{"id":"https://openalex.org/W4384299935","doi":"https://doi.org/10.3390/cells12141844","title":"S1P Lyase Deficiency in the Brain Promotes Astrogliosis and NLRP3 Inflammasome Activation via Purinergic Signaling","display_name":"S1P Lyase Deficiency in the Brain Promotes Astrogliosis and NLRP3 Inflammasome Activation via Purinergic Signaling","publication_year":2023,"publication_date":"2023-07-13","ids":{"openalex":"https://openalex.org/W4384299935","doi":"https://doi.org/10.3390/cells12141844","pmid":"https://pubmed.ncbi.nlm.nih.gov/37508508","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10378183"},"language":"en","primary_location":{"id":"doi:10.3390/cells12141844","doi":"https://doi.org/10.3390/cells12141844","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells12141844","pdf_url":"https://www.mdpi.com/2073-4409/12/14/1844/pdf?version=1689317544","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2073-4409/12/14/1844/pdf?version=1689317544","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shah Alam","orcid":"https://orcid.org/0000-0002-5806-5603","observed_orcids":["https://orcid.org/0000-0002-5806-5603"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Shah Alam","raw_affiliation_strings":["LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0002-5806-5603","affiliations":[{"raw_affiliation_string":"LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061281840","display_name":"Sumaiya Yasmeen Afsar","orcid":"https://orcid.org/0000-0003-1378-787X","observed_orcids":["https://orcid.org/0000-0003-1378-787X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sumaiya Yasmeen Afsar","raw_affiliation_strings":["LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1378-787X","affiliations":[{"raw_affiliation_string":"LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112959949","display_name":"Maya Anik Wolter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Maya Anik Wolter","raw_affiliation_strings":["LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106185654","display_name":"Luisa Michelle Volk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luisa Michelle Volk","raw_affiliation_strings":["Institute for General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, 60590 Frankfurt am Main, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, 60590 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015819062","display_name":"Daniel Nicolae Mitroi","orcid":"https://orcid.org/0000-0001-5689-139X","observed_orcids":["https://orcid.org/0000-0001-5689-139X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Nicolae Mitroi","raw_affiliation_strings":["LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5689-139X","affiliations":[{"raw_affiliation_string":"LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061649877","display_name":"Dagmar Meyer zu Heringdorf","orcid":"https://orcid.org/0000-0003-1246-9677","observed_orcids":["https://orcid.org/0000-0003-1246-9677"]},"institutions":[{"id":"https://openalex.org/I114090438","display_name":"Goethe University Frankfurt","ror":"https://ror.org/04cvxnb49","country_code":"DE","type":"education","lineage":["https://openalex.org/I114090438"]},{"id":"https://openalex.org/I4210132578","display_name":"University Hospital Frankfurt","ror":"https://ror.org/03f6n9m15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210132578"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dagmar Meyer zu Heringdorf","raw_affiliation_strings":["Institute for General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, 60590 Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0003-1246-9677","affiliations":[{"raw_affiliation_string":"Institute for General Pharmacology and Toxicology, University Hospital, Goethe University Frankfurt am Main, 60590 Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I114090438","https://openalex.org/I4210132578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029156785","display_name":"Gerhild van Echten\u2010Deckert","orcid":"https://orcid.org/0000-0002-2816-7852","observed_orcids":["https://orcid.org/0000-0002-2816-7852"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Gerhild van Echten-Deckert","raw_affiliation_strings":["LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany"],"raw_orcid":"https://orcid.org/0000-0002-2816-7852","affiliations":[{"raw_affiliation_string":"LIMES Institute for Membrane Biology and Lipid Biochemistry, Kekul\u00e9-Institute, University of Bonn, 53115 Bonn, Germany","institution_ids":["https://openalex.org/I135140700"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029156785"],"corresponding_institution_ids":["https://openalex.org/I135140700"],"apc_list":{"value":2400,"currency":"CHF","value_usd":2669},"apc_paid":{"value":2400,"currency":"CHF","value_usd":2669},"fwci":1.3903,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.8058875,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"12","issue":"14","first_page":"1844","last_page":"1844"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.6348000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.20970000326633453,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.12150000035762787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingosine-1-phosphate-lyase","display_name":"sphingosine-1-phosphate