{"id":"https://openalex.org/W4384818993","doi":"https://doi.org/10.1007/s40263-023-01021-8","title":"Amyloid-Lowering Monoclonal Antibodies for the Treatment of Early Alzheimer\u2019s Disease","display_name":"Amyloid-Lowering Monoclonal Antibodies for the Treatment of Early Alzheimer\u2019s Disease","publication_year":2023,"publication_date":"2023-07-20","ids":{"openalex":"https://openalex.org/W4384818993","doi":"https://doi.org/10.1007/s40263-023-01021-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37470978","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10439019"},"language":"en","primary_location":{"id":"doi:10.1007/s40263-023-01021-8","doi":"https://doi.org/10.1007/s40263-023-01021-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40263-023-01021-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40263-023-01021-8.pdf","source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s40263-023-01021-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092499964","display_name":"Solana Leisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Solana Leisher","raw_affiliation_strings":["Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Adriana Bohorquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Bohorquez","raw_affiliation_strings":["Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089706461","display_name":"Marcus Gay","orcid":"https://orcid.org/0009-0008-6995-9013","observed_orcids":["https://orcid.org/0009-0008-6995-9013"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marcus Gay","raw_affiliation_strings":["Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Victoria Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Garcia","raw_affiliation_strings":["Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104145246","display_name":"Renarda Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Renarda Jones","raw_affiliation_strings":["Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032657520","display_name":"Dobri Baldaranov","orcid":"https://orcid.org/0000-0001-9216-9564","observed_orcids":["https://orcid.org/0000-0001-9216-9564"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dobri Baldaranov","raw_affiliation_strings":["Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026799001","display_name":"Michael S. Rafii","orcid":"https://orcid.org/0000-0003-2640-2094","observed_orcids":["https://orcid.org/0000-0003-2640-2094"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael S. Rafii","raw_affiliation_strings":["Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA. mrafii@usc.edu","Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA"],"raw_orcid":"https://orcid.org/0000-0003-2640-2094","affiliations":[{"raw_affiliation_string":"Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA. mrafii@usc.edu","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Alzheimer's Therapeutic Research Institute, Keck School of Medicine of University of Southern California, San Diego, CA, 92130, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026799001"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.7639,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.61555934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"37","issue":"8","first_page":"671","last_page":"677"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9879999756813049},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6769999861717224},{"id":"https://openalex.org/keywords/anti-amyloid-monoclonal-antibodies","display_name":"anti-amyloid monoclonal antibodies","score":0.9710000157356262},{"id":"https://openalex.org/keywords/early-alzheimer-s-disease","display_name":"early Alzheimer's disease","score":0.6570000052452087},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.9150000214576721},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9570000171661377},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.7730000019073486},{"id":"https://openalex.org/keywords/fda-approved-drugs","display_name":"FDA-approved drugs","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.6253712773323059},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6186944842338562},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.5734136700630188},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.556267261505127},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5392540693283081},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5240347981452942},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5054333209991455},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.46934688091278076},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.4657585918903351},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4270646572113037},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40186363458633423},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.33780637383461},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32865801453590393},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2625638246536255},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21351245045661926},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15852057933807373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13075044751167297},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s40263-023-01021-8","doi":"https://doi.org/10.1007/s40263-023-01021-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40263-023-01021-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40263-023-01021-8.pdf","source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10439019","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10439019","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10439019/pdf/40263_2023_Article_1021.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"Text"},{"id":"pmid:37470978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37470978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS drugs","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s40263-023-01021-8","doi":"https://doi.org/10.1007/s40263-023-01021-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40263-023-01021-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s40263-023-01021-8.pdf","source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2710331009","display_name":"Clinical trials to prevent Alzheimer's Disease in Down Syndrome","funder_award_id":"R33AG066543","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4503456190","display_name":"Clinical trials to prevent Alzheimer's Disease in Down Syndrome","funder_award_id":"R61AG066543","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000881314","display_name":"Alzheimer's Clinical Trials Consortium (ACTC)","funder_award_id":"U24AG057437","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320308668","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384818993.pdf","grobid_xml":"https://content.openalex.org/works/W4384818993.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1520284233","https://openalex.org/W1974015070","https://openalex.org/W1993571512","https://openalex.org/W1998616945","https://openalex.org/W2036172794","https://openalex.org/W2099751992","https://openalex.org/W2108216694","https://openalex.org/W2313725855","https://openalex.org/W2734651019","https://openalex.org/W2743373469","https://openalex.org/W2753434084","https://openalex.org/W2798054687","https://openalex.org/W2808028315","https://openalex.org/W2884108666","https://openalex.org/W2951707943","https://openalex.org/W3112722171","https://openalex.org/W3137826907","https://openalex.org/W3152692563","https://openalex.org/W3200352393","https://openalex.org/W3205749467","https://openalex.org/W4210807180","https://openalex.org/W4211238543","https://openalex.org/W4225741213","https://openalex.org/W4226454711","https://openalex.org/W4291824893","https://openalex.org/W4310461604","https://openalex.org/W4324309277","https://openalex.org/W4360591479"],"related_works":["https://openalex.org/W6946098652","https://openalex.org/W6903528755","https://openalex.org/W4415350377","https://openalex.org/W4221103783","https://openalex.org/W4409316616","https://openalex.org/W7126247970","https://openalex.org/W4324356868","https://openalex.org/W4414206714","https://openalex.org/W4365810791","https://openalex.org/W4390476783"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1,76],"(AD)":[2],"is":[3],"the":[4,24,35,61,68,82,93],"leading":[5],"cause":[6],"of":[7,26,37,47,71],"dementia":[8],"worldwide.":[9],"Numerous":[10],"biomarker":[11],"studies":[12],"have":[13],"clearly":[14],"demonstrated":[15],"that":[16],"AD":[17],"has":[18],"a":[19,44],"long":[20],"asymptomatic":[21],"phase,":[22],"with":[23,96],"development":[25,36,46],"pathology":[27],"occurring":[28],"at":[29],"least":[30],"2":[31],"decades":[32],"prior":[33],"to":[34,74,78],"any":[38],"symptoms.":[39],"These":[40],"pathological":[41],"changes":[42],"include":[43],"stepwise":[45],"amyloid-\u03b2":[48],"(A\u03b2)":[49],"plaques,":[50],"followed":[51],"by":[52,81],"tau":[53],"neurofibrillary":[54],"tangles":[55],"and":[56,85],"subsequently":[57],"extensive":[58],"neurodegeneration":[59],"in":[60],"brain.":[62],"In":[63],"this":[64],"review,":[65],"we":[66],"discuss":[67],"first":[69],"class":[70],"drugs":[72],"intended":[73],"be":[75,79],"modifying":[77],"approved":[80],"US":[83],"Food":[84],"Drug":[86],"Administration":[87],"(FDA)":[88],"for":[89],"AD-anti-A\u03b2":[90],"monoclonal":[91],"antibodies-and":[92],"scientific":[94],"rationale":[95],"which":[97],"they":[98],"were":[99],"developed.":[100]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-07-21T00:00:00"}