{"id":"https://openalex.org/W4384929271","doi":"https://doi.org/10.3889/seejca.2023.6045","title":"The Role of Microtubules in Heart Failure","display_name":"The Role of Microtubules in Heart Failure","publication_year":2023,"publication_date":"2023-07-15","ids":{"openalex":"https://openalex.org/W4384929271","doi":"https://doi.org/10.3889/seejca.2023.6045"},"language":"en","primary_location":{"id":"doi:10.3889/seejca.2023.6045","doi":"https://doi.org/10.3889/seejca.2023.6045","is_oa":true,"landing_page_url":"https://doi.org/10.3889/seejca.2023.6045","pdf_url":"https://seejca.eu/index.php/seejca/article/download/6045/5529","source":{"id":"https://openalex.org/S4210210270","display_name":"South East European Journal of Cardiology","issn_l":"1857-9361","issn":["1857-9361"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South East European Journal of Cardiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://seejca.eu/index.php/seejca/article/download/6045/5529","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113094123","display_name":"Sidhi Laksono","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113907","display_name":"Universitas Muhammadiyah Prof Dr Hamka","ror":"https://ror.org/01wqn3353","country_code":"ID","type":"education","lineage":["https://openalex.org/I4210113907"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Sidhi Laksono Purwowiyoto","raw_affiliation_strings":["Department of Cardiology and Vascular Medicine, Diagram Siloam Heart Hospital, Depok, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Prof. DR. Hamka, Tangerang, Indonesia","Department of Cardiology and Vascular Medicine, Diagram Siloam Heart Hospital, Depok, Indonesia","Faculty of Medicine, Universitas Muhammadiyah Prof. DR. Hamka, Tangerang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-2959-8937","affiliations":[{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Diagram Siloam Heart Hospital, Depok, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Prof. DR. Hamka, Tangerang, Indonesia","institution_ids":["https://openalex.org/I4210113907"]},{"raw_affiliation_string":"Department of Cardiology and Vascular Medicine, Diagram Siloam Heart Hospital, Depok, Indonesia","institution_ids":[]},{"raw_affiliation_string":"Faculty of Medicine, Universitas Muhammadiyah Prof. DR. Hamka, Tangerang, Indonesia","institution_ids":["https://openalex.org/I4210113907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092005034","display_name":"Nadia Afiyani","orcid":"https://orcid.org/0000-0002-1330-1326","observed_orcids":["https://orcid.org/0000-0002-1330-1326"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nadia Afiyani","raw_affiliation_strings":["Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0002-1330-1326","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia","institution_ids":["https://openalex.org/I11855966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101658796","display_name":"Axel Jusuf","orcid":"https://orcid.org/0000-0003-4151-5839","observed_orcids":["https://orcid.org/0000-0003-4151-5839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Axel Jusuf","raw_affiliation_strings":["Faculty of Medicine"],"raw_orcid":"https://orcid.org/0000-0003-4151-5839","affiliations":[{"raw_affiliation_string":"Faculty of Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086970467","display_name":"Hillary Kusharsamita","orcid":"https://orcid.org/0000-0001-5242-2393","observed_orcids":["https://orcid.org/0000-0001-5242-2393"]},"institutions":[{"id":"https://openalex.org/I11855966","display_name":"Diponegoro University","ror":"https://ror.org/056bjta22","country_code":"ID","type":"education","lineage":["https://openalex.org/I11855966"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Hillary Kusharsamita","raw_affiliation_strings":["Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-5242-2393","affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia","institution_ids":["https://openalex.org/I11855966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"4","issue":"1","first_page":"22","last_page":"28"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.5976999998092651,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.30489999055862427,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.824999988079071},{"id":"https://openalex.org/keywords/microtubules","display_name":"microtubules","score":0.9350000023841858},{"id":"https://openalex.org/keywords/microtubule-cytoskeleton","display_name":"microtubule cytoskeleton","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/myocardial-stiffness","display_name":"myocardial stiffness","score":0.902999997138977},{"id":"https://openalex.org/keywords/cardiomyocyte-contractile-dysfunction","display_name":"cardiomyocyte contractile dysfunction","score":0.972000002861023},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/microtubule-detyrosination","display_name":"microtubule detyrosination","score":0.9739999771118164}],"concepts":[{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.8664238452911377},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.6854364275932312},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.555283784866333},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.5358314514160156},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.519638180732727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47173941135406494},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.4599624574184418},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.45112648606300354},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.4429183900356293},{"id":"https://openalex.org/C3018686881","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac