{"id":"https://openalex.org/W4384297912","doi":"https://doi.org/10.21203/rs.3.rs-3158460/v1","title":"Comprehensive analysis of fatty acid metabolism-related genes in prognosis, tumor microenvironment infiltration and core gene identification of bladder cancer","display_name":"Comprehensive analysis of fatty acid metabolism-related genes in prognosis, tumor microenvironment infiltration and core gene identification of bladder cancer","publication_year":2023,"publication_date":"2023-07-14","ids":{"openalex":"https://openalex.org/W4384297912","doi":"https://doi.org/10.21203/rs.3.rs-3158460/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-3158460/v1","doi":"https://doi.org/10.21203/rs.3.rs-3158460/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3158460/v1","pdf_url":"https://www.researchsquare.com/article/rs-3158460/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-3158460/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100324821","display_name":"Haoran Wang","orcid":"https://orcid.org/0000-0002-1630-4813","observed_orcids":["https://orcid.org/0000-0002-1630-4813","https://orcid.org/0009-0003-8166-0042"]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoran Wang","raw_affiliation_strings":["Beijing Hospital","Beijing Hospital Jianye Wang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Hospital","institution_ids":["https://openalex.org/I4210119648"]},{"raw_affiliation_string":"Beijing Hospital Jianye Wang","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108893462","display_name":"Runhua Tang","orcid":"https://orcid.org/0009-0004-0398-7469","observed_orcids":["https://orcid.org/0009-0004-0398-7469"]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runhua Tang","raw_affiliation_strings":["Beijing Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Hospital","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107865722","display_name":"Jingchao Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingchao Liu","raw_affiliation_strings":["Beijing Hospital","Beijing Hospital Jianye Wang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Hospital","institution_ids":["https://openalex.org/I4210119648"]},{"raw_affiliation_string":"Beijing Hospital Jianye Wang","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021964629","display_name":"Haoran Xia","orcid":"https://orcid.org/0000-0002-4040-3061","observed_orcids":["https://orcid.org/0000-0002-4040-3061"]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoran Xia","raw_affiliation_strings":["Beijing Hospital","Beijing Hospital Jianye Wang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Hospital","institution_ids":["https://openalex.org/I4210119648"]},{"raw_affiliation_string":"Beijing Hospital Jianye Wang","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092469461","display_name":"Ming Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Liu","raw_affiliation_strings":["Beijing Hospital","Beijing Hospital Jianye Wang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Hospital","institution_ids":["https://openalex.org/I4210119648"]},{"raw_affiliation_string":"Beijing Hospital Jianye Wang","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100666570","display_name":"Jianlong Wang","orcid":"https://orcid.org/0000-0002-1317-6457","observed_orcids":["https://orcid.org/0000-0002-1317-6457","https://orcid.org/0000-0003-4667-9365"]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianlong Wang","raw_affiliation_strings":["Beijing Hospital","Beijing Hospital Jianye Wang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Hospital","institution_ids":["https://openalex.org/I4210119648"]},{"raw_affiliation_string":"Beijing Hospital Jianye Wang","institution_ids":["https://openalex.org/I4210119648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073657241","display_name":"Jianye Wang","orcid":"https://orcid.org/0000-0001-7173-566X","observed_orcids":["https://orcid.org/0000-0001-7173-566X"]},"institutions":[{"id":"https://openalex.org/I4210119648","display_name":"Beijing Hospital","ror":"https://ror.org/02jwb5s28","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianye Wang","raw_affiliation_strings":["Beijing Hospital","Beijing Hospital Jianye Wang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Hospital","institution_ids":["https://openalex.org/I4210119648"]},{"raw_affiliation_string":"Beijing Hospital Jianye Wang","institution_ids":["https://openalex.org/I4210119648"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210119648"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.5238999724388123,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.4004000127315521,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":1.0},{"id":"https://openalex.org/keywords/fatty-acid-metabolism","display_name":"fatty acid metabolism","score":0.7889999747276306},{"id":"https://openalex.org/keywords/prognostic-gene-signature","display_name":"prognostic gene signature","score":0.9169999957084656},{"id":"https://openalex.org/keywords/risk-model","display_name":"risk model","score":0.6710000038146973},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tumor-infiltrating-immune-cells","display_name":"tumor-infiltrating immune cells","score":0.8429999947547913},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7730000019073486},{"id":"https://openalex.org/keywords/col1a1","display_name":"COL1A1","score":1.0},{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":0.8059999942779541},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.8999999761581421},{"id":"https://openalex.org/keywords/core-genes","display_name":"core