{"id":"https://openalex.org/W4384822305","doi":"https://doi.org/10.3390/ijms241411635","title":"Exosome from IFN-\u03b3-Primed Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Improved Skin Inflammation and Barrier Function","display_name":"Exosome from IFN-\u03b3-Primed Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Improved Skin Inflammation and Barrier Function","publication_year":2023,"publication_date":"2023-07-19","ids":{"openalex":"https://openalex.org/W4384822305","doi":"https://doi.org/10.3390/ijms241411635","pmid":"https://pubmed.ncbi.nlm.nih.gov/37511392","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10380988"},"language":"en","primary_location":{"id":"doi:10.3390/ijms241411635","doi":"https://doi.org/10.3390/ijms241411635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241411635","pdf_url":"https://www.mdpi.com/1422-0067/24/14/11635/pdf?version=1689835548","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/24/14/11635/pdf?version=1689835548","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102829979","display_name":"Jin Ho Yoon","orcid":"https://orcid.org/0000-0003-4355-6888","observed_orcids":["https://orcid.org/0000-0003-4355-6888"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Yoon","raw_affiliation_strings":["Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-4355-6888","affiliations":[{"raw_affiliation_string":"Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114114963","display_name":"Seul Ki Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seul Ki Lee","raw_affiliation_strings":["Brexogen Research Center, Brexogen Inc., Seoul 05855, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brexogen Research Center, Brexogen Inc., Seoul 05855, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Arum Park","orcid":"https://orcid.org/0000-0001-7415-8220","observed_orcids":["https://orcid.org/0000-0001-7415-8220"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Arum Park","raw_affiliation_strings":["Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7415-8220","affiliations":[{"raw_affiliation_string":"Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jiho Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jiho Lee","raw_affiliation_strings":["Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Asan Institute for Life Sciences, Asan Medical Center, Seoul 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004249952","display_name":"Inuk Jung","orcid":"https://orcid.org/0000-0003-0675-4244","observed_orcids":["https://orcid.org/0000-0003-0675-4244"]},"institutions":[{"id":"https://openalex.org/I31419693","display_name":"Kyungpook National University","ror":"https://ror.org/040c17130","country_code":"KR","type":"education","lineage":["https://openalex.org/I31419693"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Inuk Jung","raw_affiliation_strings":["School of Computer Science and Engineering, Kyungpook National University, Daegu 41566, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-0675-4244","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Kyungpook National University, Daegu 41566, Republic of Korea","institution_ids":["https://openalex.org/I31419693"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014914435","display_name":"Kun Baek Song","orcid":"https://orcid.org/0000-0001-6981-6292","observed_orcids":["https://orcid.org/0000-0001-6981-6292"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kun Baek Song","raw_affiliation_strings":["Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051012813","display_name":"Eom Ji Choi","orcid":"https://orcid.org/0000-0002-1122-1592","observed_orcids":["https://orcid.org/0000-0002-1122-1592"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eom Ji Choi","raw_affiliation_strings":["Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101579318","display_name":"Soo Kim","orcid":"https://orcid.org/0000-0002-1818-0551","observed_orcids":["https://orcid.org/0000-0002-1818-0551"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Soo Kim","raw_affiliation_strings":["Brexogen Research Center, Brexogen Inc., Seoul 05855, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-1818-0551","affiliations":[{"raw_affiliation_string":"Brexogen Research Center, Brexogen Inc., Seoul 05855, Republic of Korea","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011638971","display_name":"Jinho Yu","orcid":"https://orcid.org/0000-0002-1226-8077","observed_orcids":["https://orcid.org/0000-0002-1226-8077"]},"institutions":[{"id":"https://openalex.org/I2801680663","display_name":"Asan Medical Center","ror":"https://ror.org/03s5q0090","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I2801680663","https://openalex.org/I4210167194"]},{"id":"https://openalex.org/I40542001","display_name":"University of Ulsan","ror":"https://ror.org/02c2f8975","country_code":"KR","type":"education","lineage":["https://openalex.org/I40542001"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jinho