{"id":"https://openalex.org/W4384407681","doi":"https://doi.org/10.1021/acscentsci.3c00389","title":"Biocompatible Lysine Protecting Groups for the Chemoenzymatic Synthesis of K48/K63 Heterotypic and Branched Ubiquitin Chains","display_name":"Biocompatible Lysine Protecting Groups for the Chemoenzymatic Synthesis of K48/K63 Heterotypic and Branched Ubiquitin Chains","publication_year":2023,"publication_date":"2023-07-15","ids":{"openalex":"https://openalex.org/W4384407681","doi":"https://doi.org/10.1021/acscentsci.3c00389","pmid":"https://pubmed.ncbi.nlm.nih.gov/37637747","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10450881"},"language":"en","primary_location":{"id":"doi:10.1021/acscentsci.3c00389","doi":"https://doi.org/10.1021/acscentsci.3c00389","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acscentsci.3c00389","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.3c00389","source":{"id":"https://openalex.org/S2765035057","display_name":"ACS Central Science","issn_l":"2374-7943","issn":["2374-7943","2374-7951"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-3","ki-jl-1","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Central Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.3c00389","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091869457","display_name":"Toshiki Mikami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Toshiki Mikami","raw_affiliation_strings":["Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 3, CH-8093 Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 3, CH-8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024503121","display_name":"Sohei Majima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sohei Majima","raw_affiliation_strings":["Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 3, CH-8093 Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 3, CH-8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012213557","display_name":"Haewon Song","orcid":"https://orcid.org/0000-0002-3524-1379","observed_orcids":["https://orcid.org/0000-0002-3524-1379"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Haewon Song","raw_affiliation_strings":["Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 3, CH-8093 Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-3524-1379","affiliations":[{"raw_affiliation_string":"Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 3, CH-8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058457451","display_name":"Jeffrey W. Bode","orcid":"https://orcid.org/0000-0001-8394-8910","observed_orcids":["https://orcid.org/0000-0001-8394-8910"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4405255184","display_name":"Laboratory of Organic Chemistry","ror":"https://ror.org/02q73ep21","country_code":"CH","type":"facility","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088","https://openalex.org/I4405255184"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Jeffrey W. Bode","raw_affiliation_strings":["Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 3, CH-8093 Z\u00fcrich, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8394-8910","affiliations":[{"raw_affiliation_string":"Laboratory for Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 3, CH-8093 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058457451"],"corresponding_institution_ids":["https://openalex.org/I35440088","https://openalex.org/I4405255184"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.9506,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.70706444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"8","first_page":"1633","last_page":"1641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.6044999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.38040000200271606,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/branched-ubiquitin-chains","display_name":"branched ubiquitin chains","score":0.8119999766349792},{"id":"https://openalex.org/keywords/chemoenzymatic-synthesis","display_name":"chemoenzymatic synthesis","score":0.8930000066757202},{"id":"https://openalex.org/keywords/carbamate-protecting-groups","display_name":"carbamate protecting groups","score":0.9079999923706055},{"id":"https://openalex.org/keywords/periodate-cleavage","display_name":"periodate cleavage","score":0.9860000014305115},{"id":"https://openalex.org/keywords/e2-conjugating-enzyme","display_name":"E2 conjugating enzyme","score":0.8799999952316284},{"id":"https://openalex.org/keywords/e1-activating-enzyme","display_name":"E1 activating