{"id":"https://openalex.org/W4384338951","doi":"https://doi.org/10.1038/s41392-023-01556-8","title":"SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells","display_name":"SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells","publication_year":2023,"publication_date":"2023-07-14","ids":{"openalex":"https://openalex.org/W4384338951","doi":"https://doi.org/10.1038/s41392-023-01556-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37452066","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10349149"},"language":"en","primary_location":{"id":"doi:10.1038/s41392-023-01556-8","doi":"https://doi.org/10.1038/s41392-023-01556-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-023-01556-8","pdf_url":"https://www.nature.com/articles/s41392-023-01556-8.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41392-023-01556-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031961745","display_name":"Kai Yang","orcid":"https://orcid.org/0000-0003-3044-2240","observed_orcids":["https://orcid.org/0000-0003-3044-2240","https://orcid.org/0000-0003-1923-2859","https://orcid.org/0000-0002-9966-1380","https://orcid.org/0009-0006-2782-4888","https://orcid.org/0009-0007-5482-1081"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kai Yang","raw_affiliation_strings":["State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. kyang28@pku.edu.cn","State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":"https://orcid.org/0000-0003-3044-2240","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. kyang28@pku.edu.cn","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]},{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089015746","display_name":"Shiyun Liu","orcid":"https://orcid.org/0000-0002-4174-6189","observed_orcids":["https://orcid.org/0000-0002-4174-6189"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiyun Liu","raw_affiliation_strings":["State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101842995","display_name":"Han Yan","orcid":"https://orcid.org/0000-0003-2307-3918","observed_orcids":["https://orcid.org/0000-0003-2307-3918"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405252760","display_name":"Guangzhou Laboratory","ror":"https://ror.org/03ybmxt82","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405252760"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Yan","raw_affiliation_strings":["Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China","State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4405252760"]},{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002123396","display_name":"Wenju Lu","orcid":"https://orcid.org/0000-0002-5035-9287","observed_orcids":["https://orcid.org/0000-0002-5035-9287","https://orcid.org/0000-0001-8352-1802"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenju Lu","raw_affiliation_strings":["State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080451538","display_name":"Xiaoqian Shan","orcid":"https://orcid.org/0000-0002-0745-8343","observed_orcids":["https://orcid.org/0000-0002-0745-8343"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]},{"id":"https://openalex.org/I44673925","display_name":"Inner Mongolia Medical University","ror":"https://ror.org/01mtxmr84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I44673925"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqian Shan","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China","State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China","institution_ids":["https://openalex.org/I44673925"]},{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713032","display_name":"H\u1ea1ixia Chen","orcid":"https://orcid.org/0000-0002-2596-9622","observed_orcids":["https://orcid.org/0000-0002-2596-9622"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210153921","display_name":"Guangzhou Medical University Cancer Hospital","ror":"https://ror.org/046c18a90","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153921"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haixia Chen","raw_affiliation_strings":["Department of Pathology, The Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210153921"]},{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072111152","display_name":"Changlei Bao","orcid":"https://orcid.org/0000-0002-1773-3986","observed_orcids":["https://orcid.org/0000-0002-1773-3986"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Changlei Bao","raw_affiliation_strings":["State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045166049","display_name":"Huazhuo Feng","orcid":"https://orcid.org/0009-0006-5565-2876","observed_orcids":["https://orcid.org/0009-0006-5565-2876"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huazhuo Feng","raw_affiliation_strings":["State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026216464","display_name":"Jing Liao","orcid":"https://orcid.org/0000-0001-6613-2696","observed_orcids":["https://orcid.org/0000-0001-6613-2696"]},"institutions":[{"id":"https://openalex.org/I3045169105","display_name":"Southern University of Science and Technology","ror":"https://ror.org/049tv2d57","country_code":"CN","type":"education","lineage":["https://openalex.org/I3045169105"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Liao","raw_affiliation_strings":["School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China","institution_ids":["https://openalex.org/I3045169105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007824285","display_name":"Shuxin Liang","orcid":"https://orcid.org/0000-0002-5663-5326","observed_orcids":["https://orcid.org/0000-0002-5663-5326"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuxin Liang","raw_affiliation_strings":["State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101820158","display_name":"Lei