Yu","raw_affiliation_strings":["Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea","institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011638971","https://openalex.org/A5101579318"],"corresponding_institution_ids":["https://openalex.org/I2801680663","https://openalex.org/I40542001"],"apc_list":{"value":2500,"currency":"CHF","value_usd":2780},"apc_paid":{"value":2500,"currency":"CHF","value_usd":2780},"fwci":7.5616,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.98002773,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"24","issue":"14","first_page":"11635","last_page":"11635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8610000014305115},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/induced-pluripotent-stem-cell-derived-mesenchymal-stem-cells","display_name":"induced pluripotent stem cell-derived mesenchymal stem cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/interferon-gamma-priming","display_name":"interferon-gamma priming","score":0.9079999923706055},{"id":"https://openalex.org/keywords/aspergillus-fumigatus","display_name":"Aspergillus fumigatus","score":0.8849999904632568},{"id":"https://openalex.org/keywords/skin-barrier-function","display_name":"skin barrier function","score":0.878000020980835},{"id":"https://openalex.org/keywords/transepidermal-water-loss","display_name":"transepidermal water loss","score":0.9520000219345093},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.6970000267028809},{"id":"https://openalex.org/keywords/indoleamine-2-3-dioxygenase","display_name":"indoleamine 2,3-dioxygenase","score":0.9350000023841858},{"id":"https://openalex.org/keywords/il-25","display_name":"IL-25","score":0.8149999976158142},{"id":"https://openalex.org/keywords/il-33","display_name":"IL-33","score":0.9890000224113464},{"id":"https://openalex.org/keywords/thymic-stromal-lymphopoietin","display_name":"thymic stromal lymphopoietin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/t-cell-mediated-immunity","display_name":"T cell immunity","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6516625285148621},{"id":"https://openalex.org/C2778070265","wikidata":"https://www.wikidata.org/wiki/Q18048067","display_name":"Thymic stromal lymphopoietin","level":3,"score":0.6094828248023987},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5923861265182495},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.566270112991333},{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.5187223553657532},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.505474328994751},{"id":"https://openalex.org/C170178370","wikidata":"https://www.wikidata.org/wiki/Q14907905","display_name":"Keratin 5","level":3,"score":0.48297181725502014},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.47580060362815857},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.45209628343582153},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4480555057525635},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4408296048641205},{"id":"https://openalex.org/C95150158","wikidata":"https://www.wikidata.org/wiki/Q7833972","display_name":"Transepidermal water loss","level":3,"score":0.4370790719985962},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4197292625904083},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38838648796081543},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.34865230321884155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32500025629997253},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2465927004814148},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22652721405029297},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1698390543460846},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.09302395582199097},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.08258980512619019},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055354","descriptor_name":"Exosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D057026","descriptor_name":"Induced Pluripotent Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.3390/ijms241411635","doi":"https://doi.org/10.3390/ijms241411635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241411635","pdf_url":"https://www.mdpi.com/1422-0067/24/14/11635/pdf?version=1689835548","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10380988","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10380988","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10380988/pdf/ijms-24-11635.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:37511392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37511392","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3390/ijms241411635","doi":"https://doi.org/10.3390/ijms241411635","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms241411635","pdf_url":"https://www.mdpi.com/1422-0067/24/14/11635/pdf?version=1689835548","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7263987160","display_name":null,"funder_award_id":"HI18C2439","funder_id":"https://openalex.org/F4320322107","funder_display_name":"Korea Health Industry Development Institute"}],"funders":[{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384822305.pdf","grobid_xml":"https://content.openalex.org/works/W4384822305.