{"id":"https://openalex.org/W4384298121","doi":"https://doi.org/10.1093/rheumatology/kead333","title":"The COMPARE head-to-head, randomized controlled trial of SEL-212 (pegadricase plus rapamycin-containing nanoparticle, ImmTOR\u2122) versus pegloticase for refractory gout","display_name":"The COMPARE head-to-head, randomized controlled trial of SEL-212 (pegadricase plus rapamycin-containing nanoparticle, ImmTOR\u2122) versus pegloticase for refractory gout","publication_year":2023,"publication_date":"2023-07-13","ids":{"openalex":"https://openalex.org/W4384298121","doi":"https://doi.org/10.1093/rheumatology/kead333","pmid":"https://pubmed.ncbi.nlm.nih.gov/37449908","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10986798"},"language":"en","primary_location":{"id":"doi:10.1093/rheumatology/kead333","doi":"https://doi.org/10.1093/rheumatology/kead333","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rheumatology/kead333","pdf_url":"https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/kead333/50883171/kead333.pdf","source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/kead333/50883171/kead333.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019605448","display_name":"Herbert S. B. Baraf","orcid":"https://orcid.org/0000-0002-0162-9930","observed_orcids":["https://orcid.org/0000-0002-0162-9930"]},"institutions":[{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Herbert S B Baraf","raw_affiliation_strings":["Rheumatology, Center for Rheumatology and Bone Research , Wheaton, MD, USA","Rheumatology, George Washington University , Washington DC, USA","The Center for Rheumatology and Bone Research, Rheumatology, Wheaton, Maryland, USA","The George Washington University, Rheumatology, Washington DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Center for Rheumatology and Bone Research , Wheaton, MD, USA","institution_ids":[]},{"raw_affiliation_string":"Rheumatology, George Washington University , Washington DC, USA","institution_ids":["https://openalex.org/I193531525"]},{"raw_affiliation_string":"The Center for Rheumatology and Bone Research, Rheumatology, Wheaton, Maryland, USA","institution_ids":[]},{"raw_affiliation_string":"The George Washington University, Rheumatology, Washington DC, USA","institution_ids":["https://openalex.org/I193531525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089460885","display_name":"Puja P. Khanna","orcid":"https://orcid.org/0000-0002-0264-1317","observed_orcids":["https://orcid.org/0000-0002-0264-1317"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Puja P Khanna","raw_affiliation_strings":["Division of Rheumatology, University of Michigan , Ann Arbor, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, University of Michigan , Ann Arbor, MI, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082669130","display_name":"Alan Kivitz","orcid":"https://orcid.org/0000-0002-1045-1310","observed_orcids":["https://orcid.org/0000-0002-1045-1310"]},"institutions":[{"id":"https://openalex.org/I4210112965","display_name":"Altoona Center for Clinical Research","ror":"https://ror.org/022q8ez38","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210112965"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan J Kivitz","raw_affiliation_strings":["Department of Rheumatology, Altoona Center for Clinical Research , Duncansville, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Altoona Center for Clinical Research , Duncansville, PA, USA","institution_ids":["https://openalex.org/I4210112965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012283576","display_name":"Vibeke Strand","orcid":"https://orcid.org/0000-0003-4978-4072","observed_orcids":["https://orcid.org/0000-0003-4978-4072"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vibeke Strand","raw_affiliation_strings":["Division of Immunology/Rheumatology, Stanford University School of Medicine , Palo Alto, CA, USA"],"raw_orcid":"https://orcid.org/0000-0003-4978-4072","affiliations":[{"raw_affiliation_string":"Division of Immunology/Rheumatology, Stanford University School of Medicine , Palo Alto, CA, USA","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087655468","display_name":"Hyon K. Choi","orcid":"https://orcid.org/0000-0002-2862-0442","observed_orcids":["https://orcid.org/0000-0002-2862-0442"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyon K Choi","raw_affiliation_strings":["Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital , Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital , Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079824415","display_name":"Robert A. Terkeltaub","orcid":"https://orcid.org/0000-0001-5368-7473","observed_orcids":["https://orcid.org/0000-0001-5368-7473"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Terkeltaub","raw_affiliation_strings":["Rheumatology, Allergy