{"id":"https://openalex.org/W4384820927","doi":"https://doi.org/10.1377/hlthaff.2023.00146","title":"Early OxyContin Marketing Linked To Long-Term Spread Of Infectious Diseases Associated With Injection Drug Use","display_name":"Early OxyContin Marketing Linked To Long-Term Spread Of Infectious Diseases Associated With Injection Drug Use","publication_year":2023,"publication_date":"2023-07-19","ids":{"openalex":"https://openalex.org/W4384820927","doi":"https://doi.org/10.1377/hlthaff.2023.00146","pmid":"https://pubmed.ncbi.nlm.nih.gov/37467441","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10521060"},"language":"en","primary_location":{"id":"doi:10.1377/hlthaff.2023.00146","doi":"https://doi.org/10.1377/hlthaff.2023.00146","is_oa":false,"landing_page_url":"https://doi.org/10.1377/hlthaff.2023.00146","pdf_url":null,"source":{"id":"https://openalex.org/S4210185023","display_name":"Health Affairs","issn_l":"0278-2715","issn":["0278-2715","1544-5208","2694-233X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-a","doyens","fnege-2","jufo-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315983","host_organization_name":"Project HOPE","host_organization_lineage":["https://openalex.org/P4310315983"],"host_organization_lineage_names":["Project HOPE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Affairs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10521060/pdf/nihms-1925731.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035570331","display_name":"Julia M. Dennett","orcid":"https://orcid.org/0000-0002-5424-7522","observed_orcids":["https://orcid.org/0000-0002-5424-7522"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia M. Dennett","raw_affiliation_strings":["Julia M. Dennett, Yale University, New Haven, Connecticut"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Julia M. Dennett, Yale University, New Haven, Connecticut","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047954147","display_name":"Gregg Gonsalves","orcid":"https://orcid.org/0000-0002-5789-9841","observed_orcids":["https://orcid.org/0000-0002-5789-9841"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregg S. Gonsalves","raw_affiliation_strings":["Gregg S. Gonsalves (), Yale University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gregg S. Gonsalves (), Yale University","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":2.8027,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.90237868,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"42","issue":"8","first_page":"1081","last_page":"1090"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11860","display_name":"HIV, Drug Use, Sexual Risk","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxycontin","display_name":"OxyContin","score":0.9589999914169312},{"id":"https://openalex.org/keywords/oxycodone","display_name":"oxycodone","score":0.7480000257492065},{"id":"https://openalex.org/keywords/pharmaceutical-marketing","display_name":"pharmaceutical marketing","score":0.8560000061988831},{"id":"https://openalex.org/keywords/opioid-crisis","display_name":"opioid epidemic","score":0.8199999928474426},{"id":"https://openalex.org/keywords/injection-drug-use","display_name":"intravenous drug use","score":0.8809999823570251},{"id":"https://openalex.org/keywords/drug-overdose-deaths","display_name":"drug overdose deaths","score":0.5979999899864197},{"id":"https://openalex.org/keywords/synthetic-opioids","display_name":"synthetic opioids","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hepatitis-c","display_name":"hepatitis C","score":0.843999981880188},{"id":"https://openalex.org/keywords/hepatitis-b","display_name":"hepatitis B","score":0.8730000257492065},{"id":"https://openalex.org/keywords/hepatitis-a","display_name":"hepatitis A","score":0.996999979019165},{"id":"https://openalex.org/keywords/infective-endocarditis","display_name":"infective endocarditis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/drug-reformulation","display_name":"drug reformulation","score":0.6000000238418579},{"id":"https://openalex.org/keywords/pharmaceutical-industry-influence","display_name":"pharmaceutical industry influence","score":0.43799999356269836},{"id":"https://openalex.org/keywords/long-term-health-effects","display_name":"long-term health effects","score":0.625}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8435163497924805},{"id":"https://openalex.org/C2777170798","wikidata":"https://www.wikidata.org/wiki/Q65087481","display_name":"Opioid epidemic","level":4,"score":0.5754016041755676},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5066757798194885},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.46159929037094116},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3882324695587158},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.37024253606796265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2689429521560669},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.26868706941604614},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003141","descriptor_name":"Communicable Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009293","descriptor_name":"Opioid-Related Disorders","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D010098","descriptor_name":"Oxycodone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D040541","descriptor_name":"Marketing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062787","descriptor_name":"Drug