lyase","score":0.906000018119812},{"id":"https://openalex.org/keywords/sgpl1","display_name":"SGPL1","score":0.8230000138282776},{"id":"https://openalex.org/keywords/reactive-astrogliosis","display_name":"reactive astrogliosis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.8870000243186951},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.953000009059906},{"id":"https://openalex.org/keywords/purinergic-signaling","display_name":"purinergic signaling","score":0.8799999952316284},{"id":"https://openalex.org/keywords/p2y1-receptor","display_name":"P2Y1 receptor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ddx3x","display_name":"DDX3X","score":0.9359999895095825},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.9229999780654907},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9459999799728394},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":0.7889999747276306},{"id":"https://openalex.org/keywords/microglial-activation","display_name":"microglial activation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.7820000052452087},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2779965356","wikidata":"https://www.wikidata.org/wiki/Q4811564","display_name":"Astrogliosis","level":3,"score":0.9388575553894043},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.8451492786407471},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.6235620379447937},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5806070566177368},{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.5325438380241394},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5104119181632996},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.49324697256088257},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.47441548109054565},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.40233778953552246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3995125889778137},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3640769124031067},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.36031514406204224},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2389412224292755},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.21981337666511536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21882355213165283},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16565266251564026},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.12736129760742188},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.08763158321380615}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005911","descriptor_name":"Gliosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008190","descriptor_name":"Lyases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/cells12141844","doi":"https://doi.org/10.3390/cells12141844","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells12141844","pdf_url":"https://www.mdpi.com/2073-4409/12/14/1844/pdf?version=1689317544","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10378183","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10378183","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10378183/pdf/cells-12-01844.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Text"},{"id":"pmid:37508508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37508508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:08f9df6a206044d48bc12ef5a27d545d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/08f9df6a206044d48bc12ef5a27d545d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cells, Vol 12, Iss 14, p 1844 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cells12141844","doi":"https://doi.org/10.3390/cells12141844","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cells12141844","pdf_url":"https://www.mdpi.com/2073-4409/12/14/1844/pdf?version=1689317544","source":{"id":"https://openalex.org/S2736626452","display_name":"Cells","issn_l":"2073-4409","issn":["2073-4409"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2013436488","display_name":null,"funder_award_id":"SFB-1039","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G24579814","display_name":null,"funder_award_id":"EC-118/10-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4971540627","display_name":null,"funder_award_id":"TPB07","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384299935.pdf","grobid_xml":"https://content.openalex.org/works/W4384299935.