{"id":"https://openalex.org/W4384944579","doi":"https://doi.org/10.3389/fonc.2023.1224138","title":"A spotlight on the interplay between Wnt/\u03b2-catenin signaling and circular RNAs in hepatocellular carcinoma progression","display_name":"A spotlight on the interplay between Wnt/\u03b2-catenin signaling and circular RNAs in hepatocellular carcinoma progression","publication_year":2023,"publication_date":"2023-07-21","ids":{"openalex":"https://openalex.org/W4384944579","doi":"https://doi.org/10.3389/fonc.2023.1224138","pmid":"https://pubmed.ncbi.nlm.nih.gov/37546393","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10403753"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2023.1224138","doi":"https://doi.org/10.3389/fonc.2023.1224138","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1224138","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2023.1224138/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2023.1224138/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041633995","display_name":"Alireza Mafi","orcid":"https://orcid.org/0000-0002-9485-0326","observed_orcids":["https://orcid.org/0000-0002-9485-0326","https://orcid.org/0009-0002-2881-6223"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Alireza Mafi","raw_affiliation_strings":["Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran","Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]},{"raw_affiliation_string":"Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012506572","display_name":"Hamidreza Rismanchi","orcid":"https://orcid.org/0000-0001-5641-2643","observed_orcids":["https://orcid.org/0000-0001-5641-2643"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Hamidreza Rismanchi","raw_affiliation_strings":["School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001065397","display_name":"Mohaddese Malek Mohammadi","orcid":"https://orcid.org/0000-0002-5785-8193","observed_orcids":["https://orcid.org/0000-0002-5785-8193"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohaddese Malek Mohammadi","raw_affiliation_strings":["School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026399697","display_name":"Neda Hedayati","orcid":"https://orcid.org/0009-0000-3583-5057","observed_orcids":["https://orcid.org/0009-0000-3583-5057"]},"institutions":[{"id":"https://openalex.org/I161106909","display_name":"Iran University of Medical Sciences","ror":"https://ror.org/03w04rv71","country_code":"IR","type":"education","lineage":["https://openalex.org/I161106909"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Neda Hedayati","raw_affiliation_strings":["School of Medicine, Iran University of Medical Science, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Iran University of Medical Science, Tehran, Iran","institution_ids":["https://openalex.org/I161106909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014266158","display_name":"Seyedeh Sara Ghorbanhosseini","orcid":"https://orcid.org/0000-0002-1530-2955","observed_orcids":["https://orcid.org/0000-0002-1530-2955"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyedeh Sara Ghorbanhosseini","raw_affiliation_strings":["Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Seyed Ali Hosseini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Ali Hosseini","raw_affiliation_strings":["Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti, University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti, University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092013025","display_name":"Yasaman Gholinezhad","orcid":"https://orcid.org/0000-0003-2515-5669","observed_orcids":["https://orcid.org/0000-0003-2515-5669"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Yasaman Gholinezhad","raw_affiliation_strings":["Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040205141","display_name":"Rohollah Mousavi Dehmordi","orcid":"https://orcid.org/0009-0007-7108-4239","observed_orcids":["https://orcid.org/0009-0007-7108-4239"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]},{"id":"https://openalex.org/I119939603","display_name":"Ahvaz Jundishapur University of Medical Sciences","ror":"https://ror.org/01rws6r75","country_code":"IR","type":"education","lineage":["https://openalex.org/I119939603"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Rohollah Mousavi Dehmordi","raw_affiliation_strings":["Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran","institution_ids":["https://openalex.org/I119939603"]},{"raw_affiliation_string":"Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026467407","display_name":"Behrooz Ghezelbash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Behrooz