Overdose","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1377/hlthaff.2023.00146","doi":"https://doi.org/10.1377/hlthaff.2023.00146","is_oa":false,"landing_page_url":"https://doi.org/10.1377/hlthaff.2023.00146","pdf_url":null,"source":{"id":"https://openalex.org/S4210185023","display_name":"Health Affairs","issn_l":"0278-2715","issn":["0278-2715","1544-5208","2694-233X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["anvur-scientific","dongbi-a","doyens","fnege-2","jufo-2","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315983","host_organization_name":"Project HOPE","host_organization_lineage":["https://openalex.org/P4310315983"],"host_organization_lineage_names":["Project HOPE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health Affairs","raw_type":"journal-article"},{"id":"pmid:37467441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37467441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Health affairs (Project Hope)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10521060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10521060","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10521060/pdf/nihms-1925731.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Health Aff (Millwood)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10521060","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10521060","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10521060/pdf/nihms-1925731.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Health Aff (Millwood)","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G316364202","display_name":null,"funder_award_id":"DP2-DA049282","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8768743412","display_name":"Novel, Adaptive Approaches to Predicting and Responding to Outbreaks of Overdose, HIV and HCV Among People Who Use Drugs","funder_award_id":"1dp2da049282-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"UL1TR001863","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000918128","display_name":"Making Better Decisions: Policy Modeling for AIDS and Drug Abuse","funder_award_id":"R37DA015612","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384820927.pdf","grobid_xml":"https://content.openalex.org/works/W4384820927.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1974086725","https://openalex.org/W2018430358","https://openalex.org/W2126791898","https://openalex.org/W2411156248","https://openalex.org/W2566089772","https://openalex.org/W2573321131","https://openalex.org/W2626090933","https://openalex.org/W2736253558","https://openalex.org/W2790579393","https://openalex.org/W2792529758","https://openalex.org/W2796033216","https://openalex.org/W2890727851","https://openalex.org/W2899220521","https://openalex.org/W2912770756","https://openalex.org/W2929758866","https://openalex.org/W3009920047","https://openalex.org/W3082021367","https://openalex.org/W3094152559","https://openalex.org/W3120299020","https://openalex.org/W3138206245","https://openalex.org/W3181033293","https://openalex.org/W3185605958","https://openalex.org/W3217057051","https://openalex.org/W4210358124","https://openalex.org/W4213176274"],"related_works":["https://openalex.org/W4392906978","https://openalex.org/W3121436318","https://openalex.org/W3162550544","https://openalex.org/W2912770756","https://openalex.org/W2972916450","https://openalex.org/W2911251964","https://openalex.org/W4386584174","https://openalex.org/W2890727851","https://openalex.org/W4220910759","https://openalex.org/W2909233141"],"abstract_inverted_index":{"The":[0,134],"initial":[1,54,85,110],"marketing":[2,30,56,86,112,159],"of":[3,17,28,33,40,51,61,93,99,105,117,137,169],"the":[4,15,18,22,25,41,49,58,67,90,97,103,147,162],"opioid":[5,19],"analgesic":[6],"OxyContin":[7,55,111,152,158],"in":[8,21,66,77,143],"1996":[9],"increased":[10,115,164],"fatal":[11,118],"drug":[12,35,63,171],"overdoses":[13],"over":[14],"course":[16],"epidemic":[20],"US.":[23,68],"However,":[24],"long-term":[26,59,139],"impacts":[27],"this":[29],"on":[31,57],"complications":[32,168],"injection":[34,62,170],"use,":[36],"a":[37,71],"key":[38],"feature":[39],"ongoing":[42],"crisis,":[43],"are":[44],"undetermined.":[45],"This":[46],"study":[47],"evaluated":[48],"effects":[50],"exposure":[52,83,149],"to":[53,74,84,109,150],"trajectories":[60],"use-related":[64],"outcomes":[65,76,140],"We":[69],"used":[70],"difference-in-differences":[72],"analysis":[73],"compare":[75],"states":[78,144],"with":[79],"high":[80],"versus":[81],"low":[82],"before":[87],"and":[88,102,126,130,166,173],"after":[89],"2010":[91],"reformulation":[92],"OxyContin,":[94],"which":[95],"facilitated":[96],"use":[98,172],"illicit":[100,174],"drugs":[101],"spread":[104],"infectious":[106],"disease.":[107],"Exposure":[108],"statistically":[113],"significantly":[114],"rates":[116],"synthetic":[119],"opioid-related":[120,175],"overdoses;":[121],"acute":[122],"hepatitis":[123],"A,":[124],"B,":[125],"C":[127],"viral":[128,165],"infections;":[129],"infective":[131],"endocarditis-related":[132],"deaths.":[133],"greatest":[135],"burden":[136],"adverse":[138],"has":[141],"been":[142],"that":[145,157],"experienced":[146],"highest":[148],"early":[151],"marketing.":[153],"Our":[154],"findings":[155],"indicate":[156],"decisions":[160],"from":[161],"mid-1990s":[163],"bacterial":[167],"overdose":[176],"deaths":[177],"twenty-five":[178],"years":[179],"later.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2023-07-21T00:00:00"}