{"id":"https://openalex.org/W4384922643","doi":"https://doi.org/10.1080/07391102.2023.2236717","title":"Purification of ursolic acid and \u03b2-sitosterol from endophytic Alternaria alternata for their alpha-amylase inhibitory activity","display_name":"Purification of ursolic acid and \u03b2-sitosterol from endophytic Alternaria alternata for their alpha-amylase inhibitory activity","publication_year":2023,"publication_date":"2023-07-21","ids":{"openalex":"https://openalex.org/W4384922643","doi":"https://doi.org/10.1080/07391102.2023.2236717","pmid":"https://pubmed.ncbi.nlm.nih.gov/37477594"},"language":"en","primary_location":{"id":"doi:10.1080/07391102.2023.2236717","doi":"https://doi.org/10.1080/07391102.2023.2236717","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2023.2236717","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041950320","display_name":"Vagish Dwibedi","orcid":"https://orcid.org/0000-0002-5288-7788","observed_orcids":["https://orcid.org/0000-0002-5288-7788"]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]},{"id":"https://openalex.org/I376102","display_name":"Agricultural Research Organization","ror":"https://ror.org/05hbrxp80","country_code":"IL","type":"government","lineage":["https://openalex.org/I376102"]}],"countries":["IL","IN"],"is_corresponding":false,"raw_author_name":"Vagish Dwibedi","raw_affiliation_strings":["Institute of Soil, Water and Environmental Sciences, Volcani Resaerch Center, Agricultural Research Organization, Rishon Lezion, Israel","University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Soil, Water and Environmental Sciences, Volcani Resaerch Center, Agricultural Research Organization, Rishon Lezion, Israel","institution_ids":["https://openalex.org/I376102"]},{"raw_affiliation_string":"University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074636253","display_name":"Shashank Shekher Mishra","orcid":"https://orcid.org/0000-0003-0478-1206","observed_orcids":["https://orcid.org/0000-0003-0478-1206"]},"institutions":[{"id":"https://openalex.org/I933318745","display_name":"Dehradun Institute of Technology University","ror":"https://ror.org/01v5k4d73","country_code":"IN","type":"education","lineage":["https://openalex.org/I933318745"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shashank Shekher Mishra","raw_affiliation_strings":["School of Pharmaceuticals and Population Health Informatics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, India"],"raw_orcid":"https://orcid.org/0000-0003-0478-1206","affiliations":[{"raw_affiliation_string":"School of Pharmaceuticals and Population Health Informatics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, India","institution_ids":["https://openalex.org/I933318745"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nancy George","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nancy George","raw_affiliation_strings":["University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014896300","display_name":"Mahavir Joshi","orcid":"https://orcid.org/0000-0002-5957-6990","observed_orcids":["https://orcid.org/0000-0002-5957-6990"]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mahavir Joshi","raw_affiliation_strings":["University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100699009","display_name":"Gursharan Kaur","orcid":"https://orcid.org/0000-0002-8361-3990","observed_orcids":["https://orcid.org/0000-0002-8361-3990"]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gursharan Kaur","raw_affiliation_strings":["University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mukul Gupta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I101407740","display_name":"Chandigarh University","ror":"https://ror.org/05t4pvx35","country_code":"IN","type":"education","lineage":["https://openalex.org/I101407740"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Mukul Gupta","raw_affiliation_strings":["University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Institute of Biotechnology, Chandigarh University, Mohali, Punjab, India","institution_ids":["https://openalex.org/I101407740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051201312","display_name":"Santosh Kumar Rath","orcid":"https://orcid.org/0000-0001-8557-9450","observed_orcids":["https://orcid.org/0000-0001-8557-9450"]},"institutions":[{"id":"https://openalex.org/I933318745","display_name":"Dehradun Institute of Technology University","ror":"https://ror.org/01v5k4d73","country_code":"IN","type":"education","lineage":["https://openalex.org/I933318745"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Santosh Kumar Rath","raw_affiliation_strings":["School of Pharmaceuticals and Population Health Informatics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, India"],"raw_orcid":"https://orcid.org/0000-0001-8557-9450","affiliations":[{"raw_affiliation_string":"School of Pharmaceuticals and Population Health Informatics, Faculty of Pharmacy, DIT University, Dehradun, Uttarakhand, India","institution_ids":["https://openalex.org/I933318745"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051201312"],"corresponding_institution_ids":["https://openalex.org/I933318745"],"apc_list":null,"apc_paid":null,"fwci":1.8617,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.84887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"42","issue":"13","first_page":"6688","last_page":"6699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12257","display_name":"Bioactive natural compounds","score":0.019300000742077827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ursolic-acid","display_name":"ursolic acid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/beta-sitosterol","display_name":"\u03b2-sitosterol","score":0.9810000061988831},{"id":"https://openalex.org/keywords/alternaria-alternata","display_name":"Alternaria alternata","score":0.9890000224113464},{"id":"https://openalex.org/keywords/endophytic-fungi","display_name":"endophytic