Ghezelbash","raw_affiliation_strings":["Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065826760","display_name":"Fatemeh Zarepour","orcid":"https://orcid.org/0009-0000-8809-2680","observed_orcids":["https://orcid.org/0009-0000-8809-2680"]},"institutions":[{"id":"https://openalex.org/I198876898","display_name":"Kashan University of Medical Sciences","ror":"https://ror.org/03dc0dy65","country_code":"IR","type":"education","lineage":["https://openalex.org/I198876898"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fatemeh Zarepour","raw_affiliation_strings":["School of Medicine, Kashan University of Medical Sciences, Kashan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Kashan University of Medical Sciences, Kashan, Iran","institution_ids":["https://openalex.org/I198876898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102936667","display_name":"Seyed Pouya Taghavi","orcid":"https://orcid.org/0009-0007-3208-7568","observed_orcids":["https://orcid.org/0009-0007-3208-7568"]},"institutions":[{"id":"https://openalex.org/I198876898","display_name":"Kashan University of Medical Sciences","ror":"https://ror.org/03dc0dy65","country_code":"IR","type":"education","lineage":["https://openalex.org/I198876898"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Seyed Pouya Taghavi","raw_affiliation_strings":["School of Medicine, Kashan University of Medical Sciences, Kashan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Kashan University of Medical Sciences, Kashan, Iran","institution_ids":["https://openalex.org/I198876898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035507824","display_name":"Zatollah Asemi","orcid":"https://orcid.org/0000-0001-5265-4792","observed_orcids":["https://orcid.org/0000-0001-5265-4792","https://orcid.org/0000-0002-8985-7224","https://orcid.org/0000-0002-8773-5063"]},"institutions":[{"id":"https://openalex.org/I198876898","display_name":"Kashan University of Medical Sciences","ror":"https://ror.org/03dc0dy65","country_code":"IR","type":"education","lineage":["https://openalex.org/I198876898"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Zatollah Asemi","raw_affiliation_strings":["Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran","institution_ids":["https://openalex.org/I198876898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024028921","display_name":"Mina Alimohammadi","orcid":"https://orcid.org/0000-0002-5953-3894","observed_orcids":["https://orcid.org/0000-0002-5953-3894"]},"institutions":[{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mina Alimohammadi","raw_affiliation_strings":["Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran","institution_ids":["https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058516379","display_name":"Hamed Mirzaei","orcid":"https://orcid.org/0000-0002-9399-8281","observed_orcids":["https://orcid.org/0000-0002-9399-8281"]},"institutions":[{"id":"https://openalex.org/I198876898","display_name":"Kashan University of Medical Sciences","ror":"https://ror.org/03dc0dy65","country_code":"IR","type":"education","lineage":["https://openalex.org/I198876898"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Hamed Mirzaei","raw_affiliation_strings":["Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran","institution_ids":["https://openalex.org/I198876898"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5024028921","https://openalex.org/A5035507824","https://openalex.org/A5058516379"],"corresponding_institution_ids":["https://openalex.org/I198876898","https://openalex.org/I48379061","https://openalex.org/I58048189"],"apc_list":{"value":3295,"currency":"USD","value_usd":3295},"apc_paid":{"value":3295,"currency":"USD","value_usd":3295},"fwci":0.696,"has_fulltext":true,"cited_by_count":29,"citation_normalized_percentile":{"value":0.59330214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"1224138","last_page":"1224138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.921999990940094},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.871999979019165},{"id":"https://openalex.org/keywords/microrna-sponging","display_name":"microRNA sponging","score":0.9150000214576721},{"id":"https://openalex.org/keywords/rna-binding-proteins","display_name":"RNA-binding proteins","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8529999852180481},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6380000114440918},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9480000138282776},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.9829999804496765}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.9177614450454712},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7362458109855652},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6569536328315735},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6512807607650757},{"id":"https://openalex.org/C2775893923","wikidata":"https://www.wikidata.org/wiki/Q17113455","display_name":"Circular