Xu","orcid":"https://orcid.org/0000-0002-6642-5584","observed_orcids":["https://orcid.org/0000-0002-6642-5584"]},"institutions":[{"id":"https://openalex.org/I44673925","display_name":"Inner Mongolia Medical University","ror":"https://ror.org/01mtxmr84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I44673925"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xu","raw_affiliation_strings":["Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary and Critical Care Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia Autonomous Region, China","institution_ids":["https://openalex.org/I44673925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024165645","display_name":"Haiyang Tang","orcid":"https://orcid.org/0000-0001-9537-2891","observed_orcids":["https://orcid.org/0000-0001-9537-2891","https://orcid.org/0009-0005-5285-0634"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiyang Tang","raw_affiliation_strings":["State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034938550","display_name":"Jason X.\u2010J. Yuan","orcid":"https://orcid.org/0000-0002-0685-4862","observed_orcids":["https://orcid.org/0000-0002-0685-4862"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason X.-J. Yuan","raw_affiliation_strings":["Section of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101475024","display_name":"Nanshan Zhong","orcid":"https://orcid.org/0000-0003-2274-1427","observed_orcids":["https://orcid.org/0000-0003-2274-1427","https://orcid.org/0009-0005-1707-9119"]},"institutions":[{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405252760","display_name":"Guangzhou Laboratory","ror":"https://ror.org/03ybmxt82","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405252760"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Nanshan Zhong","raw_affiliation_strings":["Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China. nanshan@vip.163.com","State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. nanshan@vip.163.com","Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China. nanshan@vip.163.com","institution_ids":["https://openalex.org/I4405252760"]},{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. nanshan@vip.163.com","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]},{"raw_affiliation_string":"Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4405252760"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100370407","display_name":"Jian Wang","orcid":"https://orcid.org/0000-0002-1278-256X","observed_orcids":["https://orcid.org/0000-0002-1278-256X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210098361","display_name":"First Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00z0j0d77","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098361"]},{"id":"https://openalex.org/I4210154954","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210154954"]},{"id":"https://openalex.org/I4405252760","display_name":"Guangzhou Laboratory","ror":"https://ror.org/03ybmxt82","country_code":"CN","type":"government","lineage":["https://openalex.org/I4405252760"]},{"id":"https://openalex.org/I4405273215","display_name":"Guangzhou Institute of Respiratory Health","ror":"https://ror.org/05fvcq462","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4405273215"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Jian Wang","raw_affiliation_strings":["Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China. jiw037@health.ucsd.edu","Section of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA. jiw037@health.ucsd.edu","State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. jiw037@health.ucsd.edu","Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China. jiw037@health.ucsd.edu","institution_ids":["https://openalex.org/I4405252760"]},{"raw_affiliation_string":"Section of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA. jiw037@health.ucsd.edu","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China. jiw037@health.ucsd.edu","institution_ids":["https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405273215"]},{"raw_affiliation_string":"Guangzhou National Laboratory, Guangzhou International Bio Island, Guangzhou, Guangdong, China","institution_ids":["https://openalex.org/I4405252760"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5031961745","https://openalex.org/A5100370407","https://openalex.org/A5101475024"],"corresponding_institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210098361","https://openalex.org/I4210154954","https://openalex.org/I4405252760","https://openalex.org/I4405273215"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":10.9777,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.9919538,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"276","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.6449999809265137,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.2694999873638153,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spike-receptor-binding-domain","display_name":"spike protein receptor-binding domain","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pulmonary-endothelial-cells","display_name":"pulmonary endothelial cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.718999981880188},{"id":"https://openalex.org/keywords/intracellular-calcium-homeostasis","display_name":"intracellular calcium homeostasis","score":0.9309999942779541},{"id":"https://openalex.org/keywords/piezo1","display_name":"Piezo1","score":0.8539999723434448},{"id":"https://openalex.org/keywords/store-operated-calcium-entry","display_name":"store-operated calcium entry","score":0.9079999923706055},{"id":"https://openalex.org/keywords/orai1","display_name":"Orai1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/trpv4","display_name":"TRPV4","score":0.9829999804496765},{"id":"https://openalex.org/keywords/trpc1","display_name":"TRPC1","score":0.8949999809265137},{"id":"https://openalex.org/keywords/ace2","display_name":"ACE2","score":0.824999988079071},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.671999990940094},{"id":"https://openalex.org/keywords/omicron-variant","display_name":"Omicron