{"id":"https://openalex.org/W4384526054","doi":"https://doi.org/10.1101/2023.07.16.549196","title":"Deciphering the polycistronic nature of Mycobacterium tuberculosis lipoproteins of unknown functions","display_name":"Deciphering the polycistronic nature of Mycobacterium tuberculosis lipoproteins of unknown functions","publication_year":2023,"publication_date":"2023-07-16","ids":{"openalex":"https://openalex.org/W4384526054","doi":"https://doi.org/10.1101/2023.07.16.549196"},"language":"en","primary_location":{"id":"doi:10.1101/2023.07.16.549196","doi":"https://doi.org/10.1101/2023.07.16.549196","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.16.549196","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/16/2023.07.16.549196.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/16/2023.07.16.549196.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111507011","display_name":"Blanco","orcid":"https://orcid.org/0000-0002-3671-7359","observed_orcids":["https://orcid.org/0000-0002-3671-7359"]},"institutions":[{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Blanco","raw_affiliation_strings":["Buenos Aires, Paraguay 2155 (C1121ABG), Buenos Aires, Argentina","Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria, Argentina (INTA), N. Repetto and de los Reseros, Hurlingham (1686), Buenos Aires, Argentina","Buenos Aires, Prguy 2155 (C1121ABG), Buenos Aires, Argentin"],"raw_orcid":"https://orcid.org/0000-0002-3671-7359","affiliations":[{"raw_affiliation_string":"Buenos Aires, Paraguay 2155 (C1121ABG), Buenos Aires, Argentina","institution_ids":[]},{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria, Argentina (INTA), N. Repetto and de los Reseros, Hurlingham (1686), Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210153948"]},{"raw_affiliation_string":"Buenos Aires, Prguy 2155 (C1121ABG), Buenos Aires, Argentin","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005809333","display_name":"Fabiana Bigi","orcid":"https://orcid.org/0000-0001-8637-7180","observed_orcids":["https://orcid.org/0000-0001-8637-7180"]},"institutions":[{"id":"https://openalex.org/I4210153948","display_name":"National Agricultural Technology Institute","ror":"https://ror.org/04wm52x94","country_code":"AR","type":"government","lineage":["https://openalex.org/I4210153948"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Fabiana Bigi","raw_affiliation_strings":["Buenos Aires, Paraguay 2155 (C1121ABG), Buenos Aires, Argentina","Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria, Argentina (INTA), N. Repetto and de los Reseros, Hurlingham (1686), Buenos Aires, Argentina","Buenos Aires, Prguy 2155 (C1121ABG), Buenos Aires, Argentin"],"raw_orcid":"https://orcid.org/0000-0001-8637-7180","affiliations":[{"raw_affiliation_string":"Buenos Aires, Paraguay 2155 (C1121ABG), Buenos Aires, Argentina","institution_ids":[]},{"raw_affiliation_string":"Instituto de Biotecnolog\u00eda, CICVyA, Instituto Nacional de Tecnolog\u00eda Agropecuaria, Argentina (INTA), N. Repetto and de los Reseros, Hurlingham (1686), Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210153948"]},{"raw_affiliation_string":"Buenos Aires, Prguy 2155 (C1121ABG), Buenos Aires, Argentin","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5005809333"],"corresponding_institution_ids":["https://openalex.org/I4210153948"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":1.0},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.9300000071525574},{"id":"https://openalex.org/keywords/polycistronic-transcription","display_name":"polycistronic transcription","score":0.8389999866485596},{"id":"https://openalex.org/keywords/transcription-units","display_name":"transcription units","score":0.7099999785423279},{"id":"https://openalex.org/keywords/gene-function-prediction","display_name":"gene function prediction","score":0.7350000143051147}],"concepts":[{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7717418670654297},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6949875950813293},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.6478617191314697},{"id":"https://openalex.org/C66746571","wikidata":"https://www.wikidata.org/wiki/Q1134833","display_name":"ENCODE","level":3,"score":0.6188839077949524},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.5872877240180969},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48039013147354126},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46103572845458984},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.40609055757522583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11576628684997559},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2023.07.16.549196","doi":"https://doi.org/10.1101/2023.07.16.549196","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.16.549196","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/16/2023.07.16.549196.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2023.07.16.549196","doi":"https://doi.org/10.1101/2023.07.16.549196","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1101/2023.07.16.549196","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/07/16/2023.07.16.549196.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384526054.pdf","grobid_xml":"https://content.openalex.org/works/W4384526054.grobid-xml"},"referenced_works_count":7,"referenced_works":["https://openalex.org/W51024494","https://openalex.org/W1987628857","https://openalex.org/W2056761870","https://openalex.org/W2113843322","https://openalex.org/W2144778585","https://openalex.org/W2158023121","https://openalex.org/W2896685945"],"related_works":["https://openalex.org/W2100235293","https://openalex.org/W4388655360","https://openalex.org/W4407896117","https://openalex.org/W4417304907","https://openalex.org/W7128639965","https://openalex.org/W7097774803","https://openalex.org/W2113843322","https://openalex.org/W7149224167","https://openalex.org/W7008672401","https://openalex.org/W2460531585"],"abstract_inverted_index":{"Abstract":[0],"Mycobacterium":[1],"tuberculosis":[2],",":[3],"the":[4],"causative":[5],"agent":[6],"of":[7,30,33],"human":[8],"tuberculosis,":[9],"encodes":[10],"116":[11],"lipoproteins,":[12],"from":[13],"which":[14],"48":[15],"have":[16],"no":[17],"demonstrated":[18,26],"or":[19,48],"predicted":[20,56],"function.":[21],"In":[22],"this":[23],"study,":[24],"we":[25],"that":[27,49],"six":[28],"genes":[29,43],"these":[31],"lipoproteins":[32],"unknown":[34],"function":[35],"are":[36],"encoded":[37],"in":[38],"transcriptional":[39],"units":[40],"together":[41],"with":[42,44],"experimentally":[45],"verified":[46],"functions":[47,57],"encode":[50],"conserved":[51],"functional":[52],"domains.":[53],"We":[54],"assigned":[55],"to":[58],"LpqT":[59],"(Rv1016c),":[60],"LppE":[61],"(1881c),":[62],"LppO":[63],"(Rv2290),":[64],"LprE":[65],"(Rv1252c)":[66],"and":[67],"LpqF":[68],"(Rv3593).":[69]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2023-07-18T00:00:00"}