RNA","level":4,"score":0.6457349061965942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5819122791290283},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5381577610969543},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.5105606317520142},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4741750955581665},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4312966763973236},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.41107094287872314},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3618156313896179},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19514405727386475},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12446784973144531},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1112927496433258}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2023.1224138","doi":"https://doi.org/10.3389/fonc.2023.1224138","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1224138","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2023.1224138/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10403753","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10403753","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10403753/pdf/fonc-13-1224138.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmid:37546393","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37546393","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:391611bdc9f248ef952491792357b070","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/391611bdc9f248ef952491792357b070","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 13 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2023.1224138","doi":"https://doi.org/10.3389/fonc.2023.1224138","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2023.1224138","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2023.1224138/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384944579.pdf","grobid_xml":"https://content.openalex.org/works/W4384944579.grobid-xml"},"referenced_works_count":126,"referenced_works":["https://openalex.org/W266824605","https://openalex.org/W1493048246","https://openalex.org/W1828537510","https://openalex.org/W1874402154","https://openalex.org/W1966411071","https://openalex.org/W1987604182","https://openalex.org/W1991082489","https://openalex.org/W1993958351","https://openalex.org/W2024597705","https://openalex.org/W2041935553","https://openalex.org/W2054368385","https://openalex.org/W2070396671","https://openalex.org/W2076731393","https://openalex.org/W2110180164","https://openalex.org/W2123906105","https://openalex.org/W2133208956","https://openalex.org/W2139362318","https://openalex.org/W2146177796","https://openalex.org/W2147650118","https://openalex.org/W2147806662","https://openalex.org/W2156995429","https://openalex.org/W2204741763","https://openalex.org/W2294798900","https://openalex.org/W2302185643","https://openalex.org/W2340428416","https://openalex.org/W2340727484","https://openalex.org/W2410272781","https://openalex.org/W2418544662","https://openalex.org/W2488747960","https://openalex.org/W2505356027","https://openalex.org/W2514180887","https://openalex.org/W2517463990","https://openalex.org/W2521853540","https://openalex.org/W2589317690","https://openalex.org/W2604807624","https://openalex.org/W2620700193","https://openalex.org/W2623552909","https://openalex.org/W2734161211","https://openalex.org/W2745439674","https://openalex.org/W2752245937","https://openalex.org/W2752595248","https://openalex.org/W2763966161","https://openalex.org/W2765218111","https://openalex.org/W2768485889","https://openalex.org/W2783682702","https://openalex.org/W2784109259","https://openalex.org/W2789673782","https://openalex.org/W2807016011","https://openalex.org/W2887644169","https://openalex.org/W2890843793","https://openalex.org/W2892630678","https://openalex.org/W2896019639","https://openalex.org/W2896046349","https://openalex.org/W2900781189","https://openalex.org/W2900900388","https://openalex.org/W2903306073","https://openalex.org/W2906044490","https://openalex.org/W2914042729","https://openalex.org/W2917284875","https://openalex.org/W2935018975","https://openalex.org/W2937778559","https://openalex.org/W2942178020","https://openalex.org/W2943872580","https://openalex.org/W2944606734","https://openalex.org/W2946370330","https://openalex.org/W2947312378","https://openalex.org/W2952617602","https://openalex.org/W2952776850","https://openalex.