and Immunology Division, San Diego VA Healthcare Service and UCSD , San Diego, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology, Allergy and Immunology Division, San Diego VA Healthcare Service and UCSD , San Diego, CA, USA","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4210099595"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086285989","display_name":"Nicola Dalbeth","orcid":"https://orcid.org/0000-0003-4632-4476","observed_orcids":["https://orcid.org/0000-0003-4632-4476"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Nicola Dalbeth","raw_affiliation_strings":["Bone and Joint Research Group, Department of Medicine, University of Auckland , Auckland, New Zealand","Bone and Joint Research Group, Department of Medicine, The University of Auckland, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bone and Joint Research Group, Department of Medicine, University of Auckland , Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]},{"raw_affiliation_string":"Bone and Joint Research Group, Department of Medicine, The University of Auckland, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059736360","display_name":"Wesley H. DeHaan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128423","display_name":"Selecta Biosciences (United States)","ror":"https://ror.org/03g0jst60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128423"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley DeHaan","raw_affiliation_strings":["Selecta Biosciences , Watertown, MA, USA","Selecta Biosciences, Watertown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selecta Biosciences , Watertown, MA, USA","institution_ids":["https://openalex.org/I4210128423"]},{"raw_affiliation_string":"Selecta Biosciences, Watertown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210128423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064124511","display_name":"Rehan Azeem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128423","display_name":"Selecta Biosciences (United States)","ror":"https://ror.org/03g0jst60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128423"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rehan Azeem","raw_affiliation_strings":["Selecta Biosciences , Watertown, MA, USA","Selecta Biosciences, Watertown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selecta Biosciences , Watertown, MA, USA","institution_ids":["https://openalex.org/I4210128423"]},{"raw_affiliation_string":"Selecta Biosciences, Watertown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210128423"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030568693","display_name":"Peter G. Traber","orcid":"https://orcid.org/0000-0002-5952-5720","observed_orcids":["https://orcid.org/0000-0002-5952-5720"]},"institutions":[{"id":"https://openalex.org/I4210128423","display_name":"Selecta Biosciences (United States)","ror":"https://ror.org/03g0jst60","country_code":"US","type":"company","lineage":["https://openalex.org/I4210128423"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter G Traber","raw_affiliation_strings":["Selecta Biosciences , Watertown, MA, USA","Selecta Biosciences, Watertown, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Selecta Biosciences , Watertown, MA, USA","institution_ids":["https://openalex.org/I4210128423"]},{"raw_affiliation_string":"Selecta Biosciences, Watertown, Massachusetts, USA","institution_ids":["https://openalex.org/I4210128423"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051511463","display_name":"Robert T. Keenan","orcid":"https://orcid.org/0000-0002-2341-7314","observed_orcids":["https://orcid.org/0000-0002-2341-7314"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T Keenan","raw_affiliation_strings":["Arthrosi Therapeutics , San Diego, CA, USA","Duke University School of Medicine , Durham, NC, USA","Arthrosi Therapeutics Inc, San Diego, California, USA","Duke University School of Medicine, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arthrosi Therapeutics , San Diego, CA, USA","institution_ids":[]},{"raw_affiliation_string":"Duke University School of Medicine , Durham, NC, USA","institution_ids":["https://openalex.org/I170897317"]},{"raw_affiliation_string":"Arthrosi Therapeutics Inc, San Diego, California, USA","institution_ids":[]},{"raw_affiliation_string":"Duke University School of Medicine, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5019605448"],"corresponding_institution_ids":["https://openalex.org/I193531525"],"apc_list":{"value":3192,"currency":"GBP","value_usd":3970},"apc_paid":{"value":3192,"currency":"GBP","value_usd":3970},"fwci":4.1577,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.94694636,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"63","issue":"4","first_page":"1058","last_page":"1067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pegloticase","display_name":"pegloticase","score":0.9729999899864197},{"id":"https://openalex.org/keywords/anti-drug-antibodies","display_name":"anti-drug