{"id":"https://openalex.org/W4384460990","doi":"https://doi.org/10.1016/j.omtn.2023.07.014","title":"Trans-acting aptazyme for conditional gene knockdown in eukaryotic cells","display_name":"Trans-acting aptazyme for conditional gene knockdown in eukaryotic cells","publication_year":2023,"publication_date":"2023-07-16","ids":{"openalex":"https://openalex.org/W4384460990","doi":"https://doi.org/10.1016/j.omtn.2023.07.014","pmid":"https://pubmed.ncbi.nlm.nih.gov/37547296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10400872"},"language":"en","primary_location":{"id":"doi:10.1016/j.omtn.2023.07.014","doi":"https://doi.org/10.1016/j.omtn.2023.07.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2023.07.014","pdf_url":"https://doi.org/10.1016/j.omtn.2023.07.014","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.omtn.2023.07.014","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100681337","display_name":"Shan Zhou","orcid":"https://orcid.org/0000-0003-3605-7239","observed_orcids":["https://orcid.org/0000-0003-3605-7239"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Zhou","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","University of Chinese Academy of Sciences, Beijing 100049, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing 100049, P.R. China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011831550","display_name":"Meiyi Chen","orcid":"https://orcid.org/0000-0003-1761-9232","observed_orcids":["https://orcid.org/0000-0003-1761-9232"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meiyi Chen","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038560939","display_name":"Yi Yuan","orcid":"https://orcid.org/0000-0002-7188-3993","observed_orcids":["https://orcid.org/0000-0002-7188-3993","https://orcid.org/0000-0002-3414-9212","https://orcid.org/0000-0001-5342-7890","https://orcid.org/0000-0001-6933-1834","https://orcid.org/0000-0002-2653-8963","https://orcid.org/0000-0002-4270-8002","https://orcid.org/0000-0002-7330-4756","https://orcid.org/0009-0002-9485-2361","https://orcid.org/0009-0004-0703-9167","https://orcid.org/0009-0007-9957-9735","https://orcid.org/0009-0009-0664-7984","https://orcid.org/0009-0009-3284-2468"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Yuan","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102228551","display_name":"Yan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Xu","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023784479","display_name":"Qinlin Pu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinlin Pu","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077235248","display_name":"Xilei Ai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xilei Ai","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuai Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Liu","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011928394","display_name":"Feng Du","orcid":"https://orcid.org/0000-0003-0333-2687","observed_orcids":["https://orcid.org/0000-0003-0333-2687"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Du","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080088656","display_name":"Xin Huang","orcid":"https://orcid.org/0000-0001-8584-0284","observed_orcids":["https://orcid.org/0000-0001-8584-0284"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Huang","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Juan Dong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Dong","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054778343","display_name":"Xin Cui","orcid":"https://orcid.org/0000-0001-8371-353X","observed_orcids":["https://orcid.org/0000-0001-8371-353X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Cui","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024356456","display_name":"Zhuo Tang","orcid":"https://orcid.org/0000-0002-5845-3569","observed_orcids":["https://orcid.org/0000-0002-5845-3569"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhuo Tang","raw_affiliation_strings":["Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-5845-3569","affiliations":[{"raw_affiliation_string":"Natural Products Research Center, Chengdu Institution of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5024356456"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":0.8647,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.68360972,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"33","issue":null,"first_page":"367","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.16329999268054962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.05999999865889549,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hammerhead-ribozyme","display_name":"hammerhead ribozyme","score":0.9779999852180481},{"id":"https://openalex.org/keywords/conditional-gene-knockdown","display_name":"conditional gene knockdown","score":0.7929999828338623},{"id":"https://openalex.org/keywords/rna-cleavage","display_name":"RNA cleavage","score":0.6949999928474426},{"id":"https://openalex.org/keywords/eukaryotic-cells","display_name":"eukaryotic cells","score":0.7570000290870667}],"concepts":[{"id":"https://openalex.org/C2779792011","wikidata":"https://www.wikidata.org/wiki/Q3817690","display_name":"Hammerhead ribozyme","level":5,"score":0.9119746685028076},{"id":"https://openalex.org/C76346623","wikidata":"https://www.wikidata.org/wiki/Q205858","display_name":"Ribozyme","level":4,"score":0.8017894625663757},{"id":"https://openalex.org/C107745601","wikidata":"https://www.wikidata.org/wiki/Q3934265","display_name":"Hairpin ribozyme","level":5,"score":0.5976576209068298},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.5284134149551392},{"id":"https://openalex.org/C30951146","wikidata":"https://www.wikidata.org/wiki/Q6745754","display_name":"Mammalian CPEB3 ribozyme","level":5,"score":0.5232285857200623},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4734589457511902},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4649110734462738},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42057961225509644},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.417974054813385},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4145236015319824},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4068191647529602},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36519134044647217},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2730898857116699},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.omtn.2023.07.014","doi":"https://doi.org/10.1016/j.omtn.2023.07.