":[122],"but":[123],"not":[124],"anti-PD-1,":[125],"increased":[126],"CD8/CD4":[127],"cell":[129,155],"ratios":[130],"spleen":[132],"blood":[134],"inhibited":[136],"growth.":[139],"Resistance":[140],"anti-PD-1":[142],"associated":[144],"CD8+":[153],"content.":[156],"Our":[157],"findings":[158],"suggest":[159],"it":[161],"is":[162],"essential":[163],"carefully":[165],"manage":[166],"immune":[167],"editing":[168],"before":[177],"expanding":[178],"into":[181],"evaluate":[189],"therapy":[190],"response.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-07-23T00:00:00"}