myocyte","level":3,"score":0.41061919927597046},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3920731246471405},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38615110516548157},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2924386262893677},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07587823271751404},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3889/seejca.2023.6045","doi":"https://doi.org/10.3889/seejca.2023.6045","is_oa":true,"landing_page_url":"https://doi.org/10.3889/seejca.2023.6045","pdf_url":"https://seejca.eu/index.php/seejca/article/download/6045/5529","source":{"id":"https://openalex.org/S4210210270","display_name":"South East European Journal of Cardiology","issn_l":"1857-9361","issn":["1857-9361"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South East European Journal of Cardiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3889/seejca.2023.6045","doi":"https://doi.org/10.3889/seejca.2023.6045","is_oa":true,"landing_page_url":"https://doi.org/10.3889/seejca.2023.6045","pdf_url":"https://seejca.eu/index.php/seejca/article/download/6045/5529","source":{"id":"https://openalex.org/S4210210270","display_name":"South East European Journal of Cardiology","issn_l":"1857-9361","issn":["1857-9361"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322218","host_organization_name":"ID Design 2012/DOOEL Skopje","host_organization_lineage":["https://openalex.org/P4310322218"],"host_organization_lineage_names":["ID Design 2012/DOOEL Skopje"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"South East European Journal of Cardiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384929271.pdf","grobid_xml":"https://content.openalex.org/works/W4384929271.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1153335416","https://openalex.org/W1979100572","https://openalex.org/W1982275607","https://openalex.org/W2021476349","https://openalex.org/W2031426329","https://openalex.org/W2056916709","https://openalex.org/W2057948598","https://openalex.org/W2093039121","https://openalex.org/W2113436414","https://openalex.org/W2121302141","https://openalex.org/W2164535593","https://openalex.org/W2273265205","https://openalex.org/W2336853363","https://openalex.org/W2581428340","https://openalex.org/W2606547287","https://openalex.org/W2803671762","https://openalex.org/W2806056378","https://openalex.org/W2806513202","https://openalex.org/W2810890368","https://openalex.org/W2890458971","https://openalex.org/W2894850729","https://openalex.org/W2896253748","https://openalex.org/W2950652067","https://openalex.org/W2968287550","https://openalex.org/W2983619165","https://openalex.org/W3000347972","https://openalex.org/W3001318322","https://openalex.org/W3015815374","https://openalex.org/W3038929236","https://openalex.org/W3094301295","https://openalex.org/W3158220026","https://openalex.org/W3164988570","https://openalex.org/W3189445129","https://openalex.org/W3194916623","https://openalex.org/W3210100628","https://openalex.org/W4224266180","https://openalex.org/W4226064354"],"related_works":["https://openalex.org/W4224266180","https://openalex.org/W2064157036","https://openalex.org/W4205686970","https://openalex.org/W4211160324","https://openalex.org/W2968287550","https://openalex.org/W2806513202","https://openalex.org/W2810890368","https://openalex.org/W67717493","https://openalex.org/W2791110731","https://openalex.org/W2884149293"],"abstract_inverted_index":{"Heart":[0],"failure":[1],"(HF)":[2],"is":[3,111,122],"a":[4,138],"complex":[5],"pathological":[6],"state":[7],"in":[8,31,68,72,151],"which":[9],"cardiac":[10,27,125],"performance":[11],"fails":[12],"to":[13,40,46,85,141],"match":[14],"perfusion":[15],"demand,":[16],"commonly":[17],"preceded":[18],"by":[19,114],"an":[20],"enlargement":[21],"of":[22,49,61,98,108,134,163,169,178],"the":[23,32,59,62,69,96,109,115,120,132,143,161,164,176],"heart":[24],"known":[25],"as":[26,92],"hypertrophy.":[28],"Pathological":[29],"changes":[30],"microtubule":[33,63],"network":[34],"(MTN)":[35],"organization":[36],"have":[37],"been":[38],"shown":[39],"increase":[41],"cellular":[42,150],"stiffness":[43,107],"and":[44,64,127,154],"lead":[45],"contractile":[47],"dysfunction":[48],"cardiomyocytes.":[50],"In":[51],"this":[52],"narrative":[53],"review,":[54],"we":[55],"are":[56,88,103,183],"focusing":[57],"on":[58,188],"role":[60],"also":[65],"its":[66],"mechanism":[67],"heart,":[70],"especially":[71],"HF.":[73,128],"We":[74],"conducted":[75],"literature":[76],"research":[77],"for":[78,131,160,174],"published":[79],"articles":[80],"carried":[81],"out":[82],"from":[83],"2012":[84],"2022.":[86],"Microtubules":[87],"polymers":[89],"that":[90,102],"serve":[91],"structural":[93],"elements":[94],"with":[95],"shape":[97],"long,":[99],"rigid":[100],"tubes":[101],"highly":[104],"dynamic.":[105],"The":[106],"myocardium":[110],"largely":[112],"influenced":[113],"MTN.":[116],"Through":[117],"various":[118,148],"methods,":[119],"MTN":[121],"remodeled":[123],"during":[124],"hypertrophy":[126],"Targeting":[129],"microtubules":[130,170],"treatment":[133],"HF":[135],"might":[136,171],"become":[137],"new":[139],"approach":[140],"improve":[142],"outcome.":[144],"While":[145],"colchicine":[146],"inhibits":[147],"microtubule-dependent":[149],"interphase":[152],"cells":[153],"proliferation,":[155],"it":[156],"needs":[157],"further":[158],"study":[159],"safety":[162],"adjusted":[165],"dosage.":[166],"Manipulating":[167],"detyrosination":[168],"be":[172],"useful":[173],"restoring":[175],"function":[177],"failing":[179],"myocytes":[180],"although":[181],"there":[182],"still":[184],"very":[185],"limited":[186],"data":[187],"this.":[189]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-07-22T00:00:00"}