org/W2959520494","https://openalex.org/W2967043226","https://openalex.org/W2969110624","https://openalex.org/W2970725386","https://openalex.org/W2979406301","https://openalex.org/W2982051172","https://openalex.org/W2982093057","https://openalex.org/W2986464336","https://openalex.org/W2996111288","https://openalex.org/W2997950546","https://openalex.org/W3003852549","https://openalex.org/W3014005728","https://openalex.org/W3020958757","https://openalex.org/W3026298410","https://openalex.org/W3029281600","https://openalex.org/W3041192553","https://openalex.org/W3047475137","https://openalex.org/W3047744467","https://openalex.org/W3080812149","https://openalex.org/W3081587678","https://openalex.org/W3084285571","https://openalex.org/W3085572122","https://openalex.org/W3087059068","https://openalex.org/W3087098593","https://openalex.org/W3091671203","https://openalex.org/W3093286659","https://openalex.org/W3108389912","https://openalex.org/W3109204011","https://openalex.org/W3109268452","https://openalex.org/W3112029431","https://openalex.org/W3112235049","https://openalex.org/W3116470610","https://openalex.org/W3118255995","https://openalex.org/W3123692497","https://openalex.org/W3129791198","https://openalex.org/W3156228806","https://openalex.org/W3186313196","https://openalex.org/W3186374935","https://openalex.org/W3195745212","https://openalex.org/W3200015679","https://openalex.org/W3200972373","https://openalex.org/W4200037845","https://openalex.org/W4205498896","https://openalex.org/W4205523190","https://openalex.org/W4206474828","https://openalex.org/W4213309506","https://openalex.org/W4220652145","https://openalex.org/W4229015588","https://openalex.org/W4280646759","https://openalex.org/W4286633576","https://openalex.org/W4289544903","https://openalex.org/W4293547320","https://openalex.org/W4294991793","https://openalex.org/W4315472870","https://openalex.org/W4317042533","https://openalex.org/W4360873894","https://openalex.org/W4366428865","https://openalex.org/W4367322112"],"related_works":["https://openalex.org/W7161972615","https://openalex.org/W2976877817","https://openalex.org/W2949946343","https://openalex.org/W4391144233","https://openalex.org/W2973587504","https://openalex.org/W3112029431","https://openalex.org/W2789673782","https://openalex.org/W3034906239","https://openalex.org/W4383653734","https://openalex.org/W2957674485"],"abstract_inverted_index":{"Hepatocellular":[0],"carcinoma":[1],"(HCC)":[2],"is":[3],"one":[4],"of":[5,37,55,77,118,129],"the":[6,59,78,94,125,140,161],"deadliest":[7],"cancers":[8],"due":[9],"to":[10,23,30],"multifocal":[11],"development":[12],"and":[13,26,49,87,113,127,150,155,159,176],"distant":[14],"metastasis":[15,128],"resulting":[16],"from":[17],"late":[18],"diagnosis.":[19],"Consequently,":[20],"new":[21],"approaches":[22],"HCC":[24,148],"diagnosis":[25],"treatment":[27],"are":[28,44,73],"required":[29],"reduce":[31],"mortality":[32],"rates.":[33],"A":[34],"large":[35],"body":[36],"evidence":[38],"suggests":[39],"that":[40,80],"non-coding":[41],"RNAs":[42,71],"(ncRNAs)":[43],"important":[45],"in":[46,104,139,179],"cancer":[47,82],"initiation":[48],"progression.":[50],"Cancer":[51],"cells":[52],"release":[53],"many":[54,130],"these":[56],"ncRNAs":[57,79],"into":[58],"blood":[60],"or":[61,167],"urine,":[62],"enabling":[63],"their":[64],"use":[65],"as":[66,74,93],"a":[67,75],"diagnostic":[68],"tool.":[69],"Circular":[70],"(CircRNAs)":[72],"members":[76],"regulate":[81],"cell":[83,111,114],"expansion,":[84],"migration,":[85],"metastasis,":[86],"chemoresistance":[88],"through":[89],"different":[90],"mechanisms":[91],"such":[92],"Wnt/\u03b2-catenin":[95,99,162],"Signaling":[96],"pathway.":[97,164],"The":[98],"pathway":[100,170],"plays":[101],"prominent":[102],"roles":[103],"several":[105,136],"biological":[106],"processes":[107],"including":[108,132],"organogenesis,":[109],"stem":[110],"regeneration,":[112],"survival.":[115],"Aberrant":[116],"signaling":[117,163,169],"both":[119],"pathways":[120],"mentioned":[121],"above":[122],"could":[123,171],"affect":[124],"progression":[126,151],"cancers,":[131],"HCC.":[133,180],"Based":[134],"on":[135,147],"studies":[137],"investigated":[138],"current":[141],"review,":[142],"circRNAs":[143],"have":[144],"an":[145],"effect":[146],"formation":[149],"by":[152],"sponging":[153],"miRNAs":[154],"RNA-binding":[156],"proteins":[157],"(RBPs)":[158],"regulating":[160],"Therefore,":[165],"circRNAs/miRNAs":[166],"RBPs/Wnt/\u03b2-catenin":[168],"be":[172],"considered":[173],"promising":[174],"prognostic":[175],"therapeutic":[177],"targets":[178]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2023-07-22T00:00:00"}