variant","score":0.8209999799728394},{"id":"https://openalex.org/keywords/sars-cov-2-variants","display_name":"SARS-CoV-2 variants","score":0.7749999761581421},{"id":"https://openalex.org/keywords/gsmtx4","display_name":"GsMTx4","score":0.8849999904632568}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7109358906745911},{"id":"https://openalex.org/C2776610495","wikidata":"https://www.wikidata.org/wiki/Q18047835","display_name":"ORAI1","level":4,"score":0.6996231079101562},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.6028023362159729},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5863296985626221},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5452045798301697},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.49670106172561646},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.47974693775177},{"id":"https://openalex.org/C167007842","wikidata":"https://www.wikidata.org/wiki/Q15322678","display_name":"TRPC1","level":4,"score":0.4691520929336548},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.45583370327949524},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4367665648460388},{"id":"https://openalex.org/C128448793","wikidata":"https://www.wikidata.org/wiki/Q14914578","display_name":"TRPC6","level":4,"score":0.43276605010032654},{"id":"https://openalex.org/C2780785647","wikidata":"https://www.wikidata.org/wiki/Q18034667","display_name":"PIEZO1","level":5,"score":0.42159345746040344},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4189227819442749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3961646854877472},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3819640278816223},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.38158297538757324},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.26814284920692444},{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.24080386757850647},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21391728520393372},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.17187032103538513},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15422242879867554},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.1337815225124359},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08191829919815063},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000085962","descriptor_name":"Angiotensin-Converting Enzyme 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007473","descriptor_name":"Ion Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/s41392-023-01556-8","doi":"https://doi.org/10.1038/s41392-023-01556-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-023-01556-8","pdf_url":"https://www.nature.com/articles/s41392-023-01556-8.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10349149","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10349149","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10349149/pdf/41392_2023_Article_1556.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduct Target Ther","raw_type":"Text"},{"id":"pmid:37452066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37452066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal transduction and targeted therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:9c071421c38a4ef2ae02cb05443695c7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/9c071421c38a4ef2ae02cb05443695c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-14 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41392-023-01556-8","doi":"https://doi.org/10.1038/s41392-023-01556-8","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41392-023-01556-8","pdf_url":"https://www.nature.com/articles/s41392-023-01556-8.pdf","source":{"id":"https://openalex.org/S2739142469","display_name":"Signal Transduction and Targeted Therapy","issn_l":"2059-3635","issn":["2059-3635","2095-9907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Signal Transduction and Targeted Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1184424689","display_name":null,"funder_award_id":"2017BT01S155","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G1342391584","display_name":null,"funder_award_id":"82120108001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1473185050","display_name":null,"funder_award_id":"82241012","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3125981579","display_name":null,"funder_award_id":"2021A1515010767","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G4493618162","display_name":null,"funder_award_id":"2018YFC1311900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G48197593","display_name":null,"funder_award_id":"2022YFE0131500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5403812764","display_name":null,"funder_award_id":"2017BT01S155","funder_id":"https://openalex.org/F4320334009","funder_display_name":"Guangdong Provincial Pearl River Talents Program"},{"id":"https://openalex.org/G7327592067","display_name":null,"funder_award_id":"2020003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7328039498","display_name":null,"funder_award_id":"2018YFC1311900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G742884939","display_name":"\u673a\u68b0\u654f\u611f\u6027\u79bb\u5b50\u901a\u9053\u86cb\u767dPiezo1\u5728\u80ba\u52a8\u8109\u9ad8\u538b\u53d1\u751f\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528\u53ca\u673a\u5236\u7814\u7a76","funder_award_id":"81970057","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7438161009","display_name":null,"funder_award_id":"82170065","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7789573940","display_name":null,"funder_award_id":"2017BT01S155","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320311429","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61"},{"id":"https://openalex.org/F4320314148","display_name":"State