{"id":"https://openalex.org/W4384826162","doi":"https://doi.org/10.1158/1055-9965.c.6749970.v1","title":"Data from Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci","display_name":"Data from Using DEPendency of Association on the Number of Top Hits (DEPTH) as a Complementary Tool to Identify Novel Colorectal Cancer Susceptibility Loci","publication_year":2023,"publication_date":"2023-07-19","ids":{"openalex":"https://openalex.org/W4384826162","doi":"https://doi.org/10.1158/1055-9965.c.6749970.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6749970.v1","doi":"https://doi.org/10.1158/1055-9965.c.6749970.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6749970.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1055-9965.c.6749970.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051491693","display_name":"John Lai","orcid":"https://orcid.org/0000-0002-8019-7012","observed_orcids":["https://orcid.org/0000-0002-8019-7012"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Lai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8019-7012","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069668259","display_name":"Chi Kuen Wong","orcid":"https://orcid.org/0000-0001-9792-4792","observed_orcids":["https://orcid.org/0000-0001-9792-4792","https://orcid.org/0009-0007-8523-8884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chi Kuen Wong","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9792-4792","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046316602","display_name":"Daniel Francis Schmidt","orcid":"https://orcid.org/0000-0002-1788-2375","observed_orcids":["https://orcid.org/0000-0002-1788-2375"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel F. Schmidt","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1788-2375","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042522659","display_name":"Miroslaw K. Kapuscinski","orcid":"https://orcid.org/0000-0002-4561-2719","observed_orcids":["https://orcid.org/0000-0002-4561-2719"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miroslaw K. Kapuscinski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4561-2719","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044218205","display_name":"Karen Alpen","orcid":"https://orcid.org/0000-0001-8283-2422","observed_orcids":["https://orcid.org/0000-0001-8283-2422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Alpen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8283-2422","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067052917","display_name":"Robert J. MacInnis","orcid":"https://orcid.org/0000-0002-1627-5047","observed_orcids":["https://orcid.org/0000-0002-1627-5047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert J. MacInnis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1627-5047","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061298063","display_name":"Daniel D. Buchanan","orcid":"https://orcid.org/0000-0003-2225-6675","observed_orcids":["https://orcid.org/0000-0003-2225-6675"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel D. Buchanan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2225-6675","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063623376","display_name":"Aung Ko Win","orcid":"https://orcid.org/0000-0002-2794-5261","observed_orcids":["https://orcid.org/0000-0002-2794-5261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aung K. Win","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2794-5261","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023746352","display_name":"Jane C. Figueiredo","orcid":"https://orcid.org/0000-0001-8040-3341","observed_orcids":["https://orcid.org/0000-0001-8040-3341","https://orcid.org/0000-0002-2452-3194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane C. Figueiredo","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8040-3341","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068835941","display_name":"Andrew Tan Chan","orcid":"https://orcid.org/0000-0001-7284-6767","observed_orcids":["https://orcid.org/0000-0001-7284-6767","https://orcid.org/0000-0002-3662-5964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew T. Chan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7284-6767","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035274153","display_name":"Tabitha A. Harrison","orcid":"https://orcid.org/0000-0002-4173-7530","observed_orcids":["https://orcid.org/0000-0002-4173-7530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tabitha A. Harrison","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4173-7530","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036777611","display_name":"Michael Hoffmeister","orcid":"https://orcid.org/0000-0002-8307-3197","observed_orcids":["https://orcid.org/0000-0002-8307-3197"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Hoffmeister","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8307-3197","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107467351","display_name":"Emily White","orcid":"https://orcid.org/0000-0003-0544-1633","observed_orcids":["https://orcid.org/0000-0003-0544-1633","https://orcid.org/0000-0002-8935-6227","https://orcid.org/0000-0002-8177-0829"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily White","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0544-1633","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053074659","display_name":"Lo\u0131\u0308c Le Marchand","orcid":"https://orcid.org/0000-0001-5013-980X","observed_orcids":["https://orcid.org/0000-0001-5013-980X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Loic Le Marchand","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5013-980X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057225122","display_name":"Rish K. Pai","orcid":"https://orcid.org/0000-0002-2692-221X","observed_orcids":["https://orcid.org/0000-0002-2692-221X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rish K. Pai","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-2692-221X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053681099","display_name":"Ulrike