{"id":"https://openalex.org/W4384835461","doi":"https://doi.org/10.1166/sam.2023.4461","title":"Therapeutic Effect of Triptolide Polymer Mesoscale Nanoparticles on Diabetic Nephropathy Mice","display_name":"Therapeutic Effect of Triptolide Polymer Mesoscale Nanoparticles on Diabetic Nephropathy Mice","publication_year":2023,"publication_date":"2023-04-01","ids":{"openalex":"https://openalex.org/W4384835461","doi":"https://doi.org/10.1166/sam.2023.4461"},"language":"en","primary_location":{"id":"doi:10.1166/sam.2023.4461","doi":"https://doi.org/10.1166/sam.2023.4461","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1166/sam.2023.4461","pdf_url":null,"source":{"id":"https://openalex.org/S2500547560","display_name":"Science of Advanced Materials","issn_l":"1947-2935","issn":["1947-2935","1947-2943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science of Advanced Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027130874","display_name":"Min Guo","orcid":"https://orcid.org/0000-0003-4450-4270","observed_orcids":["https://orcid.org/0000-0003-4450-4270"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Guo","raw_affiliation_strings":["Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"last","author":{"id":null,"display_name":"Peng Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Cheng","raw_affiliation_strings":["Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03700903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"4","first_page":"529","last_page":"535"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5062999725341797,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.3855000138282776,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/triptolide","display_name":"triptolide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9010000228881836},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5249999761581421},{"id":"https://openalex.org/keywords/encapsulation-efficiency","display_name":"encapsulation efficiency","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.46700000762939453},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.44999998807907104},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.5450000166893005},{"id":"https://openalex.org/keywords/hk-2-cells","display_name":"HK-2 cells","score":0.7070000171661377},{"id":"https://openalex.org/keywords/renal-tubular-epithelial-cells","display_name":"renal tubular epithelial cells","score":0.6840000152587891},{"id":"https://openalex.org/keywords/drug-solubility","display_name":"drug solubility","score":0.4830000102519989},{"id":"https://openalex.org/keywords/nanoparticle-synthesis","display_name":"nanoparticle synthesis","score":0.3930000066757202},{"id":"https://openalex.org/keywords/diabetic-mouse-model","display_name":"diabetic mouse model","score":0.4560000002384186},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2781164371","wikidata":"https://www.wikidata.org/wiki/Q906351","display_name":"Triptolide","level":3,"score":0.776678204536438},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.7003321051597595},{"id":"https://openalex.org/C2776964284","wikidata":"https://www.wikidata.org/wiki/Q410083","display_name":"Polyethylene glycol","level":2,"score":0.5008113384246826},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4822733998298645},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4293504059314728},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4072924256324768},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.39597398042678833},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.36122480034828186},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16913017630577087},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1182081401348114},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.08159399032592773}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1166/sam.2023.4461","doi":"https://doi.org/10.1166/sam.2023.4461","is_oa":false,"landing_page_url":"http://dx.doi.org/10.1166/sam.2023.4461","pdf_url":null,"source":{"id":"https://openalex.org/S2500547560","display_name":"Science of Advanced Materials","issn_l":"1947-2935","issn":["1947-2935","1947-2943"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-40"],"host_organization":"https://openalex.org/P4310321646","host_organization_name":"American Scientific Publishers","host_organization_lineage":["https://openalex.org/P4310321646"],"host_organization_lineage_names":["American Scientific Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science of Advanced