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1838472703","https://openalex.org/W1858234123","https://openalex.org/W1872248581","https://openalex.org/W1979043688","https://openalex.org/W1984965755","https://openalex.org/W1989277387","https://openalex.org/W1993326869","https://openalex.org/W1994262603","https://openalex.org/W2019495971","https://openalex.org/W2028239901","https://openalex.org/W2034706779","https://openalex.org/W2045080708","https://openalex.org/W2058939618","https://openalex.org/W2068912461","https://openalex.org/W2094029007","https://openalex.org/W2104065243","https://openalex.org/W2126134953","https://openalex.org/W2133908459","https://openalex.org/W2155356620","https://openalex.org/W2159417266","https://openalex.org/W2166106062","https://openalex.org/W2233044846","https://openalex.org/W2416139822","https://openalex.org/W2506498379","https://openalex.org/W2508710172","https://openalex.org/W2565271826","https://openalex.org/W2567404056","https://openalex.org/W2569149698","https://openalex.org/W2587794239","https://openalex.org/W2605484523","https://openalex.org/W2759535657","https://openalex.org/W2765979567","https://openalex.org/W2770270415","https://openalex.org/W2789522113","https://openalex.org/W2793866333","https://openalex.org/W2829474003","https://openalex.org/W2887294251","https://openalex.org/W2896130761","https://openalex.org/W2944545583","https://openalex.org/W2947434778","https://openalex.org/W2965511575","https://openalex.org/W3096828292","https://openalex.org/W3211402536","https://openalex.org/W3213475114","https://openalex.org/W4230355606","https://openalex.org/W4231254854","https://openalex.org/W4232510995","https://openalex.org/W6749120383","https://openalex.org/W6813094581"],"related_works":["https://openalex.org/W4311664420","https://openalex.org/W4366184447","https://openalex.org/W2945760615","https://openalex.org/W4411534404","https://openalex.org/W3012118032","https://openalex.org/W2857550021","https://openalex.org/W4391021674","https://openalex.org/W2947434778","https://openalex.org/W4417263736","https://openalex.org/W6939599116"],"abstract_inverted_index":{"The":[0,63,111],"pathogenesis":[1],"of":[2,33,65,91,106,113,140,183,214],"atopic":[3],"dermatitis":[4],"(AD)":[5],"is":[6,26,193],"multifactorial,":[7],"including":[8,171],"immune":[9,203,231],"dysregulation":[10],"and":[11,15,78,99,101,145,147,156,165,178,200,211,227],"epidermal":[12,179],"barrier":[13,198,225],"defects,":[14],"a":[16],"novel":[17],"therapeutic":[18,31,83],"modality":[19],"that":[20,190],"can":[21],"simultaneously":[22],"target":[23],"multiple":[24],"pathways":[25],"needed.":[27],"We":[28],"investigated":[29,69],"the":[30,82,137,209],"effects":[32,64],"exosomes":[34],"(IFN-\u03b3-iExo)":[35],"secreted":[36],"from":[37,109,186],"IFN-\u03b3-primed":[38],"induced":[39],"pluripotent":[40],"stem":[41,44],"cell-derived":[42],"mesenchymal":[43],"cells":[45,95],"(iMSC)":[46],"in":[47,88,118,123,136,149,168,196],"mice":[48,58,188],"with":[49,59,97,131,206],"Aspergillus":[50],"fumigatus-induced":[51],"AD.":[52],"IFN-\u03b3-iExo":[53,66,132,160,191,207],"was":[54,116],"epicutaneously":[55],"administered":[56],"to":[57,134],"AD-like":[60],"skin":[61,107,184,197,224],"lesions.":[62],"treatment":[67,130,161,192],"were":[68,218],"through":[70],"clinical":[71,164,172,210],"scores,":[72,173],"transepidermal":[73],"water":[74],"loss":[75],"(TEWL)":[76],"measurements,":[77],"histopathology.":[79],"To":[80],"elucidate":[81],"mechanism,":[84],"we":[85],"used":[86],"an":[87],"vitro":[89],"model":[90],"human":[92,126],"keratinocyte":[93,127],"HaCaT":[94,128],"stimulated":[96],"IL-4":[98],"IL-13":[100],"performed":[102],"extensive":[103],"bioinformatics":[104],"analysis":[105,182],"mRNA":[108,138,185],"mice.":[110],"expression":[112,139],"indoleamine":[114],"2,3-dioxygenase":[115],"higher":[117],"IFN-\u03b3":[119],"primed":[120],"iMSCs":[121],"than":[122],"iMSCs.":[124],"In":[125],"cells,":[129],"led":[133],"decreases":[135],"thymic":[141],"stromal":[142],"lymphopoietin,":[143],"IL-25,":[144],"IL-33":[146],"increases":[148],"keratin":[150,152],"1,":[151,155],"10,":[153],"desmoglein":[154],"ceramide":[157],"synthase":[158],"3.":[159],"significantly":[162],"improved":[163,208],"histological":[166,212],"outcomes":[167,213],"AD":[169,187,215],"mice,":[170,216],"TEWL,":[174],"inflammatory":[175],"cell":[176,202],"infiltration,":[177],"thickness.":[180],"Bioinformatics":[181],"showed":[189],"predominantly":[194],"involved":[195],"function":[199,226],"T":[201,229],"response.":[204,232],"Treatment":[205],"which":[217],"likely":[219],"mediated":[220],"by":[221],"restoring":[222],"proper":[223],"suppressing":[228],"cell-mediated":[230]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2023-07-21T00:00:00"}