Peters","orcid":"https://orcid.org/0000-0001-5666-9318","observed_orcids":["https://orcid.org/0000-0001-5666-9318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrike Peters","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5666-9318","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023667273","display_name":"John Llewelyn Hopper","orcid":"https://orcid.org/0000-0002-8567-173X","observed_orcids":["https://orcid.org/0000-0002-8567-173X","https://orcid.org/0000-0003-2445-8043"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John L. Hopper","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8567-173X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090508414","display_name":"Mark A. Jenkins","orcid":"https://orcid.org/0000-0002-8964-6160","observed_orcids":["https://orcid.org/0000-0002-8964-6160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark A. Jenkins","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8964-6160","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023193568","display_name":"Enes Makalic","orcid":"https://orcid.org/0000-0003-3017-0871","observed_orcids":["https://orcid.org/0000-0003-3017-0871"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Enes Makalic","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3017-0871","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/depth","display_name":"depth","score":0.6890000104904175},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8240000009536743},{"id":"https://openalex.org/keywords/rolling-window-analysis","display_name":"sliding window analysis","score":0.5910000205039978},{"id":"https://openalex.org/keywords/colon-cancer-family-registry","display_name":"CCFR","score":0.7379999756813049},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.6399999856948853}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7424948215484619},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7278386950492859},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.6819088459014893},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5801673531532288},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5523720383644104},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5227846503257751},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5183647274971008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4415168762207031},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30563077330589294},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.21955496072769165},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21075013279914856}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1055-9965.c.6749970.v1","doi":"https://doi.org/10.1158/1055-9965.c.6749970.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6749970.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6749970.v1","doi":"https://doi.org/10.1158/1055-9965.c.6749970.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6749970.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4382047191","https://openalex.org/W4310030109","https://openalex.org/W4402801592","https://openalex.org/W4402800739","https://openalex.org/W4402800968","https://openalex.org/W4402801292","https://openalex.org/W4402800678","https://openalex.org/W4402800479","https://openalex.org/W4402802497","https://openalex.org/W4402819798"],"abstract_inverted_index":{"AbstractBackground:":[0],"DEPendency":[1],"of":[2,7,27,43,66,106,131,241],"association":[3,102],"on":[4],"the":[5,21,31,51,148,198,206,217,223,262],"number":[6],"Top":[8],"Hits":[9],"(DEPTH)":[10],"is":[11],"an":[12],"approach":[13],"to":[14,46,84,90,136,253],"identify":[15,85,229],"candidate":[16,86,128,144,185,230],"susceptibility":[17,87,116,129,145,186,231,259],"regions":[18,88,146,161,187,232,260],"by":[19,176],"considering":[20],"risk":[22],"signals":[23],"from":[24,50,99],"overlapping":[25],"groups":[26],"sequential":[28],"variants":[29],"across":[30],"genome.":[32,263],"Methods:":[33],"We":[34,93,181],"applied":[35],"a":[36,40,249],"DEPTH":[37,78,95,120,156,194,227,245],"analysis":[38,121],"using":[39,167,238],"sliding":[41],"window":[42],"200":[44],"SNPs":[45,209],"colorectal":[47,178,234],"cancer":[48,179,235],"data":[49,152],"Colon":[52],"Cancer":[53,68],"Family":[54],"Registry":[55],"(CCFR;":[56],"5,735":[57],"cases":[58,72],"and":[59,62,64,73,125,142,150,214,220],"3,688":[60],"controls),":[61],"Genetics":[63],"Epidemiology":[65],"Colorectal":[67],"Consortium":[69],"(GECCO;":[70],"8,865":[71],"10,285":[74],"controls)":[75],"studies.":[76,138],"A":[77],"score":[79],">":[80],"1":[81],"was":[82],"used":[83],"common":[89,135],"both":[91,137],"analyses.":[92],"compared":[94],"results":[96],"against":[97,113],"those":[98],"conventional":[100,168,239,254],"genome-wide":[101],"study":[103],"(GWAS)":[104],"analyses":[105,240,256],"these":[107],"two":[108],"studies":[109],"as":[110,112,248],"well":[111],"132":[114],"published":[115],"regions.":[117],"Results:":[118],"Initial":[119],"revealed":[122,140],"2,622":[123],"(CCFR)":[124],"3,686":[126],"(GECCO)":[127],"regions,":[130],"which":[132],"569":[133],"were":[134,196,210],"Bootstrapping":[139],"40":[141],"49":[143],"in":[147,197],"CCFR":[149,218],"GECCO":[151,224],"sets,":[153],"respectively.":[154],"Notably,":[155],"identified":[157,175,237],"at":[158,203],"least":[159],"82":[160],"that":[162],"would":[163],"not":[164,236],"be":[165],"detected":[166],"GWAS":[169,255],"methods,":[170],"nor":[171],"had":[172],"they":[173],"been":[174],"previous":[177],"GWASs.":[180],"found":[182],"four":[183],"reproducible":[184],"(2q22.2,":[188],"2q33.1,":[189],"6p21.32,":[190],"13q14.3).":[191],"The":[192],"highest":[193],"scores":[195],"human":[199],"leukocyte":[200],"antigen":[201],"locus":[202],"6p21":[204],"where":[205],"strongest":[207],"associated":[208],"rs762216297,":[211],"rs149490268,":[212],"rs114741460,":[213],"rs199707618":[215],"for":[216,222,233,257],"data,":[219],"rs9270761":[221],"data.":[225],"Conclusions:":[226],"can":[228],"larger":[242],"datasets.":[243],"Impact:":[244],"has":[246],"potential":[247],"powerful":[250],"complementary":[251],"tool":[252],"discovering":[258],"within":[261]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2023-07-21T00:00:00"}