antibodies","score":0.8059999942779541},{"id":"https://openalex.org/keywords/gout-flares","display_name":"gout flares","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tophi","display_name":"tophi","score":0.7730000019073486},{"id":"https://openalex.org/keywords/stomatitis","display_name":"stomatitis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/treatment-emergent-adverse-events","display_name":"treatment-emergent adverse events","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.920048713684082},{"id":"https://openalex.org/C2780402116","wikidata":"https://www.wikidata.org/wiki/Q133087","display_name":"Gout","level":2,"score":0.8757297396659851},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.6610220670700073},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6182878613471985},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5284250378608704},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4705265760421753},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4443495571613312},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.41569316387176514},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32494330406188965},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3244515061378479},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067251","descriptor_name":"Symptom Flare Up","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006073","descriptor_name":"Gout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006074","descriptor_name":"Gout Suppressants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006074","descriptor_name":"Gout Suppressants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013280","descriptor_name":"Stomatitis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D013280","descriptor_name":"Stomatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D014503","descriptor_name":"Urate Oxidase","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014503","descriptor_name":"Urate Oxidase","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014528","descriptor_name":"Uricosuric Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014528","descriptor_name":"Uricosuric Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/rheumatology/kead333","doi":"https://doi.org/10.1093/rheumatology/kead333","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rheumatology/kead333","pdf_url":"https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/kead333/50883171/kead333.pdf","source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10986798","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10986798","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10986798/pdf/kead333.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology (Oxford)","raw_type":"Text"},{"id":"pmid:37449908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37449908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology (Oxford, England)","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":{"id":"doi:10.1093/rheumatology/kead333","doi":"https://doi.org/10.1093/rheumatology/kead333","is_oa":true,"landing_page_url":"https://doi.org/10.1093/rheumatology/kead333","pdf_url":"https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/kead333/50883171/kead333.pdf","source":{"id":"https://openalex.org/S183989336","display_name":"Rheumatology","issn_l":"1462-0324","issn":["1462-0324","1462-0332"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rheumatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320307781","display_name":"Sanofi","ror":"https://ror.org/027vj4x92"},{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320309086","display_name":"Celgene","ror":"https://ror.org/0527yg379"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320316645","display_name":"Kiniksa Pharmaceuticals","ror":"https://ror.org/01352rw33"},{"id":"https://openalex.org/F4320318316","display_name":"Celltrion","ror":"https://ror.org/05k84m754"},{"id":"https://openalex.org/F4320319146","display_name":"Horizon Therapeutics","ror":null},{"id":"https://openalex.org/F4320319417","display_name":"Glenmark Pharmaceuticals","ror":"https://ror.org/037fhg487"},{"id":"https://openalex.org/F4320327470","display_name":"Swedish Orphan Biovitrum","ror":"https://ror.org/04asvbz37"},{"id":"https://openalex.org/F4320328070","display_name":"Sun Pharma","ror":"https://ror.org/04vnqkx80"},{"id":"https://openalex.org/F4320330906","display_name":"LG Chem","ror":"https://ror.org/04pjzv747"},{"id":"https://openalex.org/F4320332193","display_name":"Genentech","ror":"https://ror.org/04gndp242"},{"id":"https://openalex.org/F4320332195","display_name":"Samsung","ror":"https://ror.org/04w3jy968"},{"id":"https://openalex.org/F4320332200","display_name":"EMD Serono","ror":"https://ror.org/027zrs220"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384298121.pdf","grobid_xml":"https://content.openalex.org/works/W4384298121.