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W204348490","https://openalex.org/W1501693497","https://openalex.org/W1533399240","https://openalex.org/W1545558771","https://openalex.org/W1598922101","https://openalex.org/W1608760946","https://openalex.org/W1797578063","https://openalex.org/W1974613212","https://openalex.org/W1978836458","https://openalex.org/W1981163825","https://openalex.org/W1982231822","https://openalex.org/W1985611042","https://openalex.org/W1991899733","https://openalex.org/W1992635288","https://openalex.org/W1994208013","https://openalex.org/W2007878869","https://openalex.org/W2008367995","https://openalex.org/W2022770236","https://openalex.org/W2037600884","https://openalex.org/W2041029999","https://openalex.org/W2049154756","https://openalex.org/W2049465523","https://openalex.org/W2052870901","https://openalex.org/W2063817872","https://openalex.org/W2074661552","https://openalex.org/W2085424855","https://openalex.org/W2102478723","https://openalex.org/W2103441770","https://openalex.org/W2109380000","https://openalex.org/W2124007806","https://openalex.org/W2143068056","https://openalex.org/W2143201271","https://openalex.org/W2143882188","https://openalex.org/W2147524392","https://openalex.org/W2148236159","https://openalex.org/W2158972964","https://openalex.org/W2164377447","https://openalex.org/W2164865107","https://openalex.org/W2170899856","https://openalex.org/W2179438025","https://openalex.org/W2551695323","https://openalex.org/W2591977444","https://openalex.org/W2592008261","https://openalex.org/W2595605501","https://openalex.org/W2605685784","https://openalex.org/W2621041607","https://openalex.org/W2765841162","https://openalex.org/W2768167254","https://openalex.org/W2789755075","https://openalex.org/W2893414347","https://openalex.org/W2898395235","https://openalex.org/W2910050152","https://openalex.org/W2920191405","https://openalex.org/W2943293743","https://openalex.org/W2946201788","https://openalex.org/W2947152919","https://openalex.org/W2950329150","https://openalex.org/W2954782052","https://openalex.org/W2956093556","https://openalex.org/W2957723273","https://openalex.org/W2972371855","https://openalex.org/W2980640630","https://openalex.org/W3015175938","https://openalex.org/W3089302042","https://openalex.org/W4281721695","https://openalex.org/W4290075799","https://openalex.org/W4322502128","https://openalex.org/W6635683354","https://openalex.org/W7031876295"],"related_works":["https://openalex.org/W7009328423","https://openalex.org/W4322502128","https://openalex.org/W4388384886","https://openalex.org/W2956093556","https://openalex.org/W6977454001","https://openalex.org/W3186295290","https://openalex.org/W2621041607","https://openalex.org/W2168976923","https://openalex.org/W2143201271","https://openalex.org/W2742412339"],"abstract_inverted_index":{"Astrocytes":[0],"are":[1,13],"critical":[2],"players":[3],"in":[4,31,72,112,160,188],"brain":[5,171],"health":[6],"and":[7,11,53,83,102,115,126,132,146,150,186],"disease.":[8],"Brain":[9],"pathologies":[10],"lesions":[12],"usually":[14],"accompanied":[15],"by":[16],"astroglial":[17],"alterations":[18],"known":[19,162],"as":[20,59,61,78,80,108],"reactive":[21],"astrogliosis.":[22],"Sphingosine":[23],"1-phosphate":[24,39],"lyase":[25],"(SGPL1)":[26],"catalysis,":[27],"the":[28,65,93,106,109,118,121,151,154,167,177,189],"final":[29],"step":[30],"sphingolipid":[32],"catabolism,":[33],"irreversibly":[34],"cleaves":[35],"its":[36],"substrate":[37],"sphingosine":[38],"(S1P).":[40],"We":[41],"have":[42],"shown":[43],"that":[44],"neural":[45],"ablation":[46],"of":[47,51,92,120,129,133,153,169],"SGPL1":[48],"causes":[49,90],"accumulation":[50],"S1P":[52,88,144,184],"hence":[54],"neuronal":[55],"damage,":[56],"cognitive":[57],"deficits,":[58],"well":[60,79],"microglial":[62],"activation.":[63],"Moreover,":[64],"S1P/S1P-receptor":[66],"signaling":[67,89,147,187],"axis":[68],"enhances":[69],"ATP":[70],"production":[71],"SGPL1-deficient":[73],"astrocytes.":[74],"Using":[75],"immunohistochemical":[76],"methods":[77],"RNA":[81],"Seq":[82],"CUT&Tag":[84],"we":[85,104],"show":[86],"how":[87],"activation":[91,119,152],"astrocytic":[94],"purinoreceptor":[95],"P2Y1":[96],"(P2Y1R).":[97],"With":[98],"specific":[99],"pharmacological":[100],"agonists":[101],"antagonists,":[103],"uncover":[105],"P2Y1R":[107],"key":[110],"player":[111,159],"S1P-induced":[113],"astrogliosis,":[114],"DDX3X":[116],"mediated":[117],"NLRP3":[122,155],"inflammasome,":[123,156],"including":[124],"caspase-1":[125],"henceforward":[127],"generation":[128],"interleukin-1\u00df":[130],"(IL-1\u00df)":[131],"other":[134],"proinflammatory":[135],"cytokines.":[136],"Our":[137],"results":[138],"provide":[139],"a":[140,157],"novel":[141],"route":[142],"connecting":[143],"metabolism":[145,185],"with":[148],"astrogliosis":[149],"central":[158],"neuroinflammation,":[161],"to":[163],"be":[164],"crucial":[165],"for":[166,179],"pathogenesis":[168],"numerous":[170],"illnesses.":[172],"Thus,":[173],"our":[174],"study":[175],"opens":[176],"door":[178],"new":[180],"therapeutic":[181],"strategies":[182],"surrounding":[183],"brain.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-15T00:00:00"}