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2023.07.014","pdf_url":"https://doi.org/10.1016/j.omtn.2023.07.014","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10400872","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10400872","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10400872/pdf/main.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther Nucleic Acids","raw_type":"Text"},{"id":"pmid:37547296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37547296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy. Nucleic acids","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:49fd6d324f714b53a66d4ff6e1fef7a9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/49fd6d324f714b53a66d4ff6e1fef7a9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 367-375 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.omtn.2023.07.014","doi":"https://doi.org/10.1016/j.omtn.2023.07.014","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.omtn.2023.07.014","pdf_url":"https://doi.org/10.1016/j.omtn.2023.07.014","source":{"id":"https://openalex.org/S2764969478","display_name":"Molecular Therapy \u2014 Nucleic Acids","issn_l":"2162-2531","issn":["2162-2531"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy - Nucleic Acids","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4184974449","display_name":null,"funder_award_id":"2022YFS0012","funder_id":"https://openalex.org/F4320333335","funder_display_name":"Sichuan Province Science and Technology Support Program"},{"id":"https://openalex.org/G4985061924","display_name":null,"funder_award_id":"CAS 2020365","funder_id":"https://openalex.org/F4320335892","funder_display_name":"Youth Innovation Promotion Association"},{"id":"https://openalex.org/G5614242580","display_name":null,"funder_award_id":"2022ZYD0090","funder_id":"https://openalex.org/F4320333335","funder_display_name":"Sichuan Province Science and Technology Support Program"},{"id":"https://openalex.org/G6023942949","display_name":null,"funder_award_id":"21877108","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6517424055","display_name":null,"funder_award_id":"22177111","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6813729690","display_name":null,"funder_award_id":"21907090","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G75549270","display_name":null,"funder_award_id":"2021-YF05-01739-SN","funder_id":"https://openalex.org/F4320329514","funder_display_name":"Chenzhou Municipal Science and Technology Bureau"},{"id":"https://openalex.org/G7734679588","display_name":null,"funder_award_id":"2022YFS0432","funder_id":"https://openalex.org/F4320333335","funder_display_name":"Sichuan Province Science and Technology Support Program"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322847","display_name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","ror":"https://ror.org/031141b54"},{"id":"https://openalex.org/F4320329514","display_name":"Chenzhou Municipal Science and Technology Bureau","ror":"https://ror.org/05bdadq23"},{"id":"https://openalex.org/F4320333335","display_name":"Sichuan Province Science and Technology Support Program","ror":null},{"id":"https://openalex.org/F4320335892","display_name":"Youth Innovation Promotion Association","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384460990.pdf","grobid_xml":"https://content.openalex.org/works/W4384460990.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1965464174","https://openalex.org/W1972556803","https://openalex.org/W1975310984","https://openalex.org/W1977709085","https://openalex.org/W1981988641","https://openalex.org/W1982169838","https://openalex.org/W1992783297","https://openalex.org/W2000545509","https://openalex.org/W2024354549","https://openalex.org/W2039213643","https://openalex.org/W2047946060","https://openalex.org/W2052812744","https://openalex.org/W2061140153","https://openalex.org/W2061279639","https://openalex.org/W2064470978","https://openalex.org/W2067540509","https://openalex.org/W2092541496","https://openalex.org/W2103537794","https://openalex.org/W2106877484","https://openalex.org/W2108842036","https://openalex.org/W2123902202","https://openalex.org/W2143926802","https://openalex.org/W2144759995","https://openalex.org/W2158721036","https://openalex.org/W2312510963","https://openalex.org/W2314325548","https://openalex.org/W2547323337","https://openalex.org/W2785091318","https://openalex.org/W2910445719","https://openalex.org/W3011744431","https://openalex.org/W4297496425","https://openalex.org/W4303430986"],"related_works":["https://openalex.org/W3011744431","https://openalex.org/W2910445719","https://openalex.org/W1975310984","https://openalex.org/W1968287790","https://openalex.org/W2973034005","https://openalex.org/W2008496459","https://openalex.org/W2564694415","https://openalex.org/W2123902202","https://openalex.org/W2562789922","https://openalex.org/W2164206844"],"abstract_inverted_index":{"Trans":[0],"-acting":[1],"hammerhead":[2,50,69,95],"ribozyme":[3,51],"inherits":[4],"the":[5,9,19,27,35,47,86,98,119,132],"advantages":[6],"of":[7,29,59,68],"being":[8],"smallest":[10],"and":[11,18,55,126,131],"best-characterized":[12],"RNA-cleaving":[13],"ribozyme,":[14],"offering":[15],"high":[16],"modularity":[17],"ability":[20],"to":[21,109,129],"cleave":[22],"any":[23,30],"desired":[24],"sequence":[25,37],"without":[26],"aid":[28],"protein,":[31],"as":[32,34],"long":[33],"target":[36],"contains":[38,72],"a":[39,73,124],"cleavage":[40,133],"site.":[41],"However,":[42],"achieving":[43],"precise":[44],"control":[45],"over":[46],"trans-":[48,100],"acting":[49,94,101],"would":[52],"enable":[53],"safer":[54],"more":[56],"accurate":[57],"regulation":[58],"gene":[60],"expression.":[61],"Herein,":[62],"we":[63,89],"described":[64],"an":[65],"intracellular":[66,87],"selection":[67],"aptazyme":[70],"that":[71],"theophylline":[74,108],"aptamer":[75],"on":[76,80,85],"stem":[77],"II":[78],"based":[79],"toxin":[81],"protein":[82],"IbsC.":[83],"Based":[84],"selection,":[88],"obtained":[90],"three":[91],"new":[92],"cis-":[93],"aptazymes.":[96,141],"Moreover,":[97],"corresponding":[99],"aptazymes":[102],"could":[103,135],"be":[104,136],"efficiently":[105],"induced":[106],"by":[107,138],"knock":[110],"down":[111],"different":[112],"targeted":[113],"genes":[114],"in":[115],"eukaryotic":[116],"cells.":[117],"Notably,":[118],"best":[120],"one,":[121],"T195,":[122],"exhibited":[123],"ligand-dependent":[125],"dose-dependent":[127],"response":[128],"theophylline,":[130],"efficiency":[134],"enhanced":[137],"incorporating":[139],"multiplex":[140]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-16T00:00:00"}