Materials","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W2943344886","https://openalex.org/W2976744413","https://openalex.org/W2983762161","https://openalex.org/W2986433477","https://openalex.org/W3046377059","https://openalex.org/W3080474034","https://openalex.org/W3125944270","https://openalex.org/W3127710756","https://openalex.org/W3158615004","https://openalex.org/W3172658147","https://openalex.org/W3180700199","https://openalex.org/W3213836033","https://openalex.org/W4200266882","https://openalex.org/W4206945787","https://openalex.org/W4214651629","https://openalex.org/W4224273641","https://openalex.org/W4226087001","https://openalex.org/W4281757559","https://openalex.org/W4282574962","https://openalex.org/W4283315219","https://openalex.org/W4292869238","https://openalex.org/W4310331473","https://openalex.org/W6770323340"],"related_works":["https://openalex.org/W4415356144","https://openalex.org/W7128478071","https://openalex.org/W2317290053","https://openalex.org/W2976744413","https://openalex.org/W2375208141","https://openalex.org/W2352315251","https://openalex.org/W3137389108","https://openalex.org/W2468179825","https://openalex.org/W2313241988","https://openalex.org/W2808691716"],"abstract_inverted_index":{"Triptolide":[0],"(TP)":[1],"has":[2],"potential":[3,72,76],"adoption":[4],"value":[5],"in":[6,24,90,116,147,171,270,286,301,306,319,332,346],"the":[7,25,40,86,94,122,223,230,238,271,293,302],"treatment":[8],"of":[9,43,59,88,102,106,169,184,190,199,225,241,304],"nephropathy,":[10],"but":[11],"its":[12],"poor":[13],"water":[14],"solubility":[15],"causes":[16],"toxicity":[17],"and":[18,28,47,70,92,98,121,138,165,195,202,209,229,245,267,299,330,361,368],"side":[19],"effects":[20],"to":[21,84,277,292,337],"various":[22,172],"degrees":[23],"kidney,":[26],"liver,":[27],"other":[29,123],"organs.":[30],"In":[31,342],"this":[32,347],"research,":[33],"TP-mesoscale":[34],"nanoparticles":[35],"(TP-MNPs)":[36],"were":[37,114,128,176,204,250,274,309,322,335],"synthesized":[38],"by":[39,63,110,366],"amide":[41],"reaction":[42],"poly(lactic-co-glycolic":[44],"acid)":[45],"(PLGA)":[46],"methoxy":[48],"polyethylene":[49],"glycol":[50],"amine":[51],"(mPEG-NH2)":[52],"as":[53],"drug":[54,99],"carrier":[55],"materials.":[56],"The":[57,104,150,178,213],"structure":[58],"TP-MNPs":[60,91,107,191,203,226,249,344],"was":[61,82,108,186,192,289],"characterized":[62],"1H":[64],"NMR,":[65],"scanning":[66],"electron":[67],"microscopy":[68],"(SEM),":[69],"zeta":[71,197],"using":[73],"a":[74,233,370],"nanoparticle":[75],"analyzer.":[77],"Liquid":[78],"chromatography\u2013mass":[79],"spectrometry":[80],"(HPLC\u2013MS)":[81],"utilized":[83],"determine":[85],"content":[87,269,285],"TP":[89,134,217,221,253,320],"calculate":[93],"entrapment":[95],"rate":[96],"(ER)":[97],"loading":[100],"(DL)":[101],"TP-MNPs.":[103],"cytotoxicity":[105],"detected":[109],"CCK8.":[111],"Eight":[112],"mice":[113,146,170,305],"enrolled":[115],"Blank":[117,278,313,325],"group":[118,126,132,135,140,254,273,279,288,295,308,314,321,326,334,339],"(no":[119],"treatment),":[120],"24":[124],"model":[125,131],"animals":[127],"rolled":[129],"into":[130],"(DM),":[133],"(TP":[136],"intervention),":[137],"TP-MNP":[139,287,333],"(TP-MNPs":[141],"intervention)":[142],"randomly,":[143],"with":[144,216,248],"eight":[145],"each":[148],"group.":[149],"urine":[151,283],"protein":[152,258,284],"content,":[153,259],"serum":[154,264,303,362],"albumin":[155],"(Alb),":[156],"blood":[157],"glucose":[158],"(Glu),":[159],"creatinine":[160],"(Cre),":[161],"total":[162],"cholesterol":[163],"(TCHO),":[164],"triglyceride":[166],"(TG)":[167],"contents":[168],"groups":[173],"after":[174],"intervention":[175],"compared.":[177],"results":[179],"revealed":[180],"that":[181,189],"average":[182,196],"diameter":[183],"MNPs":[185],"(379.6\u00b126.44)":[187],"nm,":[188,194],"(424.3\u00b156.29)":[193],"potentials":[198],"TP,":[200],"MNPs,":[201],"(\u221228.29\u00b13.85)":[205],"mV,":[206,208,211],"(\u221215.51\u00b11.79)":[207],"(\u221213.45\u00b11.81)":[210],"respectively.":[212],"curve":[214],"changed":[215],"concentration.":[218],"With":[219],"increasing":[220],"concentration,":[222],"ER":[224],"decreased":[227],"drastically,":[228],"DL":[231],"demonstrated":[232],"drastic":[234],"upward":[235],"trend.":[236],"Furthermore,":[237],"cell":[239],"activities":[240],"HK-2,":[242],"NRK-52E,":[243],"LO2,":[244],"AML-12":[246],"treated":[247],"higher":[251],"versus":[252,312],"(P":[255,280,296,315,327,340],"<0.05).":[256,328,341],"Urine":[257],"body":[260,357],"weight,":[261,358],"renal":[262,359],"index,":[263,360],"Glu,":[265],"TCHO,":[266],"TG":[268],"DM":[272,294,307,338],"markedly":[275],"superior":[276,336],"<0.001),":[281],"while":[282,317],"considerably":[290],"inferior":[291],"<0.01).":[297],"Alb":[298,329],"Cre":[300,331],"substantially":[310],"lower":[311,323],"<0.01),":[316],"those":[318],"than":[324],"summary,":[343],"prepared":[345],"research":[348],"had":[349,369],"ideal":[350],"biocompatibility,":[351],"could":[352],"effectively":[353],"improve":[354],"urinary":[355],"protein,":[356],"biochemical":[363],"indexes":[364],"caused":[365],"DM,":[367],"certain":[371],"therapeutic":[372],"effect":[373],"on":[374],"diabetic":[375],"nephropathy":[376],"(DN)":[377],"mice.":[378]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2023-07-21T00:00:00"}