fungi","score":0.9350000023841858},{"id":"https://openalex.org/keywords/morus-alba","display_name":"Morus alba","score":0.9879999756813049},{"id":"https://openalex.org/keywords/alpha-amylase-inhibition","display_name":"\u03b1-amylase inhibition","score":0.8659999966621399},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/phytochemical-isolation","display_name":"phytochemical isolation","score":0.7620000243186951},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.925000011920929},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.8379999995231628},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.3199999928474426}],"concepts":[{"id":"https://openalex.org/C2780720873","wikidata":"https://www.wikidata.org/wiki/Q2704244","display_name":"Alternaria alternata","level":2,"score":0.8582520484924316},{"id":"https://openalex.org/C2779513101","wikidata":"https://www.wikidata.org/wiki/Q416260","display_name":"Ursolic acid","level":2,"score":0.7533888816833496},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.49729159474372864},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.47217220067977905},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3931204080581665},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3741006553173065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37279748916625977},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.356012761592865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09522143006324768},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000097245","descriptor_name":"Ursolic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000516","descriptor_name":"alpha-Amylases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000516","descriptor_name":"alpha-Amylases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000516","descriptor_name":"alpha-Amylases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000528","descriptor_name":"Alternaria","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007004","descriptor_name":"Hypoglycemic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012855","descriptor_name":"Sitosterols","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D012855","descriptor_name":"Sitosterols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012855","descriptor_name":"Sitosterols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014315","descriptor_name":"Triterpenes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060026","descriptor_name":"Endophytes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/07391102.2023.2236717","doi":"https://doi.org/10.1080/07391102.2023.2236717","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07391102.2023.2236717","pdf_url":null,"source":{"id":"https://openalex.org/S178711970","display_name":"Journal of Biomolecular Structure and Dynamics","issn_l":"0739-1102","issn":["0739-1102","1538-0254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biomolecular Structure and Dynamics","raw_type":"journal-article"},{"id":"pmid:37477594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37477594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of biomolecular structure & dynamics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W2051569507","https://openalex.org/W2078029501","https://openalex.org/W2108862931","https://openalex.org/W2134389003","https://openalex.org/W2609186521","https://openalex.org/W2616375782","https://openalex.org/W2622525330","https://openalex.org/W2797515596","https://openalex.org/W2801192475","https://openalex.org/W2900064725","https://openalex.org/W2937339395","https://openalex.org/W2941439763","https://openalex.org/W2964961627","https://openalex.org/W2973828898","https://openalex.org/W3010125055","https://openalex.org/W3043503597","https://openalex.org/W3080462788","https://openalex.org/W3194956508","https://openalex.org/W3212616655","https://openalex.org/W4206489966","https://openalex.org/W4280565907","https://openalex.org/W4281254650","https://openalex.org/W4285255010","https://openalex.org/W4312138105","https://openalex.org/W4327565265"],"related_works":["https://openalex.org/W2320586982","https://openalex.org/W4320205845","https://openalex.org/W2613652385","https://openalex.org/W4406907152","https://openalex.org/W4383371629","https://openalex.org/W1968014970","https://openalex.org/W2891692615","https://openalex.org/W4402895834","https://openalex.org/W4294233203","https://openalex.org/W4291139506"],"abstract_inverted_index":{"Fungal":[0],"endophytes":[1],"are":[2],"a":[3],"known":[4],"warehouse":[5],"of":[6,43,51,92],"bioactive":[7],"compounds":[8,45,76],"with":[9,33],"multifarious":[10],"applications.":[11],"In":[12,67,84],"the":[13,38,44,49,68,93,98,120],"present":[14,99],"investigation":[15],"two":[16],"compounds,":[17],"\u03b2-Sitosterol":[18],"(1)":[19,77],"and":[20,61,78],"ursolic":[21],"acid":[22],"(2),":[23],"were":[24],"isolated":[25,94],"from":[26,97],"Alternaria":[27],"alternata,":[28],"an":[29],"endophytic":[30,106],"fungus":[31],"associated":[32],"Morus":[34,109],"alba":[35,110],"Linn":[36,111],"for":[37],"first":[39],"time.":[40],"The":[41],"structure":[42],"was":[46],"elucidated":[47],"on":[48],"basis":[50],"comprehensive":[52],"spectral":[53],"analysis":[54],"(UV,":[55],"IR,":[56],"1":[57],"H-,":[58],"13":[59],"C-":[60],"2D-NMR,":[62],"as":[63,65],"well":[64],"HRESI\u2013MS).":[66],"in":[69,108,115,119],"vitro":[70],"alpha":[71],"amylase":[72],"inhibitory":[73],"assay":[74],"both":[75],"(2)":[79],"show":[80],"potent":[81],"antidiabetic":[82,116],"activity.":[83],"support,":[85],"Docking":[86],"studies":[87],"indicate":[88],"significant":[89],"binding":[90],"affinity":[91],"compounds.":[95],"Hence":[96],"study,":[100],"it":[101],"can":[102,112],"be":[103],"concluded":[104],"that":[105],"fungi":[107],"find":[113],"use":[114],"drug":[117],"development":[118],"medicinal":[121],"industry.Communicated":[122],"by":[123],"Ramaswamy":[124],"H.":[125],"Sarma":[126]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-07-22T00:00:00"}