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1561987315","https://openalex.org/W2012019710","https://openalex.org/W2014015529","https://openalex.org/W2036598926","https://openalex.org/W2134542761","https://openalex.org/W2140341488","https://openalex.org/W2326355551","https://openalex.org/W2500180409","https://openalex.org/W2504151231","https://openalex.org/W2739750353","https://openalex.org/W2910951675","https://openalex.org/W3023256684","https://openalex.org/W3028446499","https://openalex.org/W3039914719","https://openalex.org/W3087595653","https://openalex.org/W3125617342","https://openalex.org/W4205485901","https://openalex.org/W4229537562","https://openalex.org/W4231766912","https://openalex.org/W4295429982"],"related_works":["https://openalex.org/W2952473066","https://openalex.org/W2892339408","https://openalex.org/W4379522230","https://openalex.org/W4395076822","https://openalex.org/W4399481403","https://openalex.org/W2755815881","https://openalex.org/W4399481509","https://openalex.org/W4385420193","https://openalex.org/W4366160578","https://openalex.org/W2791582282"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Serum":[1],"urate":[2],"(SU)":[3],"lowering":[4],"with":[5,69,100,151,175,214,244,248,258,276,283],"PEGylated":[6,28],"uricases":[7],"in":[8,67,164,186,270,280],"gout":[9,119,187,218],"can":[10],"reduce":[11],"flares":[12,219],"and":[13,22,24,52,76,111,127,133,140,173,180,190,216,227,246,264],"tophi.":[14],"However,":[15],"treatment-emergent":[16],"anti-drug":[17],"antibodies":[18],"adversely":[19],"affect":[20],"safety":[21],"efficacy":[23,263],"the":[25,96,107,149,206],"currently":[26],"approved":[27],"uricase":[29],"pegloticase":[30,66,84,154,178,269],"requires":[31],"twice-monthly":[32],"infusions.":[33],"Investigational":[34],"SEL-212":[35,64,72,152,176,215,245,262,284],"therapy":[36],"aims":[37],"to":[38,268,286],"promote":[39],"uricase-specific":[40],"tolerance":[41],"via":[42],"monthly":[43,82,88],"sequential":[44],"infusions":[45],"of":[46,63,98,106,122,148,192,212],"a":[47,57,142,251,277],"proprietary":[48],"rapamycin-containing":[49],"nanoparticle":[50],"(ImmTOR)":[51],"pegadricase.":[53],"METHODS:":[54],"COMPARE":[55],"was":[56,80,95,238,256,274],"randomized,":[58],"phase":[59],"2,":[60],"open-label":[61],"trial":[62],"vs":[65,153,156,177,221,225,231,290],"adults":[68],"refractory":[70,271],"gout.":[71,272],"[ImmTOR":[73],"(0.15":[74],"mg/kg)":[75],"pegadricase":[77],"(0.2":[78],"mg/kg)]":[79],"infused":[81],"or":[83],"(8":[85],"mg)":[86],"twice":[87],"for":[89,104,146,254],"6":[90,112,134,174],"months.":[91,113],"The":[92,161],"primary":[93],"endpoint":[94],"proportion":[97],"participants":[99,138,242],"SU":[101,143,165],"<6":[102,144],"mg/dl":[103,145],"\u226580%":[105,147],"time":[108,150],"during":[109,170],"3":[110,132,172],"Secondary":[114],"outcomes":[115],"were":[116,167,197,202,266],"mean":[117],"SU,":[118],"flares,":[120],"number":[121,191],"tender":[123,193],"and/or":[124,194],"swollen":[125,195],"joints":[126,196],"safety.":[128],"RESULTS:":[129],"During":[130],"months":[131,171],"combined,":[135],"numerically":[136],"more":[137],"achieved":[139],"maintained":[141],"(53.0%":[155],"46.0%,":[157],"P":[158,182],"=":[159,183],"0.181).":[160],"percentage":[162],"reductions":[163],"levels":[166],"statistically":[168],"greater":[169],"(-73.79%":[179],"-47.96%,":[181],"0.0161).":[184],"Reductions":[185],"flare":[188],"incidence":[189],"comparable":[198,267],"between":[199,205],"treatments.":[200],"There":[201],"numerical":[203],"differences":[204],"most":[207],"common":[208],"treatment-related":[209],"adverse":[210],"events":[211],"interest":[213],"pegloticase:":[217],"(60.2%":[220],"50.6%),":[222],"infections":[223],"(25.3%":[224],"18.4%)":[226],"infusion-related":[228],"reactions":[229],"(15.7%":[230],"11.5%),":[232],"respectively.":[233],"Stomatitis":[234],"(and":[235],"related":[236],"terms)":[237],"experienced":[239],"by":[240],"eight":[241],"(9.6%)":[243],"none":[247],"pegloticase.":[249,291],"Stomatitis,":[250],"known":[252],"event":[253],"rapamycin,":[255],"associated":[257,275],"ImmTOR":[259],"only.":[260],"CONCLUSIONS:":[261],"tolerability":[265],"This":[273],"substantial":[278],"reduction":[279],"treatment":[281],"burden":[282],"due":[285],"decreased":[287],"infusion":[288],"frequency":[289],"CLINICAL":[292],"TRIAL":[293],"REGISTRATION:":[294],"NCT03905512.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-07-15T00:00:00"}