genes","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C34626388","wikidata":"https://www.wikidata.org/wiki/Q721129","display_name":"Nomogram","level":2,"score":0.719660758972168},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5813724994659424},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5796288251876831},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.5730534195899963},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5422230362892151},{"id":"https://openalex.org/C2776991927","wikidata":"https://www.wikidata.org/wiki/Q14860867","display_name":"Fatty acid metabolism","level":3,"score":0.5175361037254333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47315821051597595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42700257897377014},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3849031329154968},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.378060519695282},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33017438650131226},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2155551314353943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1046648621559143}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-3158460/v1","doi":"https://doi.org/10.21203/rs.3.rs-3158460/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3158460/v1","pdf_url":"https://www.researchsquare.com/article/rs-3158460/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-3158460/v1","doi":"https://doi.org/10.21203/rs.3.rs-3158460/v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.21203/rs.3.rs-3158460/v1","pdf_url":"https://www.researchsquare.com/article/rs-3158460/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4384297912.pdf","grobid_xml":"https://content.openalex.org/works/W4384297912.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1554586717","https://openalex.org/W1980568044","https://openalex.org/W1996566824","https://openalex.org/W2076494035","https://openalex.org/W2091853487","https://openalex.org/W2148658155","https://openalex.org/W2159707944","https://openalex.org/W2318531023","https://openalex.org/W2414481435","https://openalex.org/W2519490965","https://openalex.org/W2740317277","https://openalex.org/W2885029979","https://openalex.org/W2922479144","https://openalex.org/W2943709564","https://openalex.org/W2953615255","https://openalex.org/W2954107081","https://openalex.org/W2965102054","https://openalex.org/W2966796460","https://openalex.org/W2969983122","https://openalex.org/W2979586864","https://openalex.org/W2980982934","https://openalex.org/W3019567338","https://openalex.org/W3023288864","https://openalex.org/W3030487508","https://openalex.org/W3036019667","https://openalex.org/W3041991893","https://openalex.org/W3045679402","https://openalex.org/W3048201207","https://openalex.org/W3088639127","https://openalex.org/W3114796419","https://openalex.org/W3118005002","https://openalex.org/W3120729361","https://openalex.org/W3120997854","https://openalex.org/W3126505600","https://openalex.org/W3128646645","https://openalex.org/W3129079324","https://openalex.org/W3132812950","https://openalex.org/W3138197579","https://openalex.org/W3152059945","https://openalex.org/W3157598024","https://openalex.org/W3161783073","https://openalex.org/W3176742459","https://openalex.org/W3179084948","https://openalex.org/W3180733422","https://openalex.org/W3181266640","https://openalex.org/W3195953296","https://openalex.org/W3200912554","https://openalex.org/W3209171435","https://openalex.org/W4213115284","https://openalex.org/W4220751013","https://openalex.org/W4306385820"],"related_works":["https://openalex.org/W4376876494","https://openalex.org/W4390618983","https://openalex.org/W4388996499","https://openalex.org/W4309787450","https://openalex.org/W4292180430","https://openalex.org/W4311925340","https://openalex.org/W4220896278","https://openalex.org/W3180657318","https://openalex.org/W4393208039","https://openalex.org/W3209171435"],"abstract_inverted_index":{"Abstract":[0],"Bladder":[1],"cancer":[2,33],"(BLCA)":[3],"is":[4,161],"the":[5,21,37,73,78,95,165],"common":[6],"malignant":[7],"urinary":[8],"carcinoma":[9],"and":[10,23,45,53,59,63,126,140,150,167,175,184],"do":[11],"not":[12],"have":[13,131],"uniformly":[14],"poor":[15,151],"prognosis.":[16,116,152],"Hence,":[17],"we":[18],"focused":[19],"on":[20,159],"function":[22],"prognostic":[24],"value":[25],"of":[26,81,99,138],"fatty":[27,38,86],"acid":[28,39,87],"metabolism-related":[29,40,88],"genes":[30,41],"in":[31,134,171,193],"bladder":[32],"patients.":[34,83,101,173],"After":[35],"obtained":[36],"(FRGs),":[42],"gene":[43],"expression":[44,137],"corresponding":[46],"clinical":[47],"data":[48],"were":[49,69,112,120,128],"acquired":[50],"from":[51],"TCGA":[52],"GEO":[54],"databases.":[55],"Cox":[56],"regression":[57,67],"analysis":[58,68],"least":[60],"absolute":[61],"shrinkage":[62],"selection":[64],"operator":[65],"(LASSO)":[66],"employed":[70],"to":[71,76,93,114,130,163,169],"establish":[72],"risk":[74,89,149,156,182],"model":[75,157],"estimate":[77],"overall":[79,96],"survival":[80,97],"BCLA":[82],"An":[84],"eight-gene":[85],"signature":[90],"was":[91],"constructed":[92],"predict":[94,164],"(OS)":[98],"BLCA":[100,172,194],"Kaplan-Meier":[102],"curves,":[103,110],"tumor":[104],"mutation":[105],"burden,":[106],"scatter":[107],"diagram,":[108],"ROC":[109],"nomogram":[111],"used":[113],"assess":[115],"The":[117],"immunological":[118],"features":[119],"estimated":[121],"between":[122],"different":[123],"groups.":[124],"IL6":[125,139,174],"COL1A1":[127,141,176],"considered":[129],"important":[132],"role":[133],"subgroups.":[135],"Higher":[136],"are":[142,177],"positive":[143],"correlation":[144],"with":[145,180],"higher":[146,148,181],"grade,":[147],"In":[153],"conclusion,":[154],"this":[155],"based":[158],"8-FLGs":[160],"reliable":[162],"prognosis":[166],"response":[168],"immunotherapy":[170],"closely":[178],"associated":[179],"score":[183],"poorer":[185],"outcomes.":[186],"This":[187],"can":[188],"provide":[189],"a":[190],"novel":[191],"inspective":[192],"treatment.":[195]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-07-15T00:00:00"}