Key Laboratory of Respiratory Disease","ror":"https://ror.org/04hja5e04"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320334009","display_name":"Guangdong Provincial Pearl River Talents Program","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384338951.pdf","grobid_xml":"https://content.openalex.org/works/W4384338951.grobid-xml"},"referenced_works_count":58,"referenced_works":["https://openalex.org/W2021132659","https://openalex.org/W2098180530","https://openalex.org/W2126692145","https://openalex.org/W2149879031","https://openalex.org/W2152095911","https://openalex.org/W2180152072","https://openalex.org/W2769941449","https://openalex.org/W2997384931","https://openalex.org/W3007940623","https://openalex.org/W3008461878","https://openalex.org/W3019046211","https://openalex.org/W3024695741","https://openalex.org/W3027918021","https://openalex.org/W3038372263","https://openalex.org/W3040254875","https://openalex.org/W3042232681","https://openalex.org/W3043476468","https://openalex.org/W3044050454","https://openalex.org/W3109454285","https://openalex.org/W3113290471","https://openalex.org/W3120587241","https://openalex.org/W3121071822","https://openalex.org/W3126886444","https://openalex.org/W3130939396","https://openalex.org/W3131517051","https://openalex.org/W3137433707","https://openalex.org/W3145359886","https://openalex.org/W3159261548","https://openalex.org/W3162136592","https://openalex.org/W3172407460","https://openalex.org/W3176167913","https://openalex.org/W3181607748","https://openalex.org/W3183929684","https://openalex.org/W3185945882","https://openalex.org/W3194160641","https://openalex.org/W3196973066","https://openalex.org/W3200313099","https://openalex.org/W3202334541","https://openalex.org/W3209317839","https://openalex.org/W3210544241","https://openalex.org/W3211790525","https://openalex.org/W4200538400","https://openalex.org/W4200568505","https://openalex.org/W4280619796","https://openalex.org/W4281754639","https://openalex.org/W4283704819","https://openalex.org/W4309878951","https://openalex.org/W4311288827","https://openalex.org/W4311359167","https://openalex.org/W4311601659","https://openalex.org/W4312076790","https://openalex.org/W4312095635","https://openalex.org/W4313396388","https://openalex.org/W4313488719","https://openalex.org/W4317212025","https://openalex.org/W4319066889","https://openalex.org/W4319600833","https://openalex.org/W4362581039"],"related_works":["https://openalex.org/W7125705356","https://openalex.org/W4385719469","https://openalex.org/W3162929751","https://openalex.org/W3163022728","https://openalex.org/W4386215789","https://openalex.org/W3145359886","https://openalex.org/W4327622531","https://openalex.org/W7204220593","https://openalex.org/W4405922251","https://openalex.org/W3185945882"],"abstract_inverted_index":{"Abstract":[0],"Exposure":[1],"to":[2,40,54,102,122,174,224,250],"the":[3,58,113,134,154,166],"spike":[4,43],"protein":[5],"or":[6,140,203],"receptor-binding":[7],"domain":[8],"(S-RBD)":[9],"of":[10,57,71,76,105,116,146,182,234,240],"SARS-CoV-2":[11],"significantly":[12,185],"influences":[13],"endothelial":[14,36,93,158,220],"cells":[15,37,94],"and":[16,32,73,80,110,118,120,138,148,180,226,236],"induces":[17,184],"pulmonary":[18,34,46,91,156,218,253],"vascular":[19,35,47,219,254],"endotheliopathy.":[20],"In":[21,96,206],"this":[22,208],"study,":[23],"angiotensin-converting":[24],"enzyme":[25],"2":[26],"humanized":[27],"inbred":[28],"(hACE2":[29],"Tg)":[30],"mice":[31,163],"cultured":[33,89],"were":[38],"used":[39],"investigate":[41],"how":[42],"protein/S-RBD":[44],"impacts":[45,200],"endothelium.":[48],"Results":[49],"show":[50],"that":[51,193,213],"S-RBD":[52,98,137,183,195,214],"leads":[53],"acute-to-prolonged":[55],"induction":[56],"intracellular":[59,141],"free":[60],"calcium":[61,82,142],"concentration":[62],"([Ca":[63],"2+":[64,169,229,242],"]":[65,170,230,243],"i":[66,171,231,244],")":[67],"via":[68,164],"acute":[69,199],"activation":[70,115],"TRPV4,":[72],"prolonged":[74],"upregulation":[75,233],"mechanosensitive":[77],"channel":[78,83,114],"Piezo1":[79,109,117,147,235],"store-operated":[81],"(SOCC)":[84],"key":[85],"component":[86],"Orai1":[87],"in":[88,160],"human":[90],"arterial":[92],"(PAECs).":[95],"mechanism,":[97],"interacts":[99],"with":[100],"ACE2":[101,225],"induce":[103,216],"formation":[104],"clusters":[106],"involving":[107],"Orai1,":[108],"TRPC1,":[111],"facilitate":[112],"SOCC,":[119],"lead":[121],"elevated":[123,167],"apoptosis.":[124,189],"These":[125],"effects":[126],"are":[127],"blocked":[128],"by":[129,150,222],"Kobophenol":[130],"A,":[131],"which":[132],"inhibits":[133],"binding":[135,223],"between":[136],"ACE2,":[139],"chelator,":[143],"BAPTA-AM.":[144],"Blockade":[145],"SOCC":[149],"GsMTx4":[151],"effectively":[152],"protects":[153],"S-RBD-induced":[155,252],"microvascular":[157],"damage":[159,221],"hACE2":[161],"Tg":[162],"normalizing":[165],"[Ca":[168,228],".":[172],"Comparing":[173],"prototypic":[175,194],"strain,":[176],"Omicron":[177],"variants":[178],"(BA.5.2":[179],"XBB)":[181],"less":[186],"severe":[187,198],"cell":[188],"Transcriptomic":[190],"analysis":[191],"indicates":[192],"confers":[196],"more":[197],"than":[201],"Delta":[202],"Lambda":[204],"S-RBD.":[205],"summary,":[207],"study":[209],"provides":[210],"compelling":[211],"evidence":[212],"could":[215],"persistent":[217],"triggering":[227],"through":[232],"Orai1.":[237],"Targeted":[238],"inhibition":[239],"ACE2-Piezo1/SOCC-[Ca":[241],"axis":[245],"proves":[246],"a":[247],"powerful":[248],"strategy":[249],"treat":[251],"diseases.":[255]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":19},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2023-07-15T00:00:00"}