enzyme","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.7827818393707275},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.6858043670654297},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6815500259399414},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5041910409927368},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39944371581077576},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1758022904396057},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.1740761399269104},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.09656259417533875},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1021/acscentsci.3c00389","doi":"https://doi.org/10.1021/acscentsci.3c00389","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acscentsci.3c00389","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.3c00389","source":{"id":"https://openalex.org/S2765035057","display_name":"ACS Central Science","issn_l":"2374-7943","issn":["2374-7943","2374-7951"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-3","ki-jl-1","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Central Science","raw_type":"journal-article"},{"id":"doi:10.26434/chemrxiv-2023-hlk3f","doi":"https://doi.org/10.26434/chemrxiv-2023-hlk3f","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv-2023-hlk3f","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/6426abb891074bccd095c32b/original/biocompatible-lysine-protecting-groups-for-the-chemoenzymatic-synthesis-of-k48-k63-heterotypic-and-branched-ubiquitin-chains.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:10450881","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10450881","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10450881/pdf/oc3c00389.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Cent Sci","raw_type":"Text"},{"id":"pmid:37637747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37637747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS central science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1e1aaddafe4a45aeb6042dc7a0963172","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1e1aaddafe4a45aeb6042dc7a0963172","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Central Science, Vol 9, Iss 8, Pp 1633-1641 (2023)","raw_type":"article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/625340","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/625340","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ACS Central Science, 9 (8)","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.3929/ethz-b-000625340","doi":"https://doi.org/10.3929/ethz-b-000625340","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000625340","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1021/acscentsci.3c00389","doi":"https://doi.org/10.1021/acscentsci.3c00389","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acscentsci.3c00389","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acscentsci.3c00389","source":{"id":"https://openalex.org/S2765035057","display_name":"ACS Central Science","issn_l":"2374-7943","issn":["2374-7943","2374-7951"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-3","ki-jl-1","norway-1","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Central Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G177362576","display_name":null,"funder_award_id":"856581 \u2013 CHUbVi (ERC Synergy)","funder_id":"https://openalex.org/F4320335254","funder_display_name":"Horizon 2020"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G480980205","display_name":"Ubiquitin Chains in Viral Infections","funder_award_id":"856581","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320316983","display_name":"Takeda Foundation","ror":"https://ror.org/05xs52z55"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321013","display_name":"Radboud Universiteit","ror":"https://ror.org/016xsfp80"},{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320335254","display_name":"Horizon 2020","ror":null},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384407681.pdf","grobid_xml":"https://content.openalex.org/works/W4384407681.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1547431965","https://openalex.org/W1600472471","https://openalex.org/W1832030339","https://openalex.org/W1895640772","https://openalex.org/W1965414705","https://openalex.org/W1984644732","https://openalex.org/W1986429623","https://openalex.org/W1991841644","https://openalex.org/W1995740655","https://openalex.org/W2026512029","https://openalex.org/W2064655213","https://openalex.org/W2065687763","https://openalex.org/W2081617945","https://openalex.org/W2085055432","https://openalex.org/W2099464495","https://openalex.org/W2099887051","https://openalex.org/W2108762552","https://openalex.org/W2110960544","https://openalex.org/W2145216906","https://openalex.org/W2147363233","https://openalex.org/W2166440816","https://openalex.org/W2167825336","https://openalex.org/W2170153648","https://openalex.org/W2289887068","https://openalex.org/W2304335366","https://openalex.org/W2335561029","https://openalex.org/W2397650726","https://openalex.org/W2404881798","https://openalex.org/W2499269053","https://openalex.org/W2530977520","https://openalex.org/W2596330017","https://openalex.org/W2601411499","https://openalex.org/W2604798734","https://openalex.org/W2617577749","https://openalex.org/W2751521307","https://openalex.org/W2788812105","https://openalex.org/W2791146292","https://openalex.org/W2800857665","https://openalex.org/W2808739041","https://openalex.org/W2915061592","https://openalex.org/W2967405228","https://openalex.org/W2968833147","https://openalex.org/W2969197997","https://openalex.org/W2982296996","https://openalex.org/W2992467799","https://openalex.org/W3110515702","https://openalex.org/W3111133807","https://openalex.org/W3121536984","https://openalex.org/W3126821906","https://openalex.org/W3128179346","https://openalex.org/W3177897961","https://openalex.org/W3213562584","https://openalex.org/W4225978825","https://openalex.org/W4249834124","https://openalex.org/W4307715788","https://openalex.org/W4377019792","https://openalex.org/W4395070998","https://openalex.org/W4400422694","https://openalex.org/W4409279349"],"related_works":["https://openalex.org/W7105927472","https://openalex.org/W4414127861","https://openalex.org/W2081617945","https://openalex.org/W4377019792","https://openalex.org/W7127045582","https://openalex.org/W4403088993","https://openalex.org/W4315796828","https://openalex.org/W4240315516","https://openalex.org/W2776677226","https://openalex.org/W56951981"],"abstract_inverted_index":{"High":[0],"Resolution":[1],"Image":[2],"Download":[3],"MS":[4],"PowerPoint":[5],"Slide":[6],"The":[7,61,113],"elucidation":[8],"of":[9,13,48,55,63,104,142,167,176,188,212,218],"emerging":[10],"biological":[11],"functions":[12],"heterotypic":[14,105],"and":[15,29,39,65,69,87,106,111,115,121,140,148,162,194,210,229],"branched":[16,49,107,225],"ubiquitin":[17,125],"(Ub)":[18],"chains":[19,50,161],"requires":[20,52],"new":[21,71],"strategies":[22],"for":[23,101,208],"their":[24],"preparation":[25],"with":[26],"defined":[27],"lengths":[28],"connectivity.":[30],"While":[31],"in":[32],"vitro":[33],"enzymatic":[34,149],"assembly":[35],"using":[36],"expressed":[37],"E1-activating":[38],"E2-conjugating":[40,67],"enzymes":[41,68],"can":[42,154,198],"deliver":[43],"homotypic":[44],"chains,":[45,226],"the":[46,102,137,143,174,182,185,206,213,219],"synthesis":[47,103],"typically":[51],"extensive":[53],"mutations":[54],"lysines":[56,117],"or":[57,169,236],"other":[58],"sequence":[59],"modifications.":[60],"combination":[62],"K48-":[64],"K63-biased":[66],"two":[70],"carbamate":[72],"protecting":[73,152],"groups\u2500pyridoxal":[74],"5\u2032-phosphate":[75],"(PLP)-cleavable":[76],"a":[77,81,89,99,132,177,202],"mino":[78,90],"b":[79,91],"utan":[80,92],"mide":[82],"c":[83,95],"arbamate":[84,96],"(Abac":[85],"group)":[86],"periodate-cleavable":[88],"o":[93],"l":[94],"(Aboc":[97],"group)\u2500provides":[98],"strategy":[100],"Ub":[108,144,160,183,220],"trimers,":[109],"tetramers,":[110],"pentamers.":[112],"Abac-":[114],"Aboc-protected":[116],"are":[118],"readily":[119],"prepared":[120],"incorporated":[122],"into":[123],"synthetic":[124,235],"monomers.":[126],"As":[127],"these":[128],"masking":[129],"groups":[130,153],"contain":[131],"basic":[133],"amine,":[134],"they":[135],"preserve":[136],"overall":[138],"charge":[139],"properties":[141],"structure,":[145],"facilitating":[146],"folding":[147],"conjugations.":[150],"These":[151],"be":[155,199],"chemoselectively":[156],"removed":[157],"from":[158],"folded":[159],"monomers":[163,221],"by":[164,234],"buffered":[165],"solutions":[166],"PLP":[168],"NaIO":[170],"4":[171],".":[172],"Through":[173],"incorporation":[175],"cleavable":[178],"C-terminal":[179],"His-tag":[180],"on":[181,201],"acceptor,":[184],"entire":[186],"process":[187],"chain":[189],"building,":[190],"iterative":[191],"Abac":[192],"deprotections,":[193],"global":[195],"Aboc":[196],"cleavage":[197],"conducted":[200],"resin":[203],"support,":[204],"obviating":[205],"need":[207],"handling":[209],"purification":[211],"intermediate":[214],"oligomers.":[215],"Simple":[216],"modulation":[217],"affords":[222],"various":[223],"K48/K63":[224],"including":[227],"tetramers":[228],"pentamers":[230],"not":[231],"previously":[232],"accessible":[233],"biochemical":[237],"methods